{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:02:24Z","timestamp":1772128944275,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,26]]},"DOI":"10.7759\/cureus.104301","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:09:16Z","timestamp":1772125756000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of BMI on Organs at Risk Dose for Cervical Cancer Treated With Definitive Radiation Therapy Followed by Brachytherapy Boost"],"prefix":"10.7759","author":[{"given":"Justin","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Oska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Small","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyur J","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryung S","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra","family":"Yaparpalvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2020.04.002","article-title":"Radiation therapy for cervical cancer: executive summary of an ASTRO clinical practice guideline","volume":"10","author":"Chino J","year":"2020","unstructured":"Chino J, Annunziata CM, Beriwal S, et al.. Radiation therapy for cervical cancer: executive summary of an ASTRO clinical practice guideline. Pract Radiat Oncol. 2020, 10:220-34. 10.1016\/j.prro.2020.04.002","journal-title":"Pract Radiat Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.07.012","article-title":"Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer","volume":"100","author":"P\u00f6tter R","year":"2011","unstructured":"P\u00f6tter R, Georg P, Dimopoulos JC, et al.. Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer. Radiother Oncol. 2011, 100:116-23. 10.1016\/j.radonc.2011.07.012","journal-title":"Radiother Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.04.016","article-title":"Long term experience with 3D image guided brachytherapy and clinical outcome in cervical cancer patients","volume":"120","author":"Ribeiro I","year":"2016","unstructured":"Ribeiro I, Janssen H, De Brabandere M, Nulens A, De Bal D, Vergote I, Van Limbergen E. Long term experience with 3D image guided brachytherapy and clinical outcome in cervical cancer patients. Radiother Oncol. 2016, 120:447-54. 10.1016\/j.radonc.2016.04.016","journal-title":"Radiother Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.08.027","article-title":"Improved survival of patients with cervical cancer treated with image-guided brachytherapy compared with conventional brachytherapy","volume":"135","author":"Rijkmans EC","year":"2014","unstructured":"Rijkmans EC, Nout RA, Rutten IH, et al.. Improved survival of patients with cervical cancer treated with image-guided brachytherapy compared with conventional brachytherapy. Gynecol Oncol. 2014, 135:231-8. 10.1016\/j.ygyno.2014.08.027","journal-title":"Gynecol Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.03.011","article-title":"Image guided brachytherapy in locally advanced cervical cancer: improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study","volume":"120","author":"Sturdza A","year":"2016","unstructured":"Sturdza A, P\u00f6tter R, Fokdal LU, et al.. Image guided brachytherapy in locally advanced cervical cancer: improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study. Radiother Oncol. 2016, 120:428-33. 10.1016\/j.radonc.2016.03.011","journal-title":"Radiother Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.05.016","article-title":"Bowel morbidity following radiochemotherapy and image-guided adaptive brachytherapy for cervical cancer: physician- and patient reported outcome from the EMBRACE study","volume":"127","author":"Jensen NB","year":"2018","unstructured":"Jensen NB, P\u00f6tter R, Kirchheiner K, et al.. Bowel morbidity following radiochemotherapy and image-guided adaptive brachytherapy for cervical cancer: physician- and patient reported outcome from the EMBRACE study. Radiother Oncol. 2018, 127:431-9. 10.1016\/j.radonc.2018.05.016","journal-title":"Radiother Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30753-1","article-title":"MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study","volume":"22","author":"P\u00f6tter R","year":"2021","unstructured":"P\u00f6tter R, Tanderup K, Schmid MP, et al.. MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study. Lancet Oncol. 2021, 22:538-47. 10.1016\/S1470-2045(20)30753-1","journal-title":"Lancet Oncol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.09.055","article-title":"Severity and persistency of late gastrointestinal morbidity in locally advanced cervical cancer: lessons learned from EMBRACE-I and implications for the future","volume":"112","author":"Spampinato S","year":"2022","unstructured":"Spampinato S, Jensen NB, P\u00f6tter R, et al.. Severity and persistency of late gastrointestinal morbidity in locally advanced cervical cancer: lessons learned from EMBRACE-I and implications for the future. Int J Radiat Oncol Biol Phys. 2022, 112:681-93. 10.1016\/j.ijrobp.2021.09.055","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25544","article-title":"The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapy","volume":"117","author":"Kizer NT","year":"2011","unstructured":"Kizer NT, Thaker PH, Gao F, et al.. The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapy. Cancer. 2011, 117:948-56. 10.1002\/cncr.25544","journal-title":"Cancer"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2013.04.006","article-title":"The impact of body mass index on rectal dose in locally advanced cervical cancer treated with high-dose-rate brachytherapy","volume":"12","author":"Lim J","year":"2013","unstructured":"Lim J, Durbin-Johnson B, Valicenti R, Mathai M, Stern RL, Mayadev J. The impact of body mass index on rectal dose in locally advanced cervical cancer treated with high-dose-rate brachytherapy. Brachytherapy. 2013, 12:550-4. 10.1016\/j.brachy.2013.04.006","journal-title":"Brachytherapy"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001312","article-title":"The effect of body mass index and weight change on late gastrointestinal toxicity in locally advanced cervical cancer treated with intensity-modulated radiotherapy","volume":"28","author":"Lee J","year":"2018","unstructured":"Lee J, Chang CL, Lin JB, et al.. The effect of body mass index and weight change on late gastrointestinal toxicity in locally advanced cervical cancer treated with intensity-modulated radiotherapy. Int J Gynecol Cancer. 2018, 28:1377-86. 10.1097\/IGC.0000000000001312","journal-title":"Int J Gynecol Cancer"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21858","article-title":"Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019","volume":"74","author":"Islami F","year":"2024","unstructured":"Islami F, Marlow EC, Thomson B, et al.. Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019. CA Cancer J Clin. 2024, 74:405-32. 10.3322\/caac.21858","journal-title":"CA Cancer J Clin"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.14.04205","article-title":"Global obesity epidemic and rising incidence of early-onset cancers","volume":"14","author":"Chen J","year":"2024","unstructured":"Chen J, Dalerba P, Terry MB, Yang W. Global obesity epidemic and rising incidence of early-onset cancers. J Glob Health. 2024, 14:04205. 10.7189\/jogh.14.04205","journal-title":"J Glob Health"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.33132","article-title":"Excess body weight and the risk of second primary cancers among cancer survivors","volume":"7","author":"Bodelon C","year":"2024","unstructured":"Bodelon C, Sung H, Mitchell EL, et al.. Excess body weight and the risk of second primary cancers among cancer survivors. JAMA Netw Open. 2024, 7:e2433132. 10.1001\/jamanetworkopen.2024.33132","journal-title":"JAMA Netw Open"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab053","article-title":"Body mass index and risk of second cancer among women with breast cancer","volume":"113","author":"Feigelson HS","year":"2021","unstructured":"Feigelson HS, Bodelon C, Powers JD, et al.. Body mass index and risk of second cancer among women with breast cancer. J Natl Cancer Inst. 2021, 113:1156-60. 10.1093\/jnci\/djab053","journal-title":"J Natl Cancer Inst"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.121","article-title":"Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from Intergroup Trial 0114","volume":"22","author":"Meyerhardt JA","year":"2004","unstructured":"Meyerhardt JA, Tepper JE, Niedzwiecki D, et al.. Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from Intergroup Trial 0114. J Clin Oncol. 2004, 22:648-57. 10.1200\/JCO.2004.07.121","journal-title":"J Clin Oncol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.01.007","article-title":"Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors","volume":"97","author":"Courneya KS","year":"2005","unstructured":"Courneya KS, Karvinen KH, Campbell KL, Pearcey RG, Dundas G, Capstick V, Tonkin KS. Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors. Gynecol Oncol. 2005, 97:422-30. 10.1016\/j.ygyno.2005.01.007","journal-title":"Gynecol Oncol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.3442","article-title":"Epidemiologic evidence that excess body weight increases risk of cervical cancer by decreased detection of precancer","volume":"36","author":"Clarke MA","year":"2018","unstructured":"Clarke MA, Fetterman B, Cheung LC, et al.. Epidemiologic evidence that excess body weight increases risk of cervical cancer by decreased detection of precancer. J Clin Oncol. 2018, 36:1184-91. 10.1200\/JCO.2017.75.3442","journal-title":"J Clin Oncol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten FR","year":"2019","unstructured":"Greten FR, Grivennikov SI. Inflammation and cancer: triggers, mechanisms, and consequences. Immunity. 2019, 51:27-41. 10.1016\/j.immuni.2019.06.025","journal-title":"Immunity"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2024.01.003","article-title":"The obesity-autophagy-cancer axis: mechanistic insights and therapeutic perspectives","volume":"99","author":"Behrooz AB","year":"2024","unstructured":"Behrooz AB, Cordani M, Fiore A, Donadelli M, Gordon JW, Klionsky DJ, Ghavami S. The obesity-autophagy-cancer axis: mechanistic insights and therapeutic perspectives. Semin Cancer Biol. 2024, 99:24-44. 10.1016\/j.semcancer.2024.01.003","journal-title":"Semin Cancer Biol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2008.12.001","article-title":"The effect of obesity on rectal dosimetry after permanent prostate brachytherapy","volume":"8","author":"Patil N","year":"2009","unstructured":"Patil N, Crook J, Saibishkumar EP, Aneja M, Borg J, Pond G, Ma C. The effect of obesity on rectal dosimetry after permanent prostate brachytherapy. Brachytherapy. 2009, 8:218-22. 10.1016\/j.brachy.2008.12.001","journal-title":"Brachytherapy"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/464260-impact-of-bmi-on-organs-at-risk-dose-for-cervical-cancer-treated-with-definitive-radiation-therapy-followed-by-brachytherapy-boost","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:09:16Z","timestamp":1772125756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/464260-impact-of-bmi-on-organs-at-risk-dose-for-cervical-cancer-treated-with-definitive-radiation-therapy-followed-by-brachytherapy-boost"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.104301","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}