{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:22:01Z","timestamp":1772551321421,"version":"3.50.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"DOI":"10.7759\/cureus.104605","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T12:02:36Z","timestamp":1772539356000},"source":"Crossref","is-referenced-by-count":0,"title":["A Case of Three Synchronous Primary Lung Cancers of Distinct Histologies in a Patient With Severe Chronic Obstructive Pulmonary Disease"],"prefix":"10.7759","author":[{"given":"Matthew T","family":"Foley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle A","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheetal","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Pahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Karulf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)40289-4","article-title":"Multiple primary lung cancers","volume":"70","author":"Martini N","year":"1975","unstructured":"Martini N, Melamed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg. 1975, 70:606-12. 10.1016\/S0022-5223(19)40289-4","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.01.024","article-title":"The IASLC lung cancer staging project: summary of proposals for revisions of the classification of lung cancers with multiple pulmonary sites of involvement in the forthcoming eighth edition of the TNM classification","volume":"11","author":"Detterbeck FC","year":"2016","unstructured":"Detterbeck FC, Nicholson AG, Franklin WA, et al.. The IASLC lung cancer staging project: summary of proposals for revisions of the classification of lung cancers with multiple pulmonary sites of involvement in the forthcoming eighth edition of the TNM classification. J Thorac Oncol. 2016, 11:639-50. 10.1016\/j.jtho.2016.01.024","journal-title":"J Thorac Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2014.15.5.646","article-title":"Synchronous triple primary lung cancers: a case report","volume":"15","author":"Yoon HJ","year":"2014","unstructured":"Yoon HJ, Lee HY, Han J, Choi YL. Synchronous triple primary lung cancers: a case report. Korean J Radiol. 2014, 15:646-50. 10.3348\/kjr.2014.15.5.646","journal-title":"Korean J Radiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3614","article-title":"Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: a systematic review and meta-analysis of current evidence","volume":"10","author":"Tie H","year":"2021","unstructured":"Tie H, Luo J, Shi R, Li Z, Chen D, Wu Q. Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: a systematic review and meta-analysis of current evidence. Cancer Med. 2021, 10:507-20. 10.1002\/cam4.3614","journal-title":"Cancer Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivr016","article-title":"Multiple synchronous primary tumours in a single lobe","volume":"14","author":"Sepehripour AH","year":"2012","unstructured":"Sepehripour AH, Nasir A, Shah R. Multiple synchronous primary tumours in a single lobe. Interact Cardiovasc Thorac Surg. 2012, 14:340-1. 10.1093\/icvts\/ivr016","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-022-02111-x","article-title":"Triple primary lung cancer: a case report","volume":"22","author":"Choi HS","year":"2022","unstructured":"Choi HS, Sung JY. Triple primary lung cancer: a case report. BMC Pulm Med. 2022, 22:318. 10.1186\/s12890-022-02111-x","journal-title":"BMC Pulm Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2414059","article-title":"Navigational bronchoscopy or transthoracic needle biopsy for lung nodules","volume":"392","author":"Lentz RJ","year":"2025","unstructured":"Lentz RJ, Frederick-Dyer K, Planz VB, et al.. Navigational bronchoscopy or transthoracic needle biopsy for lung nodules. N Engl J Med. 2025, 392:2100-12. 10.1056\/NEJMoa2414059","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181b8cf03","article-title":"Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases","volume":"33","author":"Girard N","year":"2009","unstructured":"Girard N, Deshpande C, Lau C, Finley D, Rusch V, Pao W, Travis WD. Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases. Am J Surg Pathol. 2009, 33:1752-64. 10.1097\/PAS.0b013e3181b8cf03","journal-title":"Am J Surg Pathol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.653988","article-title":"Molecular identification and genetic characterization of early-stage multiple primary lung cancer by large-panel next-generation sequencing analysis","volume":"11","author":"Pei G","year":"2021","unstructured":"Pei G, Li M, Min X, et al.. Molecular identification and genetic characterization of early-stage multiple primary lung cancer by large-panel next-generation sequencing analysis. Front Oncol. 2021, 11:653988. 10.3389\/fonc.2021.653988","journal-title":"Front Oncol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181c814c5","article-title":"Predictors of outcomes after surgical treatment of synchronous primary lung cancers","volume":"5","author":"Finley DJ","year":"2010","unstructured":"Finley DJ, Yoshizawa A, Travis W, et al.. Predictors of outcomes after surgical treatment of synchronous primary lung cancers. J Thorac Oncol. 2010, 5:197-205. 10.1097\/JTO.0b013e3181c814c5","journal-title":"J Thorac Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30318-2","article-title":"Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial","volume":"18","author":"Faivre-Finn C","year":"2017","unstructured":"Faivre-Finn C, Snee M, Ashcroft L, et al.. Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial. Lancet Oncol. 2017, 18:1116-25. 10.1016\/S1470-2045(17)30318-2","journal-title":"Lancet Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00144208","article-title":"COPD prevalence is increased in lung cancer, independent of age, sex and smoking history","volume":"34","author":"Young RP","year":"2009","unstructured":"Young RP, Hopkins RJ, Christmas T, Black PN, Metcalf P, Gamble GD. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J. 2009, 34:380-6. 10.1183\/09031936.00144208","journal-title":"Eur Respir J"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12661","article-title":"Impact of COPD and emphysema on survival of patients with lung cancer: a meta-analysis of observational studies","volume":"21","author":"Gao YH","year":"2016","unstructured":"Gao YH, Guan WJ, Liu Q, Wang HQ, Zhu YN, Chen RC, Zhang GJ. Impact of COPD and emphysema on survival of patients with lung cancer: a meta-analysis of observational studies. Respirology. 2016, 21:269-79. 10.1111\/resp.12661","journal-title":"Respirology"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/467948-a-case-of-three-synchronous-primary-lung-cancers-of-distinct-histologies-in-a-patient-with-severe-chronic-obstructive-pulmonary-disease","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T12:02:36Z","timestamp":1772539356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/467948-a-case-of-three-synchronous-primary-lung-cancers-of-distinct-histologies-in-a-patient-with-severe-chronic-obstructive-pulmonary-disease"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.104605","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,3]]}}}