{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:20:08Z","timestamp":1772713208950,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"DOI":"10.7759\/cureus.104701","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:25:37Z","timestamp":1772709937000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of a Fixed 1 mg Dose of Granisetron for Preventing Postoperative Nausea and Vomiting (PONV) in Patients Undergoing Laparoscopic Colorectal Surgery With Multiple PONV Risk Factors: A Retrospective Observational Study"],"prefix":"10.7759","author":[{"given":"Takayuki","family":"Morimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihisa","family":"Nishigaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiha","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004833","article-title":"Fourth consensus guidelines for the management of postoperative nausea and vomiting","volume":"131","author":"Gan TJ","year":"2020","unstructured":"Gan TJ, Belani KG, Bergese S, et al.. Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2020, 131:411-48. 10.1213\/ANE.0000000000004833","journal-title":"Anesth Analg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000007816","article-title":"Fifth consensus guidelines for the management of postoperative nausea and vomiting: executive summary","author":"Gan TJ","year":"2025","unstructured":"Gan TJ, Jin Z, Ayad S, et al.. Fifth consensus guidelines for the management of postoperative nausea and vomiting: executive summary. Anesth Analg. 2025, 10.1213\/ANE.0000000000007816","journal-title":"Anesth Analg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X104830","article-title":"Postoperative nausea and vomiting following inpatient surgeries in a teaching hospital: a retrospective database analysis","volume":"22","author":"Habib AS","year":"2006","unstructured":"Habib AS, Chen YT, Taguchi A, Hu XH, Gan TJ. Postoperative nausea and vomiting following inpatient surgeries in a teaching hospital: a retrospective database analysis. Curr Med Res Opin. 2006, 22:1093-9. 10.1185\/030079906X104830","journal-title":"Curr Med Res Opin"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/medicines11070016","article-title":"Postoperative nausea and vomiting in the ambulatory surgery center: a narrative review","volume":"11","author":"Bell J","year":"2024","unstructured":"Bell J, Bindelglass A, Morrone J, Park S, Costa A, Bergese S. Postoperative nausea and vomiting in the ambulatory surgery center: a narrative review. Medicines (Basel). 2024, 11:10.3390\/medicines11070016","journal-title":"Medicines (Basel)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1748837","article-title":"A clinical risk analysis of postoperative nausea and vomiting after colorectal cancer surgery","volume":"42","author":"Hiraki M","year":"2022","unstructured":"Hiraki M, Tanaka T, Koga M, et al.. A clinical risk analysis of postoperative nausea and vomiting after colorectal cancer surgery. J Coloproctol. 2022, 42:203-9. 10.1055\/s-0042-1748837","journal-title":"J Coloproctol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15295","article-title":"Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: an abridged Cochrane network meta-analysis","volume":"76","author":"Weibel S","year":"2021","unstructured":"Weibel S, Schaefer MS, Raj D, et al.. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: an abridged Cochrane network meta-analysis. Anaesthesia. 2021, 76:962-73. 10.1111\/anae.15295","journal-title":"Anaesthesia"},{"key":"ref7","unstructured":"Pharmaceuticals and Medical Devices Agency (PMDA). Granisetron hydrochloride injection. Japanese package insert. (2022). Accessed: February 1, 2026: https:\/\/www.pmda.go.jp\/PmdaSearch\/iyakuDetail\/ResultDataSetPDF\/650014_2391400G1156_1_07."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"147","author":"von Elm E","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007, 147:573-7. 10.7326\/0003-4819-147-8-200710160-00010","journal-title":"Ann Intern Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes276","article-title":"Evidence-based analysis of risk factors for postoperative nausea and vomiting","volume":"109","author":"Apfel CC","year":"2012","unstructured":"Apfel CC, Heidrich FM, Jukar-Rao S, et al.. Evidence-based analysis of risk factors for postoperative nausea and vomiting. Br J Anaesth. 2012, 109:742-53. 10.1093\/bja\/aes276","journal-title":"Br J Anaesth"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-004-0236-6","article-title":"Efficacy of prophylactic intravenous granisetron in postoperative emesis in adults","volume":"18","author":"Hanaoka K","year":"2004","unstructured":"Hanaoka K, Toyooka H, Kugimiya T, Ohashi Y. Efficacy of prophylactic intravenous granisetron in postoperative emesis in adults. J Anesth. 2004, 18:158-65. 10.1007\/s00540-004-0236-6","journal-title":"J Anesth"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2006.05.003","article-title":"A randomized blinded study of the incidence of postoperative nausea and vomiting in women after major gynecologic laparoscopic surgery","volume":"13","author":"Tseng LH","year":"2006","unstructured":"Tseng LH, Liou SC, Chang TC, Tsai SC, Soong YK, Wong SY. A randomized blinded study of the incidence of postoperative nausea and vomiting in women after major gynecologic laparoscopic surgery. J Minim Invasive Gynecol. 2006, 13:413-7. 10.1016\/j.jmig.2006.05.003","journal-title":"J Minim Invasive Gynecol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_84_18","article-title":"Comparison of palonosetron with granisetron for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic abdominal surgery","volume":"12","author":"Tahir S","year":"2018","unstructured":"Tahir S, Mir AA, Hameed A. Comparison of palonosetron with granisetron for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic abdominal surgery. Anesth Essays Res. 2018, 12:636-43. 10.4103\/aer.AER_84_18","journal-title":"Anesth Essays Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-023-09939-2","article-title":"Effects of ondansetron, metoclopramide and granisetron on perioperative nausea and vomiting in patients undergone bariatric surgery: a randomized clinical trial","volume":"37","author":"Ebrahimian M","year":"2023","unstructured":"Ebrahimian M, Mirhashemi SH, Oshidari B, Zamani A, Shadidi-Asil R, Kialashaki M, Ghayebi N. Effects of ondansetron, metoclopramide and granisetron on perioperative nausea and vomiting in patients undergone bariatric surgery: a randomized clinical trial. Surg Endosc. 2023, 37:4495-504. 10.1007\/s00464-023-09939-2","journal-title":"Surg Endosc"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF03011739","article-title":"Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo","volume":"43","author":"Naguib M","year":"1996","unstructured":"Naguib M, el Bakry AK, Khoshim MH, et al.. Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo. Can J Anaesth. 1996, 43:226-31. 10.1007\/BF03011739","journal-title":"Can J Anaesth"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-015-0102-0","article-title":"Comparison of palonosetron, granisetron, and ramosetron for the prevention of postoperative nausea and vomiting after laparoscopic gynecologic surgery: a prospective randomized trial","volume":"15","author":"Lee WS","year":"2015","unstructured":"Lee WS, Lee KB, Lim S, Chang YG. Comparison of palonosetron, granisetron, and ramosetron for the prevention of postoperative nausea and vomiting after laparoscopic gynecologic surgery: a prospective randomized trial. BMC Anesthesiol. 2015, 15:121. 10.1186\/s12871-015-0102-0","journal-title":"BMC Anesthesiol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2007.10.003","article-title":"Effects of ondansetron and granisetron on postoperative nausea and vomiting in adult patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled clinical trial","volume":"68","author":"Bestas A","year":"2007","unstructured":"Bestas A, Onal SA, Bayar MK, Yildirim A, Aygen E. Effects of ondansetron and granisetron on postoperative nausea and vomiting in adult patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled clinical trial. Curr Ther Res Clin Exp. 2007, 68:303-12. 10.1016\/j.curtheres.2007.10.003","journal-title":"Curr Ther Res Clin Exp"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.191121","article-title":"Palonosetron and granisetron in postoperative nausea vomiting: a randomized double-blind prospective study","volume":"10","author":"Gugale AA","year":"2016","unstructured":"Gugale AA, Bhalerao PM. Palonosetron and granisetron in postoperative nausea vomiting: a randomized double-blind prospective study. Anesth Essays Res. 2016, 10:402-7. 10.4103\/0259-1162.191121","journal-title":"Anesth Essays Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-6-6","article-title":"Anesthesiologists' practice patterns for treatment of postoperative nausea and vomiting in the ambulatory Post Anesthesia Care Unit","volume":"6","author":"Macario A","year":"2006","unstructured":"Macario A, Claybon L, Pergolizzi JV. Anesthesiologists' practice patterns for treatment of postoperative nausea and vomiting in the ambulatory Post Anesthesia Care Unit. BMC Anesthesiol. 2006, 6:6. 10.1186\/1471-2253-6-6","journal-title":"BMC Anesthesiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199611000-00016","article-title":"The dose-response relation and cost-effectiveness of granisetron for the prophylaxis of pediatric postoperative emesis","volume":"85","author":"Cieslak GD","year":"1996","unstructured":"Cieslak GD, Watcha MF, Phillips MB, Pennant JH. The dose-response relation and cost-effectiveness of granisetron for the prophylaxis of pediatric postoperative emesis. Anesthesiology. 1996, 85:1076-85. 10.1097\/00000542-199611000-00016","journal-title":"Anesthesiology"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2021.02.049","article-title":"The effect of 1-mg versus 3-mg granisetron on shivering and nausea in cesarean section: a randomized, controlled, triple-blind, clinical trial","volume":"72","author":"Dehghanpisheh L","year":"2022","unstructured":"Dehghanpisheh L, Azemati S, Hamedi M, Fattahisaravi Z. The effect of 1-mg versus 3-mg granisetron on shivering and nausea in cesarean section: a randomized, controlled, triple-blind, clinical trial. Braz J Anesthesiol. 2022, 72:457-65. 10.1016\/j.bjane.2021.02.049","journal-title":"Braz J Anesthesiol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/76.4.515","article-title":"Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting","volume":"76","author":"Wilson AJ","year":"1996","unstructured":"Wilson AJ, Diemunsch P, Lindeque BG, Scheinin H, Helbo-Hansen HS, Kroeks MV, Kong KL. Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting. Br J Anaesth. 1996, 76:515-8. 10.1093\/bja\/76.4.515","journal-title":"Br J Anaesth"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/s0952-8180(97)00190-6","article-title":"A double-blind, parallel-group, placebo-controlled, dose-ranging, multicenter study of intravenous granisetron in the treatment of postoperative nausea and vomiting in patients undergoing surgery with general anesthesia","volume":"9","author":"Taylor AM","year":"1997","unstructured":"Taylor AM, Rosen M, Diemunsch PA, Thorin D, Houweling PL. A double-blind, parallel-group, placebo-controlled, dose-ranging, multicenter study of intravenous granisetron in the treatment of postoperative nausea and vomiting in patients undergoing surgery with general anesthesia. J Clin Anesth. 1997, 9:658-63. 10.1016\/s0952-8180(97)00190-6","journal-title":"J Clin Anesth"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199505000-00020","article-title":"The antiemetic efficacy of prophylactic granisetron in gynecologic surgery","volume":"80","author":"Mikawa K","year":"1995","unstructured":"Mikawa K, Takao Y, Nishina K, Maekawa N, Obara H. The antiemetic efficacy of prophylactic granisetron in gynecologic surgery. Anesth Analg. 1995, 80:970-4. 10.1097\/00000539-199505000-00020","journal-title":"Anesth Analg"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199709000-00030","article-title":"Optimal dose of granisetron for prophylaxis against postoperative emesis after gynecological surgery","volume":"85","author":"Mikawa K","year":"1997","unstructured":"Mikawa K, Takao Y, Nishina K, Shiga M, Maekawa N, Obara H. Optimal dose of granisetron for prophylaxis against postoperative emesis after gynecological surgery. Anesth Analg. 1997, 85:652-6. 10.1097\/00000539-199709000-00030","journal-title":"Anesth Analg"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254104","article-title":"A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT3 receptor antagonist: correlation with anti-emetic response","volume":"24","author":"Carmichael J","year":"1989","unstructured":"Carmichael J, Cantwell BM, Edwards CM, Zussman BD, Thompson S, Rapeport WG, Harris AL. A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT3 receptor antagonist: correlation with anti-emetic response. Cancer Chemother Pharmacol. 1989, 24:45-9. 10.1007\/BF00254104","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-004-0798-x","article-title":"Receptor occupancy theory-based analysis of antiemetic effects and standard doses of 5-HT3 receptor antagonists in cancer patients","volume":"54","author":"Yamada Y","year":"2004","unstructured":"Yamada Y, Sugiura M, Higo K, et al.. Receptor occupancy theory-based analysis of antiemetic effects and standard doses of 5-HT3 receptor antagonists in cancer patients. Cancer Chemother Pharmacol. 2004, 54:185-90. 10.1007\/s00280-004-0798-x","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-009-0912-5","article-title":"Receptor occupancy theory-based analysis of interindividual differences in antiemetic effects of 5-HT3 receptor antagonists","volume":"14","author":"Ayuhara H","year":"2009","unstructured":"Ayuhara H, Takayanagi R, Okuyama K, Yoshimoto K, Ozeki T, Yokoyama H, Yamada Y. Receptor occupancy theory-based analysis of interindividual differences in antiemetic effects of 5-HT3 receptor antagonists. Int J Clin Oncol. 2009, 14:518-24. 10.1007\/s10147-009-0912-5","journal-title":"Int J Clin Oncol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b12-00946","article-title":"Method for individualized evaluation of antiemetic effect induced by 5-HT3 receptor antagonist","volume":"36","author":"Nakamura H","year":"2013","unstructured":"Nakamura H, Yokoyama H, Yoshimoto K, Nakajima A, Okuyama K, Iwase O, Yamada Y. Method for individualized evaluation of antiemetic effect induced by 5-HT3 receptor antagonist. Biol Pharm Bull. 2013, 36:780-7. 10.1248\/bpb.b12-00946","journal-title":"Biol Pharm Bull"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.12.011","article-title":"A randomized, double-blind, placebo-controlled, multicenter, repeat-dose study of two intravenous acetaminophen dosing regimens for the treatment of pain after abdominal laparoscopic surgery","volume":"32","author":"Wininger SJ","year":"2010","unstructured":"Wininger SJ, Miller H, Minkowitz HS, Royal MA, Ang RY, Breitmeyer JB, Singla NK. A randomized, double-blind, placebo-controlled, multicenter, repeat-dose study of two intravenous acetaminophen dosing regimens for the treatment of pain after abdominal laparoscopic surgery. Clin Ther. 2010, 32:2348-69. 10.1016\/j.clinthera.2010.12.011","journal-title":"Clin Ther"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2009.08.026","article-title":"A multicenter, randomized, double-blind, placebo-controlled trial of intravenous ibuprofen 400 and 800 mg every 6 hours in the management of postoperative pain","volume":"31","author":"Southworth S","year":"2009","unstructured":"Southworth S, Peters J, Rock A, Pavliv L. A multicenter, randomized, double-blind, placebo-controlled trial of intravenous ibuprofen 400 and 800 mg every 6 hours in the management of postoperative pain. Clin Ther. 2009, 31:1922-35. 10.1016\/j.clinthera.2009.08.026","journal-title":"Clin Ther"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/464892-association-of-a-fixed-1-mg-dose-of-granisetron-for-preventing-postoperative-nausea-and-vomiting-ponv-in-patients-undergoing-laparoscopic-colorectal-surgery-with-multiple-ponv-risk-factors-a-retrospective-observational-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:25:39Z","timestamp":1772709939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/464892-association-of-a-fixed-1-mg-dose-of-granisetron-for-preventing-postoperative-nausea-and-vomiting-ponv-in-patients-undergoing-laparoscopic-colorectal-surgery-with-multiple-ponv-risk-factors-a-retrospective-observational-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.104701","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}