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Intern Med. 2021, 60:2525-6. 10.2169\/internalmedicine.7083-21","journal-title":"Intern Med"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.13114","article-title":"Increased interleukin-6 levels are associated with atrioventricular conduction delay in severe COVID-19 patients","volume":"40","author":"Accioli R","year":"2024","unstructured":"Accioli R, Lazzerini PE, Salvini V, et al.. Increased interleukin-6 levels are associated with atrioventricular conduction delay in severe COVID-19 patients. J Arrhythm. 2024, 40:1137-48. 10.1002\/joa3.13114","journal-title":"J Arrhythm"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29018","article-title":"Association of remdesivir use with bradycardia: a systematic review and meta-analysis","volume":"95","author":"Ishisaka Y","year":"2023","unstructured":"Ishisaka Y, Aikawa T, Malik A, Kampaktsis PN, Briasoulis A, Kuno T. Association of remdesivir use with bradycardia: a systematic review and meta-analysis. J Med Virol. 2023, 95:e29018. 10.1002\/jmv.29018","journal-title":"J Med Virol"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12247518","article-title":"Remdesivir-induced bradycardia and mortality in SARS-CoV-2 infection, potential risk factors assessment: a systematic review and meta-analysis","volume":"12","author":"Ai MY","year":"2023","unstructured":"Ai MY, Chang WL, Yang CJ. Remdesivir-induced bradycardia and mortality in SARS-CoV-2 infection, potential risk factors assessment: a systematic review and meta-analysis. J Clin Med. 2023, 12:7518. 10.3390\/jcm12247518","journal-title":"J Clin Med"},{"key":"ref64","unstructured":"International Classification of Diseases 11th revision (ICD-11). The global standard for diagnostic health information. (2024). Accessed. February 1, 2026: https:\/\/icd.who.int\/en\/."},{"key":"ref65","unstructured":"CARE Case Report Guidelines. Writing a case report. (2026). Accessed. February 1, 2026: https:\/\/www.care-statement.org\/writing-a-case-report."},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.03.001","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"134","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. J Clin Epidemiol. 2021, 134:178-89. 10.1016\/j.jclinepi.2021.03.001","journal-title":"J Clin Epidemiol"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1080\/02763869.2019.1588072","article-title":"PROSPERO: An International Register of Systematic Review Protocols","volume":"38","author":"Schiavo JH","year":"2019","unstructured":"Schiavo JH. PROSPERO: An International Register of Systematic Review Protocols. Med Ref Serv Q. 2019, 38:171-80. 10.1080\/02763869.2019.1588072","journal-title":"Med Ref Serv Q"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.5847\/wjem.j.1920-8642.2025.107","article-title":"BRASH syndrome: a systematic review of clinical manifestations and associated risk factors","volume":"16","author":"Tomulescu SA","year":"2025","unstructured":"Tomulescu SA, Bavestrello Piccini G, Ni\u021b\u0103 C, et al.. BRASH syndrome: a systematic review of clinical manifestations and associated risk factors. World J Emerg Med. 2025, 16:521-31. 10.5847\/wjem.j.1920-8642.2025.107","journal-title":"World J Emerg Med"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.101663","article-title":"BRASH syndrome: a systematic review of reported cases","volume":"48","author":"Majeed H","year":"2023","unstructured":"Majeed H, Khan U, Khan AM, et al.. BRASH syndrome: a systematic review of reported cases. 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