{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:35:27Z","timestamp":1773203727434,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,10]]},"DOI":"10.7759\/cureus.104961","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:13:37Z","timestamp":1773126817000},"source":"Crossref","is-referenced-by-count":0,"title":["Neuropeptide Y Promoter Variant rs16147 (-399 T\/C) Is Associated With Susceptibility to Polycystic Ovary Syndrome"],"prefix":"10.7759","author":[{"given":"Fulya","family":"Yukcu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raziye","family":"Akcilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Biyik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil Ibrahim","family":"Sisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/26334941241270372","article-title":"Validation of the follicular and ovarian thresholds by an 18-MHz ultrasound imaging in polycystic ovary syndrome: a pilot cutoff for North African patients","volume":"18","author":"Ach T","year":"2024","unstructured":"Ach T, Guesmi A, Kalboussi M, Ben Abdessalem F, Mraihi E, El Mhabrech H. Validation of the follicular and ovarian thresholds by an 18-MHz ultrasound imaging in polycystic ovary syndrome: a pilot cutoff for North African patients. Ther Adv Reprod Health. 2024, 18:26334941241270372. 10.1177\/26334941241270372","journal-title":"Ther Adv Reprod Health"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105716","article-title":"A blocking antibody against anti-M\u00fcllerian hormone restores ovulation and normal androgen levels in a spontaneous rat model of polycystic ovary syndrome","volume":"115","author":"Racine C","year":"2025","unstructured":"Racine C, Fraissinet F, Tolu S, et al.. A blocking antibody against anti-M\u00fcllerian hormone restores ovulation and normal androgen levels in a spontaneous rat model of polycystic ovary syndrome. EBioMedicine. 2025, 115:105716. 10.1016\/j.ebiom.2025.105716","journal-title":"EBioMedicine"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-04120-z","article-title":"Unveiling lipoprotein subfractions signature in high-FNPO PCOS: implications for PCOM diagnosis and risk assessment using advanced machine learning models","volume":"23","author":"Yan X","year":"2025","unstructured":"Yan X, Yang Z, Zhao H, et al.. Unveiling lipoprotein subfractions signature in high-FNPO PCOS: implications for PCOM diagnosis and risk assessment using advanced machine learning models. BMC Med. 2025, 23:289. 10.1186\/s12916-025-04120-z","journal-title":"BMC Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2174\/0109298665309949240822105900","article-title":"Neuropeptide network of polycystic ovary syndrome - a review","volume":"31","author":"Jayamurali D","year":"2024","unstructured":"Jayamurali D, Ravishankar N, Manoharan N, Parasuraman R, Jayashankar SK, Govindarajulu SN. Neuropeptide network of polycystic ovary syndrome - a review. Protein Pept Lett. 2024, 31:667-80. 10.2174\/0109298665309949240822105900","journal-title":"Protein Pept Lett"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/gmit.gmit_106_23","article-title":"Association of gene polymorphisms with polycystic ovary syndrome: a meta-analysis","volume":"13","author":"Abinaya GP","year":"2024","unstructured":"Abinaya GP, Iyshwarya BK, Veerabathiran R. Association of gene polymorphisms with polycystic ovary syndrome: a meta-analysis. Gynecol Minim Invasive Ther. 2024, 13:232-40. 10.4103\/gmit.gmit_106_23","journal-title":"Gynecol Minim Invasive Ther"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-021-00879-w","article-title":"The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis","volume":"14","author":"Chaudhary H","year":"2021","unstructured":"Chaudhary H, Patel J, Jain NK, Joshi R. The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis. J Ovarian Res. 2021, 14:125. 10.1186\/s13048-021-00879-w","journal-title":"J Ovarian Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-023-00460-8","article-title":"Potential for NPY receptor-related therapies for polycystic ovary syndrome: an updated review","volume":"22","author":"Chen WH","year":"2023","unstructured":"Chen WH, Shi YC, Huang QY, Chen JM, Wang ZY, Lin S, Shi QY. Potential for NPY receptor-related therapies for polycystic ovary syndrome: an updated review. Hormones (Athens). 2023, 22:441-51. 10.1007\/s42000-023-00460-8","journal-title":"Hormones (Athens)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-023-01261-8","article-title":"Neuropeptide Y directly reduced apoptosis of granulosa cells, and the expression of NPY and its receptors in PCOS subjects","volume":"16","author":"Urata Y","year":"2023","unstructured":"Urata Y, Salehi R, Wyse BA, et al.. Neuropeptide Y directly reduced apoptosis of granulosa cells, and the expression of NPY and its receptors in PCOS subjects. J Ovarian Res. 2023, 16:182. 10.1186\/s13048-023-01261-8","journal-title":"J Ovarian Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000346799","article-title":"Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women","volume":"62","author":"Mutschler J","year":"2013","unstructured":"Mutschler J, Abbruzzese E, Wiedemann K, et al.. Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women. Ann Nutr Metab. 2013, 62:271-6. 10.1159\/000346799","journal-title":"Ann Nutr Metab"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group","year":"2004","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004, 19:41-7. 10.1093\/humrep\/deh098","journal-title":"Hum Reprod"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.humgen.2023.201251","article-title":"Promoter polymorphisms of neuropeptide Y, interleukin-1B and increased IL-1\u03b2 levels are associated with rheumatoid arthritis susceptibility in South Gujarat population","volume":"39","author":"Giri P","year":"2024","unstructured":"Giri P, Parmar M, Ezhuthachan DD, Desai T, Dwivedi M. Promoter polymorphisms of neuropeptide Y, interleukin-1B and increased IL-1\u03b2 levels are associated with rheumatoid arthritis susceptibility in South Gujarat population. Hum Gene. 2024, 39:201251. 10.1016\/j.humgen.2023.201251","journal-title":"Hum Gene"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170524","article-title":"Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: a longitudinal birth cohort study","volume":"139","author":"Katus U","year":"2021","unstructured":"Katus U, Villa I, Ringmets I, Veidebaum T, Harro J. Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: a longitudinal birth cohort study. Peptides. 2021, 139:170524. 10.1016\/j.peptides.2021.170524","journal-title":"Peptides"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-025-01621-6","article-title":"Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation","volume":"18","author":"Su P","year":"2025","unstructured":"Su P, Chen C, Sun Y. Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation. J Ovarian Res. 2025, 18:34. 10.1186\/s13048-025-01621-6","journal-title":"J Ovarian Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1085656","article-title":"Relationship between body composition, insulin resistance, and hormonal profiles in women with polycystic ovary syndrome","volume":"13","author":"Zhang H","year":"2022","unstructured":"Zhang H, Wang W, Zhao J, et al.. Relationship between body composition, insulin resistance, and hormonal profiles in women with polycystic ovary syndrome. Front Endocrinol (Lausanne). 2022, 13:1085656. 10.3389\/fendo.2022.1085656","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12964","article-title":"Comparison of regional fat mass measurement by whole body DXA scans and anthropometric measures to predict insulin resistance in women with polycystic ovary syndrome and controls","volume":"95","author":"Glintborg D","year":"2016","unstructured":"Glintborg D, Petersen MH, Ravn P, Hermann AP, Andersen M. Comparison of regional fat mass measurement by whole body DXA scans and anthropometric measures to predict insulin resistance in women with polycystic ovary syndrome and controls. Acta Obstet Gynecol Scand. 2016, 95:1235-43. 10.1111\/aogs.12964","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218","article-title":"The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"31","author":"Bozdag G","year":"2016","unstructured":"Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2016, 31:2841-55. 10.1093\/humrep\/dew218","journal-title":"Hum Reprod"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz R","year":"2016","unstructured":"Azziz R, Carmina E, Chen Z, et al.. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016, 2:16057. 10.1038\/nrdp.2016.57","journal-title":"Nat Rev Dis Primers"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081922","article-title":"Hirsutism, normal androgens and diagnosis of PCOS","volume":"12","author":"Spritzer PM","year":"2022","unstructured":"Spritzer PM, Marchesan LB, Santos BR, Fighera TM. Hirsutism, normal androgens and diagnosis of PCOS. Diagnostics (Basel). 2022, 12:1922. 10.3390\/diagnostics12081922","journal-title":"Diagnostics (Basel)"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168713","article-title":"Impact of smoking and obesity on the selected peptide hormones and metabolic parameters in the blood of women with polycystic ovary syndrome-preliminary study","volume":"25","author":"Niepsuj J","year":"2024","unstructured":"Niepsuj J, Piwowar A, Franik G, Bizo\u0144 A. Impact of smoking and obesity on the selected peptide hormones and metabolic parameters in the blood of women with polycystic ovary syndrome-preliminary study. Int J Mol Sci. 2024, 25:8713. 10.3390\/ijms25168713","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_576_17","article-title":"Oxidative stress and polycystic ovary syndrome: a brief review","volume":"10","author":"Mohammadi M","year":"2019","unstructured":"Mohammadi M. Oxidative stress and polycystic ovary syndrome: a brief review. Int J Prev Med. 2019, 10:86. 10.4103\/ijpvm.IJPVM_576_17","journal-title":"Int J Prev Med"},{"key":"ref21","article-title":"Relationship between NPY gene polymorphism in rs16147 region and some physiological variables in type 2 diabetic patients in Al-Anbar province\u2014Iraq","volume":"11","author":"Al-Barzanji SJ","year":"2019","unstructured":"Al-Barzanji SJ, Al-Darraji MN. Relationship between NPY gene polymorphism in rs16147 region and some physiological variables in type 2 diabetic patients in Al-Anbar province\u2014Iraq. J Pharm Sci Res. 2019, 11:140-3.","journal-title":"J Pharm Sci Res"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5080\/u25044","article-title":"Relationship between alcohol dependence and neuropeptide Y (NPY) gene promoter polymorphisms in a Turkish sample (Article in Turkish)","volume":"31","author":"Akel Bilgi\u00e7 H","year":"2020","unstructured":"Akel Bilgi\u00e7 H, G\u00fcrel \u015eC, Ayhan Y, et al.. Relationship between alcohol dependence and neuropeptide Y (NPY) gene promoter polymorphisms in a Turkish sample (Article in Turkish). Turk Psikiyatri Derg. 2020, 31:232-8. 10.5080\/u25044","journal-title":"Turk Psikiyatri Derg"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2023.23","article-title":"Neuropeptide Y gene variants and agreeableness: interaction effect with the birth cohort and the serotonin transporter promoter polymorphism","volume":"36","author":"Kiive E","year":"2024","unstructured":"Kiive E, Kanarik M, Veidebaum T, Harro J. Neuropeptide Y gene variants and agreeableness: interaction effect with the birth cohort and the serotonin transporter promoter polymorphism. Acta Neuropsychiatr. 2024, 36:1-8. 10.1017\/neu.2023.23","journal-title":"Acta Neuropsychiatr"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.9734\/BJMMR\/2016\/24670","article-title":"Association of the lipoprotein lipase S447X and neuropeptide Y Leu7Pro genetic polymorphisms with the lipid profiles of individuals with and without evidence of coronary artery disease","volume":"16","author":"Pinheiro WO","year":"2016","unstructured":"Pinheiro WO, Marques CR, Rios-Santos F, et al.. Association of the lipoprotein lipase S447X and neuropeptide Y Leu7Pro genetic polymorphisms with the lipid profiles of individuals with and without evidence of coronary artery disease. J Adv Med Med Res. 2016, 16:1-10. 10.9734\/BJMMR\/2016\/24670","journal-title":"J Adv Med Med Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-025-07312-1","article-title":"The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome","volume":"18","author":"Hamidi H","year":"2025","unstructured":"Hamidi H, Kheirollahi A, Vatannejad A. The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome. BMC Res Notes. 2025, 18:242. 10.1186\/s13104-025-07312-1","journal-title":"BMC Res Notes"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-021-01787-7","article-title":"Nutrigenetic variants and response to diet\/lifestyle intervention in obese subjects: a pilot study","volume":"59","author":"Franzago M","year":"2022","unstructured":"Franzago M, Di Nicola M, Fraticelli F, Marchioni M, Stuppia L, Vitacolonna E. Nutrigenetic variants and response to diet\/lifestyle intervention in obese subjects: a pilot study. Acta Diabetol. 2022, 59:69-81. 10.1007\/s00592-021-01787-7","journal-title":"Acta Diabetol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/472531-neuropeptide-y-promoter-variant-rs16147--399-tc-is-associated-with-susceptibility-to-polycystic-ovary-syndrome","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:13:38Z","timestamp":1773126818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/472531-neuropeptide-y-promoter-variant-rs16147--399-tc-is-associated-with-susceptibility-to-polycystic-ovary-syndrome"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.104961","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,10]]}}}