{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:28:56Z","timestamp":1773314936772,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,11]]},"DOI":"10.7759\/cureus.105046","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:15:37Z","timestamp":1773249337000},"source":"Crossref","is-referenced-by-count":0,"title":["Tumefactive Multiple Sclerosis Mimicking an Intracranial Mass in a 34-Year-Old Man: A Case Report"],"prefix":"10.7759","author":[{"given":"Zaid","family":"Al Hassani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razan","family":"Darwish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashar","family":"Al Samirraie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Aal Yaseen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Areen","family":"Said","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2010.00502.x","article-title":"Characteristic neuroimaging in patients with tumefactive demyelinating lesions exceeding 30 mm","volume":"21","author":"Kiriyama T","year":"2011","unstructured":"Kiriyama T, Kataoka H, Taoka T, et al.. Characteristic neuroimaging in patients with tumefactive demyelinating lesions exceeding 30 mm. J Neuroimaging. 2011, 21:e69-77. 10.1111\/j.1552-6569.2010.00502.x","journal-title":"J Neuroimaging"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2008.09.002","article-title":"The clinical epidemiology of multiple sclerosis","volume":"18","author":"Confavreux C","year":"2008","unstructured":"Confavreux C, Vukusic S. The clinical epidemiology of multiple sclerosis. Neuroimaging Clin N Am. 2008, 18:589-622. 10.1016\/j.nic.2008.09.002","journal-title":"Neuroimaging Clin N Am"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000319","article-title":"Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms","volume":"7","author":"Lin X","year":"2017","unstructured":"Lin X, Yu WY, Liauw L, Chander RJ, Soon WE, Lee HY, Tan K. Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms. Neurol Clin Pract. 2017, 7:53-64. 10.1212\/CPJ.0000000000000319","journal-title":"Neurol Clin Pract"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn098","article-title":"Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis","volume":"131","author":"Lucchinetti CF","year":"2008","unstructured":"Lucchinetti CF, Gavrilova RH, Metz I, et al.. Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis. Brain. 2008, 131:1759-75. 10.1093\/brain\/awn098","journal-title":"Brain"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15182","article-title":"Population-based incidence and clinico-radiological characteristics of tumefactive demyelination in Olmsted County, Minnesota, United States","volume":"29","author":"Fereidan-Esfahani M","year":"2022","unstructured":"Fereidan-Esfahani M, Decker PA, Eckel Passow JE, Lucchinetti CF, Flanagan EP, Tobin WO. Population-based incidence and clinico-radiological characteristics of tumefactive demyelination in Olmsted County, Minnesota, United States. Eur J Neurol. 2022, 29:782-9. 10.1111\/ene.15182","journal-title":"Eur J Neurol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0178-z","article-title":"The pathological spectrum of CNS inflammatory demyelinating diseases","volume":"31","author":"Hu W","year":"2009","unstructured":"Hu W, Lucchinetti CF. The pathological spectrum of CNS inflammatory demyelinating diseases. Semin Immunopathol. 2009, 31:439-53. 10.1007\/s00281-009-0178-z","journal-title":"Semin Immunopathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304498","article-title":"Tumefactive demyelination: an approach to diagnosis and management","volume":"84","author":"Hardy TA","year":"2013","unstructured":"Hardy TA, Chataway J. Tumefactive demyelination: an approach to diagnosis and management. J Neurol Neurosurg Psychiatry. 2013, 84:1047-53. 10.1136\/jnnp-2012-304498","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3348\/jksr.2013.69.5.337","article-title":"A tumefactive multiple sclerosis lesion in the brain: an uncommon site with atypical magnetic resonance image findings","volume":"69","author":"Jeong MS","year":"2013","unstructured":"Jeong MS, Kim HS, Kim JH, et al.. A tumefactive multiple sclerosis lesion in the brain: an uncommon site with atypical magnetic resonance image findings. J Korean Soc Radiol. 2013, 69:337-41. 10.3348\/jksr.2013.69.5.337","journal-title":"J Korean Soc Radiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.3738","article-title":"Tumefactive multiple sclerosis, a rare variant presenting as multiple ring-enhancing lesions in an immunocompetent patient: a case report","volume":"10","author":"Zaheer K","year":"2018","unstructured":"Zaheer K, Ajmeri AN, Singh M, Suliman MS, Teka S. Tumefactive multiple sclerosis, a rare variant presenting as multiple ring-enhancing lesions in an immunocompetent patient: a case report. Cureus. 2018, 10:e3738. 10.7759\/cureus.3738","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/363705","article-title":"Multiple large tumefactive MS plaques in a young man: a diagnostic enigma and therapeutic challenge","volume":"2012","author":"Kalanie H","year":"2012","unstructured":"Kalanie H, Harandi AA, Bakhshandehpour R, Heidari D. Multiple large tumefactive MS plaques in a young man: a diagnostic enigma and therapeutic challenge. Case Rep Radiol. 2012, 2012:363705. 10.1155\/2012\/363705","journal-title":"Case Rep Radiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.41845","article-title":"Tumefactive multiple sclerosis: challenges with treatment modalities","volume":"15","author":"ElSaygh J","year":"2023","unstructured":"ElSaygh J, Kandinova N, Zaher A, Sunner GK, Kostanyan S. Tumefactive multiple sclerosis: challenges with treatment modalities. Cureus. 2023, 15:e41845. 10.7759\/cureus.41845","journal-title":"Cureus"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/470396-tumefactive-multiple-sclerosis-mimicking-an-intracranial-mass-in-a-34-year-old-man-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:15:37Z","timestamp":1773249337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/470396-tumefactive-multiple-sclerosis-mimicking-an-intracranial-mass-in-a-34-year-old-man-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":11,"URL":"https:\/\/doi.org\/10.7759\/cureus.105046","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,11]]}}}