{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:55:14Z","timestamp":1773323714431,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,11]]},"DOI":"10.7759\/cureus.105067","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:23:46Z","timestamp":1773267826000},"source":"Crossref","is-referenced-by-count":0,"title":["A Novel Protocol to Accelerate Functional Orthopedic Treatment Using Low-Intensity Pulsed Ultrasound in Patients With Skeletal Class II Malocclusion: A Preliminary Clinical Report"],"prefix":"10.7759","author":[{"given":"Dima M.","family":"Almrayati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Y.","family":"Hajeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad S.","family":"Burhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael H.","family":"Almahdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer T.","family":"Jaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"En-masse retraction of upper anterior teeth in adult patients with maxillary or bimaxillary dentoalveolar protrusion: a systematic review and meta-analysis","volume":"20","author":"Khlef HN","year":"2019","unstructured":"Khlef HN, Hajeer MY, Ajaj MA, Heshmeh O. En-masse retraction of upper anterior teeth in adult patients with maxillary or bimaxillary dentoalveolar protrusion: a systematic review and meta-analysis. J Contemp Dent Pract. 2019, 20:113-27.","journal-title":"J Contemp Dent Pract"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1093\/ejo\/cjy014","article-title":"Soft- and hard-tissue changes following treatment of Class II division 1 malocclusion with Activator versus Trainer: a randomized controlled trial","volume":"41","author":"Idris G","year":"2019","unstructured":"Idris G, Hajeer MY, Al-Jundi A. Soft- and hard-tissue changes following treatment of Class II division 1 malocclusion with Activator versus Trainer: a randomized controlled trial. Eur J Orthod. 2019, 41:21-8.","journal-title":"Eur J Orthod"},{"key":"ref3","article-title":"Orthodontic Management of Uncrowded Class II Division 1 Malocclusion in Children","author":"Bennett JC","year":"2006","unstructured":"Bennett JC. Orthodontic Management of Uncrowded Class II Division 1 Malocclusion in Children. Elsevier\/Mosby, London, UK; 2006."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2017.03.019","article-title":"Compliance with removable orthodontic appliances and adjuncts: a systematic review and meta-analysis","volume":"152","author":"Al-Moghrabi D","year":"2017","unstructured":"Al-Moghrabi D, Salazar FC, Pandis N, Fleming PS. Compliance with removable orthodontic appliances and adjuncts: a systematic review and meta-analysis. Am J Orthod Dentofacial Orthop. 2017, 152:17-32. 10.1016\/j.ajodo.2017.03.019","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"ref5","article-title":"Acceptance and discomfort in growing patients during treatment with two functional appliances: a randomised controlled trial","volume":"13","author":"Idris G","year":"2012","unstructured":"Idris G, Hajeer MY, Al-Jundi A. Acceptance and discomfort in growing patients during treatment with two functional appliances: a randomised controlled trial. Eur J Paediatr Dent. 2012, 13:219-24.","journal-title":"Eur J Paediatr Dent"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-016-0146-9","article-title":"Effectiveness of minimally invasive surgical procedures in the acceleration of tooth movement: a systematic review and meta-analysis","volume":"17","author":"Alfawal AM","year":"2016","unstructured":"Alfawal AM, Hajeer MY, Ajaj MA, Hamadah O, Brad B. Effectiveness of minimally invasive surgical procedures in the acceleration of tooth movement: a systematic review and meta-analysis. Prog Orthod. 2016, 17:33. 10.1186\/s40510-016-0146-9","journal-title":"Prog Orthod"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.32879","article-title":"The efficacy of accelerating orthodontic tooth movement by combining self-ligating brackets with one or more acceleration methods: a systematic review","volume":"14","author":"Al-Ibrahim HM","year":"2022","unstructured":"Al-Ibrahim HM, Hajeer MY, Burhan AS, Sultan K, Ajaj MA, Mahaini L. The efficacy of accelerating orthodontic tooth movement by combining self-ligating brackets with one or more acceleration methods: a systematic review. Cureus. 2022, 14:e32879. 10.7759\/cureus.32879","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4261248","article-title":"Is it possible to achieve favorable accelerated dental changes with no periodontal complications when retracting upper anterior teeth assisted by flapless corticotomy compared to traditional corticotomy? A two-arm randomized controlled trial","volume":"2022","author":"Khlef HN","year":"2022","unstructured":"Khlef HN, Hajeer MY. Is it possible to achieve favorable accelerated dental changes with no periodontal complications when retracting upper anterior teeth assisted by flapless corticotomy compared to traditional corticotomy? A two-arm randomized controlled trial. ScientificWorldJournal. 2022, 2022:4261248. 10.1155\/2022\/4261248","journal-title":"ScientificWorldJournal"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.62368","article-title":"An evaluation of the rate and type of orthodontic tooth movement when injecting platelet-rich plasma during mini-implant-based segmented en-masse retraction of upper anterior teeth","volume":"16","author":"Al-Bozaie MW","year":"2024","unstructured":"Al-Bozaie MW, Baba F, Hajeer MY. An evaluation of the rate and type of orthodontic tooth movement when injecting platelet-rich plasma during mini-implant-based segmented en-masse retraction of upper anterior teeth. Cureus. 2024, 16:e62368. 10.7759\/cureus.62368","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjad056","article-title":"Evaluation of the effectiveness of the platelet-rich plasma compared to the injectable platelet-rich fibrin on the rate of maxillary canine retraction: a three-arm randomized controlled trial","volume":"46","author":"Ammar AM","year":"2024","unstructured":"Ammar AM, Al-Sabbagh R, Hajeer MY. Evaluation of the effectiveness of the platelet-rich plasma compared to the injectable platelet-rich fibrin on the rate of maxillary canine retraction: a three-arm randomized controlled trial. Eur J Orthod. 2024, 46:10.1093\/ejo\/cjad056","journal-title":"Eur J Orthod"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejwf.2021.09.002","article-title":"Leveling and alignment time and the periodontal status in patients with severe upper crowding treated by corticotomy-assisted self-ligating brackets in comparison with conventional or self-ligating brackets only: a 3-arm randomized controlled clinical trial","volume":"11","author":"Al-Ibrahim HM","year":"2022","unstructured":"Al-Ibrahim HM, Hajeer MY, Alkhouri I, Zinah E. Leveling and alignment time and the periodontal status in patients with severe upper crowding treated by corticotomy-assisted self-ligating brackets in comparison with conventional or self-ligating brackets only: a 3-arm randomized controlled clinical trial. J World Fed Orthod. 2022, 11:3-11. 10.1016\/j.ejwf.2021.09.002","journal-title":"J World Fed Orthod"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.05.003","article-title":"Does alveolar corticotomy accelerate orthodontic tooth movement when retracting upper canines? A split-mouth design randomized controlled trial","volume":"72","author":"Al-Naoum F","year":"2014","unstructured":"Al-Naoum F, Hajeer MY, Al-Jundi A. Does alveolar corticotomy accelerate orthodontic tooth movement when retracting upper canines? A split-mouth design randomized controlled trial. J Oral Maxillofac Surg. 2014, 72:1880-9. 10.1016\/j.joms.2014.05.003","journal-title":"J Oral Maxillofac Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.35733","article-title":"Assessment of dentoalveolar changes following leveling and alignment of severely crowded upper anterior teeth using self-ligating brackets alone or with flapless piezocision compared to traditional brackets: a randomized controlled clinical trial","volume":"15","author":"Al-Ibrahim HM","year":"2023","unstructured":"Al-Ibrahim HM, Hajeer MY, Burhan AS, Haj Hamed Y, Alkhouri I, Zinah E. Assessment of dentoalveolar changes following leveling and alignment of severely crowded upper anterior teeth using self-ligating brackets alone or with flapless piezocision compared to traditional brackets: a randomized controlled clinical trial. Cureus. 2023, 15:e35733. 10.7759\/cureus.35733","journal-title":"Cureus"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ortho.2025.101077","article-title":"Patient-reported outcome measures of accelerated upper canine retraction with low-amperage electrical stimulation: a randomized controlled trial","volume":"24","author":"Kheshfeh MN","year":"2026","unstructured":"Kheshfeh MN, Hajeer MY, Alam MK, Al Hinnawi MF, Latifeh Y. Patient-reported outcome measures of accelerated upper canine retraction with low-amperage electrical stimulation: a randomized controlled trial. Int Orthod. 2026, 24:101077. 10.1016\/j.ortho.2025.101077","journal-title":"Int Orthod"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ortho.2021.10.005","article-title":"Evaluation of the acceleration, skeletal and dentoalveolar effects of low-level laser therapy combined with fixed posterior bite blocks in children with skeletal anterior open bite: A three-arm randomised controlled trial","volume":"20","author":"Hasan AA","year":"2022","unstructured":"Hasan AA, Rajeh N, Hajeer MY, Hamadah O, Ajaj MA. Evaluation of the acceleration, skeletal and dentoalveolar effects of low-level laser therapy combined with fixed posterior bite blocks in children with skeletal anterior open bite: A three-arm randomised controlled trial. Int Orthod. 2022, 20:100597. 10.1016\/j.ortho.2021.10.005","journal-title":"Int Orthod"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjaf026","article-title":"Evaluation of low-level laser therapy and piezocision in the en-masse retraction of upper anterior teeth","volume":"47","author":"Mousa MM","year":"2025","unstructured":"Mousa MM, Hajeer MY, Alam MK, Aljabban O, Almahdi WH. Evaluation of low-level laser therapy and piezocision in the en-masse retraction of upper anterior teeth. Eur J Orthod. 2025, 47:026. 10.1093\/ejo\/cjaf026","journal-title":"Eur J Orthod"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068926","article-title":"Low-intensity pulsed ultrasound accelerates tooth movement via activation of the BMP-2 signaling pathway","volume":"8","author":"Xue H","year":"2013","unstructured":"Xue H, Zheng J, Cui Z, et al.. Low-intensity pulsed ultrasound accelerates tooth movement via activation of the BMP-2 signaling pathway. PLoS One. 2013, 8:e68926. 10.1371\/journal.pone.0068926","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.51779","article-title":"Evaluation of patient-reported outcome measures (PROMS) associated with the acceleration of canine retraction by piezosurgery in comparison with low-level laser therapy: a three-arm randomized controlled clinical trial","volume":"16","author":"Alfailany DT","year":"2024","unstructured":"Alfailany DT, Hajeer MY, Awawdeh MA, et al.. Evaluation of patient-reported outcome measures (PROMS) associated with the acceleration of canine retraction by piezosurgery in comparison with low-level laser therapy: a three-arm randomized controlled clinical trial. Cureus. 2024, 16:e51779. 10.7759\/cureus.51779","journal-title":"Cureus"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.06.007","article-title":"Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: an in vitro study","volume":"70","author":"Feres MF","year":"2016","unstructured":"Feres MF, Kucharski C, Diar-Bakirly S, El-Bialy T. Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: an in vitro study. Arch Oral Biol. 2016, 70:73-8. 10.1016\/j.archoralbio.2016.06.007","journal-title":"Arch Oral Biol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1192720","article-title":"Low-intensity pulsed ultrasound regulates osteoblast-osteoclast crosstalk via EphrinB2\/EphB4 signaling for orthodontic alveolar bone remodeling","volume":"11","author":"Zhou J","year":"2023","unstructured":"Zhou J, Zhu Y, Ai D, Zhou M, Li H, Fu Y, Song J. Low-intensity pulsed ultrasound regulates osteoblast-osteoclast crosstalk via EphrinB2\/EphB4 signaling for orthodontic alveolar bone remodeling. Front Bioeng Biotechnol. 2023, 11:1192720. 10.3389\/fbioe.2023.1192720","journal-title":"Front Bioeng Biotechnol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.06063","article-title":"Effect of increasing low-intensity pulsed ultrasound and a functional appliance on the mandibular condyle in growing rats","volume":"36","author":"Kaur H","year":"2017","unstructured":"Kaur H, Uluda\u011f H, Dederich DN, El-Bialy T. Effect of increasing low-intensity pulsed ultrasound and a functional appliance on the mandibular condyle in growing rats. J Ultrasound Med. 2017, 36:109-20. 10.7863\/ultra.15.06063","journal-title":"J Ultrasound Med"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.17219\/dmp\/112321","article-title":"Effects of low-intensity pulsed ultrasound (LIPUS) applied on the temporomandibular joint (TMJ) region on the functional treatment of class II malocclusion: a randomized controlled trial","volume":"57","author":"Namera MO","year":"2020","unstructured":"Namera MO, Mahmoud G, Abdulhadi A, Burhan A. Effects of low-intensity pulsed ultrasound (LIPUS) applied on the temporomandibular joint (TMJ) region on the functional treatment of class II malocclusion: a randomized controlled trial. Dent Med Probl. 2020, 57:53-60.","journal-title":"Dent Med Probl"},{"key":"ref23","article-title":"The Principles and Practice of Dentofacial Orthopaedics","author":"Stockfisch H","year":"1995","unstructured":"Stockfisch H. The Principles and Practice of Dentofacial Orthopaedics. Quintessence Puplishing Co. Inc., London, UK; 1995."},{"key":"ref24","article-title":"Radiographic Cephalometry: From Basics to Videoimaging","author":"Jacobson A","year":"1995","unstructured":"Jacobson A. Radiographic Cephalometry: From Basics to Videoimaging. Quintessence Publishing Co., Chicago, IL; 1995."},{"key":"ref25","article-title":"An Atlas of Craniofacial Growth: Cephalometric Standards from the University School Growth Study","author":"Riolo ML","year":"1974","unstructured":"Riolo ML, Moyers RE, McNamara JA, Hunter WS. An Atlas of Craniofacial Growth: Cephalometric Standards from the University School Growth Study. The University of Michigan, Ann Arbor; 1974."},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2147\/OAJCT.S7060","article-title":"Nonsurgical treatment of hemifacial microsomia by therapeutic ultrasound and hybrid functional appliance","author":"El-Bialy T","year":"2010","unstructured":"El-Bialy T, Hasan A, Janadas A, Albaghdadi T. Nonsurgical treatment of hemifacial microsomia by therapeutic ultrasound and hybrid functional appliance. Open Access J Clin Trials. 2010, 29-36. 10.2147\/OAJCT.S7060","journal-title":"Open Access J Clin Trials"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cju071","article-title":"Treatment effects of removable functional appliances in patients with Class II malocclusion: a systematic review and meta-analysis","volume":"37","author":"Koretsi V","year":"2015","unstructured":"Koretsi V, Zymperdikas VF, Papageorgiou SN, Papadopoulos MA. Treatment effects of removable functional appliances in patients with Class II malocclusion: a systematic review and meta-analysis. Eur J Orthod. 2015, 37:418-34. 10.1093\/ejo\/cju071","journal-title":"Eur J Orthod"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/472811-a-novel-protocol-to-accelerate-functional-orthopedic-treatment-using-low-intensity-pulsed-ultrasound-in-patients-with-skeletal-class-ii-malocclusion-a-preliminary-clinical-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:23:47Z","timestamp":1773267827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/472811-a-novel-protocol-to-accelerate-functional-orthopedic-treatment-using-low-intensity-pulsed-ultrasound-in-patients-with-skeletal-class-ii-malocclusion-a-preliminary-clinical-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.105067","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,11]]}}}