{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:59:40Z","timestamp":1773413980004,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,13]]},"DOI":"10.7759\/cureus.105154","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:56:33Z","timestamp":1773399393000},"source":"Crossref","is-referenced-by-count":0,"title":["Non-operative Management of Uncomplicated Appendicitis: A Review of Indications, Safety, and Clinical Algorithms"],"prefix":"10.7759","author":[{"given":"Mohamed","family":"Baana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghana","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Banfa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laraib","family":"Tariq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Antoni Barbaroux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faryal","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaikha","family":"Alhajeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy W","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudharsan","family":"Ramapriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00275-5","article-title":"Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management","volume":"386","author":"Bhangu A","year":"2015","unstructured":"Bhangu A, S\u00f8reide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015, 386:1278-87. 10.1016\/S0140-6736(15)00275-5","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-020-00306-3","article-title":"Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines","volume":"15","author":"Di Saverio S","year":"2020","unstructured":"Di Saverio S, Podda M, De Simone B, et al.. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020, 15:27. 10.1186\/s13017-020-00306-3","journal-title":"World J Emerg Surg"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6154","article-title":"Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial","volume":"313","author":"Salminen P","year":"2015","unstructured":"Salminen P, Paajanen H, Rautio T, et al.. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA. 2015, 313:2340-8. 10.1001\/jama.2015.6154","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13201","article-title":"Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial","volume":"320","author":"Salminen P","year":"2018","unstructured":"Salminen P, Tuominen R, Paajanen H, et al.. Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA. 2018, 320:1259-65. 10.1001\/jama.2018.13201","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2014320","article-title":"A randomized trial comparing antibiotics with appendectomy for appendicitis","volume":"383","author":"Flum DR","year":"2020","unstructured":"Flum DR, Davidson GH, Monsell SE, et al.. A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med. 2020, 383:1907-19. 10.1056\/NEJMoa2014320","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-023-00531-6","article-title":"A meta-analysis and trial sequential analysis comparing nonoperative versus operative management for uncomplicated appendicitis: a focus on randomized controlled trials","volume":"19","author":"Brucchi F","year":"2024","unstructured":"Brucchi F, Bracchetti G, Fugazzola P, et al.. A meta-analysis and trial sequential analysis comparing nonoperative versus operative management for uncomplicated appendicitis: a focus on randomized controlled trials. World J Emerg Surg. 2024, 19:2. 10.1186\/s13017-023-00531-6","journal-title":"World J Emerg Surg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002137","article-title":"Methods of conservative antibiotic treatment of acute uncomplicated appendicitis: a systematic review","volume":"86","author":"Talan DA","year":"2019","unstructured":"Talan DA, Saltzman DJ, DeUgarte DA, Moran GJ. Methods of conservative antibiotic treatment of acute uncomplicated appendicitis: a systematic review. J Trauma Acute Care Surg. 2019, 86:722-36. 10.1097\/TA.0000000000002137","journal-title":"J Trauma Acute Care Surg"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v89i9-S.7905","article-title":"Conservative treatment of acute appendicitis","volume":"89","author":"Coccolini F","year":"2018","unstructured":"Coccolini F, Fugazzola P, Sartelli M, et al.. Conservative treatment of acute appendicitis. Acta Biomed. 2018, 89:119-34. 10.23750\/abm.v89i9-S.7905","journal-title":"Acta Biomed"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-022-05284-y","article-title":"Non-operative management of acute appendicitis in children","volume":"39","author":"Jumah S","year":"2022","unstructured":"Jumah S, Wester T. Non-operative management of acute appendicitis in children. Pediatr Surg Int. 2022, 39:11. 10.1007\/s00383-022-05284-y","journal-title":"Pediatr Surg Int"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jpm15030112","article-title":"Exploring the immunological role of the microbial composition of the appendix and the associated risks of appendectomies","volume":"15","author":"Islam T","year":"2025","unstructured":"Islam T, Sagor MS, Tamanna NT, Bappy MK, Danishuddin, Haque MA, Lackner M. Exploring the immunological role of the microbial composition of the appendix and the associated risks of appendectomies. J Pers Med. 2025, 15:112. 10.3390\/jpm15030112","journal-title":"J Pers Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.2937","article-title":"Nonoperative vs operative management of uncomplicated acute appendicitis: a systematic review and meta-analysis","volume":"157","author":"de Almeida Leite RM","year":"2022","unstructured":"de Almeida Leite RM, Seo DJ, Gomez-Eslava B, et al.. Nonoperative vs operative management of uncomplicated acute appendicitis: a systematic review and meta-analysis. JAMA Surg. 2022, 157:828-34. 10.1001\/jamasurg.2022.2937","journal-title":"JAMA Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v13.i11.1293","article-title":"Acute appendicitis-advances and controversies","volume":"13","author":"Teng TZ","year":"2021","unstructured":"Teng TZ, Thong XR, Lau KY, Balasubramaniam S, Shelat VG. Acute appendicitis-advances and controversies. World J Gastrointest Surg. 2021, 13:1293-314. 10.4240\/wjgs.v13.i11.1293","journal-title":"World J Gastrointest Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70549-1","article-title":"The mesenteric circulation","volume":"77","author":"Rosenblum JD","year":"1997","unstructured":"Rosenblum JD, Boyle CM, Schwartz LB. The mesenteric circulation. Surg Clin North America. 1997, 77:289-306. 10.1016\/S0039-6109(05)70549-1","journal-title":"Surg Clin North America"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004471","article-title":"Current management of acute appendicitis in adults: what you need to know","volume":"98","author":"Diaz JJ","year":"2025","unstructured":"Diaz JJ, Ceresoli M, Herron T, Coccolini F. Current management of acute appendicitis in adults: what you need to know. J Trauma Acute Care Surg. 2025, 98:181-9. 10.1097\/TA.0000000000004471","journal-title":"J Trauma Acute Care Surg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2023.00192.0027","article-title":"Clinical outcomes and optimal indications for nonoperative management of acute appendicitis in adult patients: a comprehensive literature review","volume":"41","author":"Lee HG","year":"2025","unstructured":"Lee HG, Park IJ. Clinical outcomes and optimal indications for nonoperative management of acute appendicitis in adult patients: a comprehensive literature review. Ann Coloproctol. 2025, 41:107-18. 10.3393\/ac.2023.00192.0027","journal-title":"Ann Coloproctol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.jpbs_1889_24","article-title":"Assessment of non-operative management of appendicitis in adults","volume":"17","author":"Komari LK","year":"2025","unstructured":"Komari LK, Katikam SM, Parimi SB. Assessment of non-operative management of appendicitis in adults. J Pharm Bioallied Sci. 2025, 17:S1451-3. 10.4103\/jpbs.jpbs_1889_24","journal-title":"J Pharm Bioallied Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.88948","article-title":"Predictive value of clinical and CT scan findings for complicated appendicitis: a retrospective analysis","volume":"17","author":"Alsayaf Alghamdi AG","year":"2025","unstructured":"Alsayaf Alghamdi AG, Alzhrani SM, Fayraq A, Alzahrani SA. Predictive value of clinical and CT scan findings for complicated appendicitis: a retrospective analysis. Cureus. 2025, 17:e88948. 10.7759\/cureus.88948","journal-title":"Cureus"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/14574969211008330","article-title":"Diagnosis of uncomplicated and complicated appendicitis in adults","volume":"110","author":"Bom WJ","year":"2021","unstructured":"Bom WJ, Scheijmans JC, Salminen P, Boermeester MA. Diagnosis of uncomplicated and complicated appendicitis in adults. Scand J Surg. 2021, 110:170-9. 10.1177\/14574969211008330","journal-title":"Scand J Surg"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10888","article-title":"Association of nonoperative management using antibiotic therapy vs laparoscopic appendectomy with treatment success and disability days in children with uncomplicated appendicitis","volume":"324","author":"Minneci PC","year":"2020","unstructured":"Minneci PC, Hade EM, Lawrence AE, et al.. Association of nonoperative management using antibiotic therapy vs laparoscopic appendectomy with treatment success and disability days in children with uncomplicated appendicitis. JAMA. 2020, 324:581-93. 10.1001\/jama.2020.10888","journal-title":"JAMA"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.72873","article-title":"Efficacy of the modified Alvarado scoring system and radiologic studies in diagnosing appendicitis in children: a retrospective comparative study","volume":"16","author":"Mnofala A","year":"2024","unstructured":"Mnofala A, Tashkandi A, Halawani M, et al.. Efficacy of the modified Alvarado scoring system and radiologic studies in diagnosing appendicitis in children: a retrospective comparative study. Cureus. 2024, 16:e72873. 10.7759\/cureus.72873","journal-title":"Cureus"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac086","article-title":"Antibiotics versus placebo in adults with CT-confirmed uncomplicated acute appendicitis (APPAC III): randomized double-blind superiority trial","volume":"109","author":"Salminen P","year":"2022","unstructured":"Salminen P, Sippola S, Haijanen J, et al.. Antibiotics versus placebo in adults with CT-confirmed uncomplicated acute appendicitis (APPAC III): randomized double-blind superiority trial. Br J Surg. 2022, 109:503-9. 10.1093\/bjs\/znac086","journal-title":"Br J Surg"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.90271","article-title":"Appendicoliths in children: diagnostic considerations and postoperative implications","volume":"17","author":"Mahadevappa K","year":"2025","unstructured":"Mahadevappa K, Asha J, Raju RS, Susan John D, Kumar P. Appendicoliths in children: diagnostic considerations and postoperative implications. Cureus. 2025, 17:e90271. 10.7759\/cureus.90271","journal-title":"Cureus"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v13.i23.106532","article-title":"Leaving no stone unturned: impact of appendicolith and characteristics on long-term recurrence after non-operative appendicitis","volume":"13","author":"Kupietzky A","year":"2025","unstructured":"Kupietzky A, Bar-Moshe Y, Lavie N, et al.. Leaving no stone unturned: impact of appendicolith and characteristics on long-term recurrence after non-operative appendicitis. World J Clin Cases. 2025, 13:106532. 10.12998\/wjcc.v13.i23.106532","journal-title":"World J Clin Cases"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v13.i28.109664","article-title":"Appendicolith in non-operative management of acute appendicitis: Implications for recurrence and future directions","volume":"13","author":"Tian J","year":"2025","unstructured":"Tian J. Appendicolith in non-operative management of acute appendicitis: Implications for recurrence and future directions. World J Clin Cases. 2025, 13:109664. 10.12998\/wjcc.v13.i28.109664","journal-title":"World J Clin Cases"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2023.05.007","article-title":"Higher rates of complicated appendicitis during the COVID-19 pandemic: a\u00a0year-to-year analysis","volume":"290","author":"Kupietzky A","year":"2023","unstructured":"Kupietzky A, Finkin M, Dover R, et al.. Higher rates of complicated appendicitis during the COVID-19 pandemic: a\u00a0year-to-year analysis. J Surg Res. 2023, 290:304-9. 10.1016\/j.jss.2023.05.007","journal-title":"J Surg Res"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2023.12.021","article-title":"Systematic review and meta-analysis to compare the short- and long-term outcomes of non-operative management with early operative management of simple appendicitis in children after the COVID-19 pandemic","volume":"59","author":"Decker E","year":"2024","unstructured":"Decker E, Ndzi A, Kenny S, Harwood R. Systematic review and meta-analysis to compare the short- and long-term outcomes of non-operative management with early operative management of simple appendicitis in children after the COVID-19 pandemic. J Pediatr Surg. 2024, 59:1050-7. 10.1016\/j.jpedsurg.2023.12.021","journal-title":"J Pediatr Surg"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/children11030340","article-title":"Suspected simple appendicitis in children: should we use a nonoperative, antibiotic-free approach? An observational study","volume":"11","author":"Reis Wolfertstetter P","year":"2024","unstructured":"Reis Wolfertstetter P, Ebert JB, Barop J, Denzinger M, Kertai M, Schlitt HJ, Knorr C. Suspected simple appendicitis in children: should we use a nonoperative, antibiotic-free approach? An observational study. Children (Basel). 2024, 11:10.3390\/children11030340","journal-title":"Children (Basel)"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1620279","article-title":"Nonoperative treatment of appendicitis during pregnancy in a remote area","volume":"8","author":"Carstens AK","year":"2018","unstructured":"Carstens AK, Fensby L, Penninga L. Nonoperative treatment of appendicitis during pregnancy in a remote area. AJP Rep. 2018, 8:e37-8. 10.1055\/s-0037-1620279","journal-title":"AJP Rep"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-214722","article-title":"Appendicitis during pregnancy in a Greenlandic Inuit woman; antibiotic treatment as a bridge-to-surgery in a remote area","volume":"2016","author":"Jensen TD","year":"2016","unstructured":"Jensen TD, Penninga L. Appendicitis during pregnancy in a Greenlandic Inuit woman; antibiotic treatment as a bridge-to-surgery in a remote area. BMJ Case Rep. 2016, 2016:10.1136\/bcr-2016-214722","journal-title":"BMJ Case Rep"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S536394","article-title":"Conservative treatment of third trimester appendicitis misdiagnosed as round ligament pain. A case report and review of the literature in a resource-limited setting","volume":"17","author":"Hassan RA","year":"2025","unstructured":"Hassan RA, Ali IA, Elmi AH, Omar AA. Conservative treatment of third trimester appendicitis misdiagnosed as round ligament pain. A case report and review of the literature in a resource-limited setting. Int J Womens Health. 2025, 17:2413-20. 10.2147\/IJWH.S536394","journal-title":"Int J Womens Health"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.04.046","article-title":"Outcomes of antibiotic therapy for uncomplicated appendicitis in pregnancy","volume":"130","author":"Joo JI","year":"2017","unstructured":"Joo JI, Park HC, Kim MJ, Lee BH. Outcomes of antibiotic therapy for uncomplicated appendicitis in pregnancy. Am J Med. 2017, 130:1467-9. 10.1016\/j.amjmed.2017.04.046","journal-title":"Am J Med"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i20.5372","article-title":"Revisiting delayed appendectomy in patients with acute appendicitis","volume":"9","author":"Li J","year":"2021","unstructured":"Li J. Revisiting delayed appendectomy in patients with acute appendicitis. World J Clin Cases. 2021, 9:5372-90. 10.12998\/wjcc.v9.i20.5372","journal-title":"World J Clin Cases"},{"key":"ref33","unstructured":"Comparing antibiotics versus surgery for treating appendicitis - the CODA study. (2023). Accessed. November 10, 2025: https:\/\/www.pcori.org\/research-results\/2015\/comparing-antibiotics-versus-surgery-treating-appendicitis-coda-study."},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-025-03811-8","article-title":"Nonoperative management of uncomplicated acute appendicitis; results of 5 years follow","volume":"410","author":"Sevin\u00e7 B","year":"2025","unstructured":"Sevin\u00e7 B, Damburac\u0131 N, Karahan \u00d6. Nonoperative management of uncomplicated acute appendicitis; results of 5 years follow. Langenbecks Arch Surg. 2025, 410:292. 10.1007\/s00423-025-03811-8","journal-title":"Langenbecks Arch Surg"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znaf143","article-title":"Prognostic factors associated with primary non-responsiveness to antibiotics and appendicitis recurrence for CT-diagnosed uncomplicated acute appendicitis: secondary analysis of two randomized clinical trials","volume":"112","author":"Sel\u00e4nne L","year":"2025","unstructured":"Sel\u00e4nne L, Hurme S, Sippola S, et al.. Prognostic factors associated with primary non-responsiveness to antibiotics and appendicitis recurrence for CT-diagnosed uncomplicated acute appendicitis: secondary analysis of two randomized clinical trials. Br J Surg. 2025, 112:10.1093\/bjs\/znaf143","journal-title":"Br J Surg"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23525","article-title":"Effect of oral moxifloxacin vs intravenous ertapenem plus oral levofloxacin for treatment of uncomplicated acute appendicitis: the APPAC II randomized clinical trial","volume":"325","author":"Sippola S","year":"2021","unstructured":"Sippola S, Haijanen J, Gr\u00f6nroos J, et al.. Effect of oral moxifloxacin vs intravenous ertapenem plus oral levofloxacin for treatment of uncomplicated acute appendicitis: the APPAC II randomized clinical trial. JAMA. 2021, 325:353-62. 10.1001\/jama.2020.23525","journal-title":"JAMA"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1177\/14574969241293018","article-title":"A randomized double-blind noninferiority clinical multicenter trial on oral moxifloxacin versus placebo in the outpatient treatment of uncomplicated acute appendicitis: APPAC IV study protocol","volume":"114","author":"Lund H","year":"2025","unstructured":"Lund H, Haijanen J, Suominen S, et al.. A randomized double-blind noninferiority clinical multicenter trial on oral moxifloxacin versus placebo in the outpatient treatment of uncomplicated acute appendicitis: APPAC IV study protocol. Scand J Surg. 2025, 114:3-12. 10.1177\/14574969241293018","journal-title":"Scand J Surg"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-054693","article-title":"Nonoperative management of uncomplicated appendicitis","volume":"149","author":"Lipsett SC","year":"2022","unstructured":"Lipsett SC, Monuteaux MC, Shanahan KH, Bachur RG. Nonoperative management of uncomplicated appendicitis. Pediatrics. 2022, 149:10.1542\/peds.2021-054693","journal-title":"Pediatrics"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.37.5.4016","article-title":"Non-operative treatment versus appendectomy for acute uncomplicated appendicitis: a randomized controlled trial","volume":"37","author":"Sajjad MN","year":"2021","unstructured":"Sajjad MN, Naumeri F, Hina S. Non-operative treatment versus appendectomy for acute uncomplicated appendicitis: a randomized controlled trial. Pak J Med Sci. 2021, 37:1276-81. 10.12669\/pjms.37.5.4016","journal-title":"Pak J Med Sci"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.20039","article-title":"Analysis of outcomes associated with outpatient management of nonoperatively treated patients with appendicitis","volume":"5","author":"Talan DA","year":"2022","unstructured":"Talan DA, Moran GJ, Krishnadasan A, et al.. Analysis of outcomes associated with outpatient management of nonoperatively treated patients with appendicitis. JAMA Netw Open. 2022, 5:e2220039. 10.1001\/jamanetworkopen.2022.20039","journal-title":"JAMA Netw Open"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-019-04610-1","article-title":"Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis","volume":"36","author":"Maita S","year":"2020","unstructured":"Maita S, Andersson B, Svensson JF, Wester T. Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis. Pediatr Surg Int. 2020, 36:261-9. 10.1007\/s00383-019-04610-1","journal-title":"Pediatr Surg Int"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1177\/2381468319866448","article-title":"Operative versus nonoperative management of appendicitis: a long-term cost effectiveness analysis","volume":"4","author":"Sceats LA","year":"2019","unstructured":"Sceats LA, Ku S, Coughran A, et al.. Operative versus nonoperative management of appendicitis: a long-term cost effectiveness analysis. MDM Policy Pract. 2019, 4:2381468319866448. 10.1177\/2381468319866448","journal-title":"MDM Policy Pract"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1186\/s12962-021-00288-2","article-title":"Cost-effectiveness analysis of nonoperative management versus open and laparoscopic surgery for uncomplicated acute appendicitis in Colombia","volume":"19","author":"Guevara-Cuellar CA","year":"2021","unstructured":"Guevara-Cuellar CA, Rengifo-Mosquera MP, Parody-R\u00faa E. Cost-effectiveness analysis of nonoperative management versus open and laparoscopic surgery for uncomplicated acute appendicitis in Colombia. Cost Eff Resour Alloc. 2021, 19:34. 10.1186\/s12962-021-00288-2","journal-title":"Cost Eff Resour Alloc"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02420-6","article-title":"Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial","volume":"405","author":"St Peter SD","year":"2025","unstructured":"St Peter SD, Noel-MacDonnell JR, Hall NJ, et al.. Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial. Lancet. 2025, 405:233-40. 10.1016\/S0140-6736(24)02420-6","journal-title":"Lancet"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.01.003","article-title":"Long-term outcomes of patients with nonsurgically managed uncomplicated appendicitis","volume":"218","author":"McCutcheon BA","year":"2014","unstructured":"McCutcheon BA, Chang DC, Marcus LP, et al.. Long-term outcomes of patients with nonsurgically managed uncomplicated appendicitis. J Am Coll Surg. 2014, 218:905-13. 10.1016\/j.jamcollsurg.2014.01.003","journal-title":"J Am Coll Surg"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-023-02210-4","article-title":"Predictors of in-hospital appendiceal perforation in patients with non- perforated acute appendicitis with appendicolithiasis at presentation","volume":"23","author":"Sohail AH","year":"2023","unstructured":"Sohail AH, Hakmi H, Cohen K, et al.. Predictors of in-hospital appendiceal perforation in patients with non- perforated acute appendicitis with appendicolithiasis at presentation. BMC Surg. 2023, 23:317. 10.1186\/s12893-023-02210-4","journal-title":"BMC Surg"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrac100","article-title":"Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis","volume":"6","author":"Herrod PJ","year":"2022","unstructured":"Herrod PJ, Kwok AT, Lobo DN. Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis. BJS Open. 2022, 6:10.1093\/bjsopen\/zrac100","journal-title":"BJS Open"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-023-02108-1","article-title":"Comparison of the efficacy and safety of antibiotic treatment and appendectomy for acute uncomplicated appendicitis: a systematic review and meta-analysis","volume":"23","author":"Xu H","year":"2023","unstructured":"Xu H, Yang S, Xing J, Wang Y, Sun W, Rong L, Liu H. Comparison of the efficacy and safety of antibiotic treatment and appendectomy for acute uncomplicated appendicitis: a systematic review and meta-analysis. BMC Surg. 2023, 23:208. 10.1186\/s12893-023-02108-1","journal-title":"BMC Surg"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zraa030","article-title":"Discriminating complicated from uncomplicated appendicitis by ultrasound imaging, computed tomography or magnetic resonance imaging: systematic review and meta-analysis of diagnostic accuracy","volume":"5","author":"Bom WJ","year":"2021","unstructured":"Bom WJ, Bolmers MD, Gans SL, et al.. Discriminating complicated from uncomplicated appendicitis by ultrasound imaging, computed tomography or magnetic resonance imaging: systematic review and meta-analysis of diagnostic accuracy. BJS Open. 2021, 5:10.1093\/bjsopen\/zraa030","journal-title":"BJS Open"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1055\/a-0824-6952","article-title":"EFSUMB position paper: recommendations for gastrointestinal ultrasound (GIUS) in acute appendicitis and diverticulitis","volume":"40","author":"Dirks K","year":"2019","unstructured":"Dirks K, Calabrese E, Dietrich CF, et al.. EFSUMB position paper: recommendations for gastrointestinal ultrasound (GIUS) in acute appendicitis and diverticulitis. Ultraschall Med. 2019, 40:163-75. 10.1055\/a-0824-6952","journal-title":"Ultraschall Med"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2020.0764","article-title":"Acute appendicitis in childhood and adulthood: an everyday clinical challenge","volume":"117","author":"T\u00e9oule P","year":"2020","unstructured":"T\u00e9oule P, Laffolie J, Rolle U, Reissfelder C. Acute appendicitis in childhood and adulthood: an everyday clinical challenge. Dtsch Arztebl Int. 2020, 117:764-74. 10.3238\/arztebl.2020.0764","journal-title":"Dtsch Arztebl Int"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.05.030","article-title":"One year negative appendicectomy rates at a district general hospital: a retrospective cohort study","volume":"31","author":"Lim J","year":"2016","unstructured":"Lim J, Pang Q, Alexander R. One year negative appendicectomy rates at a district general hospital: a retrospective cohort study. Int J Surg. 2016, 31:1-4. 10.1016\/j.ijsu.2016.05.030","journal-title":"Int J Surg"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-022-05497-2","article-title":"Follow-up ultrasonographic findings among children treated conservatively for uncomplicated acute appendicitis","volume":"53","author":"Stackievicz R","year":"2023","unstructured":"Stackievicz R, Milner R, Werner M, Arnon S, Steiner Z. Follow-up ultrasonographic findings among children treated conservatively for uncomplicated acute appendicitis. Pediatr Radiol. 2023, 53:223-34. 10.1007\/s00247-022-05497-2","journal-title":"Pediatr Radiol"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-139","article-title":"The Alvarado score for predicting acute appendicitis: a systematic review","volume":"9","author":"Ohle R","year":"2011","unstructured":"Ohle R, O'Reilly F, O'Brien KK, Fahey T, Dimitrov BD. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med. 2011, 9:139. 10.1186\/1741-7015-9-139","journal-title":"BMC Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/465081-non-operative-management-of-uncomplicated-appendicitis-a-review-of-indications-safety-and-clinical-algorithms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:56:35Z","timestamp":1773399395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/465081-non-operative-management-of-uncomplicated-appendicitis-a-review-of-indications-safety-and-clinical-algorithms"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":54,"URL":"https:\/\/doi.org\/10.7759\/cureus.105154","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,13]]}}}