{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T04:27:37Z","timestamp":1773635257879,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,15]]},"DOI":"10.7759\/cureus.105277","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T03:22:10Z","timestamp":1773631330000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary Apocrine Adenocarcinoma of the Vulva: A Report of a Rare Case"],"prefix":"10.7759","author":[{"given":"Marcus","family":"Yoakam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Friday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Weitoschova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyn","family":"Borger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew","family":"Windsor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"Dunbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Shirley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3897\/folmed.63.e57633","article-title":"Primary bartholin adenocarcinoma: a rare case and radiotherapy as definitive treatment","volume":"63","author":"Lubis LD","year":"2021","unstructured":"Lubis LD, Dina S, Khaidirman DK. Primary bartholin adenocarcinoma: a rare case and radiotherapy as definitive treatment. Folia Med (Plovdiv). 2021, 63:985-9. 10.3897\/folmed.63.e57633","journal-title":"Folia Med (Plovdiv)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01568.x","article-title":"Apocrine carcinoma of the vulva in a band-like arrangement with inflammatory and telangiectatic metastasis via local lymphatic channels","volume":"42","author":"Kiyohara T","year":"2003","unstructured":"Kiyohara T, Kumakiri M, Kawami K, et al.. Apocrine carcinoma of the vulva in a band-like arrangement with inflammatory and telangiectatic metastasis via local lymphatic channels. Int J Dermatol. 2003, 42:71-4. 10.1046\/j.1365-4362.2003.01568.x","journal-title":"Int J Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/2010105819877895","article-title":"The diagnostic challenge of primary adenocarcinoma of the vulva: a case report","volume":"29","author":"Chow CY","year":"2020","unstructured":"Chow CY, Namuduri RP, Yeo YC, Mihir G. The diagnostic challenge of primary adenocarcinoma of the vulva: a case report. Proc Singap Healthc. 2020, 29:50-4. 10.1177\/2010105819877895","journal-title":"Proc Singap Healthc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.70283","article-title":"New histopathological and molecular findings in gynecological cancers","volume":"171 Suppl 1","author":"McCluggage WG","year":"2025","unstructured":"McCluggage WG. New histopathological and molecular findings in gynecological cancers. Int J Gynaecol Obstet. 2025, 171 Suppl 1:109-19. 10.1002\/ijgo.70283","journal-title":"Int J Gynaecol Obstet"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000186","article-title":"The novel marker GATA3 is significantly more sensitive than traditional markers mammaglobin and GCDFP15 for identifying breast cancer in surgical and cytology specimens of metastatic and matched primary tumors","volume":"24","author":"Sangoi AR","year":"2016","unstructured":"Sangoi AR, Shrestha B, Yang G, Mego O, Beck AH. The novel marker GATA3 is significantly more sensitive than traditional markers mammaglobin and GCDFP15 for identifying breast cancer in surgical and cytology specimens of metastatic and matched primary tumors. Appl Immunohistochem Mol Morphol. 2016, 24:229-37. 10.1097\/PAI.0000000000000186","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/his.13239","article-title":"Molecular subtyping of mammary-like adenocarcinoma of the vulva shows molecular similarity to breast carcinomas","volume":"71","author":"Tessier-Cloutier B","year":"2017","unstructured":"Tessier-Cloutier B, Asleh-Aburaya K, Shah V, McCluggage WG, Tinker A, Gilks CB. Molecular subtyping of mammary-like adenocarcinoma of the vulva shows molecular similarity to breast carcinomas. Histopathology. 2017, 71:446-52. 10.1111\/his.13239","journal-title":"Histopathology"},{"key":"ref7","article-title":"Immunohistochemical and morphologic evaluation of primary cutaneous apocrine carcinomas and cutaneous metastases from ductal breast carcinoma","volume":"53","author":"Fernandez-Flores A","year":"2012","unstructured":"Fernandez-Flores A. Immunohistochemical and morphologic evaluation of primary cutaneous apocrine carcinomas and cutaneous metastases from ductal breast carcinoma. Rom J Morphol Embryol. 2012, 53:879-92.","journal-title":"Rom J Morphol Embryol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/his.14809","article-title":"Poorly differentiated cutaneous apocrine carcinomas: histopathological clues and immunohistochemical analysis for the diagnosis of this unusual neoplasm","volume":"82","author":"Plaza JA","year":"2023","unstructured":"Plaza JA, Brenn T, Gru AA, Matoso A, Sheldon J, Sangueza M. Poorly differentiated cutaneous apocrine carcinomas: histopathological clues and immunohistochemical analysis for the diagnosis of this unusual neoplasm. Histopathology. 2023, 82:276-84. 10.1111\/his.14809","journal-title":"Histopathology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2002.6830","article-title":"Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma","volume":"87","author":"Huang GS","year":"2002","unstructured":"Huang GS, Juretzka M, Ciaravino G, Kohler S, Teng NN. Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma. Gynecol Oncol. 2002, 87:313-8. 10.1006\/gyno.2002.6830","journal-title":"Gynecol Oncol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.02.029","article-title":"Primary extramammary Paget's disease of the vulva: the clinicopathological features and treatment outcomes in a series of 43 patients","volume":"129","author":"Cai Y","year":"2013","unstructured":"Cai Y, Sheng W, Xiang L, Wu X, Yang H. Primary extramammary Paget's disease of the vulva: the clinicopathological features and treatment outcomes in a series of 43 patients. Gynecol Oncol. 2013, 129:412-6. 10.1016\/j.ygyno.2013.02.029","journal-title":"Gynecol Oncol"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.2478\/fco-2024-0008","article-title":"Primary breast adenocarcinoma in ectopic breast tissue in the vulva: a case report","author":"Al-Bairmany YS","year":"2025","unstructured":"Al-Bairmany YS, Dh Hameedi A, Majid FH, Hussein HG, Abbood AA. Primary breast adenocarcinoma in ectopic breast tissue in the vulva: a case report. Forum Clin Oncol. 2025,","journal-title":"Forum Clin Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.09.007","article-title":"Cutaneous and mammary apocrine carcinomas have different immunoprofiles","volume":"45","author":"Piris A","year":"2014","unstructured":"Piris A, Peng Y, Boussahmain C, Essary LR, Gudewicz TM, Hoang MP. Cutaneous and mammary apocrine carcinomas have different immunoprofiles. Hum Pathol. 2014, 45:320-6. 10.1016\/j.humpath.2013.09.007","journal-title":"Hum Pathol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2006.apm_434.x","article-title":"Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast","volume":"114","author":"Honma N","year":"2006","unstructured":"Honma N, Takubo K, Arai T, Younes M, Kasumi F, Akiyama F, Sakamoto G. Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast. APMIS. 2006, 114:712-9. 10.1111\/j.1600-0463.2006.apm_434.x","journal-title":"APMIS"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047290","article-title":"Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses","volume":"7","author":"Le LP","year":"2012","unstructured":"Le LP, Dias-Santagata D, Pawlak AC, et al.. Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses. PLoS One. 2012, 7:e47290. 10.1371\/journal.pone.0047290","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-87403-y","article-title":"Relationship between androgen receptor and androgen receptor-related protein expression in breast cancers focusing on morphologically identified carcinoma with apocrine differentiation","volume":"15","author":"Nishida H","year":"2025","unstructured":"Nishida H, Kato A, Kaimori R, Kawamura K, Daa T. Relationship between androgen receptor and androgen receptor-related protein expression in breast cancers focusing on morphologically identified carcinoma with apocrine differentiation. Sci Rep. 2025, 15:2892. 10.1038\/s41598-025-87403-y","journal-title":"Sci Rep"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2013.e40","article-title":"Apocrine adenocarcinoma of the vulva","volume":"5","author":"Kajal B","year":"2013","unstructured":"Kajal B, Talati H, Daya D, Alowami S. Apocrine adenocarcinoma of the vulva. Rare Tumors. 2013, 5:e40. 10.4081\/rt.2013.e40","journal-title":"Rare Tumors"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2008.07.012","article-title":"Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation","volume":"205","author":"Alsaad KO","year":"2009","unstructured":"Alsaad KO, Obaidat N, Dube V, Chapman W, Ghazarian D. Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. Pathol Res Pract. 2009, 205:131-5. 10.1016\/j.prp.2008.07.012","journal-title":"Pathol Res Pract"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199404000-00009","article-title":"Mammary-like glands of the vulva and their disorders","volume":"13","author":"van der Putte SC","year":"1994","unstructured":"van der Putte SC. Mammary-like glands of the vulva and their disorders. Int J Gynecol Pathol. 1994, 13:150-60. 10.1097\/00004347-199404000-00009","journal-title":"Int J Gynecol Pathol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.gynor.2013.09.001","article-title":"Primary invasive breast carcinoma arising in mammary-like glands of the vulva managed with excision and sentinel lymph node biopsy","volume":"7","author":"Butler B","year":"2014","unstructured":"Butler B, Leath CA 3rd, Barnett JC. Primary invasive breast carcinoma arising in mammary-like glands of the vulva managed with excision and sentinel lymph node biopsy. Gynecol Oncol Case Rep. 2014, 7:7-9. 10.1016\/j.gynor.2013.09.001","journal-title":"Gynecol Oncol Case Rep"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/465730-primary-apocrine-adenocarcinoma-of-the-vulva-a-report-of-a-rare-case","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T03:22:13Z","timestamp":1773631333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/465730-primary-apocrine-adenocarcinoma-of-the-vulva-a-report-of-a-rare-case"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,15]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.105277","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,15]]}}}