{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T08:48:25Z","timestamp":1773650905681,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,16]]},"DOI":"10.7759\/cureus.105288","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:52:22Z","timestamp":1773647542000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of Immunohistochemistry in the Diagnosis and Clinicopathological Stratification of Gliomas"],"prefix":"10.7759","author":[{"given":"Pragya","family":"Jaiswal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamatha","family":"K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basavaraj","family":"Badadal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis DN","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P, et al.. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. 2021, 23:1231-51. 10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-025-01683-4","article-title":"National and subnational burden of brain and central nervous system cancers in China and global from 1990 to 2021: results from the global burden of disease study 2021","volume":"83","author":"Tu S","year":"2025","unstructured":"Tu S, Huang X, Fan X, et al.. National and subnational burden of brain and central nervous system cancers in China and global from 1990 to 2021: results from the global burden of disease study 2021. Arch Public Health. 2025, 83:195. 10.1186\/s13690-025-01683-4","journal-title":"Arch Public Health"},{"key":"ref3","article-title":"Central Brain Tumor Registry of the United States (CBTRUS). CBTRUS fact sheet 2024. Chicago: CBTRUS.","author":"Central Brain Tumor Registry of the United States (CBTRUS)","year":"2024","unstructured":"Central Brain Tumor Registry of the United States (CBTRUS). CBTRUS Fact Sheet 2024. CBTRUS, Chicago, IL; 2024. https:\/\/www.cbtrus.org\/cbtrus-fact-sheet\/."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis DN","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, et al.. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007, 114:97-109. 10.1007\/s00401-007-0243-4","journal-title":"Acta Neuropathol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00447-z","article-title":"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","volume":"18","author":"Weller M","year":"2021","unstructured":"Weller M, van den Bent M, Preusser M, et al.. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat Rev Clin Oncol. 2021, 18:170-86. 10.1038\/s41571-020-00447-z","journal-title":"Nat Rev Clin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-01987-0","article-title":"cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF (V600E) mutation","volume":"137","author":"Ellison DW","year":"2019","unstructured":"Ellison DW, Hawkins C, Jones DT, Onar-Thomas A, Pfister SM, Reifenberger G, Louis DN. cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF (V600E) mutation. Acta Neuropathol. 2019, 137:683-7. 10.1007\/s00401-019-01987-0","journal-title":"Acta Neuropathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S397550","article-title":"Immunohistochemical expression of IDH1, ATRX, Ki67, GFAP, and prognosis in Indonesian glioma patients","volume":"16","author":"Priambada D","year":"2023","unstructured":"Priambada D, Thohar Arifin M, Saputro A, et al.. Immunohistochemical expression of IDH1, ATRX, Ki67, GFAP, and prognosis in Indonesian glioma patients. Int J Gen Med. 2023, 16:393-403. 10.2147\/IJGM.S397550","journal-title":"Int J Gen Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708126","article-title":"Malignant gliomas in adults","volume":"359","author":"Wen PY","year":"2008","unstructured":"Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med. 2008, 359:492-507. 10.1056\/NEJMra0708126","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.689","article-title":"Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma","volume":"3","author":"Kannan K","year":"2012","unstructured":"Kannan K, Inagaki A, Silber J, et al.. Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma. Oncotarget. 2012, 3:1194-203. 10.18632\/oncotarget.689","journal-title":"Oncotarget"},{"key":"ref10","article-title":"Practical Surgical Neuropathology: A Diagnostic Approach","author":"\u00a0Perry A","year":"2018","unstructured":"\u00a0Perry A, Brat DJ. Practical Surgical Neuropathology: A Diagnostic Approach. Elsevier, Philadelphia, PA; 2018."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-7-4","article-title":"The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma","volume":"7","author":"Bahnassy AA","year":"2007","unstructured":"Bahnassy AA, Zekri AR, Saleh M, Lotayef M, Moneir M, Shawki O. The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma. BMC Clin Pathol. 2007, 7:4. 10.1186\/1472-6890-7-4","journal-title":"BMC Clin Pathol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893360","article-title":"The clinical value of Ki-67\/MIB-1 labeling index in human astrocytomas","volume":"12","author":"Johannessen AL","year":"2006","unstructured":"Johannessen AL, Torp SH. The clinical value of Ki-67\/MIB-1 labeling index in human astrocytomas. Pathol Oncol Res. 2006, 12:143-7. 10.1007\/BF02893360","journal-title":"Pathol Oncol Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa200","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017","volume":"22","author":"Ostrom QT","year":"2020","unstructured":"Ostrom QT, Patil N, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017. Neuro Oncol. 2020, 22:iv1-iv96. 10.1093\/neuonc\/noaa200","journal-title":"Neuro Oncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1750783","article-title":"IDH1, ATRX, p53, and Ki-67 expression in glioblastoma patients: their clinical and prognostic significance\u2014a prospective study","volume":"19","author":"Meel M","year":"2024","unstructured":"Meel M, Jindal A, Kumar M, Mathur K, Singh A. IDH1, ATRX, p53, and Ki-67 expression in glioblastoma patients: their clinical and prognostic significance\u2014a prospective study. Asian J Neurosurg. 2024, 19:14-20. 10.1055\/s-0042-1750783","journal-title":"Asian J Neurosurg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1743265","article-title":"Study of surrogate immunohistochemical markers in astrocytic and oligodendroglial tumors","volume":"12","author":"Sharma S","year":"2023","unstructured":"Sharma S, Chosdol K, Suri A, et al.. Study of surrogate immunohistochemical markers in astrocytic and oligodendroglial tumors. Indian J Neurosurg. 2023, 12:138-45. 10.1055\/s-0042-1743265","journal-title":"Indian J Neurosurg"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2021.102056","article-title":"Immunohistochemical expression of HIF-1\u03b1, IDH1 and TP53: prognostic profile of Moroccan patients with diffuse glioma","volume":"119","author":"Sfifou F","year":"2022","unstructured":"Sfifou F, Ouzir M, Hakkou EM, et al.. Immunohistochemical expression of HIF-1\u03b1, IDH1 and TP53: prognostic profile of Moroccan patients with diffuse glioma. J Chem Neuroanat. 2022, 119:102056. 10.1016\/j.jchemneu.2021.102056","journal-title":"J Chem Neuroanat"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/460914-role-of-immunohistochemistry-in-the-diagnosis-and-clinicopathological-stratification-of-gliomas","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:52:23Z","timestamp":1773647543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/460914-role-of-immunohistochemistry-in-the-diagnosis-and-clinicopathological-stratification-of-gliomas"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.105288","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,16]]}}}