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Curr Opin Lipidol. 1996, 7:167-71.","journal-title":"Curr Opin Lipidol"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00215-4","article-title":"Low\u2011density lipoprotein particle size and risk factors of insulin resistance syndrome","volume":"148","author":"Friedlander Y","year":"2000","unstructured":"Friedlander Y, Kidron M, Caslake M, Lamb T, McConnell M, Bar\u2011On H. Low\u2011density lipoprotein particle size and risk factors of insulin resistance syndrome. Atherosclerosis. 2000, 148:141-9. 10.1016\/S0021-9150(99)00215-4","journal-title":"Atherosclerosis"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-10-200311180-00007","article-title":"Use of metabolic markers to identify overweight individuals who are insulin resistant","volume":"139","author":"McLaughlin T","year":"2003","unstructured":"McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G. Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med. 2003, 139:802-9. 10.7326\/0003-4819-139-10-200311180-00007","journal-title":"Ann Intern Med"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2015.10.004","article-title":"Metabolic syndrome update","volume":"26","author":"Grundy SM","year":"2016","unstructured":"Grundy SM. Metabolic syndrome update. Trends Cardiovasc Med. 2016, 26:364-73. 10.1016\/j.tcm.2015.10.004","journal-title":"Trends Cardiovasc Med"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.07.008","article-title":"Usefulness of triglycerides-to-high-density lipoprotein cholesterol ratio for predicting the first coronary event in men","volume":"104","author":"Cordero A","year":"2009","unstructured":"Cordero A, Andr\u00e9s E, Ordo\u00f1ez B, et al.. Usefulness of triglycerides-to-high-density lipoprotein cholesterol ratio for predicting the first coronary event in men. 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Nutr Metab Cardiovasc Dis. 2009, 19:401-8. 10.1016\/j.numecd.2008.09.003","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12036","article-title":"Identifying cardiovascular disease risk and outcome: use of the plasma triglyceride\/high-density lipoprotein cholesterol concentration ratio versus metabolic syndrome criteria","volume":"273","author":"Salazar MR","year":"2013","unstructured":"Salazar MR, Carbajal HA, Espeche WG, et al.. Identifying cardiovascular disease risk and outcome: use of the plasma triglyceride\/high-density lipoprotein cholesterol concentration ratio versus metabolic syndrome criteria. J Intern Med. 2013, 273:595-601. 10.1111\/joim.12036","journal-title":"J Intern Med"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.12.1395","article-title":"Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans","volume":"165","author":"Sumner AE","year":"2005","unstructured":"Sumner AE, Finley KB, Genovese DJ, Criqui MH, Boston RC. Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans. Arch Intern Med. 2005, 165:1395-400. 10.1001\/archinte.165.12.1395","journal-title":"Arch Intern Med"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.036819","article-title":"Dietary cholesterol and myocardial infarction in the Million Veteran Program","volume":"14","author":"Nguyen XT","year":"2025","unstructured":"Nguyen XT, Li Y, Nyaeme MS, et al.. 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