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Photobiomodul Photomed Laser Surg. 2023, 41:147-66. 10.1089\/photob.2022.0127","journal-title":"Photobiomodul Photomed Laser Surg"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1002\/qj.4712","article-title":"Observed patterns of surface solar irradiance under cloudy and clear\u2010sky conditions","volume":"150","author":"Mol W","year":"2024","unstructured":"Mol W, Heusinkveld B, Mangan MR, Hartogensis O, Veerman M, Heerwaarden C van. Observed patterns of surface solar irradiance under cloudy and clear\u2010sky conditions. Quarterly Journal of the Royal Meteorological Society. 2024, 150:2338-63. 10.1002\/qj.4712","journal-title":"Quarterly Journal of the Royal Meteorological Society"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.12.120901","article-title":"Review of light parameters and photobiomodulation efficacy: dive into complexity","volume":"23","author":"Zein R","year":"2018","unstructured":"Zein R, Selting W, Hamblin MR. 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Lasers Med Sci. 2023, 38:66. 10.1007\/s10103-022-03664-3","journal-title":"Lasers Med Sci"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02311-1","article-title":"Weeklong improved colour contrasts sensitivity after single 670\u00a0nm exposures associated with enhanced mitochondrial function","volume":"11","author":"Shinhmar H","year":"2021","unstructured":"Shinhmar H, Hogg C, Neveu M, Jeffery G. Weeklong improved colour contrasts sensitivity after single 670\u00a0nm exposures associated with enhanced mitochondrial function. Sci Rep. 2021, 11:22872. 10.1038\/s41598-021-02311-1","journal-title":"Sci Rep"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.942536","article-title":"The effect of photobiomodulation on the brain during wakefulness and sleep","volume":"16","author":"Moro C","year":"2022","unstructured":"Moro C, Valverde A, Dole M, et al.. The effect of photobiomodulation on the brain during wakefulness and sleep. 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Protocol report on the Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD) study. Healthcare (Basel). 2023, 11:2017. 10.3390\/healthcare11142017","journal-title":"Healthcare (Basel)"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23062975","article-title":"Photobiomodulation therapy and the glymphatic system: promising applications for augmenting the brain lymphatic drainage system","volume":"23","author":"Salehpour F","year":"2022","unstructured":"Salehpour F, Khademi M, Bragin DE, DiDuro JO. Photobiomodulation therapy and the glymphatic system: promising applications for augmenting the brain lymphatic drainage system. Int J Mol Sci. 2022, 23:2975. 10.3390\/ijms23062975","journal-title":"Int J Mol Sci"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.04.003","article-title":"The brain's glymphatic system: current controversies","volume":"43","author":"Mestre H","year":"2020","unstructured":"Mestre H, Mori Y, Nedergaard M. The brain's glymphatic system: current controversies. Trends Neurosci. 2020, 43:458-66. 10.1016\/j.tins.2020.04.003","journal-title":"Trends Neurosci"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax5440","article-title":"Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep","volume":"366","author":"Fultz NE","year":"2019","unstructured":"Fultz NE, Bonmassar G, Setsompop K, Stickgold RA, Rosen BR, Polimeni JR, Lewis LD. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019, 366:628-31. 10.1126\/science.aax5440","journal-title":"Science"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13789","article-title":"Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease","volume":"20","author":"Huang SY","year":"2024","unstructured":"Huang SY, Zhang YR, Guo Y, et al.. Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease. Alzheimers Dement. 2024, 20:3251-69. 10.1002\/alz.13789","journal-title":"Alzheimers Dement"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07132-6","article-title":"Multisensory gamma stimulation promotes glymphatic clearance of amyloid","volume":"627","author":"Murdock MH","year":"2024","unstructured":"Murdock MH, Yang CY, Sun N, et al.. Multisensory gamma stimulation promotes glymphatic clearance of amyloid. 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