{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:52:11Z","timestamp":1774241531086,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,22]]},"DOI":"10.7759\/cureus.105665","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:01:08Z","timestamp":1774238468000},"source":"Crossref","is-referenced-by-count":0,"title":["Simvastatin as a Biological Adjunct to Guided Bone Regeneration and Related Implant Regenerative Procedures: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Shubham B","family":"Tale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Gaikwad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshaya","family":"Banodkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshda S","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranav","family":"Kudale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini","family":"Metaliya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanpreet S","family":"Sachdev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/1758736012456543","article-title":"Alveolar ridge resorption after tooth extraction: a consequence of a fundamental principle of bone physiology","volume":"3","author":"Hansson S","year":"2012","unstructured":"Hansson S, Halldin A. Alveolar ridge resorption after tooth extraction: a consequence of a fundamental principle of bone physiology. J Dent Biomech. 2012, 3:1758736012456543. 10.1177\/1758736012456543","journal-title":"J Dent Biomech"},{"key":"ref2","article-title":"The long-term efficacy of currently used dental implants: a review and proposed criteria of success","volume":"1","author":"Albrektsson T","year":"1986","unstructured":"Albrektsson T, Zarb G, Worthington P, Eriksson AR. The long-term efficacy of currently used dental implants: a review and proposed criteria of success. Int J Oral Maxillofac Implants. 1986, 1:11-25.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01699.x","article-title":"Atrophy of the residual alveolar ridge following tooth loss in an historical population","volume":"17","author":"Reich KM","year":"2011","unstructured":"Reich KM, Huber CD, Lippnig WR, Ulm C, Watzek G, Tangl S. Atrophy of the residual alveolar ridge following tooth loss in an historical population. Oral Dis. 2011, 17:33-44. 10.1111\/j.1601-0825.2010.01699.x","journal-title":"Oral Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02060.x","article-title":"Analysis of the pattern of the alveolar ridge remodelling following single tooth extraction","volume":"22","author":"Covani U","year":"2011","unstructured":"Covani U, Ricci M, Bozzolo G, Mangano F, Zini A, Barone A. Analysis of the pattern of the alveolar ridge remodelling following single tooth extraction. Clin Oral Implants Res. 2011, 22:820-5. 10.1111\/j.1600-0501.2010.02060.x","journal-title":"Clin Oral Implants Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12108","article-title":"Ridge dimensional changes following single-tooth extraction in the aesthetic zone","volume":"25","author":"Farmer M","year":"2014","unstructured":"Farmer M, Darby I. Ridge dimensional changes following single-tooth extraction in the aesthetic zone. Clin Oral Implants Res. 2014, 25:272-7. 10.1111\/clr.12108","journal-title":"Clin Oral Implants Res"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(62)90124-5","article-title":"Factors of bone resorption of the residual ridge","volume":"12","author":"Ortman HR","year":"1962","unstructured":"Ortman HR. Factors of bone resorption of the residual ridge. J Prosthet Dent. 1962, 12:429-40. 10.1016\/0022-3913(62)90124-5","journal-title":"J Prosthet Dent"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2015.04.005","article-title":"Strategies for alveolar ridge reconstruction and preservation for implant therapy","volume":"59","author":"Masaki C","year":"2015","unstructured":"Masaki C, Nakamoto T, Mukaibo T, Kondo Y, Hosokawa R. Strategies for alveolar ridge reconstruction and preservation for implant therapy. J Prosthodont Res. 2015, 59:220-8. 10.1016\/j.jpor.2015.04.005","journal-title":"J Prosthodont Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.12.004","article-title":"Are there specific indications for the different alveolar bone augmentation procedures for implant placement? A systematic review","volume":"43","author":"Milinkovic I","year":"2014","unstructured":"Milinkovic I, Cordaro L. Are there specific indications for the different alveolar bone augmentation procedures for implant placement? A systematic review. Int J Oral Maxillofac Surg. 2014, 43:606-25. 10.1016\/j.ijom.2013.12.004","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.11607\/prd.1845","article-title":"Soft tissue contour changes at immediate implants: a randomized controlled clinical study","volume":"34","author":"Cardaropoli D","year":"2014","unstructured":"Cardaropoli D, Gaveglio L, Gherlone E, Cardaropoli G. Soft tissue contour changes at immediate implants: a randomized controlled clinical study. Int J Periodontics Restorative Dent. 2014, 34:631-7. 10.11607\/prd.1845","journal-title":"Int J Periodontics Restorative Dent"},{"key":"ref10","article-title":"Immediate or early placement of implants following tooth extraction: review of biologic basis, clinical procedures, and outcomes","volume":"19 Suppl","author":"Chen ST","year":"2004","unstructured":"Chen ST, Wilson TG Jr, H\u00e4mmerle CH. Immediate or early placement of implants following tooth extraction: review of biologic basis, clinical procedures, and outcomes. Int J Oral Maxillofac Implants. 2004, 19 Suppl:12-25.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01782.x","article-title":"Critical horizontal dimensions of interproximal and buccal bone around implants for optimal aesthetic outcomes: a systematic review","volume":"20 Suppl 4","author":"Teughels W","year":"2009","unstructured":"Teughels W, Merheb J, Quirynen M. Critical horizontal dimensions of interproximal and buccal bone around implants for optimal aesthetic outcomes: a systematic review. Clin Oral Implants Res. 2009, 20 Suppl 4:134-45. 10.1111\/j.1600-0501.2009.01782.x","journal-title":"Clin Oral Implants Res"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1002\/j.0022-0337.2003.67.8.tb03681.x","article-title":"Understanding peri-implant endosseous healing","volume":"67","author":"Davies JE","year":"2003","unstructured":"Davies JE. Understanding peri-implant endosseous healing. J Dent Educ. 2003, 67:932-49.","journal-title":"J Dent Educ"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2022.09.012","article-title":"Immediate implant placement with simultaneous bone augmentation versus delayed implant placement following alveolar ridge preservation: a clinical and radiographic study","volume":"124","author":"Al-Aroomi OA","year":"2023","unstructured":"Al-Aroomi OA, Sakran KA, Al-Aroomi MA, Mashrah MA, Ashour SH, Al-Attab R, Yin L. Immediate implant placement with simultaneous bone augmentation versus delayed implant placement following alveolar ridge preservation: a clinical and radiographic study. J Stomatol Oral Maxillofac Surg. 2023, 124:101291. 10.1016\/j.jormas.2022.09.012","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13052","article-title":"Efficacy of lateral bone augmentation prior to implant placement: a systematic review and meta-analysis","volume":"46 Suppl 21","author":"Naenni N","year":"2019","unstructured":"Naenni N, Lim HC, Papageorgiou SN, H\u00e4mmerle CH. Efficacy of lateral bone augmentation prior to implant placement: a systematic review and meta-analysis. J Clin Periodontol. 2019, 46 Suppl 21:287-306. 10.1111\/jcpe.13052","journal-title":"J Clin Periodontol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2019.01.003","article-title":"Guided bone regeneration in alveolar bone reconstruction","volume":"31","author":"Urban IA","year":"2019","unstructured":"Urban IA, Monje A. Guided bone regeneration in alveolar bone reconstruction. Oral Maxillofac Surg Clin North Am. 2019, 31:331-8. 10.1016\/j.coms.2019.01.003","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01922.x","article-title":"Guided bone regeneration: biological principle and therapeutic applications","volume":"21","author":"Retzepi M","year":"2010","unstructured":"Retzepi M, Donos N. Guided bone regeneration: biological principle and therapeutic applications. Clin Oral Implants Res. 2010, 21:567-76. 10.1111\/j.1600-0501.2010.01922.x","journal-title":"Clin Oral Implants Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2019.02.008","article-title":"Resorbable versus nonresorbable membranes: when and why?","volume":"63","author":"Naung NY","year":"2019","unstructured":"Naung NY, Shehata E, Van Sickels JE. Resorbable versus nonresorbable membranes: when and why?. Dent Clin North Am. 2019, 63:419-31. 10.1016\/j.cden.2019.02.008","journal-title":"Dent Clin North Am"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113318","article-title":"Underestimated microbial infection of resorbable membranes on guided regeneration","volume":"226","author":"Abdo VL","year":"2023","unstructured":"Abdo VL, Suarez LJ, de Paula LG, et al.. Underestimated microbial infection of resorbable membranes on guided regeneration. Colloids Surf B Biointerfaces. 2023, 226:113318. 10.1016\/j.colsurfb.2023.113318","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e13488","article-title":"Evaluation of efficacy of non-resorbable membranes compared to resorbable membranes in patients undergoing guided bone regeneration","volume":"9","author":"Patil S","year":"2023","unstructured":"Patil S, Bhandi S, Bakri MM, et al.. Evaluation of efficacy of non-resorbable membranes compared to resorbable membranes in patients undergoing guided bone regeneration. Heliyon. 2023, 9:e13488. 10.1016\/j.heliyon.2023.e13488","journal-title":"Heliyon"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314987","article-title":"Barrier membranes for guided bone regeneration (GBR): a focus on recent advances in collagen membranes","volume":"23","author":"Ren Y","year":"2022","unstructured":"Ren Y, Fan L, Alkildani S, et al.. Barrier membranes for guided bone regeneration (GBR): a focus on recent advances in collagen membranes. Int J Mol Sci. 2022, 23:10.3390\/ijms232314987","journal-title":"Int J Mol Sci"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/s0030-5898(05)70107-3","article-title":"Biology of bone grafts","volume":"30","author":"Stevenson S","year":"1999","unstructured":"Stevenson S. Biology of bone grafts. Orthop Clin North Am. 1999, 30:543-52. 10.1016\/s0030-5898(05)70107-3","journal-title":"Orthop Clin North Am"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2012.04.022","article-title":"Recent advances in the development of GTR\/GBR membranes for periodontal regeneration--a materials perspective","volume":"28","author":"Bottino MC","year":"2012","unstructured":"Bottino MC, Thomas V, Schmidt G, Vohra YK, Chu TM, Kowolik MJ, Janowski GM. Recent advances in the development of GTR\/GBR membranes for periodontal regeneration--a materials perspective. Dent Mater. 2012, 28:703-21. 10.1016\/j.dental.2012.04.022","journal-title":"Dent Mater"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/521547","article-title":"Surgical approaches based on biological objectives: GTR versus GBR techniques","volume":"2013","author":"Pellegrini G","year":"2013","unstructured":"Pellegrini G, Pagni G, Rasperini G. Surgical approaches based on biological objectives: GTR versus GBR techniques. Int J Dent. 2013, 2013:521547. 10.1155\/2013\/521547","journal-title":"Int J Dent"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2023.0040","article-title":"Periodontal guided tissue regeneration membranes: limitations and possible solutions for the bottleneck analysis","volume":"29","author":"Ma YF","year":"2023","unstructured":"Ma YF, Yan XZ. Periodontal guided tissue regeneration membranes: limitations and possible solutions for the bottleneck analysis. Tissue Eng Part B Rev. 2023, 29:532-44. 10.1089\/ten.TEB.2023.0040","journal-title":"Tissue Eng Part B Rev"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.512","article-title":"The effect of membrane exposure on the outcome of regenerative procedures in humans: a meta-analysis","volume":"72","author":"Machtei EE","year":"2001","unstructured":"Machtei EE. The effect of membrane exposure on the outcome of regenerative procedures in humans: a meta-analysis. J Periodontol. 2001, 72:512-6. 10.1902\/jop.2001.72.4.512","journal-title":"J Periodontol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103341","article-title":"An overview of guided tissue regeneration (GTR) systems designed and developed as drug carriers for management of periodontitis","volume":"71","author":"Mirzaeei S","year":"2022","unstructured":"Mirzaeei S, Ezzati A, Mehrandish S, Asare-Addo K, Nokhodchi A. An overview of guided tissue regeneration (GTR) systems designed and developed as drug carriers for management of periodontitis. J Drug Deliv Sci Technol. 2022, 71:103341. 10.1016\/j.jddst.2022.103341","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.9.1026","article-title":"Bone regeneration by recombinant human bone morphogenetic protein-2 in rat mandibular defects. An experimental model of defect filling","volume":"70","author":"Higuchi T","year":"1999","unstructured":"Higuchi T, Kinoshita A, Takahashi K, Oda S, Ishikawa I. Bone regeneration by recombinant human bone morphogenetic protein-2 in rat mandibular defects. An experimental model of defect filling. J Periodontol. 1999, 70:1026-31. 10.1902\/jop.1999.70.9.1026","journal-title":"J Periodontol"},{"key":"ref28","article-title":"A reentry study on the use of bovine porous bone mineral, GTR, and platelet-rich plasma in the regenerative treatment of intrabony defects in humans","volume":"25","author":"Camargo PM","year":"2005","unstructured":"Camargo PM, Lekovic V, Weinlaender M, Vasilic N, Madzarevic M, Kenney EB. A reentry study on the use of bovine porous bone mineral, GTR, and platelet-rich plasma in the regenerative treatment of intrabony defects in humans. Int J Periodontics Restorative Dent. 2005, 25:49-59.","journal-title":"Int J Periodontics Restorative Dent"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.12.2583","article-title":"Simvastatin: a review","volume":"5","author":"Pedersen TR","year":"2004","unstructured":"Pedersen TR, Tobert JA. Simvastatin: a review. Expert Opin Pharmacother. 2004, 5:2583-96. 10.1517\/14656566.5.12.2583","journal-title":"Expert Opin Pharmacother"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1177\/1074248413492906","article-title":"Lipid-lowering agents","volume":"18","author":"Ewang-Emukowhate M","year":"2013","unstructured":"Ewang-Emukowhate M, Wierzbicki AS. Lipid-lowering agents. J Cardiovasc Pharmacol Ther. 2013, 18:401-11. 10.1177\/1074248413492906","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.210337","article-title":"Pleiotropic effects on proliferation and mineralization of primary human adipose tissue-derived stromal cells induced by simvastatin","volume":"12","author":"Sabandal MM","year":"2022","unstructured":"Sabandal MM, Sch\u00e4fer E, Petsching S, Jung S, Kleinheinz J, Sielker S. Pleiotropic effects on proliferation and mineralization of primary human adipose tissue-derived stromal cells induced by simvastatin. Open Biol. 2022, 12:210337. 10.1098\/rsob.210337","journal-title":"Open Biol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2010.03.003","article-title":"Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling","volume":"162","author":"Yamashita M","year":"2010","unstructured":"Yamashita M, Otsuka F, Mukai T, et al.. Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling. Regul Pept. 2010, 162:99-108. 10.1016\/j.regpep.2010.03.003","journal-title":"Regul Pept"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.2.295","article-title":"Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells","volume":"76","author":"Yazawa H","year":"2005","unstructured":"Yazawa H, Zimmermann B, Asami Y, Bernimoulin JP. Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. J Periodontol. 2005, 76:295-302. 10.1902\/jop.2005.76.2.295","journal-title":"J Periodontol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.2174\/156800905774932824","article-title":"Anti-angiogenic and anti-inflammatory effects of statins: relevance to anti-cancer therapy","volume":"5","author":"Dulak J","year":"2005","unstructured":"Dulak J, J\u00f3zkowicz A. Anti-angiogenic and anti-inflammatory effects of statins: relevance to anti-cancer therapy. Curr Cancer Drug Targets. 2005, 5:579-94. 10.2174\/156800905774932824","journal-title":"Curr Cancer Drug Targets"},{"key":"ref35","article-title":"The use of simvastatin in bone regeneration","volume":"14","author":"Park JB","year":"2009","unstructured":"Park JB. The use of simvastatin in bone regeneration. Med Oral Patol Oral Cir Bucal. 2009, 14:e485-8.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.11.011","article-title":"Effects of local application of simvastatin on bone regeneration in femoral bone defects in rabbit","volume":"43","author":"Papadimitriou K","year":"2015","unstructured":"Papadimitriou K, Karkavelas G, Vouros I, Kessopoulou E, Konstantinidis A. Effects of local application of simvastatin on bone regeneration in femoral bone defects in rabbit. J Craniomaxillofac Surg. 2015, 43:232-7. 10.1016\/j.jcms.2014.11.011","journal-title":"J Craniomaxillofac Surg"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c00462","article-title":"Simvastatin-incorporated drug delivery systems for bone regeneration","volume":"7","author":"Jin H","year":"2021","unstructured":"Jin H, Ji Y, Cui Y, Xu L, Liu H, Wang J. Simvastatin-incorporated drug delivery systems for bone regeneration. ACS Biomater Sci Eng. 2021, 7:2177-91. 10.1021\/acsbiomaterials.1c00462","journal-title":"ACS Biomater Sci Eng"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042378","article-title":"Statins-their role in bone tissue metabolism and local applications with different carriers","volume":"25","author":"Granat MM","year":"2024","unstructured":"Granat MM, Eifler-Zydel J, Kolmas J. Statins-their role in bone tissue metabolism and local applications with different carriers. Int J Mol Sci. 2024, 25:10.3390\/ijms25042378","journal-title":"Int J Mol Sci"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.1007399","article-title":"Use of statins after bone osteotomy and augmentation and their antibacterial effect: narrative review of literature","volume":"60","author":"Katanec T","year":"2021","unstructured":"Katanec T, Kuna T, Gabri\u0107 D. Use of statins after bone osteotomy and augmentation and their antibacterial effect: narrative review of literature. Acta Clin Croat. 2021, 60:410-6. 10.5772\/intechopen.1007399","journal-title":"Acta Clin Croat"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.ED000148","article-title":"Risk of Bias 2 in Cochrane reviews: a phased approach for the introduction of new methodology","volume":"10","author":"Flemyng E","year":"2020","unstructured":"Flemyng E, Dwan K, Moore TH, Page MJ, Higgins JP. Risk of Bias 2 in Cochrane reviews: a phased approach for the introduction of new methodology. Cochrane Database Syst Rev. 2020, 10:ED000148. 10.1002\/14651858.ED000148","journal-title":"Cochrane Database Syst Rev"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne JA","year":"2016","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, et al.. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016, 355:i4919. 10.1136\/bmj.i4919","journal-title":"BMJ"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans CR","year":"2014","unstructured":"Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol. 2014, 14:43. 10.1186\/1471-2288-14-43","journal-title":"BMC Med Res Methodol"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.4103\/jips.jips_258_21","article-title":"Effect of local application of platelet-rich fibrin scaffold loaded with simvastatin on peri-implant bone changes","volume":"22","author":"El Shafei SF","year":"2022","unstructured":"El Shafei SF, Raafat SN, Amin AH, Rizk FN. Effect of local application of platelet-rich fibrin scaffold loaded with simvastatin on peri-implant bone changes. J Indian Prosthodont Soc. 2022, 22:152-60. 10.4103\/jips.jips_258_21","journal-title":"J Indian Prosthodont Soc"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.jpbs_492_23","article-title":"Evaluation of crestal bone levels using simvastatin as an adjuvant around immediate implants - a clinico radiographic study","volume":"16","author":"Betha H","year":"2024","unstructured":"Betha H, Rajmohan M, Thakkar R, Surya BR, Shetty M, Sankla P, Tiwari R. Evaluation of crestal bone levels using simvastatin as an adjuvant around immediate implants - a clinico radiographic study. J Pharm Bioallied Sci. 2024, 16:S279-82. 10.4103\/jpbs.jpbs_492_23","journal-title":"J Pharm Bioallied Sci"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000051","article-title":"Evaluation of simvastatin grafting around immediate dental implants in dogs","volume":"23","author":"Mansour G","year":"2014","unstructured":"Mansour G, Al Ashwah A, Koura A. Evaluation of simvastatin grafting around immediate dental implants in dogs. Implant Dent. 2014, 23:195-9. 10.1097\/ID.0000000000000051","journal-title":"Implant Dent"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3390\/ma14133707","article-title":"Improvement of osseointegration by ultraviolet and\/or simvastatin treatment on titanium implants with or without bone graft materials","volume":"14","author":"Jun JH","year":"2021","unstructured":"Jun JH, Oh KC, Park KH, Jung N, Li J, Moon HS. Improvement of osseointegration by ultraviolet and\/or simvastatin treatment on titanium implants with or without bone graft materials. Materials (Basel). 2021, 14:10.3390\/ma14133707","journal-title":"Materials (Basel)"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05427-y","article-title":"Alveolar ridge splitting and simvastatin loaded xenograft for guided bone regeneration and simultaneous implant placement: randomized controlled clinical trial","volume":"28","author":"Issa DR","year":"2024","unstructured":"Issa DR, Elamrousy W, Gamal AY. Alveolar ridge splitting and simvastatin loaded xenograft for guided bone regeneration and simultaneous implant placement: randomized controlled clinical trial. Clin Oral Investig. 2024, 28:71. 10.1007\/s00784-023-05427-y","journal-title":"Clin Oral Investig"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/450172-simvastatin-as-a-biological-adjunct-to-guided-bone-regeneration-and-related-implant-regenerative-procedures-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:01:09Z","timestamp":1774238469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/450172-simvastatin-as-a-biological-adjunct-to-guided-bone-regeneration-and-related-implant-regenerative-procedures-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,22]]},"references-count":48,"URL":"https:\/\/doi.org\/10.7759\/cureus.105665","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,22]]}}}