{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:17:13Z","timestamp":1774376233935,"version":"3.50.1"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,24]]},"DOI":"10.7759\/cureus.105772","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:52:17Z","timestamp":1774367537000},"source":"Crossref","is-referenced-by-count":0,"title":["From Benign to Lethal: A Case of Aggressive Choriocarcinoma With Systemic Metastases"],"prefix":"10.7759","author":[{"given":"Esperance  M","family":"Madera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parag","family":"Gajurel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domonick K","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa","family":"Ayyad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Lefko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prathyusha","family":"Pinnamaneni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Orenshteyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gautam","family":"Valecha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manubolu","family":"Devanand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Saini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12615","article-title":"Update on the diagnosis and management of gestational trophoblastic disease","volume":"143 Suppl 2","author":"Ngan HY","year":"2018","unstructured":"Ngan HY, Seckl MJ, Berkowitz RS, et al.. Update on the diagnosis and management of gestational trophoblastic disease. Int J Gynaecol Obstet. 2018, 143 Suppl 2:79-85. 10.1002\/ijgo.12615","journal-title":"Int J Gynaecol Obstet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl MJ","year":"2010","unstructured":"Seckl MJ, Sebire NJ, Berkowitz RS. Gestational trophoblastic disease. Lancet. 2010, 376:717-29. 10.1016\/S0140-6736(10)60280-2","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.072","article-title":"Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia","volume":"204","author":"Lurain JR","year":"2011","unstructured":"Lurain JR. Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia. Am J Obstet Gynecol. 2011, 204:11-8. 10.1016\/j.ajog.2010.06.072","journal-title":"Am J Obstet Gynecol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.073","article-title":"Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole","volume":"203","author":"Lurain JR","year":"2010","unstructured":"Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010, 203:531-9. 10.1016\/j.ajog.2010.06.073","journal-title":"Am J Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00063-2","article-title":"FIGO staging for gestational trophoblastic neoplasia 2000","volume":"77","year":"2002","unstructured":"FIGO staging for gestational trophoblastic neoplasia 2000. Int J Gynaecol Obstet. 2002, 77.285-7. 10.1016\/S0020-7292(02)00063-2","journal-title":"Int J Gynaecol Obstet"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.06.008","article-title":"Update on the diagnosis and management of gestational trophoblastic disease","volume":"131 Suppl 2","author":"Ngan HY","year":"2015","unstructured":"Ngan HY, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR. Update on the diagnosis and management of gestational trophoblastic disease. Int J Gynaecol Obstet. 2015, 131 Suppl 2:123-6. 10.1016\/j.ijgo.2015.06.008","journal-title":"Int J Gynaecol Obstet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.4386","article-title":"Phase III trial of weekly methotrexate versus pulsed dactinomycin for low-risk gestational trophoblastic neoplasia: a gynecologic oncology group study","volume":"29","author":"Osborne RJ","year":"2011","unstructured":"Osborne RJ, Filiaci V, Schink JC, et al.. Phase III trial of weekly methotrexate versus pulsed dactinomycin for low-risk gestational trophoblastic neoplasia: a gynecologic oncology group study. J Clin Oncol. 2011, 29:825-31. 10.1200\/JCO.2010.30.4386","journal-title":"J Clin Oncol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.1817","article-title":"EMA\/CO for high-risk gestational trophoblastic neoplasia: good outcomes with induction low-dose etoposide-cisplatin and genetic analysis","volume":"31","author":"Alifrangis C","year":"2013","unstructured":"Alifrangis C, Agarwal R, Short D, et al.. EMA\/CO for high-risk gestational trophoblastic neoplasia: good outcomes with induction low-dose etoposide-cisplatin and genetic analysis. J Clin Oncol. 2013, 31:280-6. 10.1200\/JCO.2012.43.1817","journal-title":"J Clin Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/389463-from-benign-to-lethal-a-case-of-aggressive-choriocarcinoma-with-systemic-metastases","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:52:18Z","timestamp":1774367538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/389463-from-benign-to-lethal-a-case-of-aggressive-choriocarcinoma-with-systemic-metastases"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":8,"URL":"https:\/\/doi.org\/10.7759\/cureus.105772","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,24]]}}}