{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T21:24:47Z","timestamp":1774387487654,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,24]]},"DOI":"10.7759\/cureus.105779","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:37:18Z","timestamp":1774377438000},"source":"Crossref","is-referenced-by-count":0,"title":["Emerging Sedation Strategies in Pediatric Emergency Care: Pharmacological Advances and Clinical Applications"],"prefix":"10.7759","author":[{"given":"Sabrina","family":"Montoya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Alvarez Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Chavarr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia L","family":"Zamora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Andr\u00e9s","family":"Soto Cordero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-024-00659-1","article-title":"Optimizing pediatric sedation: evaluating remimazolam and dexmedetomidine for safety and efficacy in clinical practice","volume":"27","author":"Scheckenbach V","year":"2025","unstructured":"Scheckenbach V, Fideler F. Optimizing pediatric sedation: evaluating remimazolam and dexmedetomidine for safety and efficacy in clinical practice. Paediatr Drugs. 2025, 27:181-9. 10.1007\/s40272-024-00659-1","journal-title":"Paediatr Drugs"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12185937","article-title":"Remimazolam for pediatric procedural sedation: results of an institutional pilot program","volume":"12","author":"Hirano T","year":"2023","unstructured":"Hirano T, Kimoto Y, Kuratani N, Cavanaugh D, Mason KP. Remimazolam for pediatric procedural sedation: results of an institutional pilot program. J Clin Med. 2023, 12:5937. 10.3390\/jcm12185937","journal-title":"J Clin Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S536873","article-title":"Safety of remimazolam in vulnerable populations","volume":"19","author":"Ge JY","year":"2025","unstructured":"Ge JY, Deng BR, Cao XH, Liu XJ. Safety of remimazolam in vulnerable populations. Drug Des Devel Ther. 2025, 19:8691-709. 10.2147\/DDDT.S536873","journal-title":"Drug Des Devel Ther"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S453440","article-title":"Clinical application and research progress of remimazolam for pediatric patients","volume":"18","author":"Bai C","year":"2024","unstructured":"Bai C, Xu M, Guo Y, Jin Y, Zhao X. Clinical application and research progress of remimazolam for pediatric patients. Drug Des Devel Ther. 2024, 18:1221-9. 10.2147\/DDDT.S453440","journal-title":"Drug Des Devel Ther"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16475","article-title":"Safety and efficacy of remimazolam tosilate for general anaesthesia in paediatric patients undergoing elective surgery: a multicentre, randomised, single-blind, controlled trial","volume":"80","author":"Fang YB","year":"2025","unstructured":"Fang YB, Zhong JW, Szmuk P, et al.. Safety and efficacy of remimazolam tosilate for general anaesthesia in paediatric patients undergoing elective surgery: a multicentre, randomised, single-blind, controlled trial. Anaesthesia. 2025, 80:259-68. 10.1111\/anae.16475","journal-title":"Anaesthesia"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-1623","article-title":"Intranasal dexmedetomidine for procedural distress in children: a systematic review","volume":"145","author":"Poonai N","year":"2020","unstructured":"Poonai N, Spohn J, Vandermeer B, et al.. Intranasal dexmedetomidine for procedural distress in children: a systematic review. Pediatrics. 2020, 145:e20191623. 10.1542\/peds.2019-1623","journal-title":"Pediatrics"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.974917","article-title":"Efficacy and safety of the combination of propofol and S(+)-ketamine for procedural sedation in pediatric patients undergoing totally implantable venous access port implantation: a prospective randomized controlled study","volume":"10","author":"Zhang Y","year":"2022","unstructured":"Zhang Y, Ou C, Bai X, Lai J, Huang W, Ouyang H. Efficacy and safety of the combination of propofol and S(+)-ketamine for procedural sedation in pediatric patients undergoing totally implantable venous access port implantation: a prospective randomized controlled study. Front Pediatr. 2022, 10:974917. 10.3389\/fped.2022.974917","journal-title":"Front Pediatr"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-025-01548-7","article-title":"Clinical pharmacokinetics and pharmacodynamics of remimazolam","volume":"64","author":"de Jong BT","year":"2025","unstructured":"de Jong BT, Eleveld DJ, Mason KP, Struys MM. Clinical pharmacokinetics and pharmacodynamics of remimazolam. Clin Pharmacokinet. 2025, 64:1263-82. 10.1007\/s40262-025-01548-7","journal-title":"Clin Pharmacokinet"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003103","article-title":"Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: part I: pharmacokinetics and clinical pharmacodynamics","volume":"132","author":"Sch\u00fcttler J","year":"2020","unstructured":"Sch\u00fcttler J, Eisenried A, Lerch M, Fechner J, Jeleazcov C, Ihmsen H. Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: part I: pharmacokinetics and clinical pharmacodynamics. Anesthesiology. 2020, 132:636-51. 10.1097\/ALN.0000000000003103","journal-title":"Anesthesiology"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16091122","article-title":"Toward model-informed precision dosing for remimazolam: a population pharmacokinetic-pharmacodynamic analysis","volume":"16","author":"Chen Y","year":"2024","unstructured":"Chen Y, Gong C, Liu F, Jiao Z, Zheng X. Toward model-informed precision dosing for remimazolam: a population pharmacokinetic-pharmacodynamic analysis. Pharmaceutics. 2024, 16:1122. 10.3390\/pharmaceutics16091122","journal-title":"Pharmaceutics"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004258","article-title":"Population pharmacokinetics of intranasal dexmedetomidine in infants and young children","volume":"137","author":"Li BL","year":"2022","unstructured":"Li BL, Guan YP, Yuen VM, et al.. Population pharmacokinetics of intranasal dexmedetomidine in infants and young children. Anesthesiology. 2022, 137:163-75. 10.1097\/ALN.0000000000004258","journal-title":"Anesthesiology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/aas.14439","article-title":"Remimazolam for sedation and anesthesia in children: a scoping review","volume":"68","author":"Kuklin V","year":"2024","unstructured":"Kuklin V, Hansen TG. Remimazolam for sedation and anesthesia in children: a scoping review. Acta Anaesthesiol Scand. 2024, 68:862-70. 10.1111\/aas.14439","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S384155","article-title":"Remimazolam: an updated review of a new sedative and anaesthetic","volume":"16","author":"Hu Q","year":"2022","unstructured":"Hu Q, Liu X, Wen C, Li D, Lei X. Remimazolam: an updated review of a new sedative and anaesthetic. Drug Des Devel Ther. 2022, 16:3957-74. 10.2147\/DDDT.S384155","journal-title":"Drug Des Devel Ther"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1298409","article-title":"Comparison of remimazolam and propofol combined with low dose esketamine for pediatric same-day painless bidirectional endoscopy: a randomized, controlled clinical trial","volume":"15","author":"Chu T","year":"2024","unstructured":"Chu T, Zhou S, Wan Y, et al.. Comparison of remimazolam and propofol combined with low dose esketamine for pediatric same-day painless bidirectional endoscopy: a randomized, controlled clinical trial. Front Pharmacol. 2024, 15:1298409. 10.3389\/fphar.2024.1298409","journal-title":"Front Pharmacol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2025.1662752","article-title":"Remimazolam in pediatric anesthesia: a systematic review for clinical decision-making","volume":"13","author":"Zhang Y","year":"2025","unstructured":"Zhang Y, Chen Q, Wang L, et al.. Remimazolam in pediatric anesthesia: a systematic review for clinical decision-making. Front Pediatr. 2025, 13:1662752. 10.3389\/fped.2025.1662752","journal-title":"Front Pediatr"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S474854","article-title":"Remimazolam in general anesthesia: a comprehensive review of its applications and clinical efficacy","volume":"18","author":"Zhang H","year":"2024","unstructured":"Zhang H, Li H, Zhao S, Bao F. Remimazolam in general anesthesia: a comprehensive review of its applications and clinical efficacy. Drug Des Devel Ther. 2024, 18:3487-98. 10.2147\/DDDT.S474854","journal-title":"Drug Des Devel Ther"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ph17111506","article-title":"Analgosedation in pediatric emergency care: a comprehensive scoping review","volume":"17","author":"Ciavola L","year":"2024","unstructured":"Ciavola L, Sogni F, Mucci B, Alfieri E, Tinella A, Mariotti Zani E, Esposito S. Analgosedation in pediatric emergency care: a comprehensive scoping review. Pharmaceuticals (Basel). 2024, 17:1506. 10.3390\/ph17111506","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2023.01.046","article-title":"Intranasal ketamine for procedural sedation in children: an open-label multicenter clinical trial","volume":"67","author":"Rached-d'Astous S","year":"2023","unstructured":"Rached-d'Astous S, Finkelstein Y, Bailey B, Marquis C, Lebel D, Desjardins MP, Trottier ED. Intranasal ketamine for procedural sedation in children: an open-label multicenter clinical trial. Am J Emerg Med. 2023, 67:10-6. 10.1016\/j.ajem.2023.01.046","journal-title":"Am J Emerg Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2020.12.033","article-title":"The use of esketamine sedation in the emergency department for manipulation of paediatric forearm fractures: a 5 year study","volume":"52","author":"Patel D","year":"2021","unstructured":"Patel D, Talbot C, Luo W, Mulvaney S, Byrne E. The use of esketamine sedation in the emergency department for manipulation of paediatric forearm fractures: a 5 year study. Injury. 2021, 52:1321-30. 10.1016\/j.injury.2020.12.033","journal-title":"Injury"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15973","article-title":"Nurse-led dexmedetomidine sedation for magnetic resonance imaging in children: a 6-year quality improvement project","volume":"78","author":"Lin R","year":"2023","unstructured":"Lin R, Lin H, Elder E, Cerullo A, Carrington A, Stuart G. Nurse-led dexmedetomidine sedation for magnetic resonance imaging in children: a 6-year quality improvement project. Anaesthesia. 2023, 78:598-606. 10.1111\/anae.15973","journal-title":"Anaesthesia"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0317406","article-title":"Paediatric sedation with intranasal dexmedetomidine: protocol for a systematic review and meta-analysis","volume":"20","author":"Nissen KD","year":"2025","unstructured":"Nissen KD, Moos CM, Wolf A, Str\u00f8m T. Paediatric sedation with intranasal dexmedetomidine: protocol for a systematic review and meta-analysis. PLoS One. 2025, 20:e0317406. 10.1371\/journal.pone.0317406","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-022-00498-y","article-title":"Best evidence-based dosing recommendations for dexmedetomidine for premedication and procedural sedation in pediatrics: outcome of a risk-benefit analysis by the Dutch Pediatric Formulary","volume":"24","author":"Freriksen JJ","year":"2022","unstructured":"Freriksen JJ, van der Zanden TM, Holsappel IG, Molenbuur B, de Wildt SN. Best evidence-based dosing recommendations for dexmedetomidine for premedication and procedural sedation in pediatrics: outcome of a risk-benefit analysis by the Dutch Pediatric Formulary. Paediatr Drugs. 2022, 24:247-57. 10.1007\/s40272-022-00498-y","journal-title":"Paediatr Drugs"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1184663","article-title":"Evaluating efficacy and safety of sub-anesthetic dose esketamine as an adjuvant to propofol\/remifentanil analgosedation and spontaneous respiration for children flexible fibreoptic bronchoscopy: a prospective, double-blinded, randomized, and placebo-controlled clinical trial","volume":"14","author":"Zhong Y","year":"2023","unstructured":"Zhong Y, Jiang M, Wang Y, et al.. Evaluating efficacy and safety of sub-anesthetic dose esketamine as an adjuvant to propofol\/remifentanil analgosedation and spontaneous respiration for children flexible fibreoptic bronchoscopy: a prospective, double-blinded, randomized, and placebo-controlled clinical trial. Front Pharmacol. 2023, 14:1184663. 10.3389\/fphar.2023.1184663","journal-title":"Front Pharmacol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14473","article-title":"Late airway complications following pediatric liver transplantation: a case series","volume":"27","author":"Rajasekaran V","year":"2023","unstructured":"Rajasekaran V, McCaffer C, Bishop J, Van Der Meer G, Toll EC, Evans H. Late airway complications following pediatric liver transplantation: a case series. Pediatr Transplant. 2023, 27:e14473. 10.1111\/petr.14473","journal-title":"Pediatr Transplant"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S544592","article-title":"Determination of the 90% effective dose of remimazolam continuous infusion for preventing emergence delirium in pediatric patients undergoing adenoidectomy or adenotonsillectomy with sevoflurane: a biased coin up-and-down sequential trial design","volume":"19","author":"Yang ZS","year":"2025","unstructured":"Yang ZS, Li D, Jiang Y, Xiao F, Yan HY. Determination of the 90% effective dose of remimazolam continuous infusion for preventing emergence delirium in pediatric patients undergoing adenoidectomy or adenotonsillectomy with sevoflurane: a biased coin up-and-down sequential trial design. Drug Des Devel Ther. 2025, 19:7735-44. 10.2147\/DDDT.S544592","journal-title":"Drug Des Devel Ther"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S532565","article-title":"Low-dose alfentanil effectively reduces the ED50 of remimazolam for loss of consciousness in pediatric patients undergoing general anesthesia: a study using up-and-down sequential allocation method","volume":"19","author":"Shi X","year":"2025","unstructured":"Shi X, Yi F, Xiao H, et al.. Low-dose alfentanil effectively reduces the ED50 of remimazolam for loss of consciousness in pediatric patients undergoing general anesthesia: a study using up-and-down sequential allocation method. Drug Des Devel Ther. 2025, 19:7459-66. 10.2147\/DDDT.S532565","journal-title":"Drug Des Devel Ther"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4103\/ija.ija_415_22","article-title":"Search for the ideal route of premedication in children: far from over?","volume":"66","author":"Sengupta S","year":"2022","unstructured":"Sengupta S, Bhattacharya P, Nag DS, Sahay N. Search for the ideal route of premedication in children: far from over?. Indian J Anaesth. 2022, 66:S188-92. 10.4103\/ija.ija_415_22","journal-title":"Indian J Anaesth"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001561","article-title":"Oral melatonin as part of multimodal anxiolysis decreases emergence delirium in children whereas midazolam does not: a randomised, double-blind, placebo-controlled study","volume":"38","author":"Singla L","year":"2021","unstructured":"Singla L, Mathew PJ, Jain A, Yaddanapudi S, Peters NJ. Oral melatonin as part of multimodal anxiolysis decreases emergence delirium in children whereas midazolam does not: a randomised, double-blind, placebo-controlled study. Eur J Anaesthesiol. 2021, 38:1130-7. 10.1097\/EJA.0000000000001561","journal-title":"Eur J Anaesthesiol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000908448.13952.5e","article-title":"679: Enteral pentobarbital in difficult-to-sedate critically ill children","volume":"51","author":"Aljabari S","year":"2023","unstructured":"Aljabari S, Keaveney S, Anderson J. 679: Enteral pentobarbital in difficult-to-sedate critically ill children. Crit Care Med. 2023, 51:330. 10.1097\/01.ccm.0000908448.13952.5e","journal-title":"Crit Care Med"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001350","article-title":"The synergistic effect of dexmedetomidine on propofol for paediatric deep sedation: a randomised trial","volume":"38","author":"Mason KP","year":"2021","unstructured":"Mason KP, Park RS, Sullivan CA, et al.. The synergistic effect of dexmedetomidine on propofol for paediatric deep sedation: a randomised trial. Eur J Anaesthesiol. 2021, 38:541-7. 10.1097\/EJA.0000000000001350","journal-title":"Eur J Anaesthesiol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13377","article-title":"A comparative evaluation of dexmedetomidine and midazolam in pediatric sedation: a meta-analysis of randomized controlled trials with trial sequential analysis","volume":"26","author":"Lang B","year":"2020","unstructured":"Lang B, Zhang L, Zhang W, Lin Y, Fu Y, Chen S. A comparative evaluation of dexmedetomidine and midazolam in pediatric sedation: a meta-analysis of randomized controlled trials with trial sequential analysis. CNS Neurosci Ther. 2020, 26:862-75. 10.1111\/cns.13377","journal-title":"CNS Neurosci Ther"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-024-01190-5","article-title":"A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children","volume":"32","author":"Nikula A","year":"2024","unstructured":"Nikula A, Lundeberg S, Ryd Rinder M, L\u00e4\u00e4peri M, Sandholm K, Castr\u00e9n M, Kurland L. A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children. Scand J Trauma Resusc Emerg Med. 2024, 32:16. 10.1186\/s13049-024-01190-5","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S525687","article-title":"Compare the effects of 0 mg\/kg, 0.1 mg\/kg, 0.3 mg\/kg and 0.5 mg\/kg esketamine on emergence agitation after tonsillectomy and adenoidectomy in children: a randomized control trial","volume":"19","author":"Jiang P","year":"2025","unstructured":"Jiang P, Liu W, Peng Q, Feng Y, Wang D, Luo K, Huang S. Compare the effects of 0 mg\/kg, 0.1 mg\/kg, 0.3 mg\/kg and 0.5 mg\/kg esketamine on emergence agitation after tonsillectomy and adenoidectomy in children: a randomized control trial. Drug Des Devel Ther. 2025, 19:6543-52. 10.2147\/DDDT.S525687","journal-title":"Drug Des Devel Ther"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000005232","article-title":"Short-term outcomes in infants after general anesthesia with low-dose sevoflurane\/dexmedetomidine\/remifentanil versus standard-dose sevoflurane (the TREX Trial)","volume":"141","author":"Saynhalath R","year":"2024","unstructured":"Saynhalath R, Disma N, Taverner FJ, et al.. Short-term outcomes in infants after general anesthesia with low-dose sevoflurane\/dexmedetomidine\/remifentanil versus standard-dose sevoflurane (the TREX Trial). Anesthesiology. 2024, 141:1075-85. 10.1097\/ALN.0000000000005232","journal-title":"Anesthesiology"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13041174","article-title":"Oral dexmedetomidine achieves superior effects in mitigating emergence agitation and demonstrates comparable sedative effects to oral midazolam for pediatric premedication: a systematic review and meta-analysis of randomized controlled studies","volume":"13","author":"Jen CK","year":"2024","unstructured":"Jen CK, Lu KC, Chen KW, Lu YR, Huang IT, Huang YC, Huang CJ. Oral dexmedetomidine achieves superior effects in mitigating emergence agitation and demonstrates comparable sedative effects to oral midazolam for pediatric premedication: a systematic review and meta-analysis of randomized controlled studies. J Clin Med. 2024, 13:1174. 10.3390\/jcm13041174","journal-title":"J Clin Med"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1177\/10600280211009845","article-title":"The safety and efficacy evaluation of dexmedetomidine for procedural sedation and postoperative behaviors in pediatric populations: a systematic review and meta-analysis","volume":"56","author":"Gan L","year":"2022","unstructured":"Gan L, Zhao X, Chen X. The safety and efficacy evaluation of dexmedetomidine for procedural sedation and postoperative behaviors in pediatric populations: a systematic review and meta-analysis. Ann Pharmacother. 2022, 56:16-26. 10.1177\/10600280211009845","journal-title":"Ann Pharmacother"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/471890-emerging-sedation-strategies-in-pediatric-emergency-care-pharmacological-advances-and-clinical-applications","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:37:19Z","timestamp":1774377439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/471890-emerging-sedation-strategies-in-pediatric-emergency-care-pharmacological-advances-and-clinical-applications"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":36,"URL":"https:\/\/doi.org\/10.7759\/cureus.105779","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,24]]}}}