{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:59:19Z","timestamp":1774598359607,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,27]]},"DOI":"10.7759\/cureus.105950","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:27:41Z","timestamp":1774596461000},"source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Petri Dish: The Performance of a Multiplex PCR-Based Pneumonia Panel in Hospitalized Patients With Lower Respiratory Tract Infection"],"prefix":"10.7759","author":[{"given":"Pooja","family":"Naharia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhil K","family":"Ravi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Karade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30396-1","article-title":"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015","volume":"17","author":"GBD 2015 LRI Collaborators","year":"2017","unstructured":"GBD 2015 LRI Collaborators. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Infect Dis. 2017, 17:1133-61. 10.1016\/S1473-3099(17)30396-1","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8844420","article-title":"Clinical and epidemiological determinants of lower respiratory tract infections in hospitalized pediatric patients","volume":"2020","author":"Mirkarimi M","year":"2020","unstructured":"Mirkarimi M, Alisamir M, Saraf S, Heidari S, Barouti S, Mohammadi S. Clinical and epidemiological determinants of lower respiratory tract infections in hospitalized pediatric patients. Int J Pediatr. 2020, 2020:8844420. 10.1155\/2020\/8844420","journal-title":"Int J Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir054","article-title":"Are we ready for novel detection methods to treat respiratory pathogens in hospital-acquired pneumonia?","volume":"52","author":"Endimiani A","year":"2011","unstructured":"Endimiani A, Hujer KM, Hujer AM, Kurz S, Jacobs MR, Perlin DS, Bonomo RA. Are we ready for novel detection methods to treat respiratory pathogens in hospital-acquired pneumonia?. Clin Infect Dis. 2011, 52:S373-83. 10.1093\/cid\/cir054","journal-title":"Clin Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1086\/511159","article-title":"Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults","volume":"44","author":"Mandell LA","year":"2007","unstructured":"Mandell LA, Wunderink RG, Anzueto A, et al.. Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007, 44:S27-72. 10.1086\/511159","journal-title":"Clin Infect Dis"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14226.1","article-title":"Appropriate antibiotic management of bacterial lower respiratory tract infections","volume":"7","author":"Feldman C","year":"2018","unstructured":"Feldman C, Richards G. Appropriate antibiotic management of bacterial lower respiratory tract infections. F1000Res. 2018, 7:F1000. 10.12688\/f1000research.14226.1","journal-title":"F1000Res"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03102-2","article-title":"Usefulness of point-of-care multiplex PCR to rapidly identify pathogens responsible for ventilator-associated pneumonia and their resistance to antibiotics: an observational study","volume":"24","author":"Luyt CE","year":"2020","unstructured":"Luyt CE, H\u00e9kimian G, Bonnet I, et al.. Usefulness of point-of-care multiplex PCR to rapidly identify pathogens responsible for ventilator-associated pneumonia and their resistance to antibiotics: an observational study. Crit Care. 2020, 24:378. 10.1186\/s13054-020-03102-2","journal-title":"Crit Care"},{"key":"ref7","unstructured":"BIOFIRE\u00ae FILMARRAY\u00ae  Pneumonia (PN) Panels. (2026). https.\/\/www.biomerieux.com\/us\/en\/our-offer\/clinical-products\/biofire-pneumonia-panel.html."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1028525","article-title":"Global burden of lower respiratory infections during the last three decades","volume":"10","author":"Safiri S","year":"2022","unstructured":"Safiri S, Mahmoodpoor A, Kolahi AA, et al.. Global burden of lower respiratory infections during the last three decades. Front Public Health. 2022, 10:1028525. 10.3389\/fpubh.2022.1028525","journal-title":"Front Public Health"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00283-22","article-title":"Sex and gender differences in bacterial infections","volume":"90","author":"Dias SP","year":"2022","unstructured":"Dias SP, Brouwer MC, van de Beek D. Sex and gender differences in bacterial infections. Infect Immun. 2022, 90:e0028322. 10.1128\/iai.00283-22","journal-title":"Infect Immun"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00135-20","article-title":"Practical comparison of the BioFire FilmArray Pneumonia Panel to routine diagnostic methods and potential impact on antimicrobial stewardship in adult hospitalized patients with lower respiratory tract infections","volume":"58","author":"Buchan BW","year":"2020","unstructured":"Buchan BW, Windham S, Balada-Llasat JM, et al.. Practical comparison of the BioFire FilmArray Pneumonia Panel to routine diagnostic methods and potential impact on antimicrobial stewardship in adult hospitalized patients with lower respiratory tract infections. J Clin Microbiol. 2020, 58:e00135-20. 10.1128\/JCM.00135-20","journal-title":"J Clin Microbiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlac139","article-title":"Utility of the BioFire(\u00ae) FilmArray(\u00ae) Pneumonia Panel plus assay for syndromic testing of lower respiratory tract infections in a low\/middle-income setting","volume":"5","author":"Van Der Westhuyzen M","year":"2023","unstructured":"Van Der Westhuyzen M, Samodien N, Brink AJ, Moodley C. Utility of the BioFire(\u00ae) FilmArray(\u00ae) Pneumonia Panel plus assay for syndromic testing of lower respiratory tract infections in a low\/middle-income setting. JAC Antimicrob Resist. 2023, 5:dlac139. 10.1093\/jacamr\/dlac139","journal-title":"JAC Antimicrob Resist"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2023.101300","article-title":"Performance evaluation of a PCR panel (FilmArray\u00ae Pneumonia Plus) for detection of respiratory bacterial pathogens in respiratory specimens: a systematic review and meta-analysis","volume":"42","author":"Moy AC","year":"2023","unstructured":"Moy AC, Kimmoun A, Merkling T, et al.. Performance evaluation of a PCR panel (FilmArray\u00ae Pneumonia Plus) for detection of respiratory bacterial pathogens in respiratory specimens: a systematic review and meta-analysis. Anaesth Crit Care Pain Med. 2023, 42:101300. 10.1016\/j.accpm.2023.101300","journal-title":"Anaesth Crit Care Pain Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_994_19","article-title":"Bacterial pathogens from lower respiratory tract infections: a study from Western Rajasthan","volume":"9","author":"Singh S","year":"2020","unstructured":"Singh S, Sharma A, Nag VL. Bacterial pathogens from lower respiratory tract infections: a study from Western Rajasthan. J Family Med Prim Care. 2020, 9:1407-12. 10.4103\/jfmpc.jfmpc_994_19","journal-title":"J Family Med Prim Care"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.05.011","article-title":"Epidemiology, etiology, and diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia in Asian countries","volume":"36","author":"Chawla R","year":"2008","unstructured":"Chawla R. Epidemiology, etiology, and diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia in Asian countries. Am J Infect Control. 2008, 36:S93-100. 10.1016\/j.ajic.2007.05.011","journal-title":"Am J Infect Control"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/JLP.JLP_122_18","article-title":"Prevalence and characterization of beta-lactamase-producing Escherichia coli isolates from a tertiary care hospital in India","volume":"11","author":"Govindaswamy A","year":"2019","unstructured":"Govindaswamy A, Bajpai V, Khurana S, Aravinda A, Batra P, Malhotra R, Mathur P. Prevalence and characterization of beta-lactamase-producing Escherichia coli isolates from a tertiary care hospital in India. J Lab Physicians. 2019, 11:123-7. 10.4103\/JLP.JLP_122_18","journal-title":"J Lab Physicians"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1086\/656623","article-title":"An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus\/S. aureus blood culture test in patients with S. aureus bacteremia","volume":"51","author":"Bauer KA","year":"2010","unstructured":"Bauer KA, West JE, Balada-Llasat JM, Pancholi P, Stevenson KB, Goff DA. An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus\/S. aureus blood culture test in patients with S. aureus bacteremia. Clin Infect Dis. 2010, 51:1074-80. 10.1086\/656623","journal-title":"Clin Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00376-16","article-title":"Clinical impact of laboratory implementation of Verigene BC-GN microarray-based assay for detection of Gram-negative bacteria in positive blood cultures","volume":"54","author":"Walker T","year":"2016","unstructured":"Walker T, Dumadag S, Lee CJ, Lee SH, Bender JM, Cupo Abbott J, She RC. Clinical impact of laboratory implementation of Verigene BC-GN microarray-based assay for detection of Gram-negative bacteria in positive blood cultures. J Clin Microbiol. 2016, 54:1789-96. 10.1128\/JCM.00376-16","journal-title":"J Clin Microbiol"},{"key":"ref18","article-title":"Commensals: Underappreciated reservoir of antibiotic resistance","volume":"4","author":"Marshall BM","year":"2009","unstructured":"Marshall BM, Ochieng DJ, Levy SB. Commensals: Underappreciated reservoir of antibiotic resistance. Microbe. 2009, 4:231-8.","journal-title":"Microbe"},{"key":"ref19","unstructured":"The BIOFIRE\u00ae SPOTFIRE\u00ae  Respiratory\/Sore Throat (R\/ST) Panels. (2026). https.\/\/www.biofiredx.com\/products\/filmarray\/spotfire-system\/."},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-021-04195-5","article-title":"Multinational evaluation of the BioFire\u00ae FilmArray\u00ae Pneumonia plus Panel as compared to standard of care testing","volume":"40","author":"Ginocchio CC","year":"2021","unstructured":"Ginocchio CC, Garcia-Mondragon C, Mauerhofer B, Rindlisbacher C. Multinational evaluation of the BioFire\u00ae FilmArray\u00ae Pneumonia plus Panel as compared to standard of care testing. Eur J Clin Microbiol Infect Dis. 2021, 40:1609-22. 10.1007\/s10096-021-04195-5","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2019.10.009","article-title":"Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units","volume":"52","author":"Lee SH","year":"2019","unstructured":"Lee SH, Ruan SY, Pan SC, Lee TF, Chien JY, Hsueh PR. Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units. J Microbiol Immunol Infect. 2019, 52:920-8. 10.1016\/j.jmii.2019.10.009","journal-title":"J Microbiol Immunol Infect"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/469455-beyond-the-petri-dish-the-performance-of-a-multiplex-pcr-based-pneumonia-panel-in-hospitalized-patients-with-lower-respiratory-tract-infection","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:27:43Z","timestamp":1774596463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/469455-beyond-the-petri-dish-the-performance-of-a-multiplex-pcr-based-pneumonia-panel-in-hospitalized-patients-with-lower-respiratory-tract-infection"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.105950","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}