{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:48:27Z","timestamp":1780058907003,"version":"3.54.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,28]]},"DOI":"10.7759\/cureus.106042","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:46:37Z","timestamp":1774745197000},"source":"Crossref","is-referenced-by-count":1,"title":["Novel Human Epidermal Growth Factor Receptor 2 (HER2)-Targeted Therapy in a Non-Smoking Asian-American Woman Diagnosed With Never-Smoker Non-Small Cell Lung Cancer (NSCLC): A Case Report"],"prefix":"10.7759","author":[{"given":"Kyle S","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.8015","article-title":"Lung cancer in never smokers","volume":"25","author":"Sun S","year":"2007","unstructured":"Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers. J Clin Oncol. 2007, 25:561-570. 10.1200\/JCO.2006.06.8015","journal-title":"J Clin Oncol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji055","article-title":"Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers","volume":"97","author":"Shigematsu H","year":"2005","unstructured":"Shigematsu H, Gazdar AF. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers . J Natl Cancer Inst. 2005, 97:339-346. 10.1093\/jnci\/dji055","journal-title":"J Natl Cancer Inst"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2511","article-title":"Frequency of driver mutations in lung adenocarcinoma from female never smokers varies with histologic subtypes and age at diagnosis","volume":"18","author":"Zhang Y","year":"2012","unstructured":"Zhang Y, Sun Y, Pan Y, et al.. Frequency of driver mutations in lung adenocarcinoma from female never smokers varies with histologic subtypes and age at diagnosis. Clin Cancer Res. 2012, 18:1947-1953. 10.1158\/1078-0432.CCR-11-2511","journal-title":"Clin Cancer Res"},{"key":"ref4","article-title":"Lung cancer incidence among never smokers by race and ethnicity in the United States","volume":"116","author":"Shiels MS","year":"2024","unstructured":"Shiels MS, Liu L, Yang L, et al.. Lung cancer incidence among never smokers by race and ethnicity in the United States. J Natl Cancer Inst. 2024, 116:123.","journal-title":"J Natl Cancer Inst"},{"key":"ref5","article-title":"HER2-mutant lung cancers: molecular characteristics and targeted therapy approaches","volume":"36","author":"Li BT","year":"2018","unstructured":"Li BT, Ross DS, Aisner DL, et al.. HER2-mutant lung cancers: molecular characteristics and targeted therapy approaches. J Clin Oncol. 2018, 36:2532-2537.","journal-title":"J Clin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2023.01.094","article-title":"Low-dose computed tomography (LDCT) lung cancer screening in Asian female never-smokers is as efficacious in detecting lung cancer as in Asian male ever-smokers: a systematic review and meta-analysis","volume":"18","author":"Triphuridet N","year":"2023","unstructured":"Triphuridet N, Zhang SS, Nagasaka M, et al.. Low-dose computed tomography (LDCT) lung cancer screening in Asian female never-smokers is as efficacious in detecting lung cancer as in Asian male ever-smokers: a systematic review and meta-analysis. J Thorac Oncol. 2023, 18:698-717. 10.1016\/j.jtho.2023.01.094","journal-title":"J Thorac Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388","article-title":"The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \"personalized\" approach to cancer staging","volume":"67","author":"Amin MB","year":"2017","unstructured":"Amin MB, Greene FL, Edge SB, et al.. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \"personalized\" approach to cancer staging. CA Cancer J Clin. 2017, 67:93-9. 10.3322\/caac.21388","journal-title":"CA Cancer J Clin"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer EA","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, et al.. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 2009, 45:228-247. 10.1016\/j.ejca.2008.10.026","journal-title":"Eur J Cancer"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/471546-novel-human-epidermal-growth-factor-receptor-2-her2-targeted-therapy-in-a-non-smoking-asian-american-woman-diagnosed-with-never-smoker-non-small-cell-lung-cancer-nsclc-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:46:38Z","timestamp":1774745198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/471546-novel-human-epidermal-growth-factor-receptor-2-her2-targeted-therapy-in-a-non-smoking-asian-american-woman-diagnosed-with-never-smoker-non-small-cell-lung-cancer-nsclc-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":8,"URL":"https:\/\/doi.org\/10.7759\/cureus.106042","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,28]]}}}