{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:20:55Z","timestamp":1775186455862,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,2]]},"DOI":"10.7759\/cureus.106343","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:27:52Z","timestamp":1775183272000},"source":"Crossref","is-referenced-by-count":0,"title":["Rupatadine as an Add-On Therapy for Dengue Hemorrhagic Fever: A Case Report"],"prefix":"10.7759","author":[{"given":"Mauricio E","family":"Flores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt S","year":"2013","unstructured":"Bhatt S, Gething PW, Brady OJ, et al.. The global distribution and burden of dengue. Nature. 2013, 496:504-7. 10.1038\/nature12060","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed10060173","article-title":"Epidemiological trends and age-period-cohort effects on dengue incidence across high-risk regions from 1992 to 2021","volume":"10","author":"Cao Y","year":"2025","unstructured":"Cao Y, Chen H, Wu H, et al.. Epidemiological trends and age-period-cohort effects on dengue incidence across high-risk regions from 1992 to 2021. Trop Med Infect Dis. 2025, 10:173. 10.3390\/tropicalmed10060173","journal-title":"Trop Med Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(19)32531-0","article-title":"Dengue in the Americas: Honduras' worst outbreak","volume":"394","author":"Dos Santos TH","year":"2019","unstructured":"Dos Santos TH, Martin JL, Castellanos LG, Espinal MA. Dengue in the Americas: Honduras' worst outbreak. Lancet. 2019, 394:2149.","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2023.08.001","article-title":"Dengue overview: an updated systemic review","volume":"16","author":"Khan MB","year":"2023","unstructured":"Khan MB, Yang ZS, Lin CY, et al.. Dengue overview: an updated systemic review. J Infect Public Health. 2023, 16:1625-42. 10.1016\/j.jiph.2023.08.001","journal-title":"J Infect Public Health"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-03-0208","article-title":"Plasma leakage in dengue haemorrhagic fever","volume":"102","author":"Srikiatkhachorn A","year":"2009","unstructured":"Srikiatkhachorn A. Plasma leakage in dengue haemorrhagic fever. Thromb Haemost. 2009, 102:1042-9. 10.1160\/TH09-03-0208","journal-title":"Thromb Haemost"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2020.03.007","article-title":"Dengue hemorrhagic fever - a systemic literature review of current perspectives on pathogenesis, prevention and control","volume":"53","author":"Wang WH","year":"2020","unstructured":"Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF. Dengue hemorrhagic fever - a systemic literature review of current perspectives on pathogenesis, prevention and control. J Microbiol Immunol Infect. 2020, 53:963-78. 10.1016\/j.jmii.2020.03.007","journal-title":"J Microbiol Immunol Infect"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-022-04394-8","article-title":"Management of dengue: an updated review","volume":"90","author":"Tayal A","year":"2023","unstructured":"Tayal A, Kabra SK, Lodha R. Management of dengue: an updated review. Indian J Pediatr. 2023, 90:168-77. 10.1007\/s12098-022-04394-8","journal-title":"Indian J Pediatr"},{"key":"ref8","unstructured":"Centers for Disease Control (CDC). Dengue clinical management pocket guideline. (2025). Accessed. July 16, 2025: https:\/\/www.cdc.gov\/dengue\/hcp\/pocketguide\/index.html."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22285-x","article-title":"A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection","volume":"8","author":"Malavige GN","year":"2018","unstructured":"Malavige GN, Wijewickrama A, Fernando S, et al.. A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection. Sci Rep. 2018, 8:3857. 10.1038\/s41598-018-22285-x","journal-title":"Sci Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-3-S2-O6","article-title":"Platelet activating factor-induced mast cell degranulation is inhibited by rupatadine, and to a lower extent by levocetirizine and desoratadine, in a mast cell line (LAD-2)","volume":"3","author":"Mullol J","year":"2013","unstructured":"Mullol J, Mu\u00f1oz-Cano R, Torres-Atencio I, et al.. Platelet activating factor-induced mast cell degranulation is inhibited by rupatadine, and to a lower extent by levocetirizine and desoratadine, in a mast cell line (LAD-2). Clin Transl Allergy. 2013, 3:O6. 10.1186\/2045-7022-3-S2-O6","journal-title":"Clin Transl Allergy"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000232569","article-title":"Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli","volume":"151","author":"Vasiadi M","year":"2010","unstructured":"Vasiadi M, Kalogeromitros D, Kempuraj D, et al.. Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli. Int Arch Allergy Immunol. 2010, 151:38-45. 10.1159\/000232569","journal-title":"Int Arch Allergy Immunol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-014-0011-7","article-title":"Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects","volume":"23","author":"Shamizadeh S","year":"2014","unstructured":"Shamizadeh S, Brockow K, Ring J. Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects. Allergo J Int. 2014, 23:87-95. 10.1007\/s40629-014-0011-7","journal-title":"Allergo J Int"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.08.025","article-title":"Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor","volume":"111","author":"Alevizos M","year":"2013","unstructured":"Alevizos M, Karagkouni A, Vasiadi M, Sismanopoulos N, Makris M, Kalogeromitros D, Theoharides TC. Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. Ann Allergy Asthma Immunol. 2013, 111:542-7. 10.1016\/j.anai.2013.08.025","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2023-9-5","article-title":"How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review","volume":"13","author":"Izquierdo I","year":"2024","unstructured":"Izquierdo I, Casas L, Cabrera S, Fernandez A. How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review. Drugs Context. 2024, 13:10.7573\/dic.2023-9-5","journal-title":"Drugs Context"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.31877","article-title":"Dengue & COVID-19: a comparison and the challenges at hand","volume":"14","author":"Alla D","year":"2022","unstructured":"Alla D, Alla SS, Vempati R, et al.. Dengue & COVID-19: a comparison and the challenges at hand. Cureus. 2022, 14:e31877. 10.7759\/cureus.31877","journal-title":"Cureus"},{"key":"ref16","unstructured":"Direcci\u00f3n de Salud Ambiental. (2024). Lineamientos t\u00e9cnicos para la prevenci\u00f3n, vigilancia y control de enfermedades transmitidas por vectores y zoonosis. Ministerio de Salud, El Salvador. (2024). Accessed. July 16, 2025: https:\/\/docs.bvsalud.org\/biblioref\/2025\/02\/1561142\/lineamientostecnicosparalaprevencionvigilanciaycontroldeenferm_w5E...."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1155\/crdi\/8029446","article-title":"Severe dengue with hyperinflammatory state and associated acute pancreatitis","volume":"2025","author":"Gonzalez SA","year":"2025","unstructured":"Gonzalez SA, Banegas L, Cantillano Quintero EM, Dom\u00ednguez-Rojas J. Severe dengue with hyperinflammatory state and associated acute pancreatitis. Case Rep Infect Dis. 2025, 2025:8029446. 10.1155\/crdi\/8029446","journal-title":"Case Rep Infect Dis"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-0983","article-title":"Dengue infections and the surgical patient","volume":"104","author":"Jayarajah U","year":"2021","unstructured":"Jayarajah U, Lahiru M, De Zoysa I, Seneviratne SL. Dengue infections and the surgical patient. Am J Trop Med Hyg. 2021, 104:52-9. 10.4269\/ajtmh.20-0983","journal-title":"Am J Trop Med Hyg"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.10-0117","article-title":"Early diagnosis of dengue infection using a commercial dengue duo rapid test kit for the detection of NS1, IGM, and IGG","volume":"83","author":"Wang SM","year":"2010","unstructured":"Wang SM, Sekaran SD. Early diagnosis of dengue infection using a commercial dengue duo rapid test kit for the detection of NS1, IGM, and IGG. Am J Trop Med Hyg. 2010, 83:690-5. 10.4269\/ajtmh.2010.10-0117","journal-title":"Am J Trop Med Hyg"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011223","article-title":"Understanding antibody-dependent enhancement in dengue: are afucosylated IgG1s a concern?","volume":"19","author":"Teo A","year":"2023","unstructured":"Teo A, Tan HD, Loy T, Chia PY, Chua CL. Understanding antibody-dependent enhancement in dengue: are afucosylated IgG1s a concern?. PLoS Pathog. 2023, 19:e1011223. 10.1371\/journal.ppat.1011223","journal-title":"PLoS Pathog"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/462807-rupatadine-as-an-add-on-therapy-for-dengue-hemorrhagic-fever-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:27:56Z","timestamp":1775183276000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/462807-rupatadine-as-an-add-on-therapy-for-dengue-hemorrhagic-fever-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.106343","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,2]]}}}