{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:54:41Z","timestamp":1780059281382,"version":"3.54.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,4]]},"DOI":"10.7759\/cureus.106426","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:58:26Z","timestamp":1775314706000},"source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Response to Epipharyngeal Abrasive Therapy (EAT) in Chronic Nasopharyngitis With Outcome Redefinition and Stratified Analysis by Tissue Type and Baseline Severity"],"prefix":"10.7759","author":[{"given":"Ito","family":"Hirobumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.06.002","article-title":"Chronic epipharyngitis: a missing background of IgA nephropathy","volume":"18","author":"Hotta O","year":"2019","unstructured":"Hotta O, Tanaka A, Oda T. Chronic epipharyngitis: a missing background of IgA nephropathy. Autoimmun Rev. 2019, 18:835-36. 10.1016\/j.autrev.2019.06.002","journal-title":"Autoimmun Rev"},{"key":"ref2","article-title":"Epipharyngeal abrasive therapy for patients with immunoglobulin A nephropathy: a retrospective study","volume":"8","author":"Mogitate M","year":"2022","unstructured":"Mogitate M. Epipharyngeal abrasive therapy for patients with immunoglobulin A nephropathy: a retrospective study. SJ Otolaryng. 2022, 8:874-81.","journal-title":"SJ Otolaryng"},{"key":"ref3","article-title":"Nasopharyngeal swabbing therapy for chronic nasopharyngitis (Article in Japanese)","volume":"128","author":"Harabuchi Y","year":"2025","unstructured":"Harabuchi Y. Nasopharyngeal swabbing therapy for chronic nasopharyngitis (Article in Japanese). J Jpn Soc Otolaryngol Head and Neck Surg. 2025, 128:205-14.","journal-title":"J Jpn Soc Otolaryngol Head and Neck Surg"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.69.4_1","article-title":"Epipharyngitis and its relationship to general diseases (Article in Japanese)","volume":"69","author":"Horigut S","year":"1966","unstructured":"Horigut S. Epipharyngitis and its relationship to general diseases (Article in Japanese). J Japan Soc Otolaryng Head Neck Surg\r\n. 1966, 69:1-78. 10.3950\/jibiinkoka.69.4_1","journal-title":"J Japan Soc Otolaryng Head Neck Surg"},{"key":"ref5","article-title":"Studies on band-limited light endoscopic diagnosis and endoscopic epipharyngeal abrasive therapy in chronic epipharyngitis (Article in Japanese)","volume":"31","author":"Tanaka A","year":"2018","unstructured":"Tanaka A. Studies on band-limited light endoscopic diagnosis and endoscopic epipharyngeal abrasive therapy in chronic epipharyngitis (Article in Japanese). Stomato Pharyngol. 2018, 31:57-67.","journal-title":"Stomato Pharyngol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4630","article-title":"Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils","volume":"106","author":"Johansen FE","year":"2005","unstructured":"Johansen FE, Baekkevold ES, Carlsen HS, Farstad IN, Soler D, Brandtzaeg P. Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils. Blood. 2005, 106:593-600. 10.1182\/blood-2004-12-4630","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50288","article-title":"Epipharynegal abrasive therapy downregulates the number of epipharyngeal abrasive CD4 cells with symptomatic recovery","volume":"15","author":"Mogitate M","year":"2023","unstructured":"Mogitate M. Epipharynegal abrasive therapy downregulates the number of epipharyngeal abrasive CD4 cells with symptomatic recovery. Cureus. 2023, 15:e50288. 10.7759\/cureus.50288","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.4172\/1948-5964.1000168","article-title":"Possible mechanisms underlying epipharyngeal abrasive therapy (EAT) with ZnCl2 solution for the treatment of autoimmune diseases and functional somatic syndrome","volume":"9","author":"Hotta O","year":"2017","unstructured":"Hotta O, Inoue C, Tanaka A, Ieiri N. Possible mechanisms underlying epipharyngeal abrasive therapy (EAT) with ZnCl2 solution for the treatment of autoimmune diseases and functional somatic syndrome. J Antivir Antiretrovir. 2017, 9:81-86.","journal-title":"J Antivir Antiretrovir"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0025-6196(12)62272-1","article-title":"The central autonomic network: functional organization, dysfunction, and perspective","volume":"68(10)","author":"Benarroch EE","year":"1993","unstructured":"Benarroch EE. The central autonomic network: functional organization, dysfunction, and perspective. Mayo Clinic Proceedings. 1993, 68(10):988-1001. 10.1016\/s0025-6196(12)62272-1","journal-title":"Mayo Clinic Proceedings"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.93254","article-title":"Epipharyngeal abrasive therapy (EAT) field theory: a clinical framework for eat in modulating psycho-neuro-endocrino-immune (PNEI) dynamics","volume":"17","author":"Hirobumi I","year":"2025","unstructured":"Hirobumi I. Epipharyngeal abrasive therapy (EAT) field theory: a clinical framework for eat in modulating psycho-neuro-endocrino-immune (PNEI) dynamics. Cureus. 2025, 17:e93254. 10.7759\/cureus.93254","journal-title":"Cureus"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.14821\/stomatopharyngology.32.33","article-title":"Effectiveness of epipharyngeal abrasive therapy for chronic epipharyngitis (Article in Japanese)","volume":"32","author":"Ohno Y","year":"2019","unstructured":"Ohno Y. Effectiveness of epipharyngeal abrasive therapy for chronic epipharyngitis (Article in Japanese). Stomato Pharyngol. 2019, 32:33-39. 10.14821\/stomatopharyngology.32.33","journal-title":"Stomato Pharyngol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.32474\/SJO.2022.09.000311","article-title":"Statistical study of the effectiveness of EAT treatment for chronic epipharyngitis","volume":"3","author":"Ito H","year":"2022","unstructured":"Ito H. Statistical study of the effectiveness of EAT treatment for chronic epipharyngitis. S J Otolaryngol. 2022, 3:1014-25. 10.32474\/SJO.2022.09.000311","journal-title":"S J Otolaryngol"},{"key":"ref13","article-title":"Evaluation of the treatment outcomes of chronic nasopharyngitis using the evaluation method of the epipharyngeal abrasive therapy review committee (Article in Japanese)","volume":"35(2)","author":"Ohno Y","year":"2022","unstructured":"Ohno Y. Evaluation of the treatment outcomes of chronic nasopharyngitis using the evaluation method of the epipharyngeal abrasive therapy review committee (Article in Japanese). Stomato Pharyngology. 2022, 35(2):138-145.","journal-title":"Stomato Pharyngology"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-92908-7","article-title":"Spatial transcriptomics of the epipharynx in long COVID identifies SARS-CoV-2 signalling pathways and the therapeutic potential of epipharyngeal abrasive therapy","volume":"15","author":"Nishi K","year":"2025","unstructured":"Nishi K, Yoshimoto S, Tanaka T, et al.. Spatial transcriptomics of the epipharynx in long COVID identifies SARS-CoV-2 signalling pathways and the therapeutic potential of epipharyngeal abrasive therapy. Sci Rep. 2025, 15:8618. 10.1038\/s41598-025-92908-7","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn TA","year":"2012","unstructured":"Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012, 18:1028-40. 10.1038\/nm.2807","journal-title":"Nat Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.54067","article-title":"Use of nasopharyngoscopy severity classification of chronic epipharyngitis and its application for evaluating the treatment outcomes of epipharyngeal abrasive therapy","volume":"16","author":"Ohno Y","year":"2024","unstructured":"Ohno Y. Use of nasopharyngoscopy severity classification of chronic epipharyngitis and its application for evaluating the treatment outcomes of epipharyngeal abrasive therapy. Cureus. 2024, 16:e54067. 10.7759\/cureus.54067","journal-title":"Cureus"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.14821\/stomatopharyngology.38.274","article-title":"Time-dependent whitening phenomenon due to nasopharyngeal swabbing therapy for chronic nasopharyngitis (Article in Japanese)","volume":"38","author":"Ohno Y","year":"2025","unstructured":"Ohno Y. Time-dependent whitening phenomenon due to nasopharyngeal swabbing therapy for chronic nasopharyngitis (Article in Japanese). Stomato Pharyngol. 2025, 38:274-79. 10.14821\/stomatopharyngology.38.274","journal-title":"Stomato Pharyngol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9761-22","article-title":"Effectiveness of epipharyngeal abrasive therapy on chronic epipharyngitis and the exhaled nitric oxide levels","volume":"62","author":"Mogitate M","year":"2023","unstructured":"Mogitate M. Effectiveness of epipharyngeal abrasive therapy on chronic epipharyngitis and the exhaled nitric oxide levels. Intern Med. 2023, 62:1139-44. 10.2169\/internalmedicine.9761-22","journal-title":"Intern Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/476309-longitudinal-response-to-epipharyngeal-abrasive-therapy-eat-in-chronic-nasopharyngitis-with-outcome-redefinition-and-stratified-analysis-by-tissue-type-and-baseline-severity","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:58:27Z","timestamp":1775314707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/476309-longitudinal-response-to-epipharyngeal-abrasive-therapy-eat-in-chronic-nasopharyngitis-with-outcome-redefinition-and-stratified-analysis-by-tissue-type-and-baseline-severity"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,4]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.106426","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,4]]}}}