{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T02:50:45Z","timestamp":1775875845063,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,10]]},"DOI":"10.7759\/cureus.106820","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T02:04:08Z","timestamp":1775873048000},"source":"Crossref","is-referenced-by-count":0,"title":["Acute Vaginal Bleeding as the Initial Manifestation of Multifactorial Thrombocytopenia: A Case Report"],"prefix":"10.7759","author":[{"given":"Alireza","family":"Izadian Bidgoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabnam","family":"Yazdanpanah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"De Guzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atharv","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Gomez Veliz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2022-0146","article-title":"Thrombocytopenia: the good, the bad and the ugly","volume":"22","author":"Ashworth I","year":"2022","unstructured":"Ashworth I, Thielemans L, Chevassut T. Thrombocytopenia: the good, the bad and the ugly. Clin Med (Lond). 2022, 22:214-7. 10.7861\/clinmed.2022-0146","journal-title":"Clin Med (Lond)"},{"key":"ref2","article-title":"Thrombocytopenia","author":"Jinna S","year":"2026","unstructured":"Jinna S, Karra S, Penney SW, Khandhar PB. Thrombocytopenia. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2026."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01401-z","article-title":"How we treat primary immune thrombocytopenia in adults","volume":"16","author":"Liu XG","year":"2023","unstructured":"Liu XG, Hou Y, Hou M. How we treat primary immune thrombocytopenia in adults. J Hematol Oncol. 2023, 16:4. 10.1186\/s13045-023-01401-z","journal-title":"J Hematol Oncol"},{"key":"ref4","article-title":"Thrombocytopenia","author":"Kessler CM","year":"2024","unstructured":"Kessler CM, Latif H, Cunningham JM. Thrombocytopenia.  Medscape, 2024."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2007.06.005","article-title":"Drug-induced thrombocytopenia","volume":"21","author":"Visentin GP","year":"2007","unstructured":"Visentin GP, Liu CY. Drug-induced thrombocytopenia. Hematol Oncol Clin North Am. 2007, 21:685-96, vi. 10.1016\/j.hoc.2007.06.005","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-017-0224-6","article-title":"The risk of thrombocytopenia during valproic acid therapy: a critical summary of available clinical data","volume":"18","author":"Buoli M","year":"2018","unstructured":"Buoli M, Serati M, Botturi A, Altamura AC. The risk of thrombocytopenia during valproic acid therapy: a critical summary of available clinical data. Drugs R D. 2018, 18:1-5. 10.1007\/s40268-017-0224-6","journal-title":"Drugs R D"},{"key":"ref7","article-title":"Thrombocytopenia: evaluation and management","volume":"106","author":"Gauer RL","year":"2022","unstructured":"Gauer RL, Whitaker DJ. Thrombocytopenia: evaluation and management. Am Fam Physician. 2022, 106:288-98.","journal-title":"Am Fam Physician"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.03.019","article-title":"Vascular disease in cocaine addiction","volume":"262","author":"Bachi K","year":"2017","unstructured":"Bachi K, Mani V, Jeyachandran D, Fayad ZA, Goldstein RZ, Alia-Klein N. Vascular disease in cocaine addiction. Atherosclerosis. 2017, 262:154-62. 10.1016\/j.atherosclerosis.2017.03.019","journal-title":"Atherosclerosis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030933","article-title":"The impact of levetiracetam and valproate on platelet functions\u2014a double-blind, placebo-controlled crossover study","volume":"12","author":"Olaizola I","year":"2023","unstructured":"Olaizola I, Brodde MF, Kehrel BE, Evers S. The impact of levetiracetam and valproate on platelet functions\u2014a double-blind, placebo-controlled crossover study. J Clin Med. 2023, 12:933. 10.3390\/jcm12030933","journal-title":"J Clin Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264351","article-title":"Assessment of need for hemostatic evaluation in patients taking valproic acid: a retrospective cross-sectional study","volume":"17","author":"Post DS","year":"2022","unstructured":"Post DS, van der Veer A, Schijns OE, et al.. Assessment of need for hemostatic evaluation in patients taking valproic acid: a retrospective cross-sectional study. PLoS One. 2022, 17:e0264351. 10.1371\/journal.pone.0264351","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2021.11.018","article-title":"Predicting the occurrence of thrombocytopenia from free valproate levels: a prospective study","volume":"94","author":"Nasreddine W","year":"2022","unstructured":"Nasreddine W, Atweh SF, Beydoun AA, Dirani M, Nawfal O, Beydoun A. Predicting the occurrence of thrombocytopenia from free valproate levels: a prospective study. Seizure. 2022, 94:33-8. 10.1016\/j.seizure.2021.11.018","journal-title":"Seizure"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.904908","article-title":"Prevalence of heavy menstrual bleeding and its associated cognitive risks and predictive factors in women with severe mental disorders","volume":"13","author":"Shan J","year":"2022","unstructured":"Shan J, Tian H, Zhou C, et al.. Prevalence of heavy menstrual bleeding and its associated cognitive risks and predictive factors in women with severe mental disorders. Front Pharmacol. 2022, 13:904908. 10.3389\/fphar.2022.904908","journal-title":"Front Pharmacol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-025-07981-3","article-title":"Thrombotic thrombocytopenic purpura: early diagnosis and effective treatment in 2025","volume":"51","author":"Azoulay E","year":"2025","unstructured":"Azoulay E, Veyradier A, Cataland S, et al.. Thrombotic thrombocytopenic purpura: early diagnosis and effective treatment in 2025. Intensive Care Med. 2025, 51:1225-39. 10.1007\/s00134-025-07981-3","journal-title":"Intensive Care Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2022.11.022","article-title":"Current approaches for the diagnosis and management of immune thrombocytopenia","volume":"108","author":"Gafter-Gvili A","year":"2023","unstructured":"Gafter-Gvili A. Current approaches for the diagnosis and management of immune thrombocytopenia. Eur J Intern Med. 2023, 108:18-24. 10.1016\/j.ejim.2022.11.022","journal-title":"Eur J Intern Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-023-03672-1","article-title":"Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition","volume":"119","author":"Kashiwagi H","year":"2024","unstructured":"Kashiwagi H, Kuwana M, Murata M, et al.. Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition. Int J Hematol. 2024, 119:1-13. 10.1007\/s12185-023-03672-1","journal-title":"Int J Hematol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/481890-acute-vaginal-bleeding-as-the-initial-manifestation-of-multifactorial-thrombocytopenia-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T02:04:10Z","timestamp":1775873050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/481890-acute-vaginal-bleeding-as-the-initial-manifestation-of-multifactorial-thrombocytopenia-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.106820","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,10]]}}}