{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T07:41:11Z","timestamp":1776498071178,"version":"3.51.2"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,17]]},"DOI":"10.7759\/cureus.107272","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:52:03Z","timestamp":1776495123000},"source":"Crossref","is-referenced-by-count":0,"title":["Lactated Ringer\u2019s Versus Normal Saline in Early-Phase Acute Pancreatitis: A Comparative Study of Inflammatory Markers and Clinical Outcomes"],"prefix":"10.7759","author":[{"given":"Zawar","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeeshan","family":"Umar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleem","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Sarwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsah","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundas","family":"Safdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malik Muaz","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahid","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moiz Inam","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081974","article-title":"Diagnosis and treatment of acute pancreatitis","volume":"12","author":"Walkowska J","year":"2022","unstructured":"Walkowska J, Zielinska N, Tubbs RS, Podg\u00f3rski M, D\u0142ubek-Ruxer J, Olewnik \u0141. Diagnosis and treatment of acute pancreatitis. Diagnostics. 2022, 12:10.3390\/diagnostics12081974","journal-title":"Diagnostics"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: a review","volume":"325","author":"Mederos MA","year":"2021","unstructured":"Mederos MA, Reber HA, Girgis MD. Acute pancreatitis: a review. JAMA. 2021, 325:382-90. 10.1001\/jama.2020.20317","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-04303-1","article-title":"Global burden of acute pancreatitis attributable to high alcohol intake from 1990 to 2021: findings and prevention potential based on GBD 2021","volume":"25","author":"Liu W","year":"2025","unstructured":"Liu W, Yan T, Lin J, Wu Q, Yu X. Global burden of acute pancreatitis attributable to high alcohol intake from 1990 to 2021: findings and prevention potential based on GBD 2021. BMC Gastroenterol. 2025, 25:10.1186\/s12876-025-04303-1","journal-title":"BMC Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6227","article-title":"Management of severe acute pancreatitis","volume":"367","author":"Hines OJ","year":"2019","unstructured":"Hines OJ, Pandol SJ. Management of severe acute pancreatitis. BMJ. 2019, 367:10.1136\/bmj.l6227","journal-title":"BMJ"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-016-0647-y","article-title":"Pathophysiological mechanisms in acute pancreatitis: current understanding","volume":"35","author":"Singh P","year":"2016","unstructured":"Singh P, Garg PK. Pathophysiological mechanisms in acute pancreatitis: current understanding. Indian J Gastroenterol. 2016, 35:153-66. 10.1007\/s12664-016-0647-y","journal-title":"Indian J Gastroenterol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i48.18092","article-title":"Fluid resuscitation in acute pancreatitis","volume":"20","author":"Aggarwal A","year":"2014","unstructured":"Aggarwal A, Manrai M, Kochhar R. Fluid resuscitation in acute pancreatitis. World J Gastroenterol. 2014, 20:18092-103. 10.3748\/wjg.v20.i48.18092","journal-title":"World J Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15070810","article-title":"Advances in the management of fluid resuscitation in acute pancreatitis: a systematic review","volume":"15","author":"Costea CN","year":"2025","unstructured":"Costea CN, Pojoga C, Seicean A. Advances in the management of fluid resuscitation in acute pancreatitis: a systematic review. Diagnostics. 2025, 15:10.3390\/diagnostics15070810","journal-title":"Diagnostics"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/ph18111601","article-title":"Fluid therapy in acute pancreatitis - current knowledge and future perspectives","volume":"18","author":"Caban M","year":"2025","unstructured":"Caban M, Zatorski H, Ma\u0142ecka-Wojciesko E. Fluid therapy in acute pancreatitis - current knowledge and future perspectives. Pharmaceuticals. 2025, 18:10.3390\/ph18111601","journal-title":"Pharmaceuticals"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000002112","article-title":"Fluid resuscitation with lactated Ringer\u2019s solution versus normal saline in acute pancreatitis: a systematic review and meta-analysis of randomized trials","volume":"51","author":"Kow CS","year":"2022","unstructured":"Kow CS, Burud IA, Hasan SS. Fluid resuscitation with lactated Ringer\u2019s solution versus normal saline in acute pancreatitis: a systematic review and meta-analysis of randomized trials. Pancreas. 2022, 51:752-5. 10.1097\/MPA.0000000000002112","journal-title":"Pancreas"},{"key":"ref10","article-title":"Chronic metabolic acidosis destroys pancreas","volume":"15","author":"Melamed P","year":"2014","unstructured":"Melamed P, Melamed F. Chronic metabolic acidosis destroys pancreas. J Pancreas. 2014, 15:552-60.","journal-title":"J Pancreas"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12606","article-title":"Ringer's lactate versus normal saline in acute pancreatitis: a systematic review and meta-analysis","volume":"19","author":"Iqbal U","year":"2018","unstructured":"Iqbal U, Anwar H, Scribani M. Ringer's lactate versus normal saline in acute pancreatitis: a systematic review and meta-analysis. J Dig Dis. 2018, 19:335-41. 10.1111\/1751-2980.12606","journal-title":"J Dig Dis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.01.168","article-title":"Early management of acute pancreatitis: a review of the best evidence","volume":"49","author":"Stigliano S","year":"2017","unstructured":"Stigliano S, Sternby H, de Madaria E, Capurso G, Petrov MS. Early management of acute pancreatitis: a review of the best evidence. Dig Liver Dis. 2017, 49:585-94. 10.1016\/j.dld.2017.01.168","journal-title":"Dig Liver Dis"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.25908943","article-title":"Role of C-reactive protein (CRP) and neutrophil lymphocyte ratio (NLR) in detecting severity & predicting outcome of acute pancreatitis patients","volume":"3","author":"Mumin A","year":"2024","unstructured":"Mumin A, Amin A, Kabir S, Noor RA, Rahman U. Role of C-reactive protein (CRP) and neutrophil lymphocyte ratio (NLR) in detecting severity & predicting outcome of acute pancreatitis patients. Dinkum J Med Innov. 2024, 3:1-12. 10.6084\/m9.figshare.25908943","journal-title":"Dinkum J Med Innov"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-024-03205-y","article-title":"Evaluating the efficacy of different volume resuscitation strategies in acute pancreatitis patients: a systematic review and meta-analysis","volume":"24","author":"Kumari R","year":"2024","unstructured":"Kumari R, Sadarat F, Luhana S, et al.. Evaluating the efficacy of different volume resuscitation strategies in acute pancreatitis patients: a systematic review and meta-analysis. BMC Gastroenterol. 2024, 24:10.1186\/s12876-024-03205-y","journal-title":"BMC Gastroenterol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2025.04.020","article-title":"International Association of Pancreatology Revised Guidelines on Acute Pancreatitis 2025: supported and endorsed by the American Pancreatic Association, European Pancreatic Club, Indian Pancreas Club, and Japan Pancreas Society","volume":"25","year":"2025","unstructured":"International Association of Pancreatology Revised Guidelines on Acute Pancreatitis 2025. supported and endorsed by the American Pancreatic Association, European Pancreatic Club, Indian Pancreas Club, and Japan Pancreas Society. Pancreatology. 2025, 25:770-814. 10.1016\/j.pan.2025.04.020","journal-title":"Pancreatology"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.152702","article-title":"The early prediction of mortality in acute pancreatitis: a large population-based study","volume":"57","author":"Wu BU","year":"2008","unstructured":"Wu BU, Johannes RS, Sun X, Tabak Y, Conwell DL, Banks PA. The early prediction of mortality in acute pancreatitis: a large population-based study. Gut. 2008, 57:1698-703. 10.1136\/gut.2008.152702","journal-title":"Gut"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.04.026","article-title":"Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis","volume":"9","author":"Wu BU","year":"2011","unstructured":"Wu BU, Hwang JQ, Gardner TH, et al.. Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol. 2011, 9:710-17. 10.1016\/j.cgh.2011.04.026","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/diseases13090300","article-title":"Fluid resuscitation with lactated Ringer vs. normal saline in acute pancreatitis: a systematic review and meta-analysis of clinical trials","volume":"13","author":"Mosquera FE","year":"2025","unstructured":"Mosquera FE, Ben\u00edtez EC, Benavides MC, Mu\u00f1oz JE, Casta\u00f1eda CA, Liscano Y. Fluid resuscitation with lactated Ringer vs. normal saline in acute pancreatitis: a systematic review and meta-analysis of clinical trials. Diseases. 2025, 13:10.3390\/diseases13090300","journal-title":"Diseases"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2025.04.002","article-title":"Fluid therapy in acute pancreatitis comparing balanced solutions and normal saline: a systematic review, meta-analysis and trial sequential analysis","volume":"24","author":"Gao L","year":"2025","unstructured":"Gao L, Wang HW, Liu ZR, Xu YZ, Ke L, Li WQ, Windsor JA. Fluid therapy in acute pancreatitis comparing balanced solutions and normal saline: a systematic review, meta-analysis and trial sequential analysis. Hepatobiliary Pancreat Dis Int. 2025, 24:371-80. 10.1016\/j.hbpd.2025.04.002","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-08187-7","article-title":"Comparison of fluid resuscitation with lactate Ringer\u2019s versus normal saline in acute pancreatitis: an updated meta-analysis","volume":"69","author":"Hong J","year":"2024","unstructured":"Hong J, Li Q, Wang Y, Xiang L, Zhou Y, Fan M, Lin R. Comparison of fluid resuscitation with lactate Ringer\u2019s versus normal saline in acute pancreatitis: an updated meta-analysis. Dig Dis Sci. 2024, 69:262-74. 10.1007\/s10620-023-08187-7","journal-title":"Dig Dis Sci"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/475146-lactated-ringers-versus-normal-saline-in-early-phase-acute-pancreatitis-a-comparative-study-of-inflammatory-markers-and-clinical-outcomes","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:52:05Z","timestamp":1776495125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/475146-lactated-ringers-versus-normal-saline-in-early-phase-acute-pancreatitis-a-comparative-study-of-inflammatory-markers-and-clinical-outcomes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.107272","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,17]]}}}