{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T07:39:05Z","timestamp":1776584345908,"version":"3.51.2"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,19]]},"DOI":"10.7759\/cureus.107319","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T07:00:46Z","timestamp":1776582046000},"source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Residual Hyperlipidemia Among Statin-Treated Adults With Diabetes and Atherosclerotic Cardiovascular Disease: A Cross-Sectional Analysis of National Health and Nutrition Examination Survey 2005 to 2018"],"prefix":"10.7759","author":[{"given":"Helen","family":"Oletu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinyele","family":"Oladimeji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeka K","family":"Okobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Okwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adewale A","family":"Kuye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Okobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azeberoje","family":"Osueni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onyekachi O","family":"Anya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwasi A","family":"Opoku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuella E","family":"Ogelebor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1227769","article-title":"Atherosclerotic cardiovascular disease risk stratification and management in type 2 diabetes: review of recent evidence-based guidelines","volume":"10","author":"Gourdy P","year":"2023","unstructured":"Gourdy P, Schiele F, Halimi JM, Kownator S, Hadjadj S, Valensi P. Atherosclerotic cardiovascular disease risk stratification and management in type 2 diabetes: review of recent evidence-based guidelines. Front Cardiovasc Med. 2023, 10:1227769. 10.3389\/fcvm.2023.1227769","journal-title":"Front Cardiovasc Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.76","article-title":"The prevalence of cardiovascular disease and antidiabetes treatment characteristics among a large type 2 diabetes population in the United States","volume":"2","author":"Weng W","year":"2019","unstructured":"Weng W, Tian Y, Kong SX, Ganguly R, Hersloev M, Brett J, Hobbs T. The prevalence of cardiovascular disease and antidiabetes treatment characteristics among a large type 2 diabetes population in the United States. Endocrinol Diabetes Metab. 2019, 2:e00076. 10.1002\/edm2.76","journal-title":"Endocrinol Diabetes Metab"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-022-00529-2","article-title":"Cholesterol-lowering therapy in patients at low-to-moderate cardiovascular risk","volume":"29","author":"Figorilli F","year":"2022","unstructured":"Figorilli F, Mannarino MR, Bianconi V, Pirro M. Cholesterol-lowering therapy in patients at low-to-moderate cardiovascular risk. High Blood Press Cardiovasc Prev. 2022, 29:327-36. 10.1007\/s40292-022-00529-2","journal-title":"High Blood Press Cardiovasc Prev"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2412373","article-title":"Landscape of statin as a cornerstone in atherosclerotic cardiovascular disease","volume":"24","author":"Yang C","year":"2023","unstructured":"Yang C, Wu YJ, Qian J, Li JJ. Landscape of statin as a cornerstone in atherosclerotic cardiovascular disease. Rev Cardiovasc Med. 2023, 24:373. 10.31083\/j.rcm2412373","journal-title":"Rev Cardiovasc Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S010","article-title":"Cardiovascular disease and risk management: standards of care in diabetes-2023","volume":"46","author":"ElSayed NA","year":"2023","unstructured":"ElSayed NA, Aleppo G, Aroda VR, et al.. Cardiovascular disease and risk management: standards of care in diabetes-2023. Diabetes Care. 2023, 46:S158-90. 10.2337\/dc23-S010","journal-title":"Diabetes Care"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2013.54.339","article-title":"Prevalence and types of persistent dyslipidemia in patients treated with statins","volume":"54","author":"Reiner \u017d","year":"2013","unstructured":"Reiner \u017d, Tedeschi-Reiner E. Prevalence and types of persistent dyslipidemia in patients treated with statins. Croat Med J. 2013, 54:339-45. 10.3325\/cmj.2013.54.339","journal-title":"Croat Med J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.05.003","article-title":"Residual dyslipidemia according to low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B among statin-treated US adults: National Health and Nutrition Examination Survey 2009-2010","volume":"9","author":"Wong ND","year":"2015","unstructured":"Wong ND, Chuang J, Zhao Y, Rosenblit PD. Residual dyslipidemia according to low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B among statin-treated US adults: National Health and Nutrition Examination Survey 2009-2010. J Clin Lipidol. 2015, 9:525-32. 10.1016\/j.jacl.2015.05.003","journal-title":"J Clin Lipidol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-011-0219-7","article-title":"Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: the evidence, etiology, and therapeutic challenges","volume":"14","author":"Sampson UK","year":"2012","unstructured":"Sampson UK, Fazio S, Linton MF. Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: the evidence, etiology, and therapeutic challenges. Curr Atheroscler Rep. 2012, 14:1-10. 10.1007\/s11883-011-0219-7","journal-title":"Curr Atheroscler Rep"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67394-1","article-title":"Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90\u2008056 participants in 14 randomised trials of statins","volume":"366","author":"Baigent C","year":"2005","unstructured":"Baigent C, Keech A, Kearney PM, et al.. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90\u2008056 participants in 14 randomised trials of statins. Lancet. 2005, 366:1267-78. 10.1016\/S0140-6736(05)67394-1","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000331429","article-title":"Predictors of residual cardiovascular risk in patients on statin therapy for primary prevention","volume":"119","author":"Afonso L","year":"2011","unstructured":"Afonso L, Veeranna V, Zalawadiya S, Ramesh K, Niraj A, Panaich S. Predictors of residual cardiovascular risk in patients on statin therapy for primary prevention. Cardiology. 2011, 119:187-90. 10.1159\/000331429","journal-title":"Cardiology"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201196","article-title":"Systematic review of the predictors of statin adherence for the primary prevention of cardiovascular disease","volume":"14","author":"Hope HF","year":"2019","unstructured":"Hope HF, Binkley GM, Fenton S, Kitas GD, Verstappen SM, Symmons DP. Systematic review of the predictors of statin adherence for the primary prevention of cardiovascular disease. PLoS One. 2019, 14:e0201196. 10.1371\/journal.pone.0201196","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1541082","article-title":"Racial and ethnic disparities in statin adherence: insights from the All of Us Research Program","volume":"12","author":"Escobar G","year":"2025","unstructured":"Escobar G, Azizi Z, de Hond A, Lewis AA, Ng MY, Rodriguez F, Hernandez-Boussard T. Racial and ethnic disparities in statin adherence: insights from the All of Us Research Program. Front Cardiovasc Med. 2025, 12:1541082. 10.3389\/fcvm.2025.1541082","journal-title":"Front Cardiovasc Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s40615-016-0247-7","article-title":"A national assessment of medication adherence to statins by the racial composition of neighborhoods","volume":"4","author":"Davis AM","year":"2017","unstructured":"Davis AM, Taitel MS, Jiang J, Qato DM, Peek ME, Chou CH, Huang ES. A national assessment of medication adherence to statins by the racial composition of neighborhoods. J Racial Ethn Health Disparities. 2017, 4:462-71. 10.1007\/s40615-016-0247-7","journal-title":"J Racial Ethn Health Disparities"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2020.107767","article-title":"Diabetes associated residual atherosclerotic cardiovascular risk in statin-treated patients with prior atherosclerotic cardiovascular disease","volume":"35","author":"Zhao Y","year":"2021","unstructured":"Zhao Y, Xiang P, Coll B, L\u00f3pez JA, Wong ND. Diabetes associated residual atherosclerotic cardiovascular risk in statin-treated patients with prior atherosclerotic cardiovascular disease. J Diabetes Complications. 2021, 35:107767. 10.1016\/j.jdiacomp.2020.107767","journal-title":"J Diabetes Complications"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v10.i5.280","article-title":"Management of diabetic dyslipidemia: an update","volume":"10","author":"Jialal I","year":"2019","unstructured":"Jialal I, Singh G. Management of diabetic dyslipidemia: an update. World J Diabetes. 2019, 10:280-90. 10.4239\/wjd.v10.i5.280","journal-title":"World J Diabetes"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03360.x","article-title":"Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study","volume":"28","author":"Leiter LA","year":"2011","unstructured":"Leiter LA, Lundman P, da Silva PM, Drexel H, J\u00fcnger C, Gitt AK. Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study. Diabet Med. 2011, 28:1343-51. 10.1111\/j.1464-5491.2011.03360.x","journal-title":"Diabet Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.04.002","article-title":"Hypertriglyceridemia and residual dyslipidemia in statin-treated, patients with diabetes at the highest risk for cardiovascular disease and achieving very-low low-density lipoprotein-cholesterol levels","volume":"6","author":"Querton L","year":"2012","unstructured":"Querton L, Buysschaert M, Hermans MP. Hypertriglyceridemia and residual dyslipidemia in statin-treated, patients with diabetes at the highest risk for cardiovascular disease and achieving very-low low-density lipoprotein-cholesterol levels. J Clin Lipidol. 2012, 6:434-42. 10.1016\/j.jacl.2012.04.002","journal-title":"J Clin Lipidol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0501","article-title":"Residual hypertriglyceridemia and estimated atherosclerotic cardiovascular disease risk by statin use in U.S. adults with diabetes: National Health and Nutrition Examination Survey 2007-2014","volume":"42","author":"Fan W","year":"2019","unstructured":"Fan W, Philip S, Granowitz C, Toth PP, Wong ND. Residual hypertriglyceridemia and estimated atherosclerotic cardiovascular disease risk by statin use in U.S. adults with diabetes: National Health and Nutrition Examination Survey 2007-2014. Diabetes Care. 2019, 42:2307-14. 10.2337\/dc19-0501","journal-title":"Diabetes Care"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1308173","article-title":"Intermediate and long-term residual cardiovascular risk in patients with established cardiovascular disease treated with statins","volume":"10","author":"Vijayaraghavan K","year":"2023","unstructured":"Vijayaraghavan K, Baum S, Desai NR, Voyce SJ. Intermediate and long-term residual cardiovascular risk in patients with established cardiovascular disease treated with statins. Front Cardiovasc Med. 2023, 10:1308173. 10.3389\/fcvm.2023.1308173","journal-title":"Front Cardiovasc Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051086","article-title":"Use of NHANES data to link chemical exposures to chronic diseases: a cautionary tale","volume":"7","author":"LaKind JS","year":"2012","unstructured":"LaKind JS, Goodman M, Naiman DQ. Use of NHANES data to link chemical exposures to chronic diseases: a cautionary tale. PLoS One. 2012, 7:e51086. 10.1371\/journal.pone.0051086","journal-title":"PLoS One"},{"key":"ref21","unstructured":"National Health and Nutrition Examination Survey. (2026). Accessed. March 25, 2026: https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/search\/default.aspx."},{"key":"ref22","unstructured":"Stata. (2025). Accessed. March 25, 2026: https:\/\/www.stata.com\/."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000625","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"139","author":"Grundy SM","year":"2019","unstructured":"Grundy SM, Stone NJ, Bailey AL, et al.. 2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019, 139:e1082-143. 10.1161\/CIR.0000000000000625","journal-title":"Circulation"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz826","article-title":"2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","year":"2020","unstructured":"2019 ESC\/EAS guidelines for the management of dyslipidaemias. lipid modification to reduce cardiovascular risk. Eur Heart J. 2020, 41:4255. 10.1093\/eurheartj\/ehz826","journal-title":"Eur Heart J"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953","article-title":"New creatinine- and cystatin C-based equations to estimate GFR without race","volume":"385","author":"Inker LA","year":"2021","unstructured":"Inker LA, Eneanya ND, Coresh J, et al.. New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med. 2021, 385:1737-49. 10.1056\/NEJMoa2102953","journal-title":"N Engl J Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.11.016","article-title":"2026 ACC\/AHA\/AACVPR\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","author":"Blumenthal RS","year":"2026","unstructured":"Blumenthal RS, Morris PB, Gaudino M, et al.. 2026 ACC\/AHA\/AACVPR\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2026, 10.1016\/j.jacc.2025.11.016","journal-title":"J Am Coll Cardiol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001186","article-title":"A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American Heart Association","volume":"148","author":"Ndumele CE","year":"2023","unstructured":"Ndumele CE, Neeland IJ, Tuttle KR, et al.. A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American Heart Association. Circulation. 2023, 148:1636-64. 10.1161\/CIR.0000000000001186","journal-title":"Circulation"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001040","article-title":"Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement from the American Heart Association","volume":"145","author":"Joseph JJ","year":"2022","unstructured":"Joseph JJ, Deedwania P, Acharya T, et al.. Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement from the American Heart Association. Circulation. 2022, 145:e722-59. 10.1161\/CIR.0000000000001040","journal-title":"Circulation"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/483907-factors-associated-with-residual-hyperlipidemia-among-statin-treated-adults-with-diabetes-and-atherosclerotic-cardiovascular-disease-a-cross-sectional-analysis-of-national-health-and-nutrition-examination-survey-2005-to-2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T07:00:47Z","timestamp":1776582047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/483907-factors-associated-with-residual-hyperlipidemia-among-statin-treated-adults-with-diabetes-and-atherosclerotic-cardiovascular-disease-a-cross-sectional-analysis-of-national-health-and-nutrition-examination-survey-2005-to-2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,19]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.107319","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,19]]}}}