{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:17:17Z","timestamp":1777630637955,"version":"3.51.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,28]]},"DOI":"10.7759\/cureus.107918","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:02:26Z","timestamp":1777431746000},"source":"Crossref","is-referenced-by-count":0,"title":["Arthropod Exposure-Associated Neurogenic Pruritus: A Complex Neuro-Immune Transition Mimicking Refractory Urticaria"],"prefix":"10.7759","author":[{"given":"Niyas Khalid","family":"Ottu Para","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Rab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-026-01255-8","article-title":"Cross-talk between neurons and immune cells in pruritus: from mechanisms to medicines","volume":"26","author":"Khalil N","year":"2026","unstructured":"Khalil N, Kagan T, Yosipovitch G. Cross-talk between neurons and immune cells in pruritus: from mechanisms to medicines. Curr Allergy Asthma Rep. 2026, 26:12. 10.1007\/s11882-026-01255-8","journal-title":"Curr Allergy Asthma Rep"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16859-5","article-title":"Central circuit mechanisms of itch","volume":"11","author":"Chen XJ","year":"2020","unstructured":"Chen XJ, Sun YG. Central circuit mechanisms of itch. Nat Commun. 2020, 11:3052. 10.1038\/s41467-020-16859-5","journal-title":"Nat Commun"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1950","article-title":"The neurobiology of itch","volume":"7","author":"Ikoma A","year":"2006","unstructured":"Ikoma A, Steinhoff M, St\u00e4nder S, Yosipovitch G, Schmelz M. The neurobiology of itch. Nat Rev Neurosci. 2006, 7:535-47. 10.1038\/nrn1950","journal-title":"Nat Rev Neurosci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2025.11.007","article-title":"Interleukin-31 targeting and other novel drugs in itch","volume":"136","author":"Olah P","year":"2026","unstructured":"Olah P, Raap U, Homey B. Interleukin-31 targeting and other novel drugs in itch. Ann Allergy Asthma Immunol. 2026, 136:141-8. 10.1016\/j.anai.2025.11.007","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0746-9","article-title":"Chronic pruritus: Current and emerging treatment options","volume":"77","author":"Pereira MP","year":"2017","unstructured":"Pereira MP, St\u00e4nder S. Chronic pruritus: Current and emerging treatment options. Drugs. 2017, 77:999-1007. 10.1007\/s40265-017-0746-9","journal-title":"Drugs"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14051774","article-title":"The relationship between chronic pruritus, attention-deficit\/hyperactivity disorder, and skin picking: a case series and narrative review","volume":"14","author":"Loos E","year":"2025","unstructured":"Loos E, Sekar S, Rosin C, Navarini AA, Schwale C, Schaefert R, M\u00fcller S. The relationship between chronic pruritus, attention-deficit\/hyperactivity disorder, and skin picking: a case series and narrative review. J Clin Med. 2025, 14:1774. 10.3390\/jcm14051774","journal-title":"J Clin Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-025-00994-0","article-title":"Menopause and common dermatoses: a systematic review","volume":"27","author":"Roster K","year":"2026","unstructured":"Roster K, Fleshner L, Karatas TB, Ecanow A, Sayegh A, Farabi B, Marmon S. Menopause and common dermatoses: a systematic review. Am J Clin Dermatol. 2026, 27:67-84. 10.1007\/s40257-025-00994-0","journal-title":"Am J Clin Dermatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-34172-4.00026-4","article-title":"Recent therapeutic advances to treat itch","author":"Iriki H","year":"2026","unstructured":"Iriki H, Auyeung K, Kim BS. Recent therapeutic advances to treat itch. The Neurological and Immunological Basis of Itch and Dermatological Disorders. Academic Press, Cambridge, Massachusetts; 2026. 405-13. 10.1016\/B978-0-443-34172-4.00026-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2025.0021","article-title":"Breaking the itch-scratch cycle: an integrative approach for atopic dermatitis","author":"Steinhoff M","year":"2025","unstructured":"Steinhoff M, Yosipovitch G, Canchy L, et al.. Breaking the itch-scratch cycle: an integrative approach for atopic dermatitis. Dermatitis. 2025, derm20250021. 10.1089\/derm.2025.0021","journal-title":"Dermatitis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03397-4","article-title":"Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria","volume":"22","author":"Yang S","year":"2025","unstructured":"Yang S, Chen L, Zhang H, et al.. Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria. J Neuroinflammation. 2025, 22:75. 10.1186\/s12974-025-03397-4","journal-title":"J Neuroinflammation"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9367-y","article-title":"Stress-related skin disorders","volume":"17","author":"Alexopoulos A","year":"2016","unstructured":"Alexopoulos A, Chrousos GP. Stress-related skin disorders. Rev Endocr Metab Disord. 2016, 17:295-304. 10.1007\/s11154-016-9367-y","journal-title":"Rev Endocr Metab Disord"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2014.907526","article-title":"Imaging the ADHD brain: disorder-specificity, medication effects and clinical translation","volume":"14","author":"Rubia K","year":"2014","unstructured":"Rubia K, Alegria A, Brinson H. Imaging the ADHD brain: disorder-specificity, medication effects and clinical translation. Expert Rev Neurother. 2014, 14:519-38. 10.1586\/14737175.2014.907526","journal-title":"Expert Rev Neurother"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/srt.70203","article-title":"Menopause, menstrual cycle, and skin barrier function","volume":"31","author":"Nikoleti\u0107 \u0110C","year":"2025","unstructured":"Nikoleti\u0107 \u0110C, Ivanov D, Levakov O, Bulaji\u0107 J, Luka\u010d S, Raki\u0107 VK, Ivkov-Simi\u0107 M. Menopause, menstrual cycle, and skin barrier function. Skin Res Technol. 2025, 31:e70203. 10.1111\/srt.70203","journal-title":"Skin Res Technol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2024.08.028","article-title":"Efficacy and safety of pregabalin and gabapentin for pruritus: a systematic review and meta-analysis","volume":"69","author":"Xu W","year":"2025","unstructured":"Xu W, Dong H, Ran H, Liu H, Wang L, Li H, Tan C. Efficacy and safety of pregabalin and gabapentin for pruritus: a systematic review and meta-analysis. J Pain Symptom Manage. 2025, 69:65-81. 10.1016\/j.jpainsymman.2024.08.028","journal-title":"J Pain Symptom Manage"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(02)00645-0","article-title":"Mirtazapine for pruritus","volume":"25","author":"Davis MP","year":"2003","unstructured":"Davis MP, Frandsen JL, Walsh D. Mirtazapine for pruritus.  J Pain Symptom Manage. 2003, 25:288-91. 10.1016\/S0885-3924(02)00645-0","journal-title":"J Pain Symptom Manage"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144675","article-title":"Burden of disease and unmet needs in the diagnosis and management of atopic dermatitis in the Arabic population of the Middle East","volume":"12","author":"Mahmoud O","year":"2023","unstructured":"Mahmoud O, Yosipovitch G, Attia E. Burden of disease and unmet needs in the diagnosis and management of atopic dermatitis in the Arabic population of the Middle East. J Clin Med. 2023, 12:4675. 10.3390\/jcm12144675","journal-title":"J Clin Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/485955-arthropod-exposure-associated-neurogenic-pruritus-a-complex-neuro-immune-transition-mimicking-refractory-urticaria","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:02:34Z","timestamp":1777431754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/485955-arthropod-exposure-associated-neurogenic-pruritus-a-complex-neuro-immune-transition-mimicking-refractory-urticaria"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.107918","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}