{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:25:23Z","timestamp":1777893923525,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"DOI":"10.7759\/cureus.108079","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:05:01Z","timestamp":1777619101000},"source":"Crossref","is-referenced-by-count":0,"title":["Addition of Clomiphene Citrate to a Low-Dose Gonadotropin-Releasing Hormone (GnRH)-Antagonist Protocol in Poor Responders: A Prospective Cohort Study"],"prefix":"10.7759","author":[{"given":"Olga","family":"Triantafyllidou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Panagodimou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stamatia","family":"Chasiakou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Gkontelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Karkalemis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Simopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despina","family":"Tzanakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Syggelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros","family":"Kalampokas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Vakas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Lazaridis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotios","family":"Vlahos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Christopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Vlahos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-022-01964-y","article-title":"Predicting IVF outcome in poor ovarian responders","volume":"22","author":"Lebovitz O","year":"2022","unstructured":"Lebovitz O, Haas J, Mor N, et al.. Predicting IVF outcome in poor ovarian responders. BMC Womens Health. 2022, 22:395. 10.1186\/s12905-022-01964-y","journal-title":"BMC Womens Health"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/2633494120941480","article-title":"Update on the management of poor ovarian response in IVF: the shift from Bologna criteria to the Poseidon concept","volume":"14","author":"Drakopoulos P","year":"2020","unstructured":"Drakopoulos P, Bardhi E, Boudry L, et al.. Update on the management of poor ovarian response in IVF: the shift from Bologna criteria to the Poseidon concept. Ther Adv Reprod Health. 2020, 14:2633494120941480. 10.1177\/2633494120941480","journal-title":"Ther Adv Reprod Health"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5644\/ama2006-124.379","article-title":"Researching the phenomenon of poor ovarian responders and management strategies in IVF: a narrative review","volume":"51","author":"Galatis D","year":"2022","unstructured":"Galatis D, Kalopita K, Grypiotis I, Flessas I, Kiriakopoulos N, Micha G. Researching the phenomenon of poor ovarian responders and management strategies in IVF: a narrative review. Acta Med Acad. 2022, 51:108-22. 10.5644\/ama2006-124.379","journal-title":"Acta Med Acad"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der092","article-title":"ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria","volume":"26","author":"Ferraretti AP","year":"2011","unstructured":"Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011, 26:1616-24. 10.1093\/humrep\/der092","journal-title":"Hum Reprod"},{"key":"ref5","article-title":"Comparison of different ovarian hyperstimulation protocols efficacy in poor ovarian responders according to the Bologna criteria","volume":"7","author":"Hu L","year":"2014","unstructured":"Hu L, Bu Z, Guo Y, Su Y, Zhai J, Sun Y. Comparison of different ovarian hyperstimulation protocols efficacy in poor ovarian responders according to the Bologna criteria. Int J Clin Exp Med. 2014, 7:1128-34.","journal-title":"Int J Clin Exp Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062110","article-title":"Novel physiology and definition of poor ovarian response; clinical recommendations","volume":"21","author":"Abu-Musa A","year":"2020","unstructured":"Abu-Musa A, Haahr T, Humaidan P. Novel physiology and definition of poor ovarian response; clinical recommendations. Int J Mol Sci. 2020, 21:2110. 10.3390\/ijms21062110","journal-title":"Int J Mol Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10382.1","article-title":"The novel Poseidon stratification of \u2018low prognosis patients in assisted reproductive technology\u2019 and its proposed marker of successful outcome","volume":"5","author":"Humaidan P","year":"2016","unstructured":"Humaidan P, Alviggi C, Fischer R, Esteves SC. The novel Poseidon stratification of \u2018low prognosis patients in assisted reproductive technology\u2019 and its proposed marker of successful outcome. F1000Res. 2016, 5:2911. 10.12688\/f1000research.10382.1","journal-title":"F1000Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0227-y","article-title":"\"Mild\" vs. \"long\" protocol for controlled ovarian hyperstimulation in patients with expected poor ovarian responsiveness undergoing in vitro fertilization (IVF): a large prospective randomized trial","volume":"31","author":"Revelli A","year":"2014","unstructured":"Revelli A, Chiad\u00f2 A, Dalmasso P, Stabile V, Evangelista F, Basso G, Benedetto C. \"Mild\" vs. \"long\" protocol for controlled ovarian hyperstimulation in patients with expected poor ovarian responsiveness undergoing in vitro fertilization (IVF): a large prospective randomized trial. J Assist Reprod Genet. 2014, 31:809-15. 10.1007\/s10815-014-0227-y","journal-title":"J Assist Reprod Genet"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.09.035","article-title":"Long gonadotropin-releasing hormone agonist versus short agonist versus antagonist regimens in poor responders undergoing in\u00a0vitro fertilization: a randomized controlled trial","volume":"101","author":"Sunkara SK","year":"2014","unstructured":"Sunkara SK, Coomarasamy A, Faris R, Braude P, Khalaf Y. Long gonadotropin-releasing hormone agonist versus short agonist versus antagonist regimens in poor responders undergoing in\u00a0vitro fertilization: a randomized controlled trial. Fertil Steril. 2014, 101:147-53. 10.1016\/j.fertnstert.2013.09.035","journal-title":"Fertil Steril"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.02.011","article-title":"Cumulative pregnancy rates in women with poor ovarian response","volume":"109","author":"Goldfarb JM","year":"2018","unstructured":"Goldfarb JM. Cumulative pregnancy rates in women with poor ovarian response. Fertil Steril. 2018, 109:1004-5. 10.1016\/j.fertnstert.2018.02.011","journal-title":"Fertil Steril"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20180070","article-title":"Use of clomiphene citrate in minimal stimulation in vitro fertilization negatively impacts endometrial thickness: an argument for a freeze-all approach","volume":"22","author":"Reed BG","year":"2018","unstructured":"Reed BG, Wu JL, Nemer LB, Carr BR, Bukulmez O. Use of clomiphene citrate in minimal stimulation in vitro fertilization negatively impacts endometrial thickness: an argument for a freeze-all approach. JBRA Assist Reprod. 2018, 22:355-62. 10.5935\/1518-0557.20180070","journal-title":"JBRA Assist Reprod"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.03.019","article-title":"Comparison of pregnancy rates for poor responders using IVF with mild ovarian stimulation versus conventional IVF: a guideline","volume":"109","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2018","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Comparison of pregnancy rates for poor responders using IVF with mild ovarian stimulation versus conventional IVF: a guideline. Fertil Steril. 2018, 109:993-9. 10.1016\/j.fertnstert.2018.03.019","journal-title":"Fertil Steril"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa035","article-title":"Mild versus conventional ovarian stimulation for IVF in poor, normal and hyper-responders: a systematic review and meta-analysis","volume":"27","author":"Datta AK","year":"2021","unstructured":"Datta AK, Maheshwari A, Felix N, Campbell S, Nargund G. Mild versus conventional ovarian stimulation for IVF in poor, normal and hyper-responders: a systematic review and meta-analysis. Hum Reprod Update. 2021, 27:229-53. 10.1093\/humupd\/dmaa035","journal-title":"Hum Reprod Update"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)36060-5","article-title":"Use of clomiphene citrate, human chorionic gonadotropin, and human menopausal gonadotropin for induction of ovulation in the human female","volume":"17","author":"Kistner RW","year":"1966","unstructured":"Kistner RW. Use of clomiphene citrate, human chorionic gonadotropin, and human menopausal gonadotropin for induction of ovulation in the human female. Fertil Steril. 1966, 17:569-83. 10.1016\/s0015-0282(16)36060-5","journal-title":"Fertil Steril"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/2.6.483","article-title":"Development, pharmacology and clinical experience with clomiphene citrate","volume":"2","author":"Dickey RP","year":"1996","unstructured":"Dickey RP, Holtkamp DE. Development, pharmacology and clinical experience with clomiphene citrate. Hum Reprod Update. 1996, 2:483-506. 10.1093\/humupd\/2.6.483","journal-title":"Hum Reprod Update"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.01.022","article-title":"A novel protocol of ovulation induction with delayed gonadotropin-releasing hormone antagonist administration combined with high-dose recombinant follicle-stimulating hormone and clomiphene citrate for poor responders and women over 35 years","volume":"81","author":"D'Amato G","year":"2004","unstructured":"D'Amato G, Caroppo E, Pasquadibisceglie A, Carone D, Vitti A, Vizziello GM. A novel protocol of ovulation induction with delayed gonadotropin-releasing hormone antagonist administration combined with high-dose recombinant follicle-stimulating hormone and clomiphene citrate for poor responders and women over 35 years. Fertil Steril. 2004, 81:1572-7. 10.1016\/j.fertnstert.2004.01.022","journal-title":"Fertil Steril"},{"key":"ref17","article-title":"Atlas of the Human Oocyte and Early Conceptus","author":"Veeck LL","year":"1991","unstructured":"Veeck LL. Atlas of the Human Oocyte and Early Conceptus. Williams &amp; Wilkins, Baltimore, MD; 1991."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr037","article-title":"The poor responder in IVF: is the prognosis always poor? A systematic review","volume":"18","author":"Oudendijk JF","year":"2012","unstructured":"Oudendijk JF, Yarde F, Eijkemans MJ, Broekmans FJ, Broer SL. The poor responder in IVF: is the prognosis always poor? A systematic review. Hum Reprod Update. 2012, 18:1-11. 10.1093\/humupd\/dmr037","journal-title":"Hum Reprod Update"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(16)33303-8","article-title":"Pregnancy following 29 cycles of clomiphene citrate therapy: a case report","volume":"124","author":"March CM","year":"1976","unstructured":"March CM, Israel R, Mishell DR Jr. Pregnancy following 29 cycles of clomiphene citrate therapy: a case report. Am J Obstet Gynecol. 1976, 124:209-10. 10.1016\/s0002-9378(16)33303-8","journal-title":"Am J Obstet Gynecol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11050","article-title":"Mild versus conventional ovarian stimulation for poor responders undergoing IVF\/ICSI","volume":"31","author":"Siristatidis C","year":"2017","unstructured":"Siristatidis C, Salamalekis G, Dafopoulos K, Basios G, Vogiatzi P, Papantoniou N. Mild versus conventional ovarian stimulation for poor responders undergoing IVF\/ICSI. In Vivo. 2017, 31:231-7. 10.21873\/invivo.11050","journal-title":"In Vivo"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-018-0408-x","article-title":"Low dose clomiphene citrate as a mild stimulation protocol in women with unsuspected poor in vitro fertilization result can generate more oocytes with optimal cumulative pregnancy rate","volume":"11","author":"Ochin H","year":"2018","unstructured":"Ochin H, Ma X, Wang L, et al.. Low dose clomiphene citrate as a mild stimulation protocol in women with unsuspected poor in vitro fertilization result can generate more oocytes with optimal cumulative pregnancy rate. J Ovarian Res. 2018, 11:37. 10.1186\/s13048-018-0408-x","journal-title":"J Ovarian Res"},{"key":"ref22","article-title":"Comparison pregnancy outcomes between minimal stimulation protocol and conventional GnRH antagonist protocols in poor ovarian responders","volume":"10","author":"Pilehvari S","year":"2016","unstructured":"Pilehvari S, ShahrokhTehraninejad E, Hosseinrashidi B, Keikhah F, Haghollahi F, Aziminekoo E. Comparison pregnancy outcomes between minimal stimulation protocol and conventional GnRH antagonist protocols in poor ovarian responders. J Family Reprod Health. 2016, 10:35-42.","journal-title":"J Family Reprod Health"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa336","article-title":"Randomised controlled trial on the effect of clomiphene citrate and gonadotropin dose on ovarian response markers and IVF outcomes in poor responders","volume":"36","author":"Moffat R","year":"2021","unstructured":"Moffat R, Hansali C, Schoetzau A, et al.. Randomised controlled trial on the effect of clomiphene citrate and gonadotropin dose on ovarian response markers and IVF outcomes in poor responders. Hum Reprod. 2021, 36:987-97. 10.1093\/humrep\/deaa336","journal-title":"Hum Reprod"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008528.pub3","article-title":"Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation","volume":"11","author":"Kamath MS","year":"2017","unstructured":"Kamath MS, Maheshwari A, Bhattacharya S, Lor KY, Gibreel A. Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation. Cochrane Database Syst Rev. 2017, 11:CD008528. 10.1002\/14651858.CD008528.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18822","article-title":"Re: clomiphene citrate and letrozole to reduce follicle-stimulating hormone consumption during ovarian stimulation: systematic review and meta-analysis. T. N. Bechtejew, M. N. Nadai, C. O. Nastri and W. P. Martins. Ultrasound Obstet Gynecol 2017; 50: 315-323","volume":"50","author":"Siristatidis C","year":"2017","unstructured":"Siristatidis C. Re: clomiphene citrate and letrozole to reduce follicle-stimulating hormone consumption during ovarian stimulation: systematic review and meta-analysis. T. N. Bechtejew, M. N. Nadai, C. O. Nastri and W. P. Martins. Ultrasound Obstet Gynecol 2017; 50: 315-323. Ultrasound Obstet Gynecol. 2017, 50:294. 10.1002\/uog.18822","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.032003","article-title":"Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro","volume":"72","author":"Roberts R","year":"2005","unstructured":"Roberts R, Iatropoulou A, Ciantar D, Stark J, Becker DL, Franks S, Hardy K. Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro. Biol Reprod. 2005, 72:107-18. 10.1095\/biolreprod.104.032003","journal-title":"Biol Reprod"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.05.026","article-title":"The addition of clomiphene citrate to ovarian stimulation protocols for poor responders","volume":"251","author":"Triantafyllidou O","year":"2020","unstructured":"Triantafyllidou O, Sigalos G, Gkoles L, Kastora S, Vakas P, Batsiou E, Vlahos N. The addition of clomiphene citrate to ovarian stimulation protocols for poor responders. Eur J Obstet Gynecol Reprod Biol. 2020, 251:136-40. 10.1016\/j.ejogrb.2020.05.026","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2022.2109069","article-title":"Clomiphene citrate priming increases sensitivity during ovarian stimulation in poor ovarian responders undergoing in\u00a0vitro fertilization treatment: a retrospective cohort study","volume":"26","author":"Liu S","year":"2023","unstructured":"Liu S, Liu X, Li H, Liu M, Lv Y, Li Y. Clomiphene citrate priming increases sensitivity during ovarian stimulation in poor ovarian responders undergoing in\u00a0vitro fertilization treatment: a retrospective cohort study. Hum Fertil (Camb). 2023, 26:1080-6. 10.1080\/14647273.2022.2109069","journal-title":"Hum Fertil (Camb)"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.09.050","article-title":"Minimal stimulation using recombinant follicle-stimulating hormone and a gonadotropin-releasing hormone antagonist in women of advanced age","volume":"81","author":"Weghofer A","year":"2004","unstructured":"Weghofer A, Margreiter M, Bassim S, Sevelda U, Beilhack E, Feichtinger W. Minimal stimulation using recombinant follicle-stimulating hormone and a gonadotropin-releasing hormone antagonist in women of advanced age. Fertil Steril. 2004, 81:1002-6. 10.1016\/j.fertnstert.2003.09.050","journal-title":"Fertil Steril"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.22074\/ijfs.2015.4542","article-title":"Comparison of the effectiveness of clomiphene citrate versus letrozole in mild IVF in poor prognosis subfertile women with failed IVF cycles","volume":"9","author":"Oktem M","year":"2015","unstructured":"Oktem M, Guler I, Erdem M, Erdem A, Bozkurt N, Karabacak O. Comparison of the effectiveness of clomiphene citrate versus letrozole in mild IVF in poor prognosis subfertile women with failed IVF cycles. Int J Fertil Steril. 2015, 9:285-91. 10.22074\/ijfs.2015.4542","journal-title":"Int J Fertil Steril"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.07.007","article-title":"Conventional versus minimal ovarian stimulation: an intra-patient comparison of ovarian response in poor-responder women according to Bologna criteria","volume":"37","author":"Labarta E","year":"2018","unstructured":"Labarta E, Marin D, Remoh\u00ed J, Bosch E. Conventional versus minimal ovarian stimulation: an intra-patient comparison of ovarian response in poor-responder women according to Bologna criteria. Reprod Biomed Online. 2018, 37:434-41. 10.1016\/j.rbmo.2018.07.007","journal-title":"Reprod Biomed Online"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.07.030","article-title":"Endometrial thickness after ovarian stimulation with gonadotropin, clomiphene, or letrozole for unexplained infertility, and association with treatment outcomes","volume":"115","author":"Quaas AM","year":"2021","unstructured":"Quaas AM, Gavrizi SZ, Peck JD, et al.. Endometrial thickness after ovarian stimulation with gonadotropin, clomiphene, or letrozole for unexplained infertility, and association with treatment outcomes. Fertil Steril. 2021, 115:213-20. 10.1016\/j.fertnstert.2020.07.030","journal-title":"Fertil Steril"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1414481","article-title":"The impact of clomiphene citrate on the endometrium in comparison to gonadotropins in intrauterine insemination cycles: is it thinner and does it matter?","volume":"15","author":"Lu Y","year":"2024","unstructured":"Lu Y, Cherouveim P, Jiang V, Dimitriadis I, James KE, Bormann C, Souter I. The impact of clomiphene citrate on the endometrium in comparison to gonadotropins in intrauterine insemination cycles: is it thinner and does it matter?. Front Endocrinol (Lausanne). 2024, 15:1414481. 10.3389\/fendo.2024.1414481","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03668-x","article-title":"Does the additional use of clomiphene citrate or letrozole for in vitro fertilization deserve more attention?","volume":"21","author":"Liang Y","year":"2021","unstructured":"Liang Y, Guo Q, Wu XH, et al.. Does the additional use of clomiphene citrate or letrozole for in vitro fertilization deserve more attention?. BMC Pregnancy Childbirth. 2021, 21:275. 10.1186\/s12884-021-03668-x","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13624","article-title":"Effect of simultaneously started clomiphene citrate and gonadotropins in antagonist regimes, on cumulative live births, fresh-cycle live births and cost of stimulation in IVF cycles","volume":"44","author":"Satwik R","year":"2018","unstructured":"Satwik R, Kochhar M. Effect of simultaneously started clomiphene citrate and gonadotropins in antagonist regimes, on cumulative live births, fresh-cycle live births and cost of stimulation in IVF cycles. J Obstet Gynaecol Res. 2018, 44:1107-17. 10.1111\/jog.13624","journal-title":"J Obstet Gynaecol Res"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz046","article-title":"Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis","volume":"26","author":"Zhang Y","year":"2020","unstructured":"Zhang Y, Zhang C, Shu J, et al.. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod Update. 2020, 26:247-63. 10.1093\/humupd\/dmz046","journal-title":"Hum Reprod Update"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa009","article-title":"ESHRE guideline: ovarian stimulation for IVF\/ICSI","volume":"2020","author":"Bosch E","year":"2020","unstructured":"Bosch E, Broer S, Griesinger G, et al.. ESHRE guideline: ovarian stimulation for IVF\/ICSI. Hum Reprod Open. 2020, 2020:hoaa009. 10.1093\/hropen\/hoaa009","journal-title":"Hum Reprod Open"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008528.pub2","article-title":"Clomiphene citrate in combination with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilization","volume":"11","author":"Gibreel A","year":"2012","unstructured":"Gibreel A, Maheshwari A, Bhattacharya S. Clomiphene citrate in combination with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilization. Cochrane Database Syst Rev. 2012, 11:CD008528. 10.1002\/14651858.CD008528.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.003","article-title":"Recombinant luteinizing hormone supplementation in assisted reproductive technology: a systematic review","volume":"109","author":"Alviggi C","year":"2018","unstructured":"Alviggi C, Conforti A, Esteves SC, et al.. Recombinant luteinizing hormone supplementation in assisted reproductive technology: a systematic review. Fertil Steril. 2018, 109:644-64. 10.1016\/j.fertnstert.2018.01.003","journal-title":"Fertil Steril"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0460-4","article-title":"The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis","volume":"17","author":"Conforti A","year":"2019","unstructured":"Conforti A, Esteves SC, Di Rella F, et al.. The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2019, 17:18. 10.1186\/s12958-019-0460-4","journal-title":"Reprod Biol Endocrinol"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew360","article-title":"Efficacy and safety of follitropin alfa\/lutropin alfa in ART: a randomized controlled trial in poor ovarian responders","volume":"32","author":"Humaidan P","year":"2017","unstructured":"Humaidan P, Chin W, Rogoff D, D'Hooghe T, Longobardi S, Hubbard J, Schertz J. Efficacy and safety of follitropin alfa\/lutropin alfa in ART: a randomized controlled trial in poor ovarian responders. Hum Reprod. 2017, 32:544-55. 10.1093\/humrep\/dew360","journal-title":"Hum Reprod"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/470879-addition-of-clomiphene-citrate-to-a-low-dose-gonadotropin-releasing-hormone-gnrh-antagonist-protocol-in-poor-responders-a-prospective-cohort-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:05:03Z","timestamp":1777619103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/470879-addition-of-clomiphene-citrate-to-a-low-dose-gonadotropin-releasing-hormone-gnrh-antagonist-protocol-in-poor-responders-a-prospective-cohort-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":41,"URL":"https:\/\/doi.org\/10.7759\/cureus.108079","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,1]]}}}