{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:11Z","timestamp":1777946171295,"version":"3.51.4"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,2]]},"DOI":"10.7759\/cureus.108141","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:07:18Z","timestamp":1777734438000},"source":"Crossref","is-referenced-by-count":0,"title":["Early-Stage Rectal Mixed Neuroendocrine-Non-neuroendocrine Neoplasm Treated With Local Excision in a Frail Elderly Patient: A Multidisciplinary Management Dilemma"],"prefix":"10.7759","author":[{"given":"Christopher  M","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rae-Anne","family":"Kastle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talyn","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harsha","family":"Kalagana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Williams-Wuch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000475527","article-title":"Digestive system mixed neuroendocrine-non-neuroendocrine neoplasms","volume":"105","author":"de Mestier L","year":"2017","unstructured":"de Mestier L, Cros J, Neuzillet C, et al.. Digestive system mixed neuroendocrine-non-neuroendocrine neoplasms. Neuroendocrinology. 2017, 105:412-25. 10.1159\/000475527","journal-title":"Neuroendocrinology"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35372","article-title":"Incidence trends and relative survival of colorectal neuroendocrine neoplasms: A population-based study using German cancer registry data","volume":"157","author":"M\u00f6ller L","year":"2025","unstructured":"M\u00f6ller L, Szentkir\u00e1lyi A, Eisfeld C, et al.. Incidence trends and relative survival of colorectal neuroendocrine neoplasms: A population-based study using German cancer registry data. Int J Cancer. 2025, 157:116-25. 10.1002\/ijc.35372","journal-title":"Int J Cancer"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2024.02.012","article-title":"Colorectal neuroendocrine carcinoma and mixed neuroendocrine-non-neuroendocrine neoplasm: prognostic factors and PD-L1 expression","volume":"145","author":"Ho YH","year":"2024","unstructured":"Ho YH, Hsu CY, Li AF, Liang WY. Colorectal neuroendocrine carcinoma and mixed neuroendocrine-non-neuroendocrine neoplasm: prognostic factors and PD-L1 expression. Hum Pathol. 2024, 145:80-5. 10.1016\/j.humpath.2024.02.012","journal-title":"Hum Pathol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000538384","article-title":"Mixed neuroendocrine-non-neuroendocrine neoplasms of the rectum: a case report","volume":"17","author":"Verdasca FR","year":"2024","unstructured":"Verdasca FR, Ferreira R, Montenegro A, et al.. Mixed neuroendocrine-non-neuroendocrine neoplasms of the rectum: a case report. Case Rep Oncol. 2024, 17:587-95. 10.1159\/000538384","journal-title":"Case Rep Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2020-2-4","article-title":"Rectal neuroendocrine carcinoma: case report of a rare entity and perspective review of promising agents","volume":"9","author":"Antelo G","year":"2020","unstructured":"Antelo G, Hierro C, Fern\u00e1ndez JP, et al.. Rectal neuroendocrine carcinoma: case report of a rare entity and perspective review of promising agents. Drugs Context. 2020, 9:10.7573\/dic.2020-2-4","journal-title":"Drugs Context"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-021-01172-1","article-title":"Rectal neuroendocrine neoplasms: why is there a global variation?","volume":"24","author":"Cope J","year":"2022","unstructured":"Cope J, Srirajaskanthan R. Rectal neuroendocrine neoplasms: why is there a global variation?. Curr Oncol Rep. 2022, 24:257-63. 10.1007\/s11912-021-01172-1","journal-title":"Curr Oncol Rep"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-022-00968-y","article-title":"An update on the management of mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN)","volume":"23","author":"Jacob A","year":"2022","unstructured":"Jacob A, Raj R, Allison DB, Soares HP, Chauhan A. An update on the management of mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN). Curr Treat Options Oncol. 2022, 23:721-35. 10.1007\/s11864-022-00968-y","journal-title":"Curr Treat Options Oncol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010273","article-title":"Mixed neuroendocrine non-neuroendocrine neoplasms: a systematic review of a controversial and underestimated diagnosis","volume":"9","author":"Frizziero M","year":"2020","unstructured":"Frizziero M, Chakrabarty B, Nagy B, Lamarca A, Hubner RA, Valle JW, McNamara MG. Mixed neuroendocrine non-neuroendocrine neoplasms: a systematic review of a controversial and underestimated diagnosis. J Clin Med. 2020, 9:273. 10.3390\/jcm9010273","journal-title":"J Clin Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i19.2076","article-title":"Mixed neuroendocrine-non-neuroendocrine neoplasms of the digestive system: a mini-review","volume":"28","author":"Toor D","year":"2022","unstructured":"Toor D, Loree JM, Gao ZH, Wang G, Zhou C. Mixed neuroendocrine-non-neuroendocrine neoplasms of the digestive system: a mini-review. World J Gastroenterol. 2022, 28:2076-87. 10.3748\/wjg.v28.i19.2076","journal-title":"World J Gastroenterol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.03.012","article-title":"Simple frailty score predicts postoperative complications across surgical specialties","volume":"206","author":"Robinson TN","year":"2013","unstructured":"Robinson TN, Wu DS, Pointer L, Dunn CL, Cleveland JC Jr, Moss M. Simple frailty score predicts postoperative complications across surgical specialties. Am J Surg. 2013, 206:544-50. 10.1016\/j.amjsurg.2013.03.012","journal-title":"Am J Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.01.028","article-title":"Frailty as a predictor of surgical outcomes in older patients","volume":"210","author":"Makary MA","year":"2010","unstructured":"Makary MA, Segev DL, Pronovost PJ, et al.. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg. 2010, 210:901-8. 10.1016\/j.jamcollsurg.2010.01.028","journal-title":"J Am Coll Surg"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/475150-early-stage-rectal-mixed-neuroendocrine-non-neuroendocrine-neoplasm-treated-with-local-excision-in-a-frail-elderly-patient-a-multidisciplinary-management-dilemma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:07:19Z","timestamp":1777734439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/475150-early-stage-rectal-mixed-neuroendocrine-non-neuroendocrine-neoplasm-treated-with-local-excision-in-a-frail-elderly-patient-a-multidisciplinary-management-dilemma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,2]]},"references-count":11,"URL":"https:\/\/doi.org\/10.7759\/cureus.108141","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,2]]}}}