{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:13:30Z","timestamp":1777968810870,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"DOI":"10.7759\/cureus.108278","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:16:53Z","timestamp":1777965413000},"source":"Crossref","is-referenced-by-count":0,"title":["Advancements in Skeletal Tumour Management: Linking Metastatic Biology With Surgical Reconstruction"],"prefix":"10.7759","author":[{"given":"Eswara","family":"Reddy G","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivakumar","family":"MS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer A","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjunath","family":"A N","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Parameswaran","family":"Namboothiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed F","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-024-03876-z","article-title":"Revolutionizing bone tumor management: cutting-edge breakthroughs in limb-saving treatments","volume":"34","author":"Rai V","year":"2024","unstructured":"Rai V, Munazzam SW, Wazir NU, Javaid I. Revolutionizing bone tumor management: cutting-edge breakthroughs in limb-saving treatments. Eur J Orthop Surg Traumatol. 2024, 34:1741-8. 10.1007\/s00590-024-03876-z","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-023-03121-7","article-title":"Biological reconstruction of bone defect after resection of malignant bone tumor by allograft: a single-center retrospective cohort study","volume":"21","author":"Liu Q","year":"2023","unstructured":"Liu Q, Long F, Zhang C, Liu Y, He H, Luo W. Biological reconstruction of bone defect after resection of malignant bone tumor by allograft: a single-center retrospective cohort study. World J Surg Oncol. 2023, 21:234. 10.1186\/s12957-023-03121-7","journal-title":"World J Surg Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/10732748221099219","article-title":"Application and development of megaprostheses in limb salvage for bone tumors around the knee joint","volume":"29","author":"Zhang HR","year":"2022","unstructured":"Zhang HR. Application and development of megaprostheses in limb salvage for bone tumors around the knee joint. Cancer Control. 2022, 29:10732748221099219. 10.1177\/10732748221099219","journal-title":"Cancer Control"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112694","article-title":"Surgical treatment of bone sarcoma","volume":"14","author":"Bl\u00e4sius F","year":"2022","unstructured":"Bl\u00e4sius F, Delbr\u00fcck H, Hildebrand F, Hofmann UK. Surgical treatment of bone sarcoma. Cancers (Basel). 2022, 14:2694. 10.3390\/cancers14112694","journal-title":"Cancers (Basel)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2022.101733","article-title":"Personalized 3D-printed guide in malignant bone tumor resection and following reconstruction - 17 cases in pelvic and extremities","volume":"42","author":"Dong C","year":"2022","unstructured":"Dong C, Beglinger I, Krieg AH. Personalized 3D-printed guide in malignant bone tumor resection and following reconstruction - 17 cases in pelvic and extremities. Surg Oncol. 2022, 42:101733. 10.1016\/j.suronc.2022.101733","journal-title":"Surg Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/cancers18040610","article-title":"Prognostic analysis of endoprosthetic reconstruction versus biological reconstruction in the treatment of extremity osteosarcoma","volume":"18","author":"Qu G","year":"2026","unstructured":"Qu G, Ma S, Li Z, et al.. Prognostic analysis of endoprosthetic reconstruction versus biological reconstruction in the treatment of extremity osteosarcoma. Cancers (Basel). 2026, 18:610. 10.3390\/cancers18040610","journal-title":"Cancers (Basel)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194599","article-title":"Biological and clinical aspects of metastatic spinal tumors","volume":"14","author":"Litak J","year":"2022","unstructured":"Litak J, Czy\u017cewski W, Szymoniuk M, et al.. Biological and clinical aspects of metastatic spinal tumors. Cancers (Basel). 2022, 14:4599. 10.3390\/cancers14194599","journal-title":"Cancers (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32040226","article-title":"Modern treatment of skeletal metastases: multidisciplinarity and the concept of oligometastasis in the recent literature","volume":"32","author":"Trovarelli G","year":"2025","unstructured":"Trovarelli G, Rizzo A, Zinnarello FD, Cerchiaro M, Angelini A, Pala E, Ruggieri P. Modern treatment of skeletal metastases: multidisciplinarity and the concept of oligometastasis in the recent literature. Curr Oncol. 2025, 32:226. 10.3390\/curroncol32040226","journal-title":"Curr Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05840-6","article-title":"Intercalary frozen autografts for reconstruction of bone defects following meta-\/diaphyseal tumor resection at the extremities","volume":"23","author":"Yang J","year":"2022","unstructured":"Yang J, Li W, Feng R, Li D. Intercalary frozen autografts for reconstruction of bone defects following meta-\/diaphyseal tumor resection at the extremities. BMC Musculoskelet Disord. 2022, 23:890. 10.1186\/s12891-022-05840-6","journal-title":"BMC Musculoskelet Disord"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-04135-3","article-title":"The application of 3D-printed auto-stable artificial vertebral body in en bloc resection and reconstruction of thoracolumbar metastases","volume":"18","author":"Cao Y","year":"2023","unstructured":"Cao Y, Yang N, Wang S, Wang C, He Q, Wu Q, Zheng Y. The application of 3D-printed auto-stable artificial vertebral body in en bloc resection and reconstruction of thoracolumbar metastases. J Orthop Surg Res. 2023, 18:638. 10.1186\/s13018-023-04135-3","journal-title":"J Orthop Surg Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0134-x","article-title":"Molecular principles of metastasis: a hallmark of cancer revisited","volume":"5","author":"Fares J","year":"2020","unstructured":"Fares J, Fares MY, Khachfe HH, Salhab HA, Fares Y. Molecular principles of metastasis: a hallmark of cancer revisited. Signal Transduct Target Ther. 2020, 5:28. 10.1038\/s41392-020-0134-x","journal-title":"Signal Transduct Target Ther"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00406-5","article-title":"Evolving cancer-niche interactions and therapeutic targets during bone metastasis","volume":"22","author":"Satcher RL","year":"2022","unstructured":"Satcher RL, Zhang XH. Evolving cancer-niche interactions and therapeutic targets during bone metastasis. Nat Rev Cancer. 2022, 22:85-101. 10.1038\/s41568-021-00406-5","journal-title":"Nat Rev Cancer"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115788","article-title":"Cancer cell foraging to explain bone-specific metastatic progression","volume":"158","author":"Mallin MM","year":"2022","unstructured":"Mallin MM, Pienta KJ, Amend SR. Cancer cell foraging to explain bone-specific metastatic progression. Bone. 2022, 158:115788. 10.1016\/j.bone.2020.115788","journal-title":"Bone"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.11.005","article-title":"Emerging role of chemokines in small cell lung cancer: road signs for metastasis, heterogeneity, and immune response","volume":"87","author":"Khan P","year":"2022","unstructured":"Khan P, Fatima M, Khan MA, Batra SK, Nasser MW. Emerging role of chemokines in small cell lung cancer: road signs for metastasis, heterogeneity, and immune response. Semin Cancer Biol. 2022, 87:117-26. 10.1016\/j.semcancer.2022.11.005","journal-title":"Semin Cancer Biol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1063815","article-title":"The RANK\/RANKL\/OPG system and tumor bone metastasis: potential mechanisms and therapeutic strategies","volume":"13","author":"Zhang Y","year":"2022","unstructured":"Zhang Y, Liang J, Liu P, Wang Q, Liu L, Zhao H. The RANK\/RANKL\/OPG system and tumor bone metastasis: potential mechanisms and therapeutic strategies. Front Endocrinol (Lausanne). 2022, 13:1063815. 10.3389\/fendo.2022.1063815","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59101752","article-title":"The RANK-RANKL-OPG system: a multifaceted regulator of homeostasis, immunity, and cancer","volume":"59","author":"De Leon-Oliva D","year":"2023","unstructured":"De Leon-Oliva D, Barrena-Bl\u00e1zquez S, Jim\u00e9nez-\u00c1lvarez L, et al.. The RANK-RANKL-OPG system: a multifaceted regulator of homeostasis, immunity, and cancer. Medicina (Kaunas). 2023, 59:1752. 10.3390\/medicina59101752","journal-title":"Medicina (Kaunas)"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04227-z","article-title":"Unraveling the intricacies of OPG\/RANKL\/RANK biology and its implications in neurological disorders\u2014a comprehensive literature review","volume":"61","author":"Freeman C","year":"2024","unstructured":"Freeman C, A S MD, A S P. Unraveling the intricacies of OPG\/RANKL\/RANK biology and its implications in neurological disorders\u2014a comprehensive literature review. Mol Neurobiol. 2024, 61:10656-70. 10.1007\/s12035-024-04227-z","journal-title":"Mol Neurobiol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.141","article-title":"Radiomics: the bridge between medical imaging and personalized medicine","volume":"14","author":"Lambin P","year":"2017","unstructured":"Lambin P, Leijenaar RT, Deist TM, et al.. Radiomics: the bridge between medical imaging and personalized medicine. Nat Rev Clin Oncol. 2017, 14:749-62. 10.1038\/nrclinonc.2017.141","journal-title":"Nat Rev Clin Oncol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151169","article-title":"Radiomics: images are more than pictures, they are data","volume":"278","author":"Gillies RJ","year":"2016","unstructured":"Gillies RJ, Kinahan PE, Hricak H. Radiomics: images are more than pictures, they are data. Radiology. 2016, 278:563-77. 10.1148\/radiol.2015151169","journal-title":"Radiology"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17091510","article-title":"Evolving and novel applications of artificial intelligence in cancer imaging","volume":"17","author":"Pallumeera M","year":"2025","unstructured":"Pallumeera M, Giang JC, Singh R, Pracha NS, Makary MS. Evolving and novel applications of artificial intelligence in cancer imaging. Cancers (Basel). 2025, 17:1510. 10.3390\/cancers17091510","journal-title":"Cancers (Basel)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s40336-016-0196-5","article-title":"Bone imaging in prostate cancer: the evolving roles of nuclear medicine and radiology","volume":"4","author":"Cook GJ","year":"2016","unstructured":"Cook GJ, Azad G, Padhani AR. Bone imaging in prostate cancer: the evolving roles of nuclear medicine and radiology. Clin Transl Imaging. 2016, 4:439-47. 10.1007\/s40336-016-0196-5","journal-title":"Clin Transl Imaging"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.86B4.14703","article-title":"Comparative analysis of risk factors for pathological fracture with femoral metastases","volume":"86","author":"Van der Linden YM","year":"2004","unstructured":"Van der Linden YM, Dijkstra PD, Kroon HM, Lok JJ, Noordijk EM, Leer JW, Marijnen CA. Comparative analysis of risk factors for pathological fracture with femoral metastases. J Bone Joint Surg Br. 2004, 86:566-73. 10.1302\/0301-620X.86B4.14703","journal-title":"J Bone Joint Surg Br"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2014.0741","article-title":"The diagnostic imaging of bone metastases","volume":"111","author":"Heindel W","year":"2014","unstructured":"Heindel W, G\u00fcbitz R, Vieth V, Weckesser M, Schober O, Sch\u00e4fers M. The diagnostic imaging of bone metastases. Dtsch Arztebl Int. 2014, 111:741-7. 10.3238\/arztebl.2014.0741","journal-title":"Dtsch Arztebl Int"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/ph17121591","article-title":"Immunotherapy in the battle against bone metastases: mechanisms and emerging treatments","volume":"17","author":"Hamza FN","year":"2024","unstructured":"Hamza FN, Mohammad KS. Immunotherapy in the battle against bone metastases: mechanisms and emerging treatments. Pharmaceuticals (Basel). 2024, 17:1591. 10.3390\/ph17121591","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00752-5","article-title":"Metastases-directed stereotactic body radiotherapy in combination with targeted therapy or immunotherapy: systematic review and consensus recommendations by the EORTC-ESTRO OligoCare consortium","volume":"24","author":"Kroeze SGC","year":"2023","unstructured":"Kroeze SGC, Pavic M, Stellamans K, et al.. Metastases-directed stereotactic body radiotherapy in combination with targeted therapy or immunotherapy: systematic review and consensus recommendations by the EORTC-ESTRO OligoCare consortium. Lancet Oncol. 2023, 24:121-32. 10.1016\/S1470-2045(22)00752-5","journal-title":"Lancet Oncol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-024-01256-7","article-title":"Immunotherapy in the fight against bone metastases: a review of recent developments and challenges","volume":"25","author":"Peng Z","year":"2024","unstructured":"Peng Z, Huang W, Xiao Z, et al.. Immunotherapy in the fight against bone metastases: a review of recent developments and challenges. Curr Treat Options Oncol. 2024, 25:1374-89. 10.1007\/s11864-024-01256-7","journal-title":"Curr Treat Options Oncol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605334","article-title":"Imaging metastatic bone disease from carcinoma of the prostate","volume":"101","author":"Messiou C","year":"2009","unstructured":"Messiou C, Cook G, deSouza NM. Imaging metastatic bone disease from carcinoma of the prostate. Br J Cancer. 2009, 101:1225-32. 10.1038\/sj.bjc.6605334","journal-title":"Br J Cancer"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.019","article-title":"Bone health in cancer: ESMO Clinical Practice Guidelines","volume":"31","author":"Coleman R","year":"2020","unstructured":"Coleman R, Hadji P, Body JJ, et al.. Bone health in cancer: ESMO Clinical Practice Guidelines. Ann Oncol. 2020, 31:1650-63. 10.1016\/j.annonc.2020.07.019","journal-title":"Ann Oncol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-145","article-title":"Bone metastases from renal cell carcinoma: patient survival after surgical treatment","volume":"11","author":"Fottner A","year":"2010","unstructured":"Fottner A, Szalantzy M, Wirthmann L, St\u00e4hler M, Baur-Melnyk A, Jansson V, D\u00fcrr HR. Bone metastases from renal cell carcinoma: patient survival after surgical treatment. BMC Musculoskelet Disord. 2010, 11:145. 10.1186\/1471-2474-11-145","journal-title":"BMC Musculoskelet Disord"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.soi.2024.100053","article-title":"The language of palliative surgery: a scoping review","volume":"1","author":"Kopecky KE","year":"2024","unstructured":"Kopecky KE, Monton O, Arbaugh C, et al.. The language of palliative surgery: a scoping review. Surg Oncol Insight. 2024, 1:100053. 10.1016\/j.soi.2024.100053","journal-title":"Surg Oncol Insight"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18772-x","article-title":"Allograft versus autograft for reconstruction after resection of primary bone tumors: a comparative study of long-term clinical outcomes and risk factors for failure of reconstruction","volume":"12","author":"Wisanuyotin T","year":"2022","unstructured":"Wisanuyotin T, Paholpak P, Sirichativapee W, Kosuwon W. Allograft versus autograft for reconstruction after resection of primary bone tumors: a comparative study of long-term clinical outcomes and risk factors for failure of reconstruction. Sci Rep. 2022, 12:14346. 10.1038\/s41598-022-18772-x","journal-title":"Sci Rep"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-2381","article-title":"Palliative surgery and the surgeon's role in the palliative care team: a review","volume":"11","author":"Louie AD","year":"2022","unstructured":"Louie AD, Miner TJ. Palliative surgery and the surgeon's role in the palliative care team: a review. Ann Palliat Med. 2022, 11:907-17. 10.21037\/apm-20-2381","journal-title":"Ann Palliat Med"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092560","article-title":"The effect of resection margin on local recurrence and survival in high grade soft tissue sarcoma of the extremities: how far is far enough?","volume":"12","author":"Bilgeri A","year":"2020","unstructured":"Bilgeri A, Klein A, Lindner LH, et al.. The effect of resection margin on local recurrence and survival in high grade soft tissue sarcoma of the extremities: how far is far enough?. Cancers (Basel). 2020, 12:2560. 10.3390\/cancers12092560","journal-title":"Cancers (Basel)"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.52312\/jdrs.2023.1289","article-title":"Evaluation of the factors affecting survival and local recurrence in thigh soft tissue sarcomas","volume":"35","author":"Y\u0131ld\u0131r\u0131m S","year":"2024","unstructured":"Y\u0131ld\u0131r\u0131m S, \u00c7iftdemir M, Ustaba\u015f\u0131o\u011flu FE, \u00dcst\u00fcn F, Usta U. Evaluation of the factors affecting survival and local recurrence in thigh soft tissue sarcomas. Jt Dis Relat Surg. 2024, 35:130-7. 10.52312\/jdrs.2023.1289","journal-title":"Jt Dis Relat Surg"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2022.11.027","article-title":"Multidisciplinary approach in patients with metastatic fractures and oligometastases","volume":"54","author":"Ruggieri P","year":"2023","unstructured":"Ruggieri P, Cerchiaro M, Angelini A. Multidisciplinary approach in patients with metastatic fractures and oligometastases. Injury. 2023, 54:268-70. 10.1016\/j.injury.2022.11.027","journal-title":"Injury"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-024-03846-5","article-title":"Similar complications, implant survival, and function following modular prosthesis and allograft-prosthesis composite reconstructions of the proximal femur for primary bone tumors: a systematic review and meta-analysis","volume":"34","author":"Atherley O'Meally A","year":"2024","unstructured":"Atherley O'Meally A, Cosentino M, Aiba H, et al.. Similar complications, implant survival, and function following modular prosthesis and allograft-prosthesis composite reconstructions of the proximal femur for primary bone tumors: a systematic review and meta-analysis. Eur J Orthop Surg Traumatol. 2024, 34:1581-95. 10.1007\/s00590-024-03846-5","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05432-4","article-title":"Outcomes of modular endoprosthesis reconstruction versus cement spacer reconstruction following resection of proximal humeral tumors","volume":"23","author":"Ebeid WA","year":"2022","unstructured":"Ebeid WA, Eldaw S, Badr IT, Mesregah MK, Hasan BZ. Outcomes of modular endoprosthesis reconstruction versus cement spacer reconstruction following resection of proximal humeral tumors. BMC Musculoskelet Disord. 2022, 23:484. 10.1186\/s12891-022-05432-4","journal-title":"BMC Musculoskelet Disord"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09873-x","article-title":"Short-term clinical outcomes of Kyocera modular limb salvage system designed cementless stems for the endoprosthetic reconstruction of lower extremities: a Japanese Musculoskeletal Oncology Group multi-institutional study","volume":"22","author":"Tsukushi S","year":"2022","unstructured":"Tsukushi S, Nishida Y, Hirose T, et al.. Short-term clinical outcomes of Kyocera modular limb salvage system designed cementless stems for the endoprosthetic reconstruction of lower extremities: a Japanese Musculoskeletal Oncology Group multi-institutional study. BMC Cancer. 2022, 22:781. 10.1186\/s12885-022-09873-x","journal-title":"BMC Cancer"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.68872","article-title":"Advances in tissue engineering and its future in regenerative medicine compared to traditional reconstructive techniques: a comparative analysis","volume":"16","author":"Meretsky CR","year":"2024","unstructured":"Meretsky CR, Polychronis A, Liovas D, Schiuma AT. Advances in tissue engineering and its future in regenerative medicine compared to traditional reconstructive techniques: a comparative analysis. Cureus. 2024, 16:e68872. 10.7759\/cureus.68872","journal-title":"Cureus"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2021.11.006","article-title":"Emerging biomaterials for reproductive medicine","volume":"2","author":"Wang X","year":"2021","unstructured":"Wang X, Wu D, Li W, Yang L. Emerging biomaterials for reproductive medicine. Eng Regen. 2021, 2:230-45. 10.1016\/j.engreg.2021.11.006","journal-title":"Eng Regen"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30040278","article-title":"Staging systems and nomograms for soft tissue sarcoma","volume":"30","author":"Danieli M","year":"2023","unstructured":"Danieli M, Gronchi A. Staging systems and nomograms for soft tissue sarcoma. Curr Oncol. 2023, 30:3648-71. 10.3390\/curroncol30040278","journal-title":"Curr Oncol"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.2147\/ORR.S360933","article-title":"Review and future\/potential application of mixed reality technology in orthopaedic oncology","volume":"14","author":"Wong KC","year":"2022","unstructured":"Wong KC, Sun YE, Kumta SM. Review and future\/potential application of mixed reality technology in orthopaedic oncology. Orthop Res Rev. 2022, 14:169-86. 10.2147\/ORR.S360933","journal-title":"Orthop Res Rev"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1177\/09760016251391547","article-title":"Imaging in orthopaedic oncology","volume":"23","author":"Raja NR","year":"2026","unstructured":"Raja NR, Uldin H, Kharwadkar S, Mahmood S, Rennie WJ. Imaging in orthopaedic oncology. Apollo Med. 2026, 23:56-62. 10.1177\/09760016251391547","journal-title":"Apollo Med"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.2217\/3dp-2022-0001","article-title":"A review of 3D printing in orthopaedic oncology","volume":"6","author":"Benady A","year":"2022","unstructured":"Benady A, Meyer JS, Freidin D, et al.. A review of 3D printing in orthopaedic oncology. J 3D Print Med. 2022, 6:147-61. 10.2217\/3dp-2022-0001","journal-title":"J 3D Print Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/485942-advancements-in-skeletal-tumour-management-linking-metastatic-biology-with-surgical-reconstruction","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:16:54Z","timestamp":1777965414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/485942-advancements-in-skeletal-tumour-management-linking-metastatic-biology-with-surgical-reconstruction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":44,"URL":"https:\/\/doi.org\/10.7759\/cureus.108278","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,5]]}}}