{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:10:31Z","timestamp":1778004631023,"version":"3.51.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"DOI":"10.7759\/cureus.108307","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:12:45Z","timestamp":1778001165000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary Signet-Ring Cell Carcinoma of the Colon: A Rare and Aggressive Tumor"],"prefix":"10.7759","author":[{"given":"Sarra","family":"El Fassi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Ouaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanae","family":"Chaib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinane","family":"Kharmoum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aicha","family":"Akjay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Meyiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariame","family":"Chraibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihsane","family":"Mellouki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2015.07.005","article-title":"Primary signet ring cell carcinoma of the colon and rectum","volume":"102","author":"Arifi S","year":"2015","unstructured":"Arifi S, Elmesbahi O, Amarti Riffi A. Primary signet ring cell carcinoma of the colon and rectum. Bull Cancer. 2015, 102:880-8. 10.1016\/j.bulcan.2015.07.005","journal-title":"Bull Cancer"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-010-1033-3","article-title":"Critical analysis of mucin and signet ring cell as prognostic factors in an Asian population of 2,764 sporadic colorectal cancers","volume":"25","author":"Chew MH","year":"2010","unstructured":"Chew MH, Yeo SA, Ng ZP, Lim KH, Koh PK, Ng KH, Eu KW. Critical analysis of mucin and signet ring cell as prognostic factors in an Asian population of 2,764 sporadic colorectal cancers. Int J Colorectal Dis. 2010, 25:1221-9. 10.1007\/s00384-010-1033-3","journal-title":"Int J Colorectal Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-016-2224-2","article-title":"Prognosis of mucinous and signet-ring cell colorectal cancer in a population-based cohort","volume":"142","author":"Nitsche U","year":"2016","unstructured":"Nitsche U, Friess H, Agha A, et al.. Prognosis of mucinous and signet-ring cell colorectal cancer in a population-based cohort. J Cancer Res Clin Oncol. 2016, 142:2357-66. 10.1007\/s00432-016-2224-2","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182a69f7e","article-title":"Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis","volume":"258","author":"Nitsche U","year":"2013","unstructured":"Nitsche U, Zimmermann A, Sp\u00e4th C, et al.. Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis. Ann Surg. 2013, 258:775-82; discussion 782-3. 10.1097\/SLA.0b013e3182a69f7e","journal-title":"Ann Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1951.01250030082009","article-title":"Primary linitis plastica type of carcinoma of the colon","volume":"62","author":"Laufman H","year":"1951","unstructured":"Laufman H, Saphir O. Primary linitis plastica type of carcinoma of the colon. AMA Arch Surg. 1951, 62:79-91. 10.1001\/archsurg.1951.01250030082009","journal-title":"AMA Arch Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2013.06.012","article-title":"Primary signet ring cell carcinoma of the prostate: a rare tumor (Article in French)","volume":"24","author":"Haddad H","year":"2014","unstructured":"Haddad H, Sellal N, Bourhaleb Z. Primary signet ring cell carcinoma of the prostate: a rare tumor (Article in French). Prog Urol. 2014, 24:161-3. 10.1016\/j.purol.2013.06.012","journal-title":"Prog Urol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236218","article-title":"Ordinary colorectal adenocarcinoma vs. primary colorectal signet-ring cell carcinoma: study matched for age, gender, grade, and stage","volume":"42","author":"Psathakis D","year":"1999","unstructured":"Psathakis D, Schiedeck TH, Krug F, Oevermann E, Kujath P, Bruch HP. Ordinary colorectal adenocarcinoma vs. primary colorectal signet-ring cell carcinoma: study matched for age, gender, grade, and stage. Dis Colon Rectum. 1999, 42:1618-25. 10.1007\/BF02236218","journal-title":"Dis Colon Rectum"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02048335","article-title":"Primary signet-ring cell carcinoma of the colon and rectum","volume":"38","author":"Messerini L","year":"1995","unstructured":"Messerini L, Palomba A, Zampi G. Primary signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum. 1995, 38:1189-92. 10.1007\/BF02048335","journal-title":"Dis Colon Rectum"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-1433.2001.02269.x","article-title":"Primary colorectal signet-ring cell carcinoma in Singapore","volume":"71","author":"Ooi BS","year":"2001","unstructured":"Ooi BS, Ho YH, Eu KW, Seow Choen F. Primary colorectal signet-ring cell carcinoma in Singapore. ANZ J Surg. 2001, 71:703-6. 10.1046\/j.1445-1433.2001.02269.x","journal-title":"ANZ J Surg"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1002\/1097-0142(19800715)46:2<420::AID-CNCR2820460236>3.0.CO;2-1","article-title":"Colorectal cancer in Jordan and Nova Scotia: a comparative epidemiologic and histopathologic study","volume":"46","author":"Dajani YF","year":"1980","unstructured":"Dajani YF, Zayid I, Malatjalian DA, Kamal MF. Colorectal cancer in Jordan and Nova Scotia: a comparative epidemiologic and histopathologic study. Cancer. 1980, 46:420-6.","journal-title":"Cancer"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1002\/1097-0142(19860801)58:3<816::AID-CNCR2820580335>3.0.CO;2-T","article-title":"Colorectal adenocarcinoma in young Lebanese adults: the American University of Beirut Medical Center experience with 32 patients","volume":"58","author":"Ibrahim NK","year":"1986","unstructured":"Ibrahim NK, Abdul-Karim FW. Colorectal adenocarcinoma in young Lebanese adults: the American University of Beirut Medical Center experience with 32 patients. Cancer. 1986, 58:816-20.","journal-title":"Cancer"},{"key":"ref12","article-title":"Scirrhous carcinoma of the colon and rectum","volume":"111","author":"Fahl JC","year":"1960","unstructured":"Fahl JC, Dockerty MB, Judd ES. Scirrhous carcinoma of the colon and rectum. Surg Gynecol Obstet. 1960, 111:759-66.","journal-title":"Surg Gynecol Obstet"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1453::aid-cncr2820520819>3.0.co;2-9","article-title":"Primary signet-ring carcinoma of the colon","volume":"52","author":"Almagro UA","year":"1983","unstructured":"Almagro UA. Primary signet-ring carcinoma of the colon. Cancer. 1983, 52:1453-7. 10.1002\/1097-0142(19831015)52:8&lt;1453::aid-cncr2820520819&gt;3.0.co;2-9","journal-title":"Cancer"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v16.i5.2141","article-title":"Systematic review of risk factors, prognosis, and management of colorectal signet-ring cell carcinoma","volume":"16","author":"Nuytens F","year":"2024","unstructured":"Nuytens F, Drubay V, Eveno C, Renaud F, Piessen G. Systematic review of risk factors, prognosis, and management of colorectal signet-ring cell carcinoma. World J Gastrointest Oncol. 2024, 16:2141-58. 10.4251\/wjgo.v16.i5.2141","journal-title":"World J Gastrointest Oncol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02586841","article-title":"Primary linitis plastica of the rectum","volume":"23","author":"Bonello JC","year":"1980","unstructured":"Bonello JC, Quan SH, Sternberg SS. Primary linitis plastica of the rectum. Dis Colon Rectum. 1980, 23:337-42U. 10.1007\/BF02586841","journal-title":"Dis Colon Rectum"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt591","article-title":"Metastatic pattern in colorectal cancer is strongly influenced by histological subtype","volume":"25","author":"Hugen N","year":"2014","unstructured":"Hugen N, van de Velde CJ, de Wilt JH, Nagtegaal ID. Metastatic pattern in colorectal cancer is strongly influenced by histological subtype. Ann Oncol. 2014, 25:651-7. 10.1093\/annonc\/mdt591","journal-title":"Ann Oncol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.11.013","article-title":"Endoscopic morphologic features of ulcerative colitis-associated dysplasia classified according to\u00a0the\u00a0SCENIC\u00a0consensus statement","volume":"85","author":"Sugimoto S","year":"2017","unstructured":"Sugimoto S, Naganuma M, Iwao Y, et al.. Endoscopic morphologic features of ulcerative colitis-associated dysplasia classified according to\u00a0the\u00a0SCENIC\u00a0consensus statement. Gastrointest Endosc. 2017, 85:639-646.e2. 10.1016\/j.gie.2016.11.013","journal-title":"Gastrointest Endosc"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.42502","article-title":"Primary gastric signet ring cell carcinoma or metastatic lobular carcinoma with signet ring cells: a diagnostic challenge","volume":"15","author":"Akouh N","year":"2023","unstructured":"Akouh N, Karich N, Haloui A, Aissaoui A, Zazour A, Ismaili Z, Bennani A. Primary gastric signet ring cell carcinoma or metastatic lobular carcinoma with signet ring cells: a diagnostic challenge. Cureus. 2023, 15:e42502. 10.7759\/cureus.42502","journal-title":"Cureus"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.063","article-title":"American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer","volume":"22","author":"Benson AB 3rd","year":"2004","unstructured":"Benson AB 3rd, Schrag D, Somerfield MR, et al.. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol. 2004, 22:3408-19. 10.1200\/JCO.2004.05.063","journal-title":"J Clin Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/479997-primary-signet-ring-cell-carcinoma-of-the-colon-a-rare-and-aggressive-tumor","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:12:47Z","timestamp":1778001167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/479997-primary-signet-ring-cell-carcinoma-of-the-colon-a-rare-and-aggressive-tumor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.108307","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,5]]}}}