{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:19:11Z","timestamp":1778246351967,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,8]]},"DOI":"10.7759\/cureus.108487","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:47:16Z","timestamp":1778244436000},"source":"Crossref","is-referenced-by-count":0,"title":["Isolated Agenesis of the Splenium of the Corpus Callosum Associated With Autism Spectrum Disorder: A Rare and Clinically Relevant Association"],"prefix":"10.7759","author":[{"given":"Claudio Roberto","family":"Ibanez Escalante","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin Dogu","family":"Goker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G","family":"Bernad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103038","article-title":"Autism and sensory processing disorders: shared white matter disruption in sensory pathways but divergent connectivity in social-emotional pathways","volume":"9","author":"Chang YS","year":"2014","unstructured":"Chang YS, Owen JP, Desai SS, et al.. Autism and sensory processing disorders: shared white matter disruption in sensory pathways but divergent connectivity in social-emotional pathways. PLoS One. 2014, 9:e103038. 10.1371\/journal.pone.0103038","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08944-1","article-title":"Atypical functional connectome hierarchy in autism","volume":"10","author":"Hong SJ","year":"2019","unstructured":"Hong SJ, Vos de Wael R, Bethlehem RA, et al.. Atypical functional connectome hierarchy in autism. Nat Commun. 2019, 10:1022. 10.1038\/s41467-019-08944-1","journal-title":"Nat Commun"},{"key":"ref3","article-title":"Epidemiology of central nervous system malformations","author":"Myrianthopoulos NC","year":"1977","unstructured":"Myrianthopoulos NC. Epidemiology of central nervous system malformations. Congenital Malformations of the Brain and Skull. Vinken PJ, Bruyn GW, Myrianthopoulos NC (ed): Elsevier, Amsterdam; 1977. 139-79."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-227366","article-title":"Agenesis of the corpus callosum with interhemispheric cyst: clinical implications and outcome","volume":"11","author":"Revanna KG","year":"2018","unstructured":"Revanna KG, Rajadurai VS, Chandran S. Agenesis of the corpus callosum with interhemispheric cyst: clinical implications and outcome. BMJ Case Rep. 2018, 11:bcr2018227366. 10.1136\/bcr-2018-227366","journal-title":"BMJ Case Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00066","article-title":"Social behavior of offspring following prenatal cocaine exposure in rodents: a comparison with prenatal alcohol","volume":"2","author":"Sobrian SK","year":"2011","unstructured":"Sobrian SK, Holson RR. Social behavior of offspring following prenatal cocaine exposure in rodents: a comparison with prenatal alcohol. Front Psychiatry. 2011, 2:66. 10.3389\/fpsyt.2011.00066","journal-title":"Front Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1242\/dev.189738","article-title":"Development and plasticity of the corpus callosum","volume":"147","author":"De Le\u00f3n Reyes NS","year":"2020","unstructured":"De Le\u00f3n Reyes NS, Bragg-Gonzalo L, Nieto M. Development and plasticity of the corpus callosum. Development. 2020, 147:dev189738. 10.1242\/dev.189738","journal-title":"Development"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902050406","article-title":"Early development of the circumferential axonal pathway in mouse and chick spinal cord","volume":"205","author":"Holley JA","year":"1982","unstructured":"Holley JA. Early development of the circumferential axonal pathway in mouse and chick spinal cord. J Comp Neurol. 1982, 205:371-82. 10.1002\/cne.902050406","journal-title":"J Comp Neurol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32476","article-title":"Agenesis and dysgenesis of the corpus callosum: clinical, genetic and neuroimaging findings in a series of 41 patients","volume":"146","author":"Schell-Apacik CC","year":"2008","unstructured":"Schell-Apacik CC, Wagner K, Bihler M, et al.. Agenesis and dysgenesis of the corpus callosum: clinical, genetic and neuroimaging findings in a series of 41 patients. Am J Med Genet A. 2008, 146:2501-11. 10.1002\/ajmg.a.32476","journal-title":"Am J Med Genet A"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-08-02749.2001","article-title":"Cortical axon guidance by the glial wedge during the development of the corpus callosum","volume":"21","author":"Shu T","year":"2001","unstructured":"Shu T, Richards LJ. Cortical axon guidance by the glial wedge during the development of the corpus callosum. J Neurosci. 2001, 21:2749-58. 10.1523\/JNEUROSCI.21-08-02749.2001","journal-title":"J Neurosci"},{"key":"ref10","article-title":"Minding the gap: a large scale survey of agenesis of the corpus callosum and other callosal anamolies","author":"Schilmoeller G","year":"2001","unstructured":"Schilmoeller G, Schilmoeller K. Minding the gap: a large scale survey of agenesis of the corpus callosum and other callosal anamolies. Callosal Connection. 2001, 1-11.","journal-title":"Callosal Connection"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.156","article-title":"Exome sequencing identifies recessive CDK5RAP2 variants in patients with isolated agenesis of corpus callosum","volume":"24","author":"Jouan L","year":"2016","unstructured":"Jouan L, Ouled Amar Bencheikh B, Daoud H, et al.. Exome sequencing identifies recessive CDK5RAP2 variants in patients with isolated agenesis of corpus callosum. Eur J Hum Genet. 2016, 24:607-10. 10.1038\/ejhg.2015.156","journal-title":"Eur J Hum Genet"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40671","article-title":"Proud syndrome: a rare cause of corpus callosum agenesis","volume":"15","author":"Devi R","year":"2023","unstructured":"Devi R, Chaurasia S, Priyadarshi M, Singh P, Basu S. Proud syndrome: a rare cause of corpus callosum agenesis. Cureus. 2023, 15:e40671. 10.7759\/cureus.40671","journal-title":"Cureus"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/135468000395781","article-title":"Cognitive and psychosocial deficits in agenesis of the corpus callosum with normal intelligence","volume":"5","author":"Brown WS","year":"2000","unstructured":"Brown WS, Paul LK. Cognitive and psychosocial deficits in agenesis of the corpus callosum with normal intelligence. Cogn Neuropsychiatry. 2000, 5:135-57. 10.1080\/135468000395781","journal-title":"Cogn Neuropsychiatry"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx003","article-title":"Partial agenesis and hypoplasia of the corpus callosum in idiopathic autism","volume":"76","author":"Wegiel J","year":"2017","unstructured":"Wegiel J, Flory M, Kaczmarski W, et al.. Partial agenesis and hypoplasia of the corpus callosum in idiopathic autism. J Neuropathol Exp Neurol. 2017, 76:225-37. 10.1093\/jnen\/nlx003","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2257-10.2010","article-title":"Changes in prefrontal axons may disrupt the network in autism","volume":"30","author":"Zikopoulos B","year":"2010","unstructured":"Zikopoulos B, Barbas H. Changes in prefrontal axons may disrupt the network in autism. J Neurosci. 2010, 30:14595-609. 10.1523\/JNEUROSCI.2257-10.2010","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-020-02203-6","article-title":"Effect of corpus callosum agenesis on the language network in children and adolescents","volume":"226","author":"Bartha-Doering L","year":"2021","unstructured":"Bartha-Doering L, Schwartz E, Kollndorfer K, et al.. Effect of corpus callosum agenesis on the language network in children and adolescents. Brain Struct Funct. 2021, 226:701-13. 10.1007\/s00429-020-02203-6","journal-title":"Brain Struct Funct"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2006.00602.x","article-title":"Health-related issues in individuals with agenesis of the corpus callosum","volume":"32","author":"Doherty D","year":"2006","unstructured":"Doherty D, Tu S, Schilmoeller K, Schilmoeller G. Health-related issues in individuals with agenesis of the corpus callosum. Child Care Health Dev. 2006, 32:333-42. 10.1111\/j.1365-2214.2006.00602.x","journal-title":"Child Care Health Dev"},{"key":"ref18","article-title":"ADHD diagnostic trends: increased recognition or overdiagnosis?","volume":"119","author":"Abdelnour E","year":"2022","unstructured":"Abdelnour E, Jansen MO, Gold JA. ADHD diagnostic trends: increased recognition or overdiagnosis?. Mo Med. 2022, 119:467-73.","journal-title":"Mo Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu070","article-title":"Agenesis of the corpus callosum and autism: a comprehensive comparison","volume":"137","author":"Paul LK","year":"2014","unstructured":"Paul LK, Corsello C, Kennedy DP, Adolphs R. Agenesis of the corpus callosum and autism: a comprehensive comparison. Brain. 2014, 137:1813-29. 10.1093\/brain\/awu070","journal-title":"Brain"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002374","article-title":"Developmental maturation of dynamic causal control signals in higher-order cognition: a neurocognitive network model","volume":"8","author":"Supekar K","year":"2012","unstructured":"Supekar K, Menon V. Developmental maturation of dynamic causal control signals in higher-order cognition: a neurocognitive network model. PLoS Comput Biol. 2012, 8:e1002374. 10.1371\/journal.pcbi.1002374","journal-title":"PLoS Comput Biol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/482351-isolated-agenesis-of-the-splenium-of-the-corpus-callosum-associated-with-autism-spectrum-disorder-a-rare-and-clinically-relevant-association","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:47:16Z","timestamp":1778244436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/482351-isolated-agenesis-of-the-splenium-of-the-corpus-callosum-associated-with-autism-spectrum-disorder-a-rare-and-clinically-relevant-association"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.108487","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,8]]}}}