{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T19:11:00Z","timestamp":1778267460403,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,8]]},"DOI":"10.7759\/cureus.108503","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:42:41Z","timestamp":1778265761000},"source":"Crossref","is-referenced-by-count":0,"title":["Human Leucocyte Antigen (HLA) B27 Allele Positivity Rate Among Patients Suffering From Spondyloarthritis and Its Distribution According to Age and Gender: A Hospital-Based Cross-Sectional Study"],"prefix":"10.7759","author":[{"given":"Himamoni","family":"Deka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Kakati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultana J","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kritanjali","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"HLA-B27 syndromes","author":"Parameswaran P","year":"2025","unstructured":"Parameswaran P, Lucke M. HLA-B27 syndromes. StatPearls Publishing, Treasure Island, FL; 2025."},{"key":"ref2","article-title":"Major histocompatibility complex: Antigen processing and presentation","author":"Cruz-Tapias P","year":"2013","unstructured":"Cruz-Tapias P, Castiblanco J, Anaya JM. Major histocompatibility complex: Antigen processing and presentation. Autoimmunity: From Bench to Bedside. Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al (ed): El Rosario University Press, Bogota, Colombia; 2013."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00865.x","article-title":"From HLA-B27 to spondyloarthritis: a journey through the ER","volume":"233","author":"Colbert RA","year":"2010","unstructured":"Colbert RA, DeLay ML, Klenk EI, Layh-Schmitt G. From HLA-B27 to spondyloarthritis: a journey through the ER. Immunol Rev. 2010, 233:181-202. 10.1111\/j.0105-2896.2009.00865.x","journal-title":"Immunol Rev"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01189-3","article-title":"HLA-B27 and spondyloarthritis: at the crossroads of innate and adaptive immunity","volume":"21","author":"Navid F","year":"2025","unstructured":"Navid F, Chen L, Bowness P, Colbert RA. HLA-B27 and spondyloarthritis: at the crossroads of innate and adaptive immunity. Nat Rev Rheumatol. 2025, 21:77-87. 10.1038\/s41584-024-01189-3","journal-title":"Nat Rev Rheumatol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21804","article-title":"Assessment of SpondyloArthritis International Society criteria for axial spondyloarthritis in chronic back pain patients with a high prevalence of HLA-B27","volume":"65","author":"Bakland G","year":"2013","unstructured":"Bakland G, Alsing R, Singh K, Nossent JC. Assessment of SpondyloArthritis International Society criteria for axial spondyloarthritis in chronic back pain patients with a high prevalence of HLA-B27. Arthritis Care Res (Hoboken). 2013, 65:448-53. 10.1002\/acr.21804","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1639-5","article-title":"HLA B27 antigen in Middle Eastern and Arab countries: systematic review of the strength of association with axial spondyloarthritis and methodological gaps","volume":"18","author":"Ziade NR","year":"2017","unstructured":"Ziade NR. HLA B27 antigen in Middle Eastern and Arab countries: systematic review of the strength of association with axial spondyloarthritis and methodological gaps. BMC Musculoskelet Disord. 2017, 18:280. 10.1186\/s12891-017-1639-5","journal-title":"BMC Musculoskelet Disord"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.609562","article-title":"Comparison of clinical features in HLA-B27 positive and negative patients with axial spondyloarthritis: results from a cohort of 4,131 patients","volume":"7","author":"Zhang S","year":"2020","unstructured":"Zhang S, Wang Y, Peng L, et al.. Comparison of clinical features in HLA-B27 positive and negative patients with axial spondyloarthritis: results from a cohort of 4,131 patients. Front Med (Lausanne). 2020, 7:609562. 10.3389\/fmed.2020.609562","journal-title":"Front Med (Lausanne)"},{"key":"ref8","article-title":"Association of genetic marker HLA-B27 with spondyloarthritis in a tertiary care centre in South India","volume":"16","author":"Jayaprakash T","year":"2022","unstructured":"Jayaprakash T, Muthamilan OL, Leela KV, Rajendran CP, Murugan AR. Association of genetic marker HLA-B27 with spondyloarthritis in a tertiary care centre in South India. J Pure Appl Microbiol. 2022, 16:901-8.","journal-title":"J Pure Appl Microbiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11555","article-title":"Human leukocyte antigen B27-negative axial spondyloarthritis: what do we know?","volume":"5","author":"Deodhar A","year":"2023","unstructured":"Deodhar A, Gill T, Magrey M. Human leukocyte antigen B27-negative axial spondyloarthritis: what do we know?. ACR Open Rheumatol. 2023, 5:333-44. 10.1002\/acr2.11555","journal-title":"ACR Open Rheumatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2174\/1573397115666191018162606","article-title":"Health-related quality of life in patients with ankylosing spondylitis: relationship with disease-related variables","volume":"16","author":"Elolemy G","year":"2020","unstructured":"Elolemy G, Aboughanima A, Ganeb S, Elziat H. Health-related quality of life in patients with ankylosing spondylitis: relationship with disease-related variables. Curr Rheumatol Rev. 2020, 16:311-8. 10.2174\/1573397115666191018162606","journal-title":"Curr Rheumatol Rev"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/0973-3698.284742","article-title":"Spondyloarthritis in India","volume":"1","author":"Malaviya AN","year":"2020","unstructured":"Malaviya AN. Spondyloarthritis in India. Indian Journal of Rheumatology. 2020, 1:S2-5. 10.4103\/0973-3698.284742","journal-title":"Indian Journal of Rheumatology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244184","article-title":"Predictive values of inflammatory back pain, positive HLA B27 antigen and acute and chronic magnetic resonance changes in early diagnosis of spondyloarthritis. A study of 133 patients","volume":"15","author":"Komsalova LY","year":"2020","unstructured":"Komsalova LY, Mart\u00ednez Salinas MP, Jim\u00e9nez JF. Predictive values of inflammatory back pain, positive HLA B27 antigen and acute and chronic magnetic resonance changes in early diagnosis of spondyloarthritis. A study of 133 patients. PLoS One. 2020, 15:e0244184. 10.1371\/journal.pone.0244184","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab544","article-title":"Age at onset in axial spondyloarthritis around the world: data from the Assessment in SpondyloArthritis International Society Peripheral Involvement in Spondyloarthritis study","volume":"61","author":"Boel A","year":"2022","unstructured":"Boel A, L\u00f3pez-Medina C, van der Heijde DM, van Gaalen FA. Age at onset in axial spondyloarthritis around the world: data from the Assessment in SpondyloArthritis International Society Peripheral Involvement in Spondyloarthritis study. Rheumatology (Oxford). 2022, 61:1468-75. 10.1093\/rheumatology\/keab544","journal-title":"Rheumatology (Oxford)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-024-00372-0","article-title":"To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis","volume":"64","author":"Resende GG","year":"2024","unstructured":"Resende GG, Saad CG, Marques CD, et al.. To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis. Adv Rheumatol. 2024, 64:33. 10.1186\/s42358-024-00372-0","journal-title":"Adv Rheumatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3329\/bmrcb.v40i3.25231","article-title":"HLA-B27 antigen frequency among suspected Spondyloarthropathy patients attaining a tertiary level hospital of Bangladesh","volume":"40","author":"Nessa A","year":"2014","unstructured":"Nessa A, Tabassum S, Sultana S. HLA-B27 antigen frequency among suspected Spondyloarthropathy patients attaining a tertiary level hospital of Bangladesh. Bangladesh Med Res Counc Bull. 2014, 40:102-6. 10.3329\/bmrcb.v40i3.25231","journal-title":"Bangladesh Med Res Counc Bull"},{"key":"ref16","article-title":"Clinical presentation and subtypes of spondyloarthritis patients in North East India","volume":"42","author":"Malakar A","year":"2020","unstructured":"Malakar A, Kakati S, Barman B, Dutta A. Clinical presentation and subtypes of spondyloarthritis patients in North East India. Egyptian Rheumatologist. 2020, 42:271-4.","journal-title":"Egyptian Rheumatologist"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.301.3896","article-title":"Association of HLA-B27 status and gender with sacroiliitis in patients with ankylosing spondylitis","volume":"30","author":"Xiong J","year":"2014","unstructured":"Xiong J, Chen J, Tu J, Ye W, Zhang Z, Liu Q, Zhu X. Association of HLA-B27 status and gender with sacroiliitis in patients with ankylosing spondylitis. Pak J Med Sci. 2014, 30:22-7. 10.12669\/pjms.301.3896","journal-title":"Pak J Med Sci"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-023-01118-5","article-title":"HLA-B*27 and ankylosing spondylitis: 50 years of insights and discoveries","volume":"25","author":"Khan MA","year":"2023","unstructured":"Khan MA. HLA-B*27 and ankylosing spondylitis: 50 years of insights and discoveries. Curr Rheumatol Rep. 2023, 25:327-40. 10.1007\/s11926-023-01118-5","journal-title":"Curr Rheumatol Rep"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160825","article-title":"Understanding how the diagnostic delay of spondyloarthritis differs between women and men: a systematic review and metaanalysis","volume":"44","author":"Jovan\u00ed V","year":"2017","unstructured":"Jovan\u00ed V, Blasco-Blasco M, Ruiz-Cantero MT, Pascual E. Understanding how the diagnostic delay of spondyloarthritis differs between women and men: a systematic review and metaanalysis. J Rheumatol. 2017, 44:174-83. 10.3899\/jrheum.160825","journal-title":"J Rheumatol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/art.40462","article-title":"Editorial: inflammatory back pain and axial spondyloarthritis: lessons for clinical practice and epidemiologic research","volume":"70","author":"Dubreuil M","year":"2018","unstructured":"Dubreuil M, Sieper J. Editorial: inflammatory back pain and axial spondyloarthritis: lessons for clinical practice and epidemiologic research. Arthritis Rheumatol. 2018, 70:981-3. 10.1002\/art.40462","journal-title":"Arthritis Rheumatol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.13560","article-title":"Detection of human leukocyte antigen B27 by flowcytometry in patients with suspected ankylosing spondylitis in a tertiary care centre","volume":"13","author":"Priyathersini N","year":"2021","unstructured":"Priyathersini N, Shanmugam SG, Devi SS, Mohana Priya CD, Rajendran S, D'Cruze L. Detection of human leukocyte antigen B27 by flowcytometry in patients with suspected ankylosing spondylitis in a tertiary care centre. Cureus. 2021, 13:e13560. 10.7759\/cureus.13560","journal-title":"Cureus"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003179","article-title":"Clinical profile and treatment utilisation based on HLA-B*27 status in axial spondyloarthritis: results from ASAS-PerSpA study","volume":"9","author":"Chaudhary H","year":"2023","unstructured":"Chaudhary H, L\u00f3pez-Medina C, Khan MA, Dougados M, Magrey M. Clinical profile and treatment utilisation based on HLA-B*27 status in axial spondyloarthritis: results from ASAS-PerSpA study. RMD Open. 2023, 9:e003179. 10.1136\/rmdopen-2023-003179","journal-title":"RMD Open"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/454172-human-leucocyte-antigen-hla-b27-allele-positivity-rate-among-patients-suffering-from-spondyloarthritis-and-its-distribution-according-to-age-and-gender-a-hospital-based-cross-sectional-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:42:42Z","timestamp":1778265762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/454172-human-leucocyte-antigen-hla-b27-allele-positivity-rate-among-patients-suffering-from-spondyloarthritis-and-its-distribution-according-to-age-and-gender-a-hospital-based-cross-sectional-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.108503","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,8]]}}}