{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T17:19:42Z","timestamp":1778347182293,"version":"3.51.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,9]]},"DOI":"10.7759\/cureus.108556","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:52:26Z","timestamp":1778345546000},"source":"Crossref","is-referenced-by-count":0,"title":["Advanced Metastatic Laryngeal Carcinoma: A Case Report on Palliative Management in Primary Care"],"prefix":"10.7759","author":[{"given":"Susana","family":"Couto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Catarina","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.18502\/ijph.v52i11.14025","article-title":"Laryngeal cancer: epidemiology, etiology, and prevention: a narrative review","volume":"52","author":"Igissin N","year":"2023","unstructured":"Igissin N, Zatonskikh V, Telmanova Z, et al.. Laryngeal cancer: epidemiology, etiology, and prevention: a narrative review. Iran J Public Health. 2023, 52:2248-59. 10.18502\/ijph.v52i11.14025","journal-title":"Iran J Public Health"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis698","article-title":"Human papillomavirus infection and laryngeal cancer risk: a systematic review and meta-analysis","volume":"207","author":"Li X","year":"2013","unstructured":"Li X, Gao L, Li H, et al.. Human papillomavirus infection and laryngeal cancer risk: a systematic review and meta-analysis. J Infect Dis. 2013, 207:479-88. 10.1093\/infdis\/jis698","journal-title":"J Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0001-6519(06)78730-1","article-title":"Met\u00e1stasis a distancia en c\u00e1ncer de cabeza y cuello [Distant metastases in head and neck cancer]","volume":"57","author":"Alvarez Marcos CA","year":"2006","unstructured":"Alvarez Marcos CA, Llorente Pend\u00e1s JL, Franco Guti\u00e9rrez V, et al.. Met\u00e1stasis a distancia en c\u00e1ncer de cabeza y cuello [Distant metastases in head and neck cancer]. Acta Otorrinolaringol Esp. 2006, 57:369-372. 10.1016\/s0001-6519(06)78730-1","journal-title":"Acta Otorrinolaringol Esp"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5244-5","article-title":"Survival analysis of distant metastasis of laryngeal carcinoma: analysis based on SEER database","volume":"276","author":"Pan Y","year":"2019","unstructured":"Pan Y, Hong Y, Liang Z, Zhuang W. Survival analysis of distant metastasis of laryngeal carcinoma: analysis based on SEER database. Eur Arch Otorhinolaryngol. 2019, 276:193-201. 10.1007\/s00405-018-5244-5","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jan.16997","article-title":"Dysphagia in head and neck cancer patients: a qualitative meta-synthesis of patient and caregiver experiences and perspectives","volume":"82","author":"Zhang Y","year":"2026","unstructured":"Zhang Y, Wang Y, Xu W, et al.. Dysphagia in head and neck cancer patients: a qualitative meta-synthesis of patient and caregiver experiences and perspectives. J Adv Nurs. 2026, 82:2101-18. 10.1111\/jan.16997","journal-title":"J Adv Nurs"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13131552","article-title":"Psychological distress and quality of life in patients with laryngeal cancer: a review","volume":"13","author":"Murariu MO","year":"2025","unstructured":"Murariu MO, Boia ER, Sitaru AM, et al.. Psychological distress and quality of life in patients with laryngeal cancer: a review. Healthcare (Basel). 2025, 13:10.3390\/healthcare13131552","journal-title":"Healthcare (Basel)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192316304","article-title":"Caregiver burden, psychological distress and quality of life among informal caregivers of patients with head and neck cancer: a longitudinal study","volume":"19","author":"Van Hof KS","year":"2022","unstructured":"Van Hof KS, Hoesseini A, Dorr MC, et al.. Caregiver burden, psychological distress and quality of life among informal caregivers of patients with head and neck cancer: a longitudinal study. Int J Environ Res Public Health. 2022, 19:10.3390\/ijerph192316304","journal-title":"Int J Environ Res Public Health"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_309_19","article-title":"Assessment of the perceived stress and burden of family caregivers of the head-and-neck cancer patients at a tertiary care cancer center: a cross-sectional study","volume":"17","author":"Priya SS","year":"2021","unstructured":"Priya SS, Shavi GR, Sanga R, et al.. Assessment of the perceived stress and burden of family caregivers of the head-and-neck cancer patients at a tertiary care cancer center: a cross-sectional study. J Cancer Res Ther. 2021, 17:1039-46. 10.4103\/jcrt.JCRT_309_19","journal-title":"J Cancer Res Ther"},{"key":"ref9","article-title":"Effect of delayed treatment on survival of patients with head and neck squamous cell cancer","volume":"15","author":"He D","year":"2025","unstructured":"He D, Yang Y, Li R, Li M. Effect of delayed treatment on survival of patients with head and neck squamous cell cancer. Sci Rep. 2025, 15:18366.","journal-title":"Sci Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.0810","article-title":"Persistent tobacco use after treatment for head and neck cancer","volume":"148","author":"Van Heest T","year":"2022","unstructured":"Van Heest T, Rubin N, Khariwala SS. Persistent tobacco use after treatment for head and neck cancer. JAMA Otolaryngol Head Neck Surg. 2022, 148:597-603. 10.1001\/jamaoto.2022.0810","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hed.28182","article-title":"Postdiagnosis smoking cessation and survival outcomes of head and neck cancer patients","volume":"47","author":"Mohebbi E","year":"2025","unstructured":"Mohebbi E, Guthrie G, Patil S, et al.. Postdiagnosis smoking cessation and survival outcomes of head and neck cancer patients. Head Neck. 2025, 47:2725-34. 10.1002\/hed.28182","journal-title":"Head Neck"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32591-7","article-title":"Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE- 048): a randomised, open-label, phase 3 study","volume":"394","author":"Burtness B","year":"2019","unstructured":"Burtness B, Harrington KJ, Greil R, et al.. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE- 048): a randomised, open-label, phase 3 study. Lancet. 2019, 394:1915-1928. 10.1016\/S0140-6736(19)32591-7","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62416-2","article-title":"Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial","volume":"15","author":"Zimmermann C","year":"2014","unstructured":"Zimmermann C, Swami N, Krzyzanowska M, et al.. Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial. Lancet Oncol. 2014, 15:1019-1028. 10.1016\/S0140-6736(13)62416-2","journal-title":"Lancet Oncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-025-01800-8","article-title":"Integrated palliative care improves the quality of life of advanced cancer patients","volume":"24","author":"Wang M","year":"2025","unstructured":"Wang M, Ding X. Integrated palliative care improves the quality of life of advanced cancer patients. BMC Palliat Care. 2025, 24:162. 10.1186\/s12904-025-01800-8","journal-title":"BMC Palliat Care"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.16872","article-title":"Caregiver burden among family caregivers of patients with advanced cancer in a palliative context: A mixed-method study","volume":"32","author":"Zhang Y","year":"2023","unstructured":"Zhang Y, Zhang S, Liu C, et al.. Caregiver burden among family caregivers of patients with advanced cancer in a palliative context: A mixed-method study. J Clin Nurs. 2023, 32:7751-64. 10.1111\/jocn.16872","journal-title":"J Clin Nurs"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.12809\/eaap2171","article-title":"Prevalence and correlates of caregiver anxiety in family caregivers of patients with advanced cancer: a cross\u2011sectional study in a palliative care unit in Hong Kong","volume":"32","author":"Chan LM","year":"2022","unstructured":"Chan LM, Ng SC. Prevalence and correlates of caregiver anxiety in family caregivers of patients with advanced cancer: a cross\u2011sectional study in a palliative care unit in Hong Kong. East Asian Arch Psychiatry. 2022, 32:27-33. 10.12809\/eaap2171","journal-title":"East Asian Arch Psychiatry"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/442753-advanced-metastatic-laryngeal-carcinoma-a-case-report-on-palliative-management-in-primary-care","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:52:28Z","timestamp":1778345548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/442753-advanced-metastatic-laryngeal-carcinoma-a-case-report-on-palliative-management-in-primary-care"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.108556","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,9]]}}}