{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:37:00Z","timestamp":1787996220865,"version":"build-2784847793"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,11]]},"DOI":"10.7759\/cureus.108688","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:53:28Z","timestamp":1778561608000},"source":"Crossref","is-referenced-by-count":1,"title":["An Overview of Virulence, Resistance, and Clinical Significance of Klebsiella Infections"],"prefix":"10.7759","author":[{"given":"Pratignya G","family":"Biradar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha V","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish R","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9112344","article-title":"Phenotypic and molecular characterization of commensal, community-acquired and nosocomial Klebsiella spp","volume":"9","author":"G\u00f3mez M","year":"2021","unstructured":"G\u00f3mez M, Valverde A, Del Campo R, Rodr\u00edguez JM, Maldonado-Barrag\u00e1n A. Phenotypic and molecular characterization of commensal, community-acquired and nosocomial Klebsiella spp. Microorganisms. 2021, 9:2344. 10.3390\/microorganisms9112344","journal-title":"Microorganisms"},{"key":"ref2","article-title":"Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses","volume":"69","author":"Herridge WP","year":"2020","unstructured":"Herridge WP, Shibu P, O'Shea J, Brook TC, Hoyles L. Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses. J Med Microbiol. 2020, 69:176-94.","journal-title":"J Med Microbiol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0297407","article-title":"Prevalence of phenotypic multi-drug resistant Klebsiella species recovered from different human specimens in Ethiopia: a systematic review and meta-analysis","volume":"19","author":"Kijineh B","year":"2024","unstructured":"Kijineh B, Alemeyhu T, Mengistu M, Ali MM. Prevalence of phenotypic multi-drug resistant Klebsiella species recovered from different human specimens in Ethiopia: a systematic review and meta-analysis. PLoS One. 2024, 19:e0297407. 10.1371\/journal.pone.0297407","journal-title":"PLoS One"},{"key":"ref4","article-title":"","author":"Koneman EW","year":"2006","unstructured":"Koneman EW. Koneman's Color Atlas and Textbook of Diagnostic Microbiology. Lippincott Williams &amp; Wilkins, Philadelphia, PA; 2006. https:\/\/books.google.co.in\/books?id=xzIsZo44GkoC."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103998","article-title":"Klebsiella species: taxonomy, hypervirulence and multidrug resistance","volume":"79","author":"Dong N","year":"2022","unstructured":"Dong N, Yang X, Chan EW, Zhang R, Chen S. Klebsiella species: taxonomy, hypervirulence and multidrug resistance. EBioMedicine. 2022, 79:103998. 10.1016\/j.ebiom.2022.103998","journal-title":"EBioMedicine"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.25083\/rbl\/26.3\/2567.2586","article-title":"A review: Klebsiella pneumoniae, Klebsiella oxytoca and biotechnology","volume":"26","author":"Tomulescu C","year":"2021","unstructured":"Tomulescu C, Moscovici M, Lupescu I, Stoica R, Vamanu A. A review: Klebsiella pneumoniae, Klebsiella oxytoca and biotechnology. Rom Biotechnol Lett. 2021, 26: 2567-86. 10.25083\/rbl\/26.3\/2567.2586","journal-title":"Rom Biotechnol Lett"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46998-9","article-title":"Molecular epidemiology of Klebsiella variicola obtained from different sources","volume":"9","author":"Barrios-Camacho H","year":"2019","unstructured":"Barrios-Camacho H, Aguilar-Vera A, Beltran-Rojel M, et al.. Molecular epidemiology of Klebsiella variicola obtained from different sources. Sci Rep. 2019, 9:10610. 10.1038\/s41598-019-46998-9","journal-title":"Sci Rep"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07583-0","article-title":"A case report of Klebsiella aerogenes-caused lumbar spine infection identified by metagenome next-generation sequencing","volume":"22","author":"Gu H","year":"2022","unstructured":"Gu H, Cai Q, Dai X, Wang H, Xu W, Cao X, Ye Y. A case report of Klebsiella aerogenes-caused lumbar spine infection identified by metagenome next-generation sequencing. BMC Infect Dis. 2022, 22:616. 10.1186\/s12879-022-07583-0","journal-title":"BMC Infect Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-025-02498-9","article-title":"Infection prevention and control measures for multidrug-resistant organisms: a systematic review and network meta-analysis","volume":"53","author":"Geng Y","year":"2025","unstructured":"Geng Y, Liu Z, Ma X, et al.. Infection prevention and control measures for multidrug-resistant organisms: a systematic review and network meta-analysis. Infection. 2025, 53:1789-800. 10.1007\/s15010-025-02498-9","journal-title":"Infection"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00118","article-title":"Introduction: drug resistance","volume":"121","author":"Kurt Yilmaz N","year":"2021","unstructured":"Kurt Yilmaz N, Schiffer CA. Introduction: drug resistance. Chem Rev. 2021, 121:3235-7. 10.1021\/acs.chemrev.1c00118","journal-title":"Chem Rev"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S502175","article-title":"A comprehensive overview of Klebsiella pneumoniae: resistance dynamics, clinical manifestations, and therapeutic options","volume":"18","author":"Jin SS","year":"2025","unstructured":"Jin SS, Wang WQ, Jiang YH, Yu YT, Wang RL. A comprehensive overview of Klebsiella pneumoniae: resistance dynamics, clinical manifestations, and therapeutic options. Infect Drug Resist. 2025, 18:1611-28. 10.2147\/IDR.S502175","journal-title":"Infect Drug Resist"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics15010037","article-title":"Antibiotic resistance in Klebsiella pneumoniae and related Enterobacterales: molecular mechanisms, mobile elements, and therapeutic challenges","volume":"15","author":"Zdarska V","year":"2026","unstructured":"Zdarska V, Arcari G, Kolar M, Mlynarcik P. Antibiotic resistance in Klebsiella pneumoniae and related Enterobacterales: molecular mechanisms, mobile elements, and therapeutic challenges. Antibiotics (Basel). 2026, 15:37. 10.3390\/antibiotics15010037","journal-title":"Antibiotics (Basel)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/JLP.JLP_155_16","article-title":"Phenotypic and genotypic characterization of carbapenem resistance mechanisms in Klebsiella pneumoniae from blood culture specimens: a study from North India","volume":"10","author":"Gupta V","year":"2018","unstructured":"Gupta V, Garg R, Kumaraswamy K, Datta P, Mohi GK, Chander J. Phenotypic and genotypic characterization of carbapenem resistance mechanisms in Klebsiella pneumoniae from blood culture specimens: a study from North India. J Lab Physicians. 2018, 10:125-9. 10.4103\/JLP.JLP_155_16","journal-title":"J Lab Physicians"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1744239","article-title":"Phenotypic detection of ESBL, AmpC, MBL, and their co-occurrence among MDR Enterobacteriaceae isolates","volume":"14","author":"Salvia T","year":"2022","unstructured":"Salvia T, Dolma KG, Dhakal OP, Khandelwal B, Singh LS. Phenotypic detection of ESBL, AmpC, MBL, and their co-occurrence among MDR Enterobacteriaceae isolates. J Lab Physicians. 2022, 14:329-35. 10.1055\/s-0042-1744239","journal-title":"J Lab Physicians"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S509016","article-title":"Mechanisms of antimicrobial resistance in Klebsiella: advances in detection methods and clinical implications","volume":"18","author":"Li J","year":"2025","unstructured":"Li J, Shi Y, Song X, Yin X, Liu H. Mechanisms of antimicrobial resistance in Klebsiella: advances in detection methods and clinical implications. Infect Drug Resist. 2025, 18:1339-54. 10.2147\/IDR.S509016","journal-title":"Infect Drug Resist"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2024.07.005","article-title":"Prediction models for diagnosis and prognosis of the colonization or infection of multidrug-resistant organisms in adults: a systematic review, critical appraisal, and meta-analysis","volume":"30","author":"Liu X","year":"2024","unstructured":"Liu X, Liu X, Jin C, et al.. Prediction models for diagnosis and prognosis of the colonization or infection of multidrug-resistant organisms in adults: a systematic review, critical appraisal, and meta-analysis. Clin Microbiol Infect. 2024, 30:1364-73. 10.1016\/j.cmi.2024.07.005","journal-title":"Clin Microbiol Infect"},{"key":"ref17","article-title":"Performance Standards for Antimicrobial Susceptibility Testing. CLSI Supplement M100","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2024","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. CLSI Supplement M100. CLSI, Wayne, PA; 2024."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir202","article-title":"Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention","volume":"53","author":"Gupta N","year":"2011","unstructured":"Gupta N, Limbago BM, Patel JB, Kallen AJ. Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis. 2011, 53:60-7. 10.1093\/cid\/cir202","journal-title":"Clin Infect Dis"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.176149","article-title":"Laboratory detection and clinical implication of oxacillinase-48 like carbapenemase: the hidden threat","volume":"8","author":"Bakthavatchalam YD","year":"2016","unstructured":"Bakthavatchalam YD, Anandan S, Veeraraghavan B. Laboratory detection and clinical implication of oxacillinase-48 like carbapenemase: the hidden threat. J Glob Infect Dis. 2016, 8:41-50. 10.4103\/0974-777X.176149","journal-title":"J Glob Infect Dis"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00001-07","article-title":"Carbapenemases: the versatile beta-lactamases","volume":"20","author":"Queenan AM","year":"2007","unstructured":"Queenan AM, Bush K. Carbapenemases: the versatile beta-lactamases. Clin Microbiol Rev. 2007, 20:440-58, table of contents. 10.1128\/CMR.00001-07","journal-title":"Clin Microbiol Rev"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/481228-an-overview-of-virulence-resistance-and-clinical-significance-of-klebsiella-infections","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:53:32Z","timestamp":1778561612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/481228-an-overview-of-virulence-resistance-and-clinical-significance-of-klebsiella-infections"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.108688","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,11]]}}}