{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:08:50Z","timestamp":1778659730885,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,13]]},"DOI":"10.7759\/cureus.108761","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:17:54Z","timestamp":1778656674000},"source":"Crossref","is-referenced-by-count":0,"title":["The Silent Threat: Unveiling Pathogenicity and Antimicrobial Resistance in Nonfermenting Gram-Negative Bacilli"],"prefix":"10.7759","author":[{"given":"Dhanashree R","family":"Chavan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra V","family":"Shinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish R","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Non-fermenting Gram negative bacteria: a study on their prevalence and anti-microbial susceptibility pattern among patients admitted in a tertiary care hospital, Prayagraj, Uttar Pradesh","volume":"5","author":"Kumar N","year":"2023","unstructured":"Kumar N, Sharma D, Singh S, Singh BN. Non-fermenting Gram negative bacteria: a study on their prevalence and anti-microbial susceptibility pattern among patients admitted in a tertiary care hospital, Prayagraj, Uttar Pradesh. Int J Acad Med Pharm. 2023, 5:1580-4.","journal-title":"Int J Acad Med Pharm"},{"key":"ref2","article-title":"Isolation and antimicrobial susceptibility pattern of non-fermenting Gram negative bacilli (NFGNB) from various clinical samples","volume":"6","author":"Ranjan R","year":"2024","unstructured":"Ranjan R, Sagar P, Kumar A, Anand AK. Isolation and antimicrobial susceptibility pattern of non-fermenting Gram negative bacilli (NFGNB) from various clinical samples. Int J Acad Med Pharm. 2024, 6:1177-81.","journal-title":"Int J Acad Med Pharm"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4102\/sajid.v38i1.538","article-title":"Non-fermenter Gram-negative bacilli at a tertiary hospital, South Africa","volume":"38","author":"Ndzabandzaba S","year":"2023","unstructured":"Ndzabandzaba S, Mothibi L, von Knorring N. Non-fermenter Gram-negative bacilli at a tertiary hospital, South Africa. S Afr J Infect Dis. 2023, 38:538. 10.4102\/sajid.v38i1.538","journal-title":"S Afr J Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.70375","article-title":"A five-year trend analysis of antibacterial resistance patterns among non-fermenting Gram-negative bacilli: a retrospective study from the ICU settings of a tertiary care hospital","volume":"16","author":"Dash RK","year":"2024","unstructured":"Dash RK, Mohapatra I, Singh N, et al.. A five-year trend analysis of antibacterial resistance patterns among non-fermenting Gram-negative bacilli: a retrospective study from the ICU settings of a tertiary care hospital. Cureus. 2024, 16:e70375. 10.7759\/cureus.70375","journal-title":"Cureus"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000969","article-title":"The microbiology and pathogenesis of nonfermenting Gram-negative infections","volume":"36","author":"Di Pilato V","year":"2023","unstructured":"Di Pilato V, Willison E, Marchese A. The microbiology and pathogenesis of nonfermenting Gram-negative infections. Curr Opin Infect Dis. 2023, 36:537-44. 10.1097\/QCO.0000000000000969","journal-title":"Curr Opin Infect Dis"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11040899","article-title":"The challenge of bacteremia treatment due to non-fermenting Gram-negative bacteria","volume":"11","author":"Sadyrbaeva-Dolgova S","year":"2023","unstructured":"Sadyrbaeva-Dolgova S, S\u00e1nchez-Su\u00e1rez MD, Reguera M\u00e1rquez JA, Hidalgo-Tenorio C. The challenge of bacteremia treatment due to non-fermenting Gram-negative bacteria. Microorganisms. 2023, 11:899. 10.3390\/microorganisms11040899","journal-title":"Microorganisms"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S387370","article-title":"Epidemiology of multidrug resistant non-fermentative Gram negative bacilli in patients with hospital acquired pneumonia: an alarming report from Somalia","volume":"15","author":"Adan FN","year":"2022","unstructured":"Adan FN, Jeele MO, Omar NM. Epidemiology of multidrug resistant non-fermentative Gram negative bacilli in patients with hospital acquired pneumonia: an alarming report from Somalia. Infect Drug Resist. 2022, 15:6297-305. 10.2147\/IDR.S387370","journal-title":"Infect Drug Resist"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39243","article-title":"Emergence of multidrug-resistant non-fermenting Gram-negative bacilli in a tertiary care teaching hospital of Central India: is colistin resistance still a distant threat?","volume":"15","author":"Soni M","year":"2023","unstructured":"Soni M, Kapoor G, Perumal N, Chaurasia D. Emergence of multidrug-resistant non-fermenting Gram-negative bacilli in a tertiary care teaching hospital of Central India: is colistin resistance still a distant threat?. Cureus. 2023, 15:e39243. 10.7759\/cureus.39243","journal-title":"Cureus"},{"key":"ref9","article-title":"Non-fermenting Gram-negative bacteria-let's be cautious","volume":"61","author":"Yordanova R","year":"2023","unstructured":"Yordanova R, Mihaylova V, Nedeva N. Non-fermenting Gram-negative bacteria-let's be cautious. Knowl Int J. 2023, 61:801-6.","journal-title":"Knowl Int J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.36348\/sjpm.2022.v07i06.002","article-title":"A study of isolation, identification & antibiotic susceptibility pattern of non-fermenting Gram negative bacilli isolated from various clinical samples at tertiary care hospital Rajkot, Gujarat, Western India","volume":"7","author":"Gondha S","year":"2022","unstructured":"Gondha S, Kavathia G, Bhattacharya A. A study of isolation, identification &amp; antibiotic susceptibility pattern of non-fermenting Gram negative bacilli isolated from various clinical samples at tertiary care hospital Rajkot, Gujarat, Western India. Saudi J Pathol Microbiol. 2022, 7:233-39. 10.36348\/sjpm.2022.v07i06.002","journal-title":"Saudi J Pathol Microbiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312892","article-title":"Genomic and metabolic characteristics of the pathogenicity in Pseudomonas aeruginosa","volume":"22","author":"de Sousa T","year":"2021","unstructured":"de Sousa T, H\u00e9braud M, Dapkevicius ML, et al.. Genomic and metabolic characteristics of the pathogenicity in Pseudomonas aeruginosa. Int J Mol Sci. 2021, 22:12892. 10.3390\/ijms222312892","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.imj.2023.05.003","article-title":"Pseudomonas aeruginosa: infections and novel approaches to treatment \"knowing the enemy\" the threat of Pseudomonas aeruginosa and exploring novel approaches to treatment","volume":"2","author":"Sathe N","year":"2023","unstructured":"Sathe N, Beech P, Croft L, Suphioglu C, Kapat A, Athan E. Pseudomonas aeruginosa: infections and novel approaches to treatment \"knowing the enemy\" the threat of Pseudomonas aeruginosa and exploring novel approaches to treatment. Infect Med (Beijing). 2023, 2:178-94. 10.1016\/j.imj.2023.05.003","journal-title":"Infect Med (Beijing)"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063128","article-title":"Pseudomonas aeruginosa: an audacious pathogen with an adaptable arsenal of virulence factors","volume":"22","author":"Jurado-Mart\u00edn I","year":"2021","unstructured":"Jurado-Mart\u00edn I, Sainz-Mej\u00edas M, McClean S. Pseudomonas aeruginosa: an audacious pathogen with an adaptable arsenal of virulence factors. Int J Mol Sci. 2021, 22:3128.","journal-title":"Int J Mol Sci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.149116","article-title":"Isolation and identification of Acinetobacter species with special reference to antibiotic resistance","volume":"6","author":"Gupta N","year":"2015","unstructured":"Gupta N, Gandham N, Jadhav S, Mishra RN. Isolation and identification of Acinetobacter species with special reference to antibiotic resistance. J Nat Sci Biol Med. 2015, 6:159-62. 10.4103\/0976-9668.149116","journal-title":"J Nat Sci Biol Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1245131","article-title":"Epidemiology and antimicrobial resistance trends of Acinetobacter species in the United Arab Emirates: a retrospective analysis of 12\u2009years of national AMR surveillance data","volume":"11","author":"Thomsen J","year":"2023","unstructured":"Thomsen J, Abdulrazzaq NM, AlRand H, Everett DB, Senok A, Menezes GA, Ayoub Moubareck C. Epidemiology and antimicrobial resistance trends of Acinetobacter species in the United Arab Emirates: a retrospective analysis of 12\u2009years of national AMR surveillance data. Front Public Health. 2023, 11:1245131. 10.3389\/fpubh.2023.1245131","journal-title":"Front Public Health"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00433-22","article-title":"Acinetobacter metabolism in infection and antimicrobial resistance","volume":"91","author":"Ren X","year":"2023","unstructured":"Ren X, Palmer LD. Acinetobacter metabolism in infection and antimicrobial resistance. Infect Immun. 2023, 91:e0043322. 10.1128\/iai.00433-22","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25136814","article-title":"Unveiling the secrets of Acinetobacter baumannii: resistance, current treatments, and future innovations","volume":"25","author":"Marino A","year":"2024","unstructured":"Marino A, Augello E, Stracquadanio S, et al.. Unveiling the secrets of Acinetobacter baumannii: resistance, current treatments, and future innovations. Int J Mol Sci. 2024, 25:6814. 10.3390\/ijms25136814","journal-title":"Int J Mol Sci"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1385631","article-title":"Stenotrophomonas maltophilia virulence: a current view","volume":"15","author":"Mikhailovich V","year":"2024","unstructured":"Mikhailovich V, Heydarov R, Zimenkov D, Chebotar I. Stenotrophomonas maltophilia virulence: a current view. Front Microbiol. 2024, 15:1385631. 10.3389\/fmicb.2024.1385631","journal-title":"Front Microbiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-11","article-title":"Stenotrophomonas maltophilia: an emerging global opportunistic pathogen","volume":"25","author":"Brooke JS","year":"2012","unstructured":"Brooke JS. Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. Clin Microbiol Rev. 2012, 25:2-41. 10.1128\/CMR.00019-11","journal-title":"Clin Microbiol Rev"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13070577","article-title":"Stenotrophomonas maltophilia: the landscape in critically ill patients and optimising management approaches","volume":"13","author":"Carbonell N","year":"2024","unstructured":"Carbonell N, Oltra MR, Clari M\u00c1. Stenotrophomonas maltophilia: the landscape in critically ill patients and optimising management approaches. Antibiotics (Basel). 2024, 13:577. 10.3390\/antibiotics13070577","journal-title":"Antibiotics (Basel)"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11050321","article-title":"An overview of metabolic activity, beneficial and pathogenic aspects of Burkholderia spp.","volume":"11","author":"Elshafie HS","year":"2021","unstructured":"Elshafie HS, Camele I. An overview of metabolic activity, beneficial and pathogenic aspects of Burkholderia spp.. Metabolites. 2021, 11:321.","journal-title":"Metabolites"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2024.104544","article-title":"Comprehensive analysis of Burkholderia species head and neck infections: a systematic review","volume":"46","author":"Nanu DP","year":"2025","unstructured":"Nanu DP, Marrero-Gonzalez AR, Nguyen SA, Newman JG. Comprehensive analysis of Burkholderia species head and neck infections: a systematic review. Am J Otolaryngol. 2025, 46:104544. 10.1016\/j.amjoto.2024.104544","journal-title":"Am J Otolaryngol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11030300","article-title":"Pathogenesis of the Pseudomonas aeruginosa biofilm: a review","volume":"11","author":"Tuon FF","year":"2022","unstructured":"Tuon FF, Dantas LR, Suss PH, Tasca Ribeiro VS. Pathogenesis of the Pseudomonas aeruginosa biofilm: a review. Pathogens. 2022, 11:300. 10.3390\/pathogens11030300","journal-title":"Pathogens"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1374466","article-title":"Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies","volume":"15","author":"Elfadadny A","year":"2024","unstructured":"Elfadadny A, Ragab RF, AlHarbi M, et al.. Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies. Front Microbiol. 2024, 15:1374466. 10.3389\/fmicb.2024.1374466","journal-title":"Front Microbiol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10061247","article-title":"Resistance is not futile: the role of quorum sensing plasticity in Pseudomonas aeruginosa infections and its link to intrinsic mechanisms of antibiotic resistance","volume":"10","author":"Simanek KA","year":"2022","unstructured":"Simanek KA, Paczkowski JE. Resistance is not futile: the role of quorum sensing plasticity in Pseudomonas aeruginosa infections and its link to intrinsic mechanisms of antibiotic resistance. Microorganisms. 2022, 10:1247. 10.3390\/microorganisms10061247","journal-title":"Microorganisms"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/v16071051","article-title":"Pseudomonas aeruginosa bacteriophages and their clinical applications","volume":"16","author":"Alipour-Khezri E","year":"2024","unstructured":"Alipour-Khezri E, Skurnik M, Zarrini G. Pseudomonas aeruginosa bacteriophages and their clinical applications. Viruses. 2024, 16:1051. 10.3390\/v16071051","journal-title":"Viruses"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13110975","article-title":"Multidrug resistant Pseudomonas aeruginosa in clinical settings: a review of resistance mechanisms and treatment strategies","volume":"13","author":"Schwartz B","year":"2024","unstructured":"Schwartz B, Klamer K, Zimmerman J, Kale-Pradhan PB, Bhargava A. Multidrug resistant Pseudomonas aeruginosa in clinical settings: a review of resistance mechanisms and treatment strategies. Pathogens. 2024, 13:975. 10.3390\/pathogens13110975","journal-title":"Pathogens"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12040644","article-title":"Acinetobacter baumannii, a multidrug-resistant opportunistic pathogen in new habitats: a systematic review","volume":"12","author":"Ahuatzin-Flores OE","year":"2024","unstructured":"Ahuatzin-Flores OE, Torres E, Ch\u00e1vez-Bravo E. Acinetobacter baumannii, a multidrug-resistant opportunistic pathogen in new habitats: a systematic review. Microorganisms. 2024, 12:644. 10.3390\/microorganisms12040644","journal-title":"Microorganisms"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2024.100331","article-title":"Multidrug resistant Acinetobacter baumannii: a study on its pathogenesis and therapeutics","volume":"8","author":"Mukhopadhyay H","year":"2025","unstructured":"Mukhopadhyay H, Bairagi A, Mukherjee A, Prasad AK, Roy AD, Nayak A. Multidrug resistant Acinetobacter baumannii: a study on its pathogenesis and therapeutics. Curr Res Microb Sci. 2025, 8:100331. 10.1016\/j.crmicr.2024.100331","journal-title":"Curr Res Microb Sci"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.1.57","article-title":"Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia","volume":"11","author":"Denton M","year":"1998","unstructured":"Denton M, Kerr KG. Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia. Clin Microbiol Rev. 1998, 11:57-80. 10.1128\/CMR.11.1.57","journal-title":"Clin Microbiol Rev"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftw070","article-title":"The art of persistence-the secrets to Burkholderia chronic infections","volume":"74","author":"Lewis ER","year":"2016","unstructured":"Lewis ER, Torres AG. The art of persistence-the secrets to Burkholderia chronic infections. Pathog Dis. 2016, 74:070. 10.1093\/femspd\/ftw070","journal-title":"Pathog Dis"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14020178","article-title":"Difficult-to-treat Pseudomonas aeruginosa infections in critically ill patients: a comprehensive review and treatment proposal","volume":"14","author":"Vidal-Cort\u00e9s P","year":"2025","unstructured":"Vidal-Cort\u00e9s P, Campos-Fern\u00e1ndez S, Cuenca-Fito E, et al.. Difficult-to-treat Pseudomonas aeruginosa infections in critically ill patients: a comprehensive review and treatment proposal. Antibiotics (Basel). 2025, 14:178. 10.3390\/antibiotics14020178","journal-title":"Antibiotics (Basel)"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01056-1","article-title":"Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics","volume":"7","author":"Qin S","year":"2022","unstructured":"Qin S, Xiao W, Zhou C, et al.. Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics. Signal Transduct Target Ther. 2022, 7:199. 10.1038\/s41392-022-01056-1","journal-title":"Signal Transduct Target Ther"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00305","article-title":"E\ufb04ux pump-mediated drug resistance in Burkholderia","volume":"6","author":"Podnecky NL","year":"2015","unstructured":"Podnecky NL, Rhodes KA, Schweizer HP. E\ufb04ux pump-mediated drug resistance in Burkholderia. Front Microbiol. 2015, 6:305. 10.3389\/fmicb.2015.00305","journal-title":"Front Microbiol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/482384-the-silent-threat-unveiling-pathogenicity-and-antimicrobial-resistance-in-nonfermenting-gram-negative-bacilli","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:17:56Z","timestamp":1778656676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/482384-the-silent-threat-unveiling-pathogenicity-and-antimicrobial-resistance-in-nonfermenting-gram-negative-bacilli"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":34,"URL":"https:\/\/doi.org\/10.7759\/cureus.108761","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,13]]}}}