{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:09:51Z","timestamp":1778929791286,"version":"3.51.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,16]]},"DOI":"10.7759\/cureus.108958","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:34:37Z","timestamp":1778927677000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Genetic and Morphological Basis of Biofilm-Linked Drug Resistance in Clinical Isolates of Acinetobacter baumannii"],"prefix":"10.7759","author":[{"given":"Upma","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parul","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atin","family":"Singhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":".","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheetal","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RajKumar","family":"Kalyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vimala","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16","article-title":"Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges","volume":"30","author":"Wong D","year":"2017","unstructured":"Wong D, Nielsen TB, Bonomo RA, Pantapalangkoor P, Luna B, Spellberg B. Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges. Clin Microbiol Rev. 2017, 30:409-47. 10.1128\/CMR.00058-16","journal-title":"Clin Microbiol Rev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2024.07.003","article-title":"WHO publishes updated list of bacterial priority pathogens","volume":"5","author":"Jesudason T","year":"2024","unstructured":"Jesudason T. WHO publishes updated list of bacterial priority pathogens. Lancet Microbe. 2024, 5:100940. 10.1016\/j.lanmic.2024.07.003","journal-title":"Lancet Microbe"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","year":"2022","unstructured":"Global burden of bacterial antimicrobial resistance in 2019. a systematic analysis. Lancet. 2022, 399:629-55. 10.1016\/S0140-6736(21)02724-0","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02185-7","article-title":"Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"400","year":"2022","unstructured":"Global mortality associated with 33 bacterial pathogens in 2019. a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2022, 400:2221-48. 10.1016\/S0140-6736(22)02185-7","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.793615","article-title":"Convergence of biofilm formation and antibiotic resistance in Acinetobacter baumannii infection","volume":"9","author":"Roy S","year":"2022","unstructured":"Roy S, Chowdhury G, Mukhopadhyay AK, Dutta S, Basu S. Convergence of biofilm formation and antibiotic resistance in Acinetobacter baumannii infection. Front Med (Lausanne). 2022, 9:793615. 10.3389\/fmed.2022.793615","journal-title":"Front Med (Lausanne)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.5812\/jjm-133999","article-title":"Expression of biofilm-related genes in extensively drug-resistant Acinetobacter baumannii","volume":"16","author":"Khosravy M","year":"2023","unstructured":"Khosravy M, Hosseini F, Razavi MR, Khavari RA. Expression of biofilm-related genes in extensively drug-resistant Acinetobacter baumannii. Jundishapur J Microbiol. 2023, 16:e133999. 10.5812\/jjm-133999","journal-title":"Jundishapur J Microbiol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S332051","article-title":"Acinetobacter baumannii biofilm formation and its role in disease pathogenesis: a review","volume":"14","author":"Gedefie A","year":"2021","unstructured":"Gedefie A, Demsis W, Ashagrie M, et al.. Acinetobacter baumannii biofilm formation and its role in disease pathogenesis: a review. Infect Drug Resist. 2021, 14:3711-9. 10.2147\/IDR.S332051","journal-title":"Infect Drug Resist"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1444781","article-title":"Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review","volume":"15","author":"Belay WY","year":"2024","unstructured":"Belay WY, Getachew M, Tegegne BA, et al.. Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review. Front Pharmacol. 2024, 15:1444781. 10.3389\/fphar.2024.1444781","journal-title":"Front Pharmacol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.18502\/ijm.v14i4.10237","article-title":"Investigation the effects of silver nanoparticles and gold nanoparticles on expression of bap and csu genes in biofilm formation of Acinetobacter baumannii","volume":"14","author":"Rezania N","year":"2022","unstructured":"Rezania N, Rahmati P, Noorbakhsh F, Farhadyar N, Lotfali E. Investigation the effects of silver nanoparticles and gold nanoparticles on expression of bap and csu genes in biofilm formation of Acinetobacter baumannii. Iran J Microbiol. 2022, 14:510-7. 10.18502\/ijm.v14i4.10237","journal-title":"Iran J Microbiol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S310081","article-title":"Phenotypic and genotypic characteristics of biofilm formation in clinical isolates of Acinetobacter baumannii","volume":"14","author":"Li Z","year":"2021","unstructured":"Li Z, Ding Z, Liu Y, et al.. Phenotypic and genotypic characteristics of biofilm formation in clinical isolates of Acinetobacter baumannii. Infect Drug Resist. 2021, 14:2613-24. 10.2147\/IDR.S310081","journal-title":"Infect Drug Resist"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_150_19","article-title":"Detection of biofilm production and its impact on antibiotic resistance profile of bacterial isolates from chronic wound infections","volume":"12","author":"Harika K","year":"2020","unstructured":"Harika K, Shenoy VP, Narasimhaswamy N, Chawla K. Detection of biofilm production and its impact on antibiotic resistance profile of bacterial isolates from chronic wound infections. J Glob Infect Dis. 2020, 12:129-34. 10.4103\/jgid.jgid_150_19","journal-title":"J Glob Infect Dis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03092-1","article-title":"Biofilm formation on three different endotracheal tubes: a prospective clinical trial","volume":"24","author":"Thorarinsdottir HR","year":"2020","unstructured":"Thorarinsdottir HR, Kander T, Holmberg A, Petronis S, Klarin B. Biofilm formation on three different endotracheal tubes: a prospective clinical trial. Crit Care. 2020, 24:382. 10.1186\/s13054-020-03092-1","journal-title":"Crit Care"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.09.5","article-title":"Regulation of Acinetobacter baumannii biofilm formation","volume":"4","author":"Gaddy JA","year":"2009","unstructured":"Gaddy JA, Actis LA. Regulation of Acinetobacter baumannii biofilm formation. Future Microbiol. 2009, 4:273-8. 10.2217\/fmb.09.5","journal-title":"Future Microbiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2016.04.006","article-title":"Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance","volume":"1","author":"Babapour E","year":"2016","unstructured":"Babapour E, Haddadi A, Mirnejad R, Angaji SA, Amirmozafari N. Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance. Asian Pacific J Trop Biomed. 2016, 1:528-33. 10.1016\/j.apjtb.2016.04.006","journal-title":"Asian Pacific J Trop Biomed"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24101849","article-title":"Biofilm formation in Acinetobacter baumannii: genotype-phenotype correlation","volume":"24","author":"Yang CH","year":"2019","unstructured":"Yang CH, Su PW, Moi SH, Chuang LY. Biofilm formation in Acinetobacter baumannii: genotype-phenotype correlation. Molecules. 2019, 24:1849. 10.3390\/molecules24101849","journal-title":"Molecules"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05913-11","article-title":"The Acinetobacter baumannii biofilm-associated protein plays a role in adherence to human epithelial cells","volume":"80","author":"Brossard KA","year":"2012","unstructured":"Brossard KA, Campagnari AA. The Acinetobacter baumannii biofilm-associated protein plays a role in adherence to human epithelial cells. Infect Immun. 2012, 80:228-33. 10.1128\/IAI.05913-11","journal-title":"Infect Immun"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5812\/archcid.12914","article-title":"Phenotypic and genotypic investigation of biofilm formation in clinical and environmental isolates of Acinetobacter baumannii","volume":"13","author":"Ghasemi E","year":"20181","unstructured":"Ghasemi E, Ghalavand Z, Goudarzi H, et al.. Phenotypic and genotypic investigation of biofilm formation in clinical and environmental isolates of Acinetobacter baumannii. Arch Clin Infect Dis. 20181, 13:e12914. 10.5812\/archcid.12914","journal-title":"Arch Clin Infect Dis"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2436\/20.1501.01.270","article-title":"Distribution of virulence genes involved in biofilm formation in multi-drug resistant Acinetobacter baumannii clinical isolates","volume":"19","author":"Thummeepak R","year":"2016","unstructured":"Thummeepak R, Kongthai P, Leungtongkam U, Sitthisak S. Distribution of virulence genes involved in biofilm formation in multi-drug resistant Acinetobacter baumannii clinical isolates. Int Microbiol. 2016, 19:121-9. 10.2436\/20.1501.01.270","journal-title":"Int Microbiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.ijmr_3470_21","article-title":"Acinetobacter baumannii in suspected bacterial infections: association between multidrug resistance, virulence genes, & biofilm production","volume":"158","author":"Gautam D","year":"2023","unstructured":"Gautam D, Dolma KG, Khandelwal B, et al.. Acinetobacter baumannii in suspected bacterial infections: association between multidrug resistance, virulence genes, & biofilm production. Indian J Med Res. 2023, 158:439-46. 10.4103\/ijmr.ijmr_3470_21","journal-title":"Indian J Med Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4272-0","article-title":"Virulence characteristics of multidrug resistant biofilm forming Acinetobacter baumannii isolated from intensive care unit patients","volume":"19","author":"Zeighami H","year":"2019","unstructured":"Zeighami H, Valadkhani F, Shapouri R, Samadi E, Haghi F. Virulence characteristics of multidrug resistant biofilm forming Acinetobacter baumannii isolated from intensive care unit patients. BMC Infect Dis. 2019, 19:629. 10.1186\/s12879-019-4272-0","journal-title":"BMC Infect Dis"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01416-07","article-title":"Identification and characterization of an Acinetobacter baumannii biofilm-associated protein","volume":"190","author":"Loehfelm TW","year":"2008","unstructured":"Loehfelm TW, Luke NR, Campagnari AA. Identification and characterization of an Acinetobacter baumannii biofilm-associated protein. J Bacteriol. 2008, 190:1036-44. 10.1128\/JB.01416-07","journal-title":"J Bacteriol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/475872-exploring-the-genetic-and-morphological-basis-of-biofilm-linked-drug-resistance-in-clinical-isolates-of-acinetobacter-baumannii","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:34:38Z","timestamp":1778927678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/475872-exploring-the-genetic-and-morphological-basis-of-biofilm-linked-drug-resistance-in-clinical-isolates-of-acinetobacter-baumannii"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.108958","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,16]]}}}