{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:07:18Z","timestamp":1778998038299,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,16]]},"DOI":"10.7759\/cureus.108996","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T05:14:35Z","timestamp":1778994875000},"source":"Crossref","is-referenced-by-count":0,"title":["Suspected Neostigmine-Associated Bronchospasm Complicated by Pulmonary Edema During General Anesthesia: A Case Report"],"prefix":"10.7759","author":[{"given":"Moe","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Haraguchi-Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Suto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0952-8180(97)00070-6","article-title":"Negative pressure pulmonary edema after acute upper airway obstruction","volume":"9","author":"Deepika K","year":"1997","unstructured":"Deepika K, Kenaan CA, Barrocas AM, Fonseca JJ, Bikazi GB. Negative pressure pulmonary edema after acute upper airway obstruction. J Clin Anesth. 1997, 9:403-8. 10.1016\/s0952-8180(97)00070-6","journal-title":"J Clin Anesth"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3307-7","article-title":"Understanding negative pressure pulmonary edema","volume":"40","author":"Lemyze M","year":"2014","unstructured":"Lemyze M, Mallat J. Understanding negative pressure pulmonary edema. Intensive Care Med. 2014, 40:1140-3. 10.1007\/s00134-014-3307-7","journal-title":"Intensive Care Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197908303010901","article-title":"Effect of intrathoracic pressure on left ventricular performance","volume":"301","author":"Buda AJ","year":"1979","unstructured":"Buda AJ, Pinsky MR, Ingels NB Jr, Daughters GT 2nd, Stinson EB, Alderman EL. Effect of intrathoracic pressure on left ventricular performance. N Engl J Med. 1979, 301:453-9. 10.1056\/NEJM197908303010901","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.91868","article-title":"Negative-pressure pulmonary edema: a perioperative emergency","volume":"17","author":"Shaikh N","year":"2025","unstructured":"Shaikh N, Alali B, Amara UE, Nashrah UE, Ummunnisa F. Negative-pressure pulmonary edema: a perioperative emergency. Cureus. 2025, 17:e91868. 10.7759\/cureus.91868","journal-title":"Cureus"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199103000-00002","article-title":"Noncardiogenic pulmonary edema following upper airway obstruction. 7 cases and a review of the literature","volume":"70","author":"Kollef MH","year":"1991","unstructured":"Kollef MH, Pluss J. Noncardiogenic pulmonary edema following upper airway obstruction. 7 cases and a review of the literature. Medicine (Baltimore). 1991, 70:91-8. 10.1097\/00005792-199103000-00002","journal-title":"Medicine (Baltimore)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)05877-X","article-title":"The direct action of prostigmine on skeletal muscle; its relationship to the choline esters","volume":"88","author":"Riker WF","year":"1946","unstructured":"Riker WF, Jr., Wescoe WC. The direct action of prostigmine on skeletal muscle; its relationship to the choline esters. J Pharmacol Exp Ther. 1946, 88:58-66. 10.1016\/S0022-3565(25)05877-X","journal-title":"J Pharmacol Exp Ther"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181da8312","article-title":"Residual neuromuscular block: lessons unlearned. Part II: methods to reduce the risk of residual weakness","volume":"111","author":"Brull SJ","year":"2010","unstructured":"Brull SJ, Murphy GS. Residual neuromuscular block: lessons unlearned. Part II: methods to reduce the risk of residual weakness. Anesth Analg. 2010, 111:129-40. 10.1213\/ANE.0b013e3181da8312","journal-title":"Anesth Analg"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.22086\/gmj.v0i0.846","article-title":"Bronchospasm during induction of anesthesia: a case report and literature review","volume":"7","author":"Vojdani S","year":"2018","unstructured":"Vojdani S. Bronchospasm during induction of anesthesia: a case report and literature review. Galen Med J. 2018, 7:e846. 10.22086\/gmj.v0i0.846","journal-title":"Galen Med J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21521","article-title":"Multiple episodes of severe bronchospasm during general anesthesia: a case report","volume":"14","author":"Garcia D","year":"2022","unstructured":"Garcia D, Kehar M, Khan ES, Mendonca R, Girshin M. Multiple episodes of severe bronchospasm during general anesthesia: a case report. Cureus. 2022, 14:e21521. 10.7759\/cureus.21521","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0529","article-title":"Negative pressure pulmonary edema following bronchospasm","volume":"140","author":"Krodel DJ","year":"2011","unstructured":"Krodel DJ, Bittner EA, Abdulnour RE, Brown RH, Eikermann M. Negative pressure pulmonary edema following bronchospasm. Chest. 2011, 140:1351-4. 10.1378\/chest.11-0529","journal-title":"Chest"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.65.1.91","article-title":"Negative pressure pulmonary edema related to bronchospasm during anesthetic recovery","volume":"65","author":"Jo YY","year":"2013","unstructured":"Jo YY, Kim KH, Kil HK. Negative pressure pulmonary edema related to bronchospasm during anesthetic recovery. Korean J Anesthesiol. 2013, 65:91-2. 10.4097\/kjae.2013.65.1.91","journal-title":"Korean J Anesthesiol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197709152971107","article-title":"Mechanical forces producing pulmonary edema in acute asthma","volume":"297","author":"Stalcup SA","year":"1977","unstructured":"Stalcup SA, Mellins RB. Mechanical forces producing pulmonary edema in acute asthma. N Engl J Med. 1977, 297:592-6. 10.1056\/NEJM197709152971107","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.17245\/jdapm.2023.23.5.287","article-title":"Sugammadex-induced bronchospasm: a case report","volume":"23","author":"Kim S","year":"2023","unstructured":"Kim S, Choo H, Jung H, Kim JH. Sugammadex-induced bronchospasm: a case report. J Dent Anesth Pain Med. 2023, 23:287-91. 10.17245\/jdapm.2023.23.5.287","journal-title":"J Dent Anesth Pain Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.10.016","article-title":"Comparison of incidence of anaphylaxis between sugammadex and neostigmine: a retrospective multicentre observational study","volume":"124","author":"Orihara M","year":"2020","unstructured":"Orihara M, Takazawa T, Horiuchi T, et al.. Comparison of incidence of anaphylaxis between sugammadex and neostigmine: a retrospective multicentre observational study. Br J Anaesth. 2020, 124:154-63. 10.1016\/j.bja.2019.10.016","journal-title":"Br J Anaesth"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X19897656","article-title":"Neostigmine anaphlaxis: a rare and missed diagnosis","volume":"48","author":"McKenzie AJ","year":"2020","unstructured":"McKenzie AJ. Neostigmine anaphlaxis: a rare and missed diagnosis. Anaesth Intensive Care. 2020, 48:59-60. 10.1177\/0310057X19897656","journal-title":"Anaesth Intensive Care"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010525","article-title":"Acute noncardiogenic pulmonary edema after neostigmine administration during the recovery period of general anesthesia: a case report","volume":"97","author":"Zhang W","year":"2018","unstructured":"Zhang W, Ning C, Zhao G, Su Z. Acute noncardiogenic pulmonary edema after neostigmine administration during the recovery period of general anesthesia: a case report. Medicine (Baltimore). 2018, 97:e10525. 10.1097\/MD.0000000000010525","journal-title":"Medicine (Baltimore)"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen176","article-title":"Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing","volume":"101","author":"Eikermann M","year":"2008","unstructured":"Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL. Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing. Br J Anaesth. 2008, 101:344-9. 10.1093\/bja\/aen176","journal-title":"Br J Anaesth"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181f70f3d","article-title":"Neostigmine\/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure","volume":"113","author":"Herbstreit F","year":"2010","unstructured":"Herbstreit F, Zigrahn D, Ochterbeck C, Peters J, Eikermann M. Neostigmine\/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure. Anesthesiology. 2010, 113:1280-8. 10.1097\/ALN.0b013e3181f70f3d","journal-title":"Anesthesiology"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo CA","year":"1981","unstructured":"Naranjo CA, Busto U, Sellers EM, et al.. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981, 30:239-45. 10.1038\/clpt.1981.154","journal-title":"Clin Pharmacol Ther"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015389","article-title":"Negative pressure pulmonary edema after general anesthesia: a case report and literature review","volume":"98","author":"Liu R","year":"2019","unstructured":"Liu R, Wang J, Zhao G, Su Z. Negative pressure pulmonary edema after general anesthesia: a case report and literature review. Medicine (Baltimore). 2019, 98:e15389. 10.1097\/MD.0000000000015389","journal-title":"Medicine (Baltimore)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/489382-suspected-neostigmine-associated-bronchospasm-complicated-by-pulmonary-edema-during-general-anesthesia-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T05:14:37Z","timestamp":1778994877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/489382-suspected-neostigmine-associated-bronchospasm-complicated-by-pulmonary-edema-during-general-anesthesia-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.108996","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,16]]}}}