{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T02:06:47Z","timestamp":1779070007037,"version":"3.51.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,17]]},"DOI":"10.7759\/cureus.109048","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T01:31:48Z","timestamp":1779067908000},"source":"Crossref","is-referenced-by-count":0,"title":["Postoperative Unilateral Neck Irradiation for Oral Cancer: Risk Factors for Contralateral Neck Recurrence and Implications for Patient Selection"],"prefix":"10.7759","author":[{"given":"Hiroaki","family":"Wakiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadamasa","family":"Yoshitake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Shirakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Hisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Takaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Imafuku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mioko","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Kumamaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousei","family":"Ishigami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung H","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021, 71:209-49. 10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"ref2","article-title":"Essentials of oral cancer","volume":"8","author":"Rivera C","year":"2015","unstructured":"Rivera C. Essentials of oral cancer. Int J Clin Exp Pathol. 2015, 8:11884-94.","journal-title":"Int J Clin Exp Pathol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26713","article-title":"Unilateral versus bilateral nodal irradiation: Current evidence in the treatment of squamous cell carcinoma of the head and neck","volume":"43","author":"Nuyts S","year":"2021","unstructured":"Nuyts S, Bollen H, Eisbruch A, et al.. Unilateral versus bilateral nodal irradiation: Current evidence in the treatment of squamous cell carcinoma of the head and neck. Head Neck. 2021, 43:2807-21. 10.1002\/hed.26713","journal-title":"Head Neck"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20423","article-title":"Management of contralateral N0 neck in oral cavity squamous cell carcinoma","volume":"28","author":"Koo BS","year":"2006","unstructured":"Koo BS, Lim YC, Lee JS, Choi EC. Management of contralateral N0 neck in oral cavity squamous cell carcinoma. Head Neck. 2006, 28:896-901. 10.1002\/hed.20423","journal-title":"Head Neck"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199903)21:2<104::AID-HED2>3.0.CO;2-L","article-title":"Factors influencing contralateral lymph node metastasis from oral carcinoma","volume":"21","author":"Kowalski LP","year":"1999","unstructured":"Kowalski LP, Bagietto R, Lara JR, Santos RL, Tagawa EK, Santos IR. Factors influencing contralateral lymph node metastasis from oral carcinoma. Head Neck. 1999, 21:104-10. 10.1002\/(SICI)1097-0347(199903)21:2&lt;104::AID-HED2&gt;3.0.CO;2-L","journal-title":"Head Neck"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.04.004","article-title":"Clinical predictors for contralateral neck lymph node metastasis from unilateral squamous cell carcinoma in the oral cavity","volume":"40","author":"Kurita H","year":"2004","unstructured":"Kurita H, Koike T, Narikawa JN, et al.. Clinical predictors for contralateral neck lymph node metastasis from unilateral squamous cell carcinoma in the oral cavity. Oral Oncol. 2004, 40:898-903. 10.1016\/j.oraloncology.2004.04.004","journal-title":"Oral Oncol"},{"key":"ref7","unstructured":"U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 (v4.03). (2009). https:\/\/evs.nci.nih.gov."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2020.00458","article-title":"Patterns of failure and clinical outcomes of post-operative buccal mucosa cancers treated with adjuvant ipsilateral radiotherapy","volume":"38","author":"Rath S","year":"2020","unstructured":"Rath S, Gandhi AK, Rastogi M, et al.. Patterns of failure and clinical outcomes of post-operative buccal mucosa cancers treated with adjuvant ipsilateral radiotherapy. Radiat Oncol J. 2020, 38:189-97. 10.3857\/roj.2020.00458","journal-title":"Radiat Oncol J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102885","article-title":"Adjuvant contralateral neck irradiation for oral cavity cancer - A systematic review and meta-analysis","volume":"42","author":"Kao YS","year":"2021","unstructured":"Kao YS, Hsu Y. Adjuvant contralateral neck irradiation for oral cavity cancer - A systematic review and meta-analysis. Am J Otolaryngol. 2021, 42:102885. 10.1016\/j.amjoto.2020.102885","journal-title":"Am J Otolaryngol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21436","article-title":"Frequency of bilateral cervical metastases in oropharyngeal squamous cell carcinoma: A retrospective analysis of 352 cases after bilateral neck dissection","volume":"33","author":"Olzowy B","year":"2011","unstructured":"Olzowy B, Tsalemchuk Y, Schotten KJ, Reichel O, Harr\u00e9us U. Frequency of bilateral cervical metastases in oropharyngeal squamous cell carcinoma: A retrospective analysis of 352 cases after bilateral neck dissection. Head Neck. 2011, 33:239-43. 10.1002\/hed.21436","journal-title":"Head Neck"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.10.014","article-title":"The topography of cervical lymph node metastases revisited: The histological findings in 526 sides of neck dissection from 439 previously untreated patients","volume":"36","author":"Woolgar JA","year":"2007","unstructured":"Woolgar JA. The topography of cervical lymph node metastases revisited: The histological findings in 526 sides of neck dissection from 439 previously untreated patients. Int J Oral Maxillofac Surg. 2007, 36:219-25. 10.1016\/j.ijom.2006.10.014","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.03.002","article-title":"Unilateral versus bilateral irradiation in squamous cell head and neck cancer in relation to patient-rated xerostomia and sticky saliva","volume":"85","author":"Jellema AP","year":"2007","unstructured":"Jellema AP, Slotman BJ, Doornaert P, Leemans CR, Langendijk JA. Unilateral versus bilateral irradiation in squamous cell head and neck cancer in relation to patient-rated xerostomia and sticky saliva. Radiother Oncol. 2007, 85:83-9. 10.1016\/j.radonc.2007.03.002","journal-title":"Radiother Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(01)01512-7","article-title":"Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer","volume":"50","author":"Eisbruch A","year":"2001","unstructured":"Eisbruch A, Kim HM, Terrell JE, Marsh LH, Dawson LA, Ship JA. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001, 50:695-704. 10.1016\/s0360-3016(01)01512-7","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.12.017","article-title":"A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer","volume":"90","author":"Langendijk JA","year":"2009","unstructured":"Langendijk JA, Doornaert P, Rietveld DH, Verdonck-de Leeuw IM, Leemans CR, Slotman BJ. A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol. 2009, 90:189-95. 10.1016\/j.radonc.2008.12.017","journal-title":"Radiother Oncol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.06.005","article-title":"Morbidity after ipsilateral radiotherapy for oropharyngeal cancer","volume":"85","author":"Jensen K","year":"2007","unstructured":"Jensen K, Overgaard M, Grau C. Morbidity after ipsilateral radiotherapy for oropharyngeal cancer. Radiother Oncol. 2007, 85:90-7. 10.1016\/j.radonc.2007.06.005","journal-title":"Radiother Oncol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23297","article-title":"Tonsillar cancer: The Peter MacCallum experience with unilateral and bilateral irradiation","volume":"36","author":"Liu C","year":"2014","unstructured":"Liu C, Dutu G, Peters LJ, Rischin D, Corry J. Tonsillar cancer: The Peter MacCallum experience with unilateral and bilateral irradiation. Head Neck. 2014, 36:317-22. 10.1002\/hed.23297","journal-title":"Head Neck"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2013.11.053","article-title":"Ipsilateral tonsil chemoradiation: Improved toxicity compared to bilateral radiation and effective rates of local-regional control: Definitive management of head-and-neck squamous cell carcinoma","volume":"88","author":"Cramer CK","year":"2014","unstructured":"Cramer CK, Palta M, Patel P, Brizel DM. Ipsilateral tonsil chemoradiation: Improved toxicity compared to bilateral radiation and effective rates of local-regional control: Definitive management of head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2014, 88:477.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.06.1975","article-title":"Unilateral radiotherapy for the treatment of tonsil cancer","volume":"83","author":"Chronowski GM","year":"2012","unstructured":"Chronowski GM, Garden AS, Morrison WH, et al.. Unilateral radiotherapy for the treatment of tonsil cancer. Int J Radiat Oncol Biol Phys. 2012, 83:204-9. 10.1016\/j.ijrobp.2011.06.1975","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/490022-postoperative-unilateral-neck-irradiation-for-oral-cancer-risk-factors-for-contralateral-neck-recurrence-and-implications-for-patient-selection","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T01:31:51Z","timestamp":1779067911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/490022-postoperative-unilateral-neck-irradiation-for-oral-cancer-risk-factors-for-contralateral-neck-recurrence-and-implications-for-patient-selection"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.109048","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,17]]}}}