{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:08:31Z","timestamp":1779260911989,"version":"3.51.4"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,19]]},"DOI":"10.7759\/cureus.109241","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:13:23Z","timestamp":1779257603000},"source":"Crossref","is-referenced-by-count":0,"title":["Late-Onset Metastatic Signet Ring Cell Adenocarcinoma Following Bladder Exstrophy Reconstruction: Diagnostic Discordance and Uncertain Primary Origin"],"prefix":"10.7759","author":[{"given":"Lorena","family":"Muro-Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivash","family":"Selvaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30316","article-title":"Bladder exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research, and an overview of the literature","volume":"157C","author":"Siffel C","year":"2011","unstructured":"Siffel C, Correa A, Amar E, et al.. Bladder exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research, and an overview of the literature. Am J Med Genet C Semin Med Genet. 2011, 157C:321-32. 10.1002\/ajmg.c.30316","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.08.038","article-title":"Augmentation cystoplasty and risk of neoplasia: fact, fiction and controversy","volume":"184","author":"Higuchi TT","year":"2010","unstructured":"Higuchi TT, Granberg CF, Fox JA, Husmann DA. Augmentation cystoplasty and risk of neoplasia: fact, fiction and controversy. J Urol. 2010, 184:2492-6. 10.1016\/j.juro.2010.08.038","journal-title":"J Urol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1836174.087","article-title":"Long-term outcomes of augmentation cystoplasty in a pediatric population with refractory bladder dysfunction: a 12-year follow-up experience at single center","volume":"22","author":"Mehmood S","year":"2018","unstructured":"Mehmood S, Alhazmi H, Al-Shayie M, et al.. Long-term outcomes of augmentation cystoplasty in a pediatric population with refractory bladder dysfunction: a 12-year follow-up experience at single center. Int Neurourol J. 2018, 22:287-94. 10.5213\/inj.1836174.087","journal-title":"Int Neurourol J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22775","article-title":"Risk of malignancy after augmentation cystoplasty: A systematic review","volume":"35","author":"Biardeau X","year":"2016","unstructured":"Biardeau X, Chartier-Kastler E, Roupr\u00eat M, Ph\u00e9 V. Risk of malignancy after augmentation cystoplasty: A systematic review. Neurourol Urodyn. 2016, 35:675-82. 10.1002\/nau.22775","journal-title":"Neurourol Urodyn"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i40.11428","article-title":"Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge","volume":"21","author":"Pernot S","year":"2015","unstructured":"Pernot S, Voron T, Perkins G, Lagorce-Pages C, Berger A, Taieb J. Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge. World J Gastroenterol. 2015, 21:11428-38. 10.3748\/wjg.v21.i40.11428","journal-title":"World J Gastroenterol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200111000-00005","article-title":"Immunohistochemical distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma","volume":"25","author":"Wang HL","year":"2001","unstructured":"Wang HL, Lu DW, Yerian LM, Alsikafi N, Steinberg G, Hart J, Yang XJ. Immunohistochemical distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. Am J Surg Pathol. 2001, 25:1380-7. 10.1097\/00000478-200111000-00005","journal-title":"Am J Surg Pathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00797.x","article-title":"Secondary neoplasms of the bladder are histological mimics of nontransitional cell primary tumours: clinicopathological and histological features of 282 cases","volume":"36","author":"Bates AW","year":"2000","unstructured":"Bates AW, Baithun SI. Secondary neoplasms of the bladder are histological mimics of nontransitional cell primary tumours: clinicopathological and histological features of 282 cases. Histopathology. 2000, 36:32-40. 10.1046\/j.1365-2559.2000.00797.x","journal-title":"Histopathology"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-37","article-title":"Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report","volume":"7","author":"El Ammari JE","year":"2013","unstructured":"El Ammari JE, Ahsaini M, Riyach O, et al.. Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report. J Med Case Rep. 2013, 7:37. 10.1186\/1752-1947-7-37","journal-title":"J Med Case Rep"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-7-151","article-title":"Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge","volume":"7","author":"Roy S","year":"2012","unstructured":"Roy S, Smith MA, Cieply KM, Acquafondata MB, Parwani AV. Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge. Diagn Pathol. 2012, 7:151. 10.1186\/1746-1596-7-151","journal-title":"Diagn Pathol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.07.002","article-title":"Role of SATB2 in distinguishing the site of origin in glandular lesions of the bladder\/urinary tract","volume":"67","author":"Giannico GA","year":"2017","unstructured":"Giannico GA, Gown AM, Epstein JI, Revetta F, Bishop JA. Role of SATB2 in distinguishing the site of origin in glandular lesions of the bladder\/urinary tract. Hum Pathol. 2017, 67:152-9. 10.1016\/j.humpath.2017.07.002","journal-title":"Hum Pathol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.229","article-title":"Distinguishing primary adenocarcinoma of the urinary bladder from secondary involvement by colorectal adenocarcinoma: extended immunohistochemical profiles emphasizing novel markers","volume":"26","author":"Rao Q","year":"2013","unstructured":"Rao Q, Williamson SR, Lopez-Beltran A, et al.. Distinguishing primary adenocarcinoma of the urinary bladder from secondary involvement by colorectal adenocarcinoma: extended immunohistochemical profiles emphasizing novel markers. Mod Pathol. 2013, 26:725-32. 10.1038\/modpathol.2012.229","journal-title":"Mod Pathol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-016-1970-5","article-title":"MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance","volume":"469","author":"Betge J","year":"2016","unstructured":"Betge J, Schneider NI, Harbaum L, et al.. MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance. Virchows Arch. 2016, 469:255-65. 10.1007\/s00428-016-1970-5","journal-title":"Virchows Arch"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2026.1763359","article-title":"Multimodal artificial intelligence in urologic precision oncology: from algorithm to translational medicine (a systemized narrative review)","volume":"16","author":"Rajaee Rizi F","year":"2026","unstructured":"Rajaee Rizi F, Jamadi MS, Rahimi S, Bighamian M, Paidar P, Taki MJ, Bahmaie N. Multimodal artificial intelligence in urologic precision oncology: from algorithm to translational medicine (a systemized narrative review). Front Oncol. 2026, 16:1763359. 10.3389\/fonc.2026.1763359","journal-title":"Front Oncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31819aa4ae","article-title":"Urachal carcinoma: a clinicopathologic analysis of 24 cases with outcome correlation","volume":"33","author":"Gopalan A","year":"2009","unstructured":"Gopalan A, Sharp DS, Fine SW, Tickoo SK, Herr HW, Reuter VE, Olgac S. Urachal carcinoma: a clinicopathologic analysis of 24 cases with outcome correlation. Am J Surg Pathol. 2009, 33:659-68. 10.1097\/PAS.0b013e31819aa4ae","journal-title":"Am J Surg Pathol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/488498-late-onset-metastatic-signet-ring-cell-adenocarcinoma-following-bladder-exstrophy-reconstruction-diagnostic-discordance-and-uncertain-primary-origin","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:13:24Z","timestamp":1779257604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/488498-late-onset-metastatic-signet-ring-cell-adenocarcinoma-following-bladder-exstrophy-reconstruction-diagnostic-discordance-and-uncertain-primary-origin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":14,"URL":"https:\/\/doi.org\/10.7759\/cureus.109241","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,19]]}}}