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Environmental exposure to endocrine disrupting chemicals influences genomic imprinting, growth, and metabolism. Genes (Basel). 2021, 12:1153. 10.3390\/genes12081153","journal-title":"Genes (Basel)"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-023-01536-3","article-title":"Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis","volume":"15","author":"Stepanyan A","year":"2023","unstructured":"Stepanyan A, Petrackova A, Hakobyan S, Savara J, Davitavyan S, Kriegova E, Arakelyan A. Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis. Clin Epigenetics. 2023, 15:126. 10.1186\/s13148-023-01536-3","journal-title":"Clin Epigenetics"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.02.019","article-title":"DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis","volume":"98","author":"Joubert BR","year":"2016","unstructured":"Joubert BR, Felix JF, Yousefi P, et al.. DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis. 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