{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:15:22Z","timestamp":1779394522163,"version":"3.53.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"DOI":"10.7759\/cureus.109384","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:51:49Z","timestamp":1779393109000},"source":"Crossref","is-referenced-by-count":0,"title":["Dysfibrinogenemia in Pregnancy: A Case Series Highlighting Diagnostic Challenges and Multidisciplinary Management"],"prefix":"10.7759","author":[{"given":"Supreet","family":"Mahurkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ejike","family":"Nnamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajitha","family":"Parveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12619","article-title":"Management of congenital dysfibrinogenemia in pregnancy: A challenging patient case","volume":"5","author":"Langer M","year":"2021","unstructured":"Langer M, Manire M, Clarkson M, Samhouri Y, Shah D, Bhagavatula R. Management of congenital dysfibrinogenemia in pregnancy: A challenging patient case. Res Pract Thromb Haemost. 2021, 5:e12619. 10.1002\/rth2.12619","journal-title":"Res Pract Thromb Haemost"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01365.x","article-title":"Fibrinogen and fibrin structure and functions","volume":"3","author":"Mosesson MW","year":"2005","unstructured":"Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost. 2005, 3:1894-904. 10.1111\/j.1538-7836.2005.01365.x","journal-title":"J Thromb Haemost"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32832aec2b","article-title":"Treatment of patients with dysfibrinogenemia and a history of abortions during pregnancy","volume":"20","author":"Miesbach W","year":"2009","unstructured":"Miesbach W, Galanakis D, Scharrer I. Treatment of patients with dysfibrinogenemia and a history of abortions during pregnancy. Blood Coagul Fibrinolysis. 2009, 20:366-70. 10.1097\/MBC.0b013e32832aec2b","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00211.x","article-title":"Dysfibrinogenemia during pregnancy treated successfully with fibrinogen","volume":"82","author":"Yamanaka Y","year":"2003","unstructured":"Yamanaka Y, Takeuchi K, Sugimoto M, Sato A, Nakago S, Maruo T. Dysfibrinogenemia during pregnancy treated successfully with fibrinogen. Acta Obstet Gynecol Scand. 2003, 82:972-3. 10.1034\/j.1600-0412.2003.00211.x","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref5","article-title":"Management of congenital dysfibrinogenemia during pregnancy through a joint obstetric-haematology clinic: shared experience of five cases","volume":"14","author":"Brini H","year":"2025","unstructured":"Brini H, Hassenien MM, Almallahi N, Elkourashy SA\r\n. Management of congenital dysfibrinogenemia during pregnancy through a joint obstetric-haematology clinic: shared experience of five cases. EC Gynaecol. 2025, 14:1-5.","journal-title":"EC Gynaecol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-025-07834-3","article-title":"Multidisciplinary team management of congenital dysfibrinogenemia in pregnancy: a case report","volume":"25","author":"He MJ","year":"2025","unstructured":"He MJ, Wei ZJ, Wang F, Zhang HY. Multidisciplinary team management of congenital dysfibrinogenemia in pregnancy: a case report. BMC Pregnancy Childbirth. 2025, 25:715. 10.1186\/s12884-025-07834-3","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.01.008","article-title":"Management of pregnancy and delivery in congenital fibrinogen disorders: communication from the ISTH SSC Subcommittee on factor XIII and fibrinogen","volume":"22","author":"Casini A","year":"2024","unstructured":"Casini A, Abdul Kadir R, Abdelwahab M, et al.. Management of pregnancy and delivery in congenital fibrinogen disorders: communication from the ISTH SSC Subcommittee on factor XIII and fibrinogen. J Thromb Haemost. 2024, 22:1516-21. 10.1016\/j.jtha.2024.01.008","journal-title":"J Thromb Haemost"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.14382","article-title":"Changes in fibrinogen and D-dimer during complicated and uncomplicated pregnancy","volume":"47","author":"Gong C","year":"2025","unstructured":"Gong C, Jiang H, Su Y, Yang J, Wei Y, Qiao R, Zhao Y. Changes in fibrinogen and D-dimer during complicated and uncomplicated pregnancy. Int J Lab Hematol. 2025, 47:156-65. 10.1111\/ijlh.14382","journal-title":"Int J Lab Hematol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.647680","article-title":"Pediatric fibrinogen PART II-overview of indications for fibrinogen use in critically ill children","volume":"9","author":"Crighton GL","year":"2021","unstructured":"Crighton GL, Huisman EJ. Pediatric fibrinogen PART II-overview of indications for fibrinogen use in critically ill children. Front Pediatr. 2021, 9:647680. 10.3389\/fped.2021.647680","journal-title":"Front Pediatr"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14216","article-title":"Diagnosis and classification of congenital fibrinogen disorders: communication from the SSC of the ISTH","volume":"16","author":"Casini A","year":"2018","unstructured":"Casini A, Undas A, Palla R, Thachil J, de Moerloose P. Diagnosis and classification of congenital fibrinogen disorders: communication from the SSC of the ISTH. J Thromb Haemost. 2018, 16:1887-90. 10.1111\/jth.14216","journal-title":"J Thromb Haemost"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1684\/abc.2016.1167","article-title":"Diagnosis of congenital fibrinogen disorders","volume":"74","author":"Lebreton A","year":"2016","unstructured":"Lebreton A, Casini A. Diagnosis of congenital fibrinogen disorders. Ann Biol Clin (Paris). 2016, 74:405-12. 10.1684\/abc.2016.1167","journal-title":"Ann Biol Clin (Paris)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24624","article-title":"Misdiagnosis of a patient with congenital dysfibrinogenemia: a\u00a0case report and literature review","volume":"36","author":"Chen X","year":"2022","unstructured":"Chen X, Yan J, Xiang L, Lin F. Misdiagnosis of a patient with congenital dysfibrinogenemia: a\u00a0case report and literature review. J Clin Lab Anal. 2022, 36:e24624. 10.1002\/jcla.24624","journal-title":"J Clin Lab Anal"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15131671","article-title":"Severe hereditary hypofibrinogenemia in pregnancy: a case report of a novel obstetrical management with thromboelastometry guided fibrinogen supplementation","volume":"15","author":"Karampas G","year":"2025","unstructured":"Karampas G, Karkalemis K, Bagiasta A, et al.. Severe hereditary hypofibrinogenemia in pregnancy: a case report of a novel obstetrical management with thromboelastometry guided fibrinogen supplementation. Diagnostics (Basel). 2025, 15:10.3390\/diagnostics15131671","journal-title":"Diagnostics (Basel)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13203219","article-title":"Basic principles of rotational thromboelastometry (ROTEM(\u00ae)) and the role of ROTEM-guided fibrinogen replacement therapy in the management of coagulopathies","volume":"13","author":"Drotarova M","year":"2023","unstructured":"Drotarova M, Zolkova J, Belakova KM, Brunclikova M, Skornova I, Stasko J, Simurda T. Basic principles of rotational thromboelastometry (ROTEM(\u00ae)) and the role of ROTEM-guided fibrinogen replacement therapy in the management of coagulopathies. Diagnostics (Basel). 2023, 13:10.3390\/diagnostics13203219","journal-title":"Diagnostics (Basel)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000001274","article-title":"Diagnostic value of clot formation parameters determined by rotational thromboelastometry in 63 patients with congenital dysfibrinogenemia","volume":"35","author":"Simurda T","year":"2024","unstructured":"Simurda T, Marchi R, Casini A, et al.. Diagnostic value of clot formation parameters determined by rotational thromboelastometry in 63 patients with congenital dysfibrinogenemia. Blood Coagul Fibrinolysis. 2024, 35:56-61. 10.1097\/MBC.0000000000001274","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s40981-025-00810-y","article-title":"Spinal anesthesia in a patient with hereditary dysfibrinogenemia who underwent emergency cesarean delivery: a case report","volume":"11","author":"Ono S","year":"2025","unstructured":"Ono S, Hosokawa Y, Kamiyama M, Ohsugi E, Gotanda M, Yamashita Y, Kato R. Spinal anesthesia in a patient with hereditary dysfibrinogenemia who underwent emergency cesarean delivery: a case report. JA Clin Rep. 2025, 11:67. 10.1186\/s40981-025-00810-y","journal-title":"JA Clin Rep"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16092","article-title":"Assisted vaginal birth: Green-top Guideline No. 26","volume":"127","author":"Murphy DJ","year":"2020","unstructured":"Murphy DJ, Strachan BK, Bahl R. Assisted vaginal birth: Green-top Guideline No. 26. BJOG. 2020, 127:e70-e112. 10.1111\/1471-0528.16092","journal-title":"BJOG"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010116","article-title":"How I treat dysfibrinogenemia","volume":"138","author":"Casini A","year":"2021","unstructured":"Casini A, de Moerloose P. How I treat dysfibrinogenemia. Blood. 2021, 138:2021-30. 10.1182\/blood.2020010116","journal-title":"Blood"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/490531-dysfibrinogenemia-in-pregnancy-a-case-series-highlighting-diagnostic-challenges-and-multidisciplinary-management","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:51:49Z","timestamp":1779393109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/490531-dysfibrinogenemia-in-pregnancy-a-case-series-highlighting-diagnostic-challenges-and-multidisciplinary-management"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.109384","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}