{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T02:19:34Z","timestamp":1779416374427,"version":"3.53.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"DOI":"10.7759\/cureus.109395","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T01:14:31Z","timestamp":1779412471000},"source":"Crossref","is-referenced-by-count":0,"title":["Anticancer Potential of Thiocolchicoside: An In-Vitro MTT Assay Study"],"prefix":"10.7759","author":[{"given":"Akash V","family":"Devi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Khanwelkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray F","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, et al.. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018, 68:394-424. 10.3322\/caac.21492","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan D","year":"2011","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011, 144:646-74. 10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"key":"ref3","article-title":"Breathing new life into old drugs: a review on drug repurposing","volume":"14","author":"Nagendra B","year":"2025","unstructured":"Nagendra B, Mennuru, Kp N, et al.. Breathing new life into old drugs: a review on drug repurposing . J Pharm Innov. 2025, 14:26-32.","journal-title":"J Pharm Innov"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.17165632","article-title":"Thiocolchicoside: a brief review","volume":"03","author":"Chakravarthi KSS","year":"2025","unstructured":"Chakravarthi KSS, Ilango KB, Ananya KD, et al.. Thiocolchicoside: a brief review. Int J of Pharm Sci. 2025, 03:2239-2251. 10.5281\/zenodo.17165632","journal-title":"Int J of Pharm Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2019.34760.8242","article-title":"Colchicine-like \u03b2-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity","volume":"22","author":"Karimikia E","year":"2019","unstructured":"Karimikia E, Behravan J, Zarghi A, et al.. Colchicine-like \u03b2-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity. Iran J Basic Med Sci. 2019, 22:1138-46. 10.22038\/ijbms.2019.34760.8242","journal-title":"Iran J Basic Med Sci"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.09.051","article-title":"Recent developments in tubulin polymerization inhibitors: an overview","volume":"87","author":"Kaur R","year":"2014","unstructured":"Kaur R, Kaur G, Gill RK, et al.. Recent developments in tubulin polymerization inhibitors: an overview. Eur J Med Chem. 2014, 87:89-124. 10.1016\/j.ejmech.2014.09.051","journal-title":"Eur J Med Chem"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1528235","article-title":"Design, synthesis and antiproliferative activity of novel colchicine derivatives: selective inhibition of melanoma cell proliferation","volume":"16","author":"Kumar P","year":"2025","unstructured":"Kumar P, Kotra T, Lone WI, et al.. Design, synthesis and antiproliferative activity of novel colchicine derivatives: selective inhibition of melanoma cell proliferation. Front Pharmacol. 2025, 16:1528235. 10.3389\/fphar.2025.1528235","journal-title":"Front Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2803","article-title":"Microtubules and resistance to tubulin-binding agents","volume":"10","author":"Kavallaris M","year":"2010","unstructured":"Kavallaris M. Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer. 2010, 10:194-204. 10.1038\/nrc2803","journal-title":"Nat Rev Cancer"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3253","article-title":"Microtubule-binding agents: a dynamic field of cancer therapeutics","volume":"9","author":"Dumontet C","year":"2010","unstructured":"Dumontet C, Jordan MA. Microtubule-binding agents: a dynamic field of cancer therapeutics. Nat Rev Drug Discov. 2010, 9:790-803. 10.1038\/nrd3253","journal-title":"Nat Rev Drug Discov"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/22311866.2020.1815575","article-title":"Thiocolchicoside and colchicine induced apoptosis in breast cancer (MCF-7) cells via up-regulated expression of p53 tumor suppressor protein gene: an in vitro and in silico docking approaches","volume":"10","author":"Mahendran D","year":"2020","unstructured":"Mahendran D, Selvam K, Kumari S, et al.. Thiocolchicoside and colchicine induced apoptosis in breast cancer (MCF-7) cells via up-regulated expression of p53 tumor suppressor protein gene: an in vitro and in silico docking approaches.  J Biol Act Prod Nat. 2020, 10:264-274. 10.1080\/22311866.2020.1815575","journal-title":"J Biol Act Prod Nat"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0037","article-title":"Thiocolchicoside exhibits anticancer effects through downregulation of NF-\u03baB pathway and its regulated gene products linked to inflammation and cancer","volume":"3","author":"Reuter S","year":"2010","unstructured":"Reuter S, Prasad S, Phromnoi K, et al.. Thiocolchicoside exhibits anticancer effects through downregulation of NF-\u03baB pathway and its regulated gene products linked to inflammation and cancer. Cancer Prev Res (Phila). 2010, 3:1462-72. 10.1158\/1940-6207.CAPR-10-0037","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0260","article-title":"NF-\u03baB in cancer: a matter of life and death","volume":"1","author":"Aggarwal BB","year":"2011","unstructured":"Aggarwal BB, Sung B. NF-\u03baB in cancer: a matter of life and death. Cancer Discov. 2011, 1:469-71. 10.1158\/2159-8290.CD-11-0260","journal-title":"Cancer Discov"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2010.05.004","article-title":"Inhibiting NF-\u03baB activation by small molecules as a therapeutic strategy","volume":"1799","author":"Gupta SC","year":"2010","unstructured":"Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Inhibiting NF-\u03baB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta. 2010, 1799:775-87. 10.1016\/j.bbagrm.2010.05.004","journal-title":"Biochim Biophys Acta"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2016.01667","article-title":"Lead phytochemicals for anticancer drug development","volume":"7","author":"Singh S","year":"2016","unstructured":"Singh S, Sharma B, Kanwar SS, Kumar A. Lead phytochemicals for anticancer drug development. Front Plant Sci. 2016, 7:1667. 10.3389\/fpls.2016.01667","journal-title":"Front Plant Sci"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070728","article-title":"Dietary natural products for prevention and treatment of breast cancer","volume":"9","author":"Li Y","year":"2017","unstructured":"Li Y, Li S, Meng X, et al.. Dietary natural products for prevention and treatment of breast cancer. Nutrients. 2017, 9:10.3390\/nu9070728","journal-title":"Nutrients"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann T","year":"1983","unstructured":"Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983, 65:55-63. 10.1016\/0022-1759(83)90303-4","journal-title":"J Immunol Methods"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer-drug screening","volume":"82","author":"Skehan P","year":"1990","unstructured":"Skehan P, Storeng R, Scudiero D, et al.. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst. 1990, 82:1107-12. 10.1093\/jnci\/82.13.1107","journal-title":"J Natl Cancer Inst"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1039\/c5ob00406c","article-title":"Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability","volume":"13","author":"Singh B","year":"2015","unstructured":"Singh B, Kumar A, Joshi P, et al.. Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability. Org Biomol Chem. 2015, 13:5674-89. 10.1039\/c5ob00406c","journal-title":"Org Biomol Chem"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673319496240911060138","article-title":"Vincristine in cancer therapy: mechanisms, efficacy, and future perspectives","volume":"32","author":"Garg N","year":"2025","unstructured":"Garg N, Farhat J, Dhankhar S, et al.. Vincristine in cancer therapy: mechanisms, efficacy, and future perspectives. Curr Med Chem. 2025, 32:6941-59. 10.2174\/0109298673319496240911060138","journal-title":"Curr Med Chem"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom S","year":"2019","unstructured":"Pushpakom S, Iorio F, Eyers PA, et al.. Drug repurposing: progress, challenges and recommendations. Nat Rev Drug Discov. 2019, 18:41-58. 10.1038\/nrd.2018.168","journal-title":"Nat Rev Drug Discov"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S576701","article-title":"Drug repurposing as an effective drug discovery strategy: a critical review","volume":"19","author":"Al Khzem AH","year":"2025","unstructured":"Al Khzem AH, Wali SM. Drug repurposing as an effective drug discovery strategy: a critical review. Drug Des Devel Ther. 2025, 19:12019-34. 10.2147\/DDDT.S576701","journal-title":"Drug Des Devel Ther"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02624-9","article-title":"Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine","volume":"22","author":"Dhyani P","year":"2022","unstructured":"Dhyani P, Quispe C, Sharma E, et al.. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 2022, 22:206. 10.1186\/s12935-022-02624-9","journal-title":"Cancer Cell Int"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: an overview","volume":"2013","author":"Kumar S","year":"2013","unstructured":"Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Sci World J. 2013, 2013:162750. 10.1155\/2013\/162750","journal-title":"Sci World J"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-023-03636-6","article-title":"Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges","volume":"13","author":"Banyal A","year":"2023","unstructured":"Banyal A, Tiwari S, Sharma A, et al.. Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges. 3 Biotech. 2023, 13:211. 10.1007\/s13205-023-03636-6","journal-title":"3 Biotech"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-04-0916","article-title":"How taxol\/paclitaxel kills cancer cells","volume":"25","author":"Weaver BA","year":"2014","unstructured":"Weaver BA. How taxol\/paclitaxel kills cancer cells. Mol Biol Cell. 2014, 25:2677-81. 10.1091\/mbc.E14-04-0916","journal-title":"Mol Biol Cell"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-60046-1","article-title":"Anticancer potential of thiocolchicoside and lauric acid loaded chitosan nanogel against oral cancer cell lines: a comprehensive study","volume":"14","author":"Mustafa A","year":"2024","unstructured":"Mustafa A, Indiran MA, Ramalingam K, et al.. Anticancer potential of thiocolchicoside and lauric acid loaded chitosan nanogel against oral cancer cell lines: a comprehensive study. Sci Rep. 2024, 14:9270. 10.1038\/s41598-024-60046-1","journal-title":"Sci Rep"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/492078-anticancer-potential-of-thiocolchicoside-an-in-vitro-mtt-assay-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T01:14:32Z","timestamp":1779412472000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/492078-anticancer-potential-of-thiocolchicoside-an-in-vitro-mtt-assay-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.109395","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}