{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T19:06:22Z","timestamp":1779476782006,"version":"3.53.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,22]]},"DOI":"10.7759\/cureus.109446","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T18:50:09Z","timestamp":1779475809000},"source":"Crossref","is-referenced-by-count":0,"title":["Herpes Simplex Virus Esophagitis in an Immunocompetent Patient: Navigating Diagnostic Challenges and Achieving Effective Treatment"],"prefix":"10.7759","author":[{"given":"Didi","family":"Mwengela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimah","family":"Ather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kunesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doy094","article-title":"Infections of the esophagus: an update on risk factors, diagnosis, and management","volume":"31","author":"Hoversten P","year":"2018","unstructured":"Hoversten P, Kamboj AK, Katzka DA. Infections of the esophagus: an update on risk factors, diagnosis, and management. Dis Esophagus. 2018, 31:10.1093\/dote\/doy094","journal-title":"Dis Esophagus"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181e949ed","article-title":"Herpes esophagitis in healthy adults and adolescents: report of 3 cases and review of the literature","volume":"89","author":"Canalejo E","year":"2010","unstructured":"Canalejo E, Garc\u00eda Dur\u00e1n F, Cabello N, Garc\u00eda Mart\u00ednez J. Herpes esophagitis in healthy adults and adolescents: report of 3 cases and review of the literature. Medicine (Baltimore). 2010, 89:204-10. 10.1097\/MD.0b013e3181e949ed","journal-title":"Medicine (Baltimore)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05493-x","article-title":"Variations in the clinical course of patients with herpes simplex virus esophagitis based on immunocompetence and presence of underlying esophageal disease","volume":"64","author":"Hoversten P","year":"2019","unstructured":"Hoversten P, Kamboj AK, Wu TT, Katzka DA. Variations in the clinical course of patients with herpes simplex virus esophagitis based on immunocompetence and presence of underlying esophageal disease. Dig Dis Sci. 2019, 64:1893-900. 10.1007\/s10620-019-05493-x","journal-title":"Dig Dis Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.1997.tb00275.x","article-title":"Herpes esophagitis: a comprehensive review","volume":"3","author":"G\u00e9n\u00e9reau T","year":"1997","unstructured":"G\u00e9n\u00e9reau T, Rozenberg F, Bouchaud O, et al.. Herpes esophagitis: a comprehensive review. Clin Microbiol Infect. 1997, 3:397-407. 10.1111\/j.1469-0691.1997.tb00275.x","journal-title":"Clin Microbiol Infect"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy381","article-title":"A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology","volume":"67","author":"Miller JM","year":"2018","unstructured":"Miller JM, Binnicker MJ, Campbell S, et al.. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis. 2018, 67:e1-e94. 10.1093\/cid\/ciy381","journal-title":"Clin Infect Dis"},{"key":"ref6","article-title":"Herpes simplex virus esophagitis in the immunocompetent host: an overview","volume":"95","author":"Ramanathan J","year":"2000","unstructured":"Ramanathan J, Rammouni M, Baran Jr J, et al.. Herpes simplex virus esophagitis in the immunocompetent host: an overview. Amr Jr Gast. 2000, 95:2171-2176.","journal-title":"Amr Jr Gast"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(84)72289-9","article-title":"Herpes simplex esophagitis in a nonimmunosuppressed host with gastroesophageal reflux","volume":"30","author":"DiPalma J","year":"1984","unstructured":"DiPalma J, Brady lll C. Herpes simplex esophagitis in a nonimmunosuppressed host with gastroesophageal reflux. Gast End. 1984, 30:24-25. 10.1016\/S0016-5107(84)72289-9","journal-title":"Gast End"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06297.x","article-title":"Mechanisms of immunosenescence: lessons from models of accelerated immune aging","volume":"1247","author":"Le Saux S","year":"2012","unstructured":"Le Saux S, Weyand CM, Goronzy JJ. Mechanisms of immunosenescence: lessons from models of accelerated immune aging. Ann N Y Acad Sci. 2012, 1247:69-82. 10.1111\/j.1749-6632.2011.06297.x","journal-title":"Ann N Y Acad Sci"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.08.027","article-title":"AGA clinical practice update on esophageal dysfunction due to disordered immunity and infection: expert review","volume":"22","author":"Reddy CA","year":"2024","unstructured":"Reddy CA, McGowan E, Yadlapati R, Peterson K. AGA clinical practice update on esophageal dysfunction due to disordered immunity and infection: expert review. Clin Gastroenterol Hepatol. 2024, 22:2378-87. 10.1016\/j.cgh.2024.08.027","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05748-11","article-title":"Virological diagnosis of herpes simplex virus 1 esophagitis by quantitative real-time PCR assay","volume":"50","author":"Jazeron JF","year":"2012","unstructured":"Jazeron JF, Barbe C, Frobert E, et al.. Virological diagnosis of herpes simplex virus 1 esophagitis by quantitative real-time PCR assay. J Clin Microbiol. 2012, 50:948-52. 10.1128\/JCM.05748-11","journal-title":"J Clin Microbiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00623.x","article-title":"Treatment of herpes simplex esophagitis in an immunocompetent patient with intravenous acyclovir: a case report and review of the literature","volume":"93","author":"Kurahara K","year":"1998","unstructured":"Kurahara K, Aoyagi K, Nakamura S, et al.. Treatment of herpes simplex esophagitis in an immunocompetent patient with intravenous acyclovir: a case report and review of the literature. Am J Gastroenterol. 1998, 93:2239-40. 10.1111\/j.1572-0241.1998.00623.x","journal-title":"Am J Gastroenterol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.4.894","article-title":"Herpes simplex esophagitis in the immunocompetent patient: report of four cases and review","volume":"14","author":"Galbraith JC","year":"1992","unstructured":"Galbraith JC, Shafran SD. Herpes simplex esophagitis in the immunocompetent patient: report of four cases and review. Clin Infect Dis. 1992, 14:894-901. 10.1093\/clinids\/14.4.894","journal-title":"Clin Infect Dis"},{"key":"ref13","article-title":"Spontaneous esophageal perforation in herpes simplex esophagitis","volume":"87","author":"Cronstedt JL","year":"1992","unstructured":"Cronstedt JL, Bouchama A, Hainau B, et al.. Spontaneous esophageal perforation in herpes simplex esophagitis. Am J Gastroenterol. 1992, 87:124-7.","journal-title":"Am J Gastroenterol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/495032-herpes-simplex-virus-esophagitis-in-an-immunocompetent-patient-navigating-diagnostic-challenges-and-achieving-effective-treatment","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T18:50:10Z","timestamp":1779475810000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/495032-herpes-simplex-virus-esophagitis-in-an-immunocompetent-patient-navigating-diagnostic-challenges-and-achieving-effective-treatment"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.109446","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,22]]}}}