{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T14:07:22Z","timestamp":1779545242676,"version":"3.53.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,23]]},"DOI":"10.7759\/cureus.109497","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:55:14Z","timestamp":1779544514000},"source":"Crossref","is-referenced-by-count":0,"title":["N-acetylcysteine in Thrombotic Thrombocytopenic Purpura: A Systematic Review"],"prefix":"10.7759","author":[{"given":"Fawad","family":"Talat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Subhan","family":"Talpur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Sardar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Solangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Usman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areeba","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Sardar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Kallem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri","family":"Yalamanchili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp053024","article-title":"Clinical practice. Thrombotic thrombocytopenic purpura","volume":"354","author":"George JN","year":"2006","unstructured":"George JN. Clinical practice. Thrombotic thrombocytopenic purpura. N Engl J Med. 2006, 354:1927-35. 10.1056\/NEJMcp053024","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-636431","article-title":"Pathophysiology of thrombotic thrombocytopenic purpura","volume":"130","author":"Sadler JE","year":"2017","unstructured":"Sadler JE. Pathophysiology of thrombotic thrombocytopenic purpura. Blood. 2017, 130:1181-8. 10.1182\/blood-2017-04-636431","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-061813-013241","article-title":"ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura","volume":"66","author":"Zheng XL","year":"2015","unstructured":"Zheng XL. ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura. Annu Rev Med. 2015, 66:211-25. 10.1146\/annurev-med-061813-013241","journal-title":"Annu Rev Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-709857","article-title":"Thrombotic thrombocytopenic purpura","volume":"129","author":"Joly BS","year":"2017","unstructured":"Joly BS, Coppo P, Veyradier A. Thrombotic thrombocytopenic purpura. Blood. 2017, 129:2836-46. 10.1182\/blood-2016-10-709857","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806311","article-title":"Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura","volume":"380","author":"Scully M","year":"2019","unstructured":"Scully M, Cataland SR, Peyvandi F, et al.. Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2019, 380:335-46. 10.1056\/NEJMoa1806311","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212023072306","article-title":"Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura","volume":"307","author":"Moake JL","year":"1982","unstructured":"Moake JL, Rudy CK, Troll JH, et al.. Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. N Engl J Med. 1982, 307:1432-5. 10.1056\/NEJM198212023072306","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12440","article-title":"Treatment of refractory thrombotic thrombocytopenic purpura with N-acetylcysteine: a case report","volume":"54","author":"Li GW","year":"2014","unstructured":"Li GW, Rambally S, Kamboj J, Reilly S, Moake JL, Udden MM, Mims MP. Treatment of refractory thrombotic thrombocytopenic purpura with N-acetylcysteine: a case report. Transfusion. 2014, 54:1221-4. 10.1111\/trf.12440","journal-title":"Transfusion"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1259-6","article-title":"The role of N-acetylcysteine in the treatment of thrombotic thrombocytopenic purpura","volume":"41","author":"Rottenstreich A","year":"2016","unstructured":"Rottenstreich A, Hochberg-Klein S, Rund D, Kalish Y. The role of N-acetylcysteine in the treatment of thrombotic thrombocytopenic purpura. J Thromb Thrombolysis. 2016, 41:678-83. 10.1007\/s11239-015-1259-6","journal-title":"J Thromb Thrombolysis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000386","article-title":"N-acetylcysteine for relapsing thrombotic thrombocytopenic purpura: more evidence of a promising drug","volume":"23","author":"Cabanillas G","year":"2016","unstructured":"Cabanillas G, Popescu-Martinez A. N-acetylcysteine for relapsing thrombotic thrombocytopenic purpura: more evidence of a promising drug. Am J Ther. 2016, 23:e1277-9. 10.1097\/MJT.0000000000000386","journal-title":"Am J Ther"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0036933018775240","article-title":"Relapsed\/refractory thrombotic thrombocytopenic purpura treated with N-acetylcysteine: a case report","volume":"63","author":"Demircio\u011flu S","year":"2018","unstructured":"Demircio\u011flu S, Ekinci \u00d6, Do\u011fan A, Demir C. Relapsed\/refractory thrombotic thrombocytopenic purpura treated with N-acetylcysteine: a case report. Scott Med J. 2018, 63:122-4. 10.1177\/0036933018775240","journal-title":"Scott Med J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05248-9","article-title":"N-acetylcistein for thrombotic thrombocytopenic purpura: an observational case series study","volume":"102","author":"Espa\u00f1ol I","year":"2023","unstructured":"Espa\u00f1ol I, Leal JD, Blanquer M, et al.. N-acetylcistein for thrombotic thrombocytopenic purpura: an observational case series study. Ann Hematol. 2023, 102:2069-75. 10.1007\/s00277-023-05248-9","journal-title":"Ann Hematol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2023.103713","article-title":"Use of n-acetylcysteine therapy in patients with relapsed refractory thrombotic thrombocytopenic purpura","volume":"62","author":"Beyler O","year":"2023","unstructured":"Beyler O, Demir C. Use of n-acetylcysteine therapy in patients with relapsed refractory thrombotic thrombocytopenic purpura. Transfus Apher Sci. 2023, 62:103713. 10.1016\/j.transci.2023.103713","journal-title":"Transfus Apher Sci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0476-1","article-title":"Pathophysiology of thrombotic thrombocytopenic purpura","volume":"91","author":"Tsai HM","year":"2010","unstructured":"Tsai HM. Pathophysiology of thrombotic thrombocytopenic purpura. Int J Hematol. 2010, 91:1-19. 10.1007\/s12185-009-0476-1","journal-title":"Int J Hematol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023780","article-title":"Management of immune thrombotic thrombocytopenic purpura without therapeutic plasma exchange","volume":"144","author":"K\u00fchne L","year":"2024","unstructured":"K\u00fchne L, Kn\u00f6bl P, Eller K, et al.. Management of immune thrombotic thrombocytopenic purpura without therapeutic plasma exchange. Blood. 2024, 144:1486-95. 10.1182\/blood.2023023780","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05295-2","article-title":"Association between N-acetylcysteine treatment and in-hospital mortality in adult patients with acquired thrombotic thrombocytopenic purpura: a cohort study","volume":"102","author":"Li J","year":"2023","unstructured":"Li J, Zhang Y, Kong D, et al.. Association between N-acetylcysteine treatment and in-hospital mortality in adult patients with acquired thrombotic thrombocytopenic purpura: a cohort study. Ann Hematol. 2023, 102:2257-65. 10.1007\/s00277-023-05295-2","journal-title":"Ann Hematol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/478581-n-acetylcysteine-in-thrombotic-thrombocytopenic-purpura-a-systematic-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:55:15Z","timestamp":1779544515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/478581-n-acetylcysteine-in-thrombotic-thrombocytopenic-purpura-a-systematic-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.109497","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,23]]}}}