{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T02:04:00Z","timestamp":1779761040914,"version":"3.53.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,25]]},"DOI":"10.7759\/cureus.109643","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T01:49:49Z","timestamp":1779760189000},"source":"Crossref","is-referenced-by-count":0,"title":["Children With Medulloblastoma: Surgical Outcomes and Survival Challenges"],"prefix":"10.7759","author":[{"given":"Armando Francisco","family":"Perez Castell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge de la Salud","family":"Rodr\u00edguez Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Meza Mata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"L\u00f3pez Facio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fany Karina","family":"Segura L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.196922","article-title":"Modern management of medulloblastoma: molecular classification, outcomes, and the role of surgery","volume":"7","author":"Srinivasan VM","year":"2016","unstructured":"Srinivasan VM, Ghali MG, North RY, Boghani Z, Hansen D, Lam S. Modern management of medulloblastoma: molecular classification, outcomes, and the role of surgery. Surg Neurol Int. 2016, 7:S1135-S1141. 10.4103\/2152-7806.196922","journal-title":"Surg Neurol Int"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/ijri.IJRI_209_19","article-title":"Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival","volume":"30","author":"Hussain IZ","year":"2020","unstructured":"Hussain IZ, Mohd Zaki F, Mukari SA, Md Pauzi SH, Loh CK, Alias H. Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival. Indian J Radiol Imaging. 2020, 30:46-51. 10.4103\/ijri.IJRI_209_19","journal-title":"Indian J Radiol Imaging"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-016-0644-7","article-title":"Medulloblastoma: tumor biology and relevance to treatment and prognosis paradigm","volume":"16","author":"Coluccia D","year":"2016","unstructured":"Coluccia D, Figuereido C, Isik S, Smith C, Rutka JT. Medulloblastoma: tumor biology and relevance to treatment and prognosis paradigm. Curr Neurol Neurosci Rep. 2016, 16:43. 10.1007\/s11910-016-0644-7","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3171\/2019.5.PEDS18381","article-title":"Medulloblastoma in the age of molecular subgroups: a review","volume":"24","author":"Juraschka K","year":"2019","unstructured":"Juraschka K, Taylor MD. Medulloblastoma in the age of molecular subgroups: a review. J Neurosurg Pediatr. 2019, 24:353-363. 10.3171\/2019.5.PEDS18381","journal-title":"J Neurosurg Pediatr"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-017-2400-5","article-title":"Demographics, patterns of care, and survival in pediatric medulloblastoma","volume":"132","author":"Dressler EV","year":"2017","unstructured":"Dressler EV, Dolecek TA, Liu M, Villano JL. Demographics, patterns of care, and survival in pediatric medulloblastoma. J Neurooncol. 2017, 132:497-506. 10.1007\/s11060-017-2400-5","journal-title":"J Neurooncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-023-01316-9","article-title":"Recent advances in pediatric medulloblastoma","volume":"23","author":"Jackson K","year":"2023","unstructured":"Jackson K, Packer RJ. Recent advances in pediatric medulloblastoma. Curr Neurol Neurosci Rep. 2023, 23:841-848. 10.1007\/s11910-023-01316-9","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref7","article-title":"Central Nervous System Tumours. WHO Classification of Tumours","volume":"6","author":"Ian A","year":"2021","unstructured":"Ian A, Louis DN, Ohgaki H, et al.. Central Nervous System Tumours. WHO Classification of Tumours. IARC. 2021, 6:1-568.","journal-title":"IARC"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13162622","article-title":"Current strategies for management of medulloblastoma","volume":"13","author":"Prados MD","year":"2023","unstructured":"Prados MD. Current strategies for management of medulloblastoma. Diagnostics (Basel). 2023, 13:1234. 10.3390\/diagnostics13162622","journal-title":"Diagnostics (Basel)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246313","article-title":"Pediatric versus adult medulloblastoma: towards a definition that goes beyond age","volume":"13","author":"Wooley JR","year":"2021","unstructured":"Wooley JR, Penas-Prado M. Pediatric versus adult medulloblastoma: towards a definition that goes beyond age. Cancers (Basel). 2021, 13:4567. 10.3390\/cancers13246313","journal-title":"Cancers (Basel)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.1930.tb06503.x","article-title":"Experiences with the cerebellar medulloblastomas: a critical review","volume":"7","author":"Cushing H","year":"1930","unstructured":"Cushing H. Experiences with the cerebellar medulloblastomas: a critical review. Acta Pathol Microbiol Scand. 1930, 7:1-86. 10.1111\/j.1600-0463.1930.tb06503.x","journal-title":"Acta Pathol Microbiol Scand"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.1.0013","article-title":"Medulloblastoma: is the 5-year survival rate improving? A review of 80 cases from a single institution","volume":"86","author":"David KM","year":"1997","unstructured":"David KM, Casey AT, Hayward RD, Harkness WF, Phipps K, Wade AM. Medulloblastoma: is the 5-year survival rate improving? A review of 80 cases from a single institution. J Neurosurg. 1997, 86:13-21. 10.3171\/jns.1997.86.1.0013","journal-title":"J Neurosurg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12811","article-title":"The molecular biology of medulloblastoma metastasis","volume":"30","author":"Van Ommeren R","year":"2020","unstructured":"Van Ommeren R, Garzia L, Holgado BL, Ramaswamy V, Taylor MD. The molecular biology of medulloblastoma metastasis. Brain Pathol. 2020, 30:691-702. 10.1111\/bpa.12811","journal-title":"Brain Pathol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.10.857","article-title":"\"Large cell\/anaplastic\" medulloblastomas: a Pediatric Oncology Group Study","volume":"59","author":"Brown HG","year":"2000","unstructured":"Brown HG, Kepner JL, Perlman EJ, et al.. \"Large cell\/anaplastic\" medulloblastomas: a Pediatric Oncology Group Study. J Neuropathol Exp Neurol. 2000, 59:857-865. 10.1093\/jnen\/59.10.857","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22339","article-title":"Large cell\/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors","volume":"54","author":"von Hoff K","year":"2010","unstructured":"von Hoff K, Hartmann W, von Bueren AO, Gerber NU, Grotzer MA, Pietsch T, Rutkowski S. Large cell\/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors. Pediatr Blood Cancer. 2010, 54:369-376. 10.1002\/pbc.22339","journal-title":"Pediatr Blood Cancer"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdaa089","article-title":"Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis","volume":"2","author":"Muskens IS","year":"2020","unstructured":"Muskens IS, Feng Q, Francis SS, et al.. Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis. Neurooncol Adv. 2020, 2:vdaa089. 10.1093\/noajnl\/vdaa089","journal-title":"Neurooncol Adv"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09862-0","article-title":"Incidence trends of childhood central nervous system tumors in Finland 1990-2017","volume":"22","author":"Abuhamed J","year":"2022","unstructured":"Abuhamed J, Nikkil\u00e4 A, Raitanen J, et al.. Incidence trends of childhood central nervous system tumors in Finland 1990-2017. BMC Cancer. 2022, 22:784. 10.1186\/s12885-022-09862-0","journal-title":"BMC Cancer"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000501913","article-title":"Medulloblastoma: distinctive histo-molecular correlation with clinical profile, radiologic characteristics, and surgical outcome","volume":"54","author":"Narayan V","year":"2019","unstructured":"Narayan V, Sugur H, Jaiswal J, Arvinda HR, Arivazhagan A, Somanna S, Santosh V. Medulloblastoma: distinctive histo-molecular correlation with clinical profile, radiologic characteristics, and surgical outcome. Pediatr Neurosurg. 2019, 54:329-340. 10.1159\/000501913","journal-title":"Pediatr Neurosurg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.181","article-title":"Medulloblastoma-translating discoveries from the bench to the bedside","volume":"11","author":"Gajjar AJ","year":"2014","unstructured":"Gajjar AJ, Robinson GW. Medulloblastoma-translating discoveries from the bench to the bedside. Nat Rev Clin Oncol. 2014, 11:714-722. 10.1038\/nrclinonc.2014.181","journal-title":"Nat Rev Clin Oncol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107516","article-title":"Medulloblastoma: molecular understanding, treatment evolution, and new developments","volume":"210","author":"Liu X","year":"2020","unstructured":"Liu X, Ding C, Tan W, Zhang A. Medulloblastoma: molecular understanding, treatment evolution, and new developments. Pharmacol Ther. 2020, 210:107516. 10.1016\/j.pharmthera.2020.107516","journal-title":"Pharmacol Ther"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000029372","article-title":"Meta of classical chemotherapy compared with high-dose chemotherapy and autologous stem cell rescue in newly diagnosed medulloblastoma after radiotherapy","volume":"101","author":"Zhang M","year":"2022","unstructured":"Zhang M, Liu C, Zhou H, Wang W, Wang L, Shi B, Xue X. Meta of classical chemotherapy compared with high-dose chemotherapy and autologous stem cell rescue in newly diagnosed medulloblastoma after radiotherapy. Medicine (Baltimore). 2022, 101:e29372. 10.1097\/MD.0000000000029372","journal-title":"Medicine (Baltimore)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-023-06239-x","article-title":"Evolution of neurosurgical advances and nuances in medulloblastoma therapy","volume":"40","author":"Rechberger JS","year":"2024","unstructured":"Rechberger JS, Power EA, DeCuypere M, Daniels DJ. Evolution of neurosurgical advances and nuances in medulloblastoma therapy. Childs Nerv Syst. 2024, 40:1031-1044. 10.1007\/s00381-023-06239-x","journal-title":"Childs Nerv Syst"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29274","article-title":"Epidemiological characteristics and survival outcomes of children with medulloblastoma treated at the National Cancer Institute (INCA) in Rio de Janeiro, Brazil","volume":"69","author":"Oigman G","year":"2022","unstructured":"Oigman G, Osorio DS, Ferman S, et al.. Epidemiological characteristics and survival outcomes of children with medulloblastoma treated at the National Cancer Institute (INCA) in Rio de Janeiro, Brazil. Pediatr Blood Cancer. 2022, 69:e29274. 10.1002\/pbc.29274","journal-title":"Pediatr Blood Cancer"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29770","article-title":"Factors influencing outcomes of older children with medulloblastoma over 15\u00a0years in Peru, a resource-limited setting","volume":"69","author":"Diaz-Coronado RY","year":"2022","unstructured":"Diaz-Coronado RY, Reinecke JB, Stanek JR, et al.. Factors influencing outcomes of older children with medulloblastoma over 15\u00a0years in Peru, a resource-limited setting. Pediatr Blood Cancer. 2022, 69:e29770. 10.1002\/pbc.29770","journal-title":"Pediatr Blood Cancer"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-024-04664-9","article-title":"Pediatric neurosurgical medulloblastoma outcomes in La Paz, Bolivia: How a Lower Middle-Income Country (LMIC) institution in South America compares to the United States","volume":"168","author":"Lu VM","year":"2024","unstructured":"Lu VM, Brun JD, Niazi TN, Brun JD. Pediatric neurosurgical medulloblastoma outcomes in La Paz, Bolivia: How a Lower Middle-Income Country (LMIC) institution in South America compares to the United States. J Neurooncol. 2024, 168:275-282. 10.1007\/s11060-024-04664-9","journal-title":"J Neurooncol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1376574","article-title":"Impact of treatment and clinical characteristics on the survival of children with medulloblastoma in Mexico","volume":"14","author":"Salceda-Rivera V","year":"2024","unstructured":"Salceda-Rivera V, Tejocote-Romero I, Osorio DS, et al.. Impact of treatment and clinical characteristics on the survival of children with medulloblastoma in Mexico. Front Oncol. 2024, 14:1376574. 10.3389\/fonc.2024.1376574","journal-title":"Front Oncol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00581-1","article-title":"Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis","volume":"17","author":"Thompson EM","year":"2016","unstructured":"Thompson EM, Hielscher T, Bouffet E, et al.. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis. Lancet Oncol. 2016, 17:484-495. 10.1016\/S1470-2045(15)00581-1","journal-title":"Lancet Oncol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdac016","article-title":"Prognostic factors related to overall survival in adolescent and young adults with medulloblastoma: a systematic review","volume":"4","author":"Yan H","year":"2022","unstructured":"Yan H, Zabih V, Bartels U, Das S, Nathan P, Gupta S. Prognostic factors related to overall survival in adolescent and young adults with medulloblastoma: a systematic review. Neurooncol Adv. 2022, 4:vdac016. 10.1093\/noajnl\/vdac016","journal-title":"Neurooncol Adv"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/475820-children-with-medulloblastoma-surgical-outcomes-and-survival-challenges","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T01:49:51Z","timestamp":1779760191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/475820-children-with-medulloblastoma-surgical-outcomes-and-survival-challenges"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.109643","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,25]]}}}