{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:04:41Z","timestamp":1779876281851,"version":"3.53.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,27]]},"DOI":"10.7759\/cureus.109722","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T09:32:17Z","timestamp":1779874337000},"source":"Crossref","is-referenced-by-count":0,"title":["Premature Myocardial Infarction in Severe Hypothyroidism: A Case Report"],"prefix":"10.7759","author":[{"given":"Tambi","family":"Isaac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khatun","family":"Mstkhaleda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Lazarescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy","family":"Matta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.13559","article-title":"Hypothyroidism: a review","volume":"334","author":"Chaker L","year":"2025","unstructured":"Chaker L, Papaleontiou M. Hypothyroidism: a review. JAMA. 2025, 334:1750-60. 10.1001\/jama.2025.13559","journal-title":"JAMA"},{"key":"ref2","article-title":"Hypothyroidism: diagnosis and treatment","volume":"103","author":"Wilson SA","year":"2021","unstructured":"Wilson SA, Stem LA, Bruehlman RD. Hypothyroidism: diagnosis and treatment. Am Fam Physician. 2021, 103:605-13.","journal-title":"Am Fam Physician"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30703-1","article-title":"Hypothyroidism","volume":"390","author":"Chaker L","year":"2017","unstructured":"Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017, 390:1550-62. 10.1016\/S0140-6736(17)30703-1","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(24)02431-8","article-title":"Association of subclinical hypothyroidism and cardiovascular disorders","volume":"83","author":"Ebrahimi R","year":"2024","unstructured":"Ebrahimi R, Dennis P. Association of subclinical hypothyroidism and cardiovascular disorders. JACC. 2024, 83:441. 10.1016\/S0735-1097(24)02431-8","journal-title":"JACC"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.21.2467","article-title":"Subclinical thyroid dysfunction as a risk factor for cardiovascular disease","volume":"165","author":"Walsh JP","year":"2005","unstructured":"Walsh JP, Bremner AP, Bulsara MK, et al.. Subclinical thyroid dysfunction as a risk factor for cardiovascular disease. Arch Intern Med. 2005, 165:2467-72. 10.1001\/archinte.165.21.2467","journal-title":"Arch Intern Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-4-200002150-00004","article-title":"Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study","volume":"132","author":"Hak AE","year":"2000","unstructured":"Hak AE, Pols HA, Visser TJ, et. al. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med. 2000, 132:270-8. 10.7326\/0003-4819-132-4-200002150-00004","journal-title":"Ann Intern Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:24:1:001","article-title":"Hypothyroidism as a risk factor for cardiovascular disease","volume":"24","author":"Biondi B","year":"2004","unstructured":"Biondi B, Klein I. Hypothyroidism as a risk factor for cardiovascular disease. Endocrine. 2004, 24:1-13. 10.1385\/ENDO:24:1:001","journal-title":"Endocrine"},{"key":"ref8","article-title":"Coexistence of hypothyroidism and myocardial infarction","volume":"11","author":"Comtois R","year":"1995","unstructured":"Comtois R, Lemay C, Lalibert\u00e9 A. Coexistence of hypothyroidism and myocardial infarction. Can J Cardiol. 1995, 11:37-42.","journal-title":"Can J Cardiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.174","article-title":"Thyroid hormones and cardiovascular disease","volume":"14","author":"Jabbar A","year":"2017","unstructured":"Jabbar A, Pingitore A, Pearce SH, Zaman A, Iervasi G, Razvi S. Thyroid hormones and cardiovascular disease. Nat Rev Cardiol. 2017, 14:39-55. 10.1038\/nrcardio.2016.174","journal-title":"Nat Rev Cardiol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.52512","article-title":"Hypothyroidism and cardiovascular disease: a review","volume":"16","author":"Z\u00fa\u00f1iga D","year":"2024","unstructured":"Z\u00fa\u00f1iga D, Balasubramanian S, Mehmood KT, Al-Baldawi S, Z\u00fa\u00f1iga Salazar G. Hypothyroidism and cardiovascular disease: a review. Cureus. 2024, 16:e52512. 10.7759\/cureus.52512","journal-title":"Cureus"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.101119","article-title":"Early-onset myocardial infarction in adults under 45: a review of five cases","volume":"18","author":"Matta S","year":"2026","unstructured":"Matta S, Isaac T, Lazarescu R, Zafar M, Prabhu H. Early-onset myocardial infarction in adults under 45: a review of five cases. Cureus. 2026, 18:e101119. 10.7759\/cureus.101119","journal-title":"Cureus"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-68-2-338","article-title":"Myxedema and coronary artery disease - a comparative autopsy study.","volume":"68","author":"Steinberg AD","year":"1968","unstructured":"Steinberg AD. Myxedema and coronary artery disease - a comparative autopsy study.. Ann Intern Med. 1968, 68:338-44. 10.7326\/0003-4819-68-2-338","journal-title":"Ann Intern Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440707","article-title":"Thyroid hormone and the cardiovascular system","volume":"344","author":"Klein I","year":"2001","unstructured":"Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med. 2001, 344:501-9. 10.1056\/NEJM200102153440707","journal-title":"N Engl J Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/480359-premature-myocardial-infarction-in-severe-hypothyroidism-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T09:32:18Z","timestamp":1779874338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/480359-premature-myocardial-infarction-in-severe-hypothyroidism-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.109722","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,27]]}}}