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J Am Soc Echocardiogr. 2022, 35:329-54. 10.1016\/j.echo.2021.12.012","journal-title":"J Am Soc Echocardiogr"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23608","article-title":"Exploratory echocardiographic strain parameters for the estimation of myocardial infarct size in ST-elevation myocardial infarction","volume":"44","author":"Dannenberg V","year":"2021","unstructured":"Dannenberg V, Christiansen F, Schneider M, et al.. Exploratory echocardiographic strain parameters for the estimation of myocardial infarct size in ST-elevation myocardial infarction. 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J Cardiovasc Dev Dis. 2022, 9:357. 10.3390\/jcdd9100357","journal-title":"J Cardiovasc Dev Dis"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2024.03.012","article-title":"Cardiac magnetic resonance evaluation of LV remodeling post-myocardial infarction: prognosis, monitoring and trial endpoints","volume":"17","author":"Gissler MC","year":"2024","unstructured":"Gissler MC, Antiochos P, Ge Y, Heydari B, Gr\u00e4ni C, Kwong RY. Cardiac magnetic resonance evaluation of LV remodeling post-myocardial infarction: prognosis, monitoring and trial endpoints. 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Biomarker assessment for early infarct size estimation in ST-elevation myocardial infarction. Eur J Intern Med. 2019, 64:57-62. 10.1016\/j.ejim.2019.03.001","journal-title":"Eur J Intern Med"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.09.537","article-title":"Predictive value of NT-pro BNP after acute myocardial infarction: relation with acute and chronic infarct size and myocardial function","volume":"147","author":"Mayr A","year":"2011","unstructured":"Mayr A, Mair J, Schocke M, et al.. Predictive value of NT-pro BNP after acute myocardial infarction: relation with acute and chronic infarct size and myocardial function. 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Clin Chem Lab Med. 2007, 45:226-31. 10.1515\/CCLM.2007.040","journal-title":"Clin Chem Lab Med"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.01.026","article-title":"Prognostic value of short-term follow-up B-type natriuretic peptide levels after hospital discharge in patients with acute myocardial infarction","volume":"289","author":"Lee JW","year":"2019","unstructured":"Lee JW, Choi E, Khanam SS, et al.. Prognostic value of short-term follow-up B-type natriuretic peptide levels after hospital discharge in patients with acute myocardial infarction. Int J Cardiol. 2019, 289:19-23. 10.1016\/j.ijcard.2019.01.026","journal-title":"Int J Cardiol"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02325-4","article-title":"Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations","volume":"29","author":"Doudesis D","year":"2023","unstructured":"Doudesis D, Lee KK, Boeddinghaus J, et al.. 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