{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:22:14Z","timestamp":1782476534348,"version":"3.54.5"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,29]]},"DOI":"10.7759\/cureus.109889","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:47:35Z","timestamp":1780080455000},"source":"Crossref","is-referenced-by-count":1,"title":["Anaphylactic Shock Following Multiple Self-Medication Exposures in a Patient With Rheumatoid Arthritis Receiving Methotrexate: A Case Report"],"prefix":"10.7759","author":[{"given":"Mobeen","family":"Sajjad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammeullah","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs in children and adolescents: selective reactions","volume":"25","author":"Blanca-L\u00f3pez N","year":"2015","unstructured":"Blanca-L\u00f3pez N, Cornejo-Garc\u00eda JA, P\u00e9rez-Alzate D, et al.. Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs in children and adolescents: selective reactions. J Investig Allergol Clin Immunol. 2015, 25:385-95.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12260","article-title":"Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs","volume":"68","author":"Kowalski ML","year":"2013","unstructured":"Kowalski ML, Asero R, Bavbek S, et al.. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy. 2013, 68:1219-32. 10.1111\/all.12260","journal-title":"Allergy"},{"key":"ref3","article-title":"Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients","volume":"22","author":"Do\u00f1a I","year":"2012","unstructured":"Do\u00f1a I, Blanca-L\u00f3pez N, Torres MJ, et al.. Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients. J Investig Allergol Clin Immunol. 2012, 22:363-71.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-857x(05)70358-6","article-title":"The mechanism of action of methotrexate","volume":"23","author":"Cronstein BN","year":"1997","unstructured":"Cronstein BN. The mechanism of action of methotrexate. Rheum Dis Clin North Am. 1997, 23:739-55. 10.1016\/s0889-857x(05)70358-6","journal-title":"Rheum Dis Clin North Am"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/106002809202600219","article-title":"Methotrexate and nonsteroidal antiinflammatory drug interactions","volume":"26","author":"Frenia ML","year":"1992","unstructured":"Frenia ML, Long KS. Methotrexate and nonsteroidal antiinflammatory drug interactions. Ann Pharmacother. 1992, 26:234-7. 10.1177\/106002809202600219","journal-title":"Ann Pharmacother"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1303","article-title":"Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease\/Food Allergy and Anaphylaxis Network symposium","volume":"117","author":"Sampson HA","year":"2006","unstructured":"Sampson HA, Mu\u00f1oz-Furlong A, Campbell RL, et al.. Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease\/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006, 117:391-7. 10.1016\/j.jaci.2005.12.1303","journal-title":"J Allergy Clin Immunol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S164806","article-title":"NSAID-induced reactions: classification, prevalence, impact, and management strategies","volume":"12","author":"Blanca-Lopez N","year":"2019","unstructured":"Blanca-Lopez N, Soriano V, Garcia-Martin E, Canto G, Blanca M. NSAID-induced reactions: classification, prevalence, impact, and management strategies. J Asthma Allergy. 2019, 12:217-33. 10.2147\/JAA.S164806","journal-title":"J Asthma Allergy"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo CA","year":"1981","unstructured":"Naranjo CA, Busto U, Sellers EM, et al.. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981, 30:239-45. 10.1038\/clpt.1981.154","journal-title":"Clin Pharmacol Ther"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194240","article-title":"Pattern of medication selling and self-medication practices: a study from Punjab, Pakistan","volume":"13","author":"Aziz MM","year":"2018","unstructured":"Aziz MM, Masood I, Yousaf M, Saleem H, Ye D, Fang Y. Pattern of medication selling and self-medication practices: a study from Punjab, Pakistan. PLoS One. 2018, 13:e0194240. 10.1371\/journal.pone.0194240","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62221-1","article-title":"Classification of allergic and pseudoallergic reactions to drugs that inhibit cyclooxygenase enzymes","volume":"87","author":"Stevenson DD","year":"2001","unstructured":"Stevenson DD, Sanchez-Borges M, Szczeklik A. Classification of allergic and pseudoallergic reactions to drugs that inhibit cyclooxygenase enzymes. Ann Allergy Asthma Immunol. 2001, 87:177-80. 10.1016\/S1081-1206(10)62221-1","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283036a90","article-title":"Understanding the mechanisms of anaphylaxis","volume":"8","author":"Peavy RD","year":"2008","unstructured":"Peavy RD, Metcalfe DD. Understanding the mechanisms of anaphylaxis. Curr Opin Allergy Clin Immunol. 2008, 8:310-5. 10.1097\/ACI.0b013e3283036a90","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-003-0289-0","article-title":"Pathologic thrombopoiesis of rheumatoid arthritis","volume":"23","author":"Ertenli I","year":"2003","unstructured":"Ertenli I, Kiraz S, Ozt\u00fcrk MA, Haznedaro\u011flu Ic, Celik I, Calg\u00fcneri M. Pathologic thrombopoiesis of rheumatoid arthritis. Rheumatol Int. 2003, 23:49-60. 10.1007\/s00296-003-0289-0","journal-title":"Rheumatol Int"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.12.012","article-title":"Prevalence and outcomes of anemia in rheumatoid arthritis: a systematic review of the literature","volume":"116","author":"Wilson A","year":"2004","unstructured":"Wilson A, Yu HT, Goodnough LT, Nissenson AR. Prevalence and outcomes of anemia in rheumatoid arthritis: a systematic review of the literature. Am J Med. 2004, 116:50S-7S. 10.1016\/j.amjmed.2003.12.012","journal-title":"Am J Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/art.20278","article-title":"Toward a better understanding of methotrexate","volume":"50","author":"Kremer JM","year":"2004","unstructured":"Kremer JM. Toward a better understanding of methotrexate. Arthritis Rheum. 2004, 50:1370-82. 10.1002\/art.20278","journal-title":"Arthritis Rheum"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e318211496c","article-title":"World Allergy Organization guidelines for the assessment and management of anaphylaxis","volume":"4","author":"Simons FE","year":"2011","unstructured":"Simons FE, Ardusso LR, Bil\u00f2 MB, et al.. World Allergy Organization guidelines for the assessment and management of anaphylaxis. World Allergy Organ J. 2011, 4:13-37. 10.1097\/WOX.0b013e318211496c","journal-title":"World Allergy Organ J"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/500618-anaphylactic-shock-following-multiple-self-medication-exposures-in-a-patient-with-rheumatoid-arthritis-receiving-methotrexate-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:47:37Z","timestamp":1780080457000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/500618-anaphylactic-shock-following-multiple-self-medication-exposures-in-a-patient-with-rheumatoid-arthritis-receiving-methotrexate-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.109889","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}