{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T02:01:25Z","timestamp":1780279285025,"version":"3.54.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,31]]},"DOI":"10.7759\/cureus.110003","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:34:46Z","timestamp":1780277686000},"source":"Crossref","is-referenced-by-count":0,"title":["Oral Contraceptive Use Associated With Lower Rates of Knee Instability After Anterior Cruciate Ligament (ACL) Reconstruction"],"prefix":"10.7759","author":[{"given":"Ronak J","family":"Mahatme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn A","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Gangavaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishanth","family":"Muthusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esha","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel K","family":"Gerak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M","family":"Grawe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2020.06.006","article-title":"Use of contraception among reproductive-aged women in the United States, 2014 and 2016","volume":"1","author":"Kavanaugh ML","year":"2020","unstructured":"Kavanaugh ML, Pliskin E. Use of contraception among reproductive-aged women in the United States, 2014 and 2016. F S Rep. 2020, 1:83-93. 10.1016\/j.xfre.2020.06.006","journal-title":"F S Rep"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-021-01410-8","article-title":"Trends in oral contraceptive and intrauterine device use among reproductive-aged women in the US from 1999 to 2017","volume":"32","author":"King LA","year":"2021","unstructured":"King LA, Michels KA, Graubard BI, Trabert B. Trends in oral contraceptive and intrauterine device use among reproductive-aged women in the US from 1999 to 2017. Cancer Causes Control. 2021, 32:587-95. 10.1007\/s10552-021-01410-8","journal-title":"Cancer Causes Control"},{"key":"ref3","article-title":"Oral contraceptives: mechanism of action, dosing, safety, and efficacy","volume":"81","author":"Sondheimer SJ","year":"2008","unstructured":"Sondheimer SJ. Oral contraceptives: mechanism of action, dosing, safety, and efficacy. Cutis. 2008, 81:19-22.","journal-title":"Cutis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00767-0","article-title":"Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause","volume":"4","author":"Camon C","year":"2024","unstructured":"Camon C, Garratt M, Correa SM. Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause. Nat Aging. 2024, 4:1731-44. 10.1038\/s43587-024-00767-0","journal-title":"Nat Aging"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46080483","article-title":"The role of estrogen across multiple disease mechanisms","volume":"46","author":"Xiang X","year":"2024","unstructured":"Xiang X, Palasuberniam P, Pare R. The role of estrogen across multiple disease mechanisms. Curr Issues Mol Biol. 2024, 46:8170-96. 10.3390\/cimb46080483","journal-title":"Curr Issues Mol Biol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16288","article-title":"Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor","volume":"111","author":"Ashcroft GS","year":"2003","unstructured":"Ashcroft GS, Mills SJ, Lei K, et al.. Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest. 2003, 111:1309-18. 10.1172\/JCI16288","journal-title":"J Clin Invest"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112325","article-title":"Estrogen effects on wound healing","volume":"18","author":"Horng HC","year":"2017","unstructured":"Horng HC, Chang WH, Yeh CC, et al.. Estrogen effects on wound healing. Int J Mol Sci. 2017, 18:2325. 10.3390\/ijms18112325","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0363546505282619","article-title":"Anterior cruciate ligament injuries in female athletes: part 2, a meta-analysis of neuromuscular interventions aimed at injury prevention","volume":"34","author":"Hewett TE","year":"2006","unstructured":"Hewett TE, Ford KR, Myer GD. Anterior cruciate ligament injuries in female athletes: part 2, a meta-analysis of neuromuscular interventions aimed at injury prevention. Am J Sports Med. 2006, 34:490-8. 10.1177\/0363546505282619","journal-title":"Am J Sports Med"},{"key":"ref9","article-title":"Menstrual cycle hormone relaxin and ACL injuries in female athletes: a systematic review","volume":"44","author":"Parker EA","year":"2024","unstructured":"Parker EA, Duchman KR, Meyer AM, Wolf BR, Westermann RW. Menstrual cycle hormone relaxin and ACL injuries in female athletes: a systematic review. Iowa Orthop J. 2024, 44:113-23.","journal-title":"Iowa Orthop J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.30574\/wjarr.2025.25.2.0497","article-title":"Jessica Amanda Hutapea. Estrogen deficiency and wound healing","volume":"25","author":"Oki AS","year":"2025","unstructured":"Oki AS, Ming CH, Nabiilah CC. Jessica Amanda Hutapea. Estrogen deficiency and wound healing. World J Adv Res Rev. 2025, 25:1479-1484. 10.30574\/wjarr.2025.25.2.0497","journal-title":"World J Adv Res Rev"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90935.2008","article-title":"Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women","volume":"106","author":"Hansen M","year":"2009","unstructured":"Hansen M, Kongsgaard M, Holm L, et al.. Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women. J Appl Physiol (1985). 2009, 106:1385-93. 10.1152\/japplphysiol.90935.2008","journal-title":"J Appl Physiol (1985)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241310145","article-title":"The effect of sex hormones on joint ligament properties: a systematic review and meta-analysis","volume":"53","author":"Gilmer G","year":"2025","unstructured":"Gilmer G, Crasta N, Tanaka MJ. The effect of sex hormones on joint ligament properties: a systematic review and meta-analysis. Am J Sports Med. 2025, 53:2738-48. 10.1177\/03635465241310145","journal-title":"Am J Sports Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003334","article-title":"Oral contraception use and musculotendinous injury in young female patients: a database study","volume":"56","author":"Rodriguez LA","year":"2024","unstructured":"Rodriguez LA, Liu Y, Soedirdjo SD, Thakur B, Dhaher YY. Oral contraception use and musculotendinous injury in young female patients: a database study. Med Sci Sports Exerc. 2024, 56:511-9. 10.1249\/MSS.0000000000003334","journal-title":"Med Sci Sports Exerc"},{"key":"ref14","unstructured":"The global truth engine for better human health. (2025). Accessed. August 6, 2025: https:\/\/trinetx.com."},{"key":"ref15","unstructured":"Current procedural terminology (CPT). (2025). Accessed. August 6, 2025: https:\/\/www.ama-assn.org\/practice-management\/cpt."},{"key":"ref16","unstructured":"ICD-10-CM. (2025). Accessed. August 6, 2025: https:\/\/www.cdc.gov\/nchs\/icd\/icd-10-cm\/index.html."},{"key":"ref17","unstructured":"RxNorm. (2025). Accessed. August 6, 2025: https:\/\/www.nlm.nih.gov\/research\/umls\/rxnorm\/."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s40634-022-00461-3","article-title":"Minimizing the risk of graft failure after anterior cruciate ligament reconstruction in athletes. A narrative review of the current evidence","volume":"9","author":"Costa GG","year":"2022","unstructured":"Costa GG, Perelli S, Grassi A, Russo A, Zaffagnini S, Monllau JC. Minimizing the risk of graft failure after anterior cruciate ligament reconstruction in athletes. A narrative review of the current evidence. J Exp Orthop. 2022, 9:26. 10.1186\/s40634-022-00461-3","journal-title":"J Exp Orthop"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080\/00913847.2019.1600334","article-title":"Oral contraceptives provide protection against anterior cruciate ligament tears: a national database study of 165,748 female patients","volume":"47","author":"DeFroda SF","year":"2019","unstructured":"DeFroda SF, Bokshan SL, Worobey S, Ready L, Daniels AH, Owens BD. Oral contraceptives provide protection against anterior cruciate ligament tears: a national database study of 165,748 female patients. Phys Sportsmed. 2019, 47:416-20. 10.1080\/00913847.2019.1600334","journal-title":"Phys Sportsmed"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s40621-020-00282-x","article-title":"Oral contraceptive use and anterior cruciate ligament injury: comparison of active comparator new user cohort and case-control study designs","volume":"7","author":"Herzog MM","year":"2020","unstructured":"Herzog MM, Young JC, Lund JL, Pate V, Mack CD, Marshall SW. Oral contraceptive use and anterior cruciate ligament injury: comparison of active comparator new user cohort and case-control study designs. Inj Epidemiol. 2020, 7:53. 10.1186\/s40621-020-00282-x","journal-title":"Inj Epidemiol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-021-00364-5","article-title":"Estrogen receptors in pain modulation: cellular signaling","volume":"12","author":"Chen Q","year":"2021","unstructured":"Chen Q, Zhang W, Sadana N, Chen X. Estrogen receptors in pain modulation: cellular signaling. Biol Sex Differ. 2021, 12:22. 10.1186\/s13293-021-00364-5","journal-title":"Biol Sex Differ"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.addicn.2023.100139","article-title":"Estradiol and mu opioid-mediated reward: the role of estrogen receptors in opioid use","volume":"9","author":"Ethridge SB","year":"2023","unstructured":"Ethridge SB, Smith MA. Estradiol and mu opioid-mediated reward: the role of estrogen receptors in opioid use. Addict Neurosci. 2023, 9:100139. 10.1016\/j.addicn.2023.100139","journal-title":"Addict Neurosci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.09.028","article-title":"Modulation of pain by estrogens","volume":"132","author":"Craft RM","year":"2007","unstructured":"Craft RM. Modulation of pain by estrogens. Pain. 2007, 132:S3-S12. 10.1016\/j.pain.2007.09.028","journal-title":"Pain"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/498289-oral-contraceptive-use-associated-with-lower-rates-of-knee-instability-after-anterior-cruciate-ligament-acl-reconstruction","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:34:47Z","timestamp":1780277687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/498289-oral-contraceptive-use-associated-with-lower-rates-of-knee-instability-after-anterior-cruciate-ligament-acl-reconstruction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.110003","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,31]]}}}