{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:20:55Z","timestamp":1785489655138,"version":"3.56.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"DOI":"10.7759\/cureus.110019","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:19:02Z","timestamp":1780301942000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinical Impact of Biofilm-Producing Carbapenem-Resistant Acinetobacter baumannii: Diagnosis and Treatment Challenges"],"prefix":"10.7759","author":[{"given":"Devika G","family":"Bhati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha V","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish R","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02260-23","article-title":"A global view on carbapenem-resistant Acinetobacter baumannii","volume":"14","author":"M\u00fcller C","year":"2023","unstructured":"M\u00fcller C, Reuter S, Wille J, et al.. A global view on carbapenem-resistant Acinetobacter baumannii. mBio. 2023, 14:e02260-23. 10.1128\/mbio.02260-23","journal-title":"mBio"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.111367","article-title":"Carbapenem-resistant Acinetobacter baumannii raises global alarm for new antibiotic regimens","volume":"27","author":"Thacharodi A","year":"2024","unstructured":"Thacharodi A, Vithlani A, Hassan S, Alqahtani A, Pugazhendhi A. Carbapenem-resistant Acinetobacter baumannii raises global alarm for new antibiotic regimens. iScience. 2024, 27:111367. 10.1016\/j.isci.2024.111367","journal-title":"iScience"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1196774","article-title":"Acinetobacter baumannii in the critically ill: complex infections get complicated","volume":"14","author":"Cavallo I","year":"2023","unstructured":"Cavallo I, Oliva A, Pages R, et al.. Acinetobacter baumannii in the critically ill: complex infections get complicated. Front Microbiol. 2023, 14:1196774. 10.3389\/fmicb.2023.1196774","journal-title":"Front Microbiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00092","article-title":"Acinetobacter baumannii ventilator-associated pneumonia: clinical efficacy of combined antimicrobial therapy and in vitro drug sensitivity test results","volume":"10","author":"Huang Y","year":"2019","unstructured":"Huang Y, Zhou Q, Wang W, et al.. Acinetobacter baumannii ventilator-associated pneumonia: clinical efficacy of combined antimicrobial therapy and in vitro drug sensitivity test results. Front Pharmacol. 2019, 10:92. 10.3389\/fphar.2019.00092","journal-title":"Front Pharmacol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2023.11908","article-title":"Drug\u2011resistant Acinetobacter\u00a0baumannii: from molecular mechanisms to potential therapeutics (Review)","volume":"25","author":"Wu HJ","year":"2023","unstructured":"Wu HJ, Xiao ZG, Lv XJ, et al.. Drug\u2011resistant Acinetobacter\u00a0baumannii: from molecular mechanisms to potential therapeutics (Review). Exp Ther Med. 2023, 25:209. 10.3892\/etm.2023.11908","journal-title":"Exp Ther Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-023-04677-8","article-title":"Co-regulation of biofilm formation and antimicrobial resistance in Acinetobacter baumannii: from mechanisms to therapeutic strategies","volume":"42","author":"Mendes SG","year":"2023","unstructured":"Mendes SG, Combo SI, Allain T, Domingues S, Buret AG, Da Silva GJ. Co-regulation of biofilm formation and antimicrobial resistance in Acinetobacter baumannii: from mechanisms to therapeutic strategies. Eur J Clin Microbiol Infect Dis. 2023, 42:1405-1423. 10.1007\/s10096-023-04677-8","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13399","article-title":"Understanding the biofilm development of Acinetobacter baumannii and novel strategies to combat infection","volume":"132","author":"Naseef Pathoor N","year":"2024","unstructured":"Naseef Pathoor N, Viswanathan A, Wadhwa G, Ganesh PS. Understanding the biofilm development of Acinetobacter baumannii and novel strategies to combat infection. APMIS. 2024, 132:317-335. 10.1111\/apm.13399","journal-title":"APMIS"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2022.100131","article-title":"Factors mediating Acinetobacter baumannii biofilm formation: opportunities for developing therapeutics","volume":"3","author":"Upmanyu K","year":"2022","unstructured":"Upmanyu K, Haq QMR, Singh R. Factors mediating Acinetobacter baumannii biofilm formation: opportunities for developing therapeutics. Curr Res Microb Sci. 2022, 3:100131. 10.1016\/j.crmicr.2022.100131","journal-title":"Curr Res Microb Sci"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11010171","article-title":"Carbapenem-resistant Acinetobacter baumannii: biofilm-associated genes, biofilm-eradication potential of disinfectants, and biofilm-inhibitory effects of selenium nanoparticles","volume":"11","author":"Smitran A","year":"2023","unstructured":"Smitran A, Lukovic B, Bozic L, et al.. Carbapenem-resistant Acinetobacter baumannii: biofilm-associated genes, biofilm-eradication potential of disinfectants, and biofilm-inhibitory effects of selenium nanoparticles. Microorganisms. 2023, 11:171. 10.3390\/microorganisms11010171","journal-title":"Microorganisms"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287211","article-title":"Prevalence of biofilm producing Acinetobacter baumannii clinical isolates: a systematic review and meta-analysis","volume":"18","author":"Gedefie A","year":"2023","unstructured":"Gedefie A, Alemayehu E, Mohammed O, Bambo GM, Kebede SS, Kebede B. Prevalence of biofilm producing Acinetobacter baumannii clinical isolates: a systematic review and meta-analysis. PLoS One. 2023, 18:e0287211. 10.1371\/journal.pone.0287211","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13080687","article-title":"Biofilm formation and antibiotic resistance profiles in Carbapenemase-producing gram-negative rods-a comparative analysis between screening and pathological isolates","volume":"13","author":"Vintil\u0103 C","year":"2024","unstructured":"Vintil\u0103 C, Co\u0219eriu RL, Mare AD, et al.. Biofilm formation and antibiotic resistance profiles in Carbapenemase-producing gram-negative rods-a comparative analysis between screening and pathological isolates. Antibiotics (Basel). 2024, 13:687. 10.3390\/antibiotics13080687","journal-title":"Antibiotics (Basel)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-09530-w","article-title":"Characterization of carbapenem-resistant biofilm forming Acinetobacter baumannii isolates from clinical and surveillance samples","volume":"15","author":"Choudhary J","year":"2025","unstructured":"Choudhary J, Shariff M. Characterization of carbapenem-resistant biofilm forming Acinetobacter baumannii isolates from clinical and surveillance samples. Sci Rep. 2025, 15:33892. 10.1038\/s41598-025-09530-w","journal-title":"Sci Rep"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02104-6","article-title":"Treatment approaches for carbapenem-resistant Acinetobacter baumannii infections","volume":"85","author":"Iovleva A","year":"2025","unstructured":"Iovleva A, Fowler VG Jr, Doi Y. Treatment approaches for carbapenem-resistant Acinetobacter baumannii infections. Drugs. 2025, 85:21-40. 10.1007\/s40265-024-02104-6","journal-title":"Drugs"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2023-0263","article-title":"Current treatment strategies for targeting virulence factors\u00a0and biofilm formation in Acinetobacter baumannii","volume":"19","author":"Rajangam SL","year":"2024","unstructured":"Rajangam SL, Narasimhan MK. Current treatment strategies for targeting virulence factors\u00a0and biofilm formation in Acinetobacter baumannii. Future Microbiol. 2024, 19:941-961. 10.2217\/fmb-2023-0263","journal-title":"Future Microbiol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-023-00525-w","article-title":"Acinetobacter baumannii biofilm and its potential therapeutic targets","volume":"9","author":"Mohamed EA","year":"2023","unstructured":"Mohamed EA, Raafat MM, Mohamed RS,  Eldin Ali AM. Acinetobacter baumannii biofilm and its potential therapeutic targets. Future J Pharm Sci. 2023, 9:82. 10.1186\/s43094-023-00525-w","journal-title":"Future J Pharm Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/ijm\/5749982","article-title":"Characterization and biofilm inhibition of multidrug-resistant Acinetobacter baumannii isolates","volume":"2024","author":"Yadav P","year":"2024","unstructured":"Yadav P, Shrestha S, Basyal D, et al.. Characterization and biofilm inhibition of multidrug-resistant Acinetobacter baumannii isolates. Int J Microbiol. 2024, 2024:5749982. 10.1155\/ijm\/5749982","journal-title":"Int J Microbiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S332051","article-title":"Acinetobacter baumannii biofilm formation and its role in disease pathogenesis: a review","volume":"14","author":"Gedefie A","year":"2021","unstructured":"Gedefie A, Demsis W, Ashagrie M, et al.. Acinetobacter baumannii biofilm formation and its role in disease pathogenesis: a review. Infect Drug Resist. 2021, 14:3711-3719. 10.2147\/IDR.S332051","journal-title":"Infect Drug Resist"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-020518-115714","article-title":"Acinetobacter baumannii: envelope determinants that control drug resistance, virulence, and surface variability","volume":"73","author":"Geisinger E","year":"2019","unstructured":"Geisinger E, Huo W, Hernandez-Bird J, Isberg RR. Acinetobacter baumannii: envelope determinants that control drug resistance, virulence, and surface variability. Annu Rev Microbiol. 2019, 73:481-506. 10.1146\/annurev-micro-020518-115714","journal-title":"Annu Rev Microbiol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/493561-clinical-impact-of-biofilm-producing-carbapenem-resistant-acinetobacter-baumannii-diagnosis-and-treatment-challenges","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:19:03Z","timestamp":1780301943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/493561-clinical-impact-of-biofilm-producing-carbapenem-resistant-acinetobacter-baumannii-diagnosis-and-treatment-challenges"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.110019","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,1]]}}}