{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:02:52Z","timestamp":1780430572542,"version":"3.54.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"DOI":"10.7759\/cureus.110138","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:19:22Z","timestamp":1780427962000},"source":"Crossref","is-referenced-by-count":0,"title":["Intracerebral Hemorrhage in a Middle-Aged Male With Classical Ehlers-Danlos Syndrome in the Absence of Macrovascular Lesions: A Case Report"],"prefix":"10.7759","author":[{"given":"Saud A","family":"Daghreeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A","family":"Laftal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaida","family":"Al Hunaif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afnan K","family":"Sibyani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552","article-title":"The 2017 international classification of the Ehlers-Danlos syndromes","volume":"175","author":"Malfait F","year":"2017","unstructured":"Malfait F, Francomano C, Byers P, et al.. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet. 2017, 175:8-26. 10.1002\/ajmg.c.31552","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421001","article-title":"Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type","volume":"342","author":"Pepin M","year":"2000","unstructured":"Pepin M, Schwarze U, Superti-Furga A, Byers PH. Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type. N Engl J Med. 2000, 342:673-80. 10.1056\/NEJM200003093421001","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.138","article-title":"Vascular phenotypes in nonvascular subtypes of the Ehlers-Danlos syndrome: a systematic review","volume":"20","author":"D'hondt S","year":"2018","unstructured":"D'hondt S, Van Damme T, Malfait F. Vascular phenotypes in nonvascular subtypes of the Ehlers-Danlos syndrome: a systematic review. Genet Med. 2018, 20:562-73. 10.1038\/gim.2017.138","journal-title":"Genet Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.043917","article-title":"Uncommon causes of nontraumatic intracerebral hemorrhage","volume":"55","author":"Tartarin H","year":"2024","unstructured":"Tartarin H, Morotti A, Van Etten ES, et al.. Uncommon causes of nontraumatic intracerebral hemorrhage. Stroke. 2024, 55:1416-27. 10.1161\/STROKEAHA.123.043917","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14310","article-title":"Hemostatic abnormalities in patients with Ehlers-Danlos syndrome","volume":"16","author":"Artoni A","year":"2018","unstructured":"Artoni A, Bassotti A, Abbattista M, et al.. Hemostatic abnormalities in patients with Ehlers-Danlos syndrome. J Thromb Haemost. 2018, 16:2425-31. 10.1111\/jth.14310","journal-title":"J Thromb Haemost"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.04.004","article-title":"Characterization of bleeding symptoms in Ehlers-Danlos syndrome","volume":"21","author":"Kumskova M","year":"2023","unstructured":"Kumskova M, Flora GD, Staber J, Lentz SR, Chauhan AK. Characterization of bleeding symptoms in Ehlers-Danlos syndrome. J Thromb Haemost. 2023, 21:1824-30. 10.1016\/j.jtha.2023.04.004","journal-title":"J Thromb Haemost"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020469","article-title":"Suspected mitochondrial dysfunction and complex pathophysiology in fatal hypermobile Ehlers-Danlos syndrome: insights from a case report and post-mortem findings","volume":"13","author":"Shirvani A","year":"2025","unstructured":"Shirvani A, Shirvani P, Jonah U, Moore BE, Holick MF. Suspected mitochondrial dysfunction and complex pathophysiology in fatal hypermobile Ehlers-Danlos syndrome: insights from a case report and post-mortem findings. Biomedicines. 2025, 13:469. 10.3390\/biomedicines13020469","journal-title":"Biomedicines"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.06.120","article-title":"Arterial complications of vascular Ehlers-Danlos syndrome","volume":"64","author":"Eagleton MJ","year":"2016","unstructured":"Eagleton MJ. Arterial complications of vascular Ehlers-Danlos syndrome. J Vasc Surg. 2016, 64:1869-80. 10.1016\/j.jvs.2016.06.120","journal-title":"J Vasc Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.32","article-title":"The type of variants at the COL3A1 gene associates with the phenotype and severity of vascular Ehlers-Danlos syndrome","volume":"23","author":"Frank M","year":"2015","unstructured":"Frank M, Albuisson J, Ranque B, et al.. The type of variants at the COL3A1 gene associates with the phenotype and severity of vascular Ehlers-Danlos syndrome. Eur J Hum Genet. 2015, 23:1657-64. 10.1038\/ejhg.2015.32","journal-title":"Eur J Hum Genet"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1514349","article-title":"A case of massive hematoma: reflections on hypermobile Ehlers-Danlos syndrome","volume":"12","author":"Liu Q","year":"2025","unstructured":"Liu Q, Zeng G, Xiong Y, Xu C. A case of massive hematoma: reflections on hypermobile Ehlers-Danlos syndrome. Front Med (Lausanne). 2025, 12:1514349. 10.3389\/fmed.2025.1514349","journal-title":"Front Med (Lausanne)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/497530-intracerebral-hemorrhage-in-a-middle-aged-male-with-classical-ehlers-danlos-syndrome-in-the-absence-of-macrovascular-lesions-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:19:23Z","timestamp":1780427963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/497530-intracerebral-hemorrhage-in-a-middle-aged-male-with-classical-ehlers-danlos-syndrome-in-the-absence-of-macrovascular-lesions-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":10,"URL":"https:\/\/doi.org\/10.7759\/cureus.110138","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,2]]}}}