{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:02:01Z","timestamp":1780729321666,"version":"3.54.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,5]]},"DOI":"10.7759\/cureus.110333","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:43:18Z","timestamp":1780728198000},"source":"Crossref","is-referenced-by-count":0,"title":["Methadone-Associated Delirium in Oncology and Palliative Care: A Clinical Perspective"],"prefix":"10.7759","author":[{"given":"Nandan M","family":"Shanbhag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehad","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1089\/10966210252785097","article-title":"Methadone use in cancer patients with pain: a review","volume":"5","author":"Bruera E","year":"2002","unstructured":"Bruera E, Sweeney C. Methadone use in cancer patients with pain: a review. J Palliat Med. 2002, 5:127-138. 10.1089\/10966210252785097","journal-title":"J Palliat Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-023-01117-9","article-title":"Opioid-induced neurotoxicity in patients with cancer pain","volume":"24","author":"Mercadante S","year":"2023","unstructured":"Mercadante S. Opioid-induced neurotoxicity in patients with cancer pain. Curr Treat Options Oncol. 2023, 24:1367-1377. 10.1007\/s11864-023-01117-9","journal-title":"Curr Treat Options Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1300\/J088v05n04_02","article-title":"Emerging neuropsychiatric toxicities of opioids","volume":"5","author":"Pereira J","year":"1997","unstructured":"Pereira J, Bruera E. Emerging neuropsychiatric toxicities of opioids. J Pharm Care Pain Symptom Control. 1997, 5:3-29. 10.1300\/J088v05n04_02","journal-title":"J Pharm Care Pain Symptom Control"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-199708010-00003","article-title":"CNS adverse effects of opioids in cancer patients","volume":"8","author":"Ripamonti C","year":"1997","unstructured":"Ripamonti C, Bruera E. CNS adverse effects of opioids in cancer patients. CNS Drugs. 1997, 8:21-37. 10.2165\/00023210-199708010-00003","journal-title":"CNS Drugs"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10389","article-title":"The panorama of opioid-related cognitive dysfunction in patients with cancer: a critical literature appraisal","volume":"94","author":"Lawlor PG","year":"2002","unstructured":"Lawlor PG. The panorama of opioid-related cognitive dysfunction in patients with cancer: a critical literature appraisal. Cancer. 2002, 94:1836-1853. 10.1002\/cncr.10389","journal-title":"Cancer"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000138294","article-title":"Reversible, narcotic-associated mental status impairment in patients with metastatic cancer","volume":"35","author":"Leipzig RM","year":"1987","unstructured":"Leipzig RM, Goodman H, Gray G, Erle H, Reidenberg MM. Reversible, narcotic-associated mental status impairment in patients with metastatic cancer. Pharmacology. 1987, 35:47-54. 10.1159\/000138294","journal-title":"Pharmacology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2018.0169","article-title":"Frequency, outcomes, and associated factors for opioid-induced neurotoxicity in patients with advanced cancer receiving opioids in inpatient palliative care","volume":"21","author":"Lim KH","year":"2018","unstructured":"Lim KH, Nguyen NN, Qian Y, Williams JL, Lui DD, Bruera E, Yennurajalingam S. Frequency, outcomes, and associated factors for opioid-induced neurotoxicity in patients with advanced cancer receiving opioids in inpatient palliative care. J Palliat Med. 2018, 21:1698-1704. 10.1089\/jpm.2018.0169","journal-title":"J Palliat Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2016.0502","article-title":"Methadone-induced neurotoxicity in advanced cancer: a case report","volume":"20","author":"Hoff AM","year":"2017","unstructured":"Hoff AM, Hartwig KN, Rosielle DA. Methadone-induced neurotoxicity in advanced cancer: a case report. J Palliat Med. 2017, 20:1042-1044. 10.1089\/jpm.2016.0502","journal-title":"J Palliat Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(00)00277-3","article-title":"Reversible delirium during opioid switching from transdermal fentanyl to methadone","volume":"21","author":"del Rosario MAB","year":"2001","unstructured":"del Rosario MAB, Feria M, Martin AS, Ortega JJM, Del Castillo LPM. Reversible delirium during opioid switching from transdermal fentanyl to methadone. J Pain Symptom Manage. 2001, 21:177-178. 10.1016\/S0885-3924(00)00277-3","journal-title":"J Pain Symptom Manage"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2019.0433","article-title":"Delirium prolonged for three days after addition of one dose of 5\u2009mg methadone to ongoing opioid","volume":"23","author":"Ikegaki J","year":"2020","unstructured":"Ikegaki J, Kizawa Y. Delirium prolonged for three days after addition of one dose of 5\u2009mg methadone to ongoing opioid. J Palliat Med. 2020, 23:164. 10.1089\/jpm.2019.0433","journal-title":"J Palliat Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24754","article-title":"Methadone initiation and rotation in the outpatient setting for patients with cancer pain","volume":"116","author":"Parsons HA","year":"2010","unstructured":"Parsons HA, de la Cruz M, El Osta B, Li Z, Calderon B, Palmer JL, Bruera E. Methadone initiation and rotation in the outpatient setting for patients with cancer pain. Cancer. 2010, 116:520-528. 10.1002\/cncr.24754","journal-title":"Cancer"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.13.128","article-title":"Rapid switching between transdermal fentanyl and methadone in cancer patients","volume":"23","author":"Mercadante S","year":"2005","unstructured":"Mercadante S, Ferrera P, Villari P, Casuccio A. Rapid switching between transdermal fentanyl and methadone in cancer patients. J Clin Oncol. 2005, 23:5229-5234. 10.1200\/JCO.2005.13.128","journal-title":"J Clin Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.10.3216","article-title":"Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?","volume":"16","author":"Ripamonti C","year":"1998","unstructured":"Ripamonti C, Groff L, Brunelli C, Polastri D, Stavrakis A, De Conno F. Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?. J Clin Oncol. 1998, 16:3216-3221. 10.1200\/JCO.1998.16.10.3216","journal-title":"J Clin Oncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s005200000180","article-title":"Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration","volume":"9","author":"Davis MP","year":"2001","unstructured":"Davis MP, Walsh D. Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration. Support Care Cancer. 2001, 9:73-83. 10.1007\/s005200000180","journal-title":"Support Care Cancer"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.11.2898","article-title":"Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study","volume":"19","author":"Mercadante S","year":"2001","unstructured":"Mercadante S, Casuccio A, Fulfaro F, et al.. Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study. J Clin Oncol. 2001, 19:2898-2904. 10.1200\/JCO.2001.19.11.2898","journal-title":"J Clin Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/495222-methadone-associated-delirium-in-oncology-and-palliative-care-a-clinical-perspective","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:43:18Z","timestamp":1780728198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/495222-methadone-associated-delirium-in-oncology-and-palliative-care-a-clinical-perspective"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.110333","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,5]]}}}