{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:13:46Z","timestamp":1780917226260,"version":"3.54.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"DOI":"10.7759\/cureus.110438","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:36:17Z","timestamp":1780914977000},"source":"Crossref","is-referenced-by-count":0,"title":["Orthopaedic Oncology in Contemporary Practice: A Comprehensive Review of Primary Bone Tumours, Metastatic Pathways, and Evolving Surgical Techniques"],"prefix":"10.7759","author":[{"given":"Parishekh Paulraj","family":"Jawahar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinandan H","family":"A","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utkarsh","family":"Mahera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parampreet Singh","family":"Mundh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jassim Rahiman","family":"K","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Kumar","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanta","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.O.01015","article-title":"What\u2019s new in orthopaedic oncology","volume":"97","author":"Lozano Calder\u00f3n SA","year":"2015","unstructured":"Lozano Calder\u00f3n SA, Raskin KA, Hornicek F, Schwab JH. What\u2019s new in orthopaedic oncology. J Bone Joint Surg Am. 2015, 97:2061-7. 10.2106\/JBJS.O.01015","journal-title":"J Bone Joint Surg Am"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00409-y","article-title":"Osteosarcoma","volume":"8","author":"Beird HC","year":"2022","unstructured":"Beird HC, Bielack SS, Flanagan AM, et al.. Osteosarcoma. Nat Rev Dis Primers. 2022, 8:77. 10.1038\/s41572-022-00409-y","journal-title":"Nat Rev Dis Primers"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388","article-title":"The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin MB","year":"2017","unstructured":"Amin MB, Greene FL, Edge SB, et al.. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging. CA Cancer J Clin. 2017, 67:93-9. 10.3322\/caac.21388","journal-title":"CA Cancer J Clin"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/PCR.0000000000000245","article-title":"Pathologic staging of bone and soft tissue tumors: what is new in the eighth edition of the American Joint Committee on Cancer staging manual?","volume":"23","author":"Laurini JA","year":"2018","unstructured":"Laurini JA, Cooper K. Pathologic staging of bone and soft tissue tumors: what is new in the eighth edition of the American Joint Committee on Cancer staging manual?. AJSP Rev Rep. 2018, 23:149-56. 10.1097\/PCR.0000000000000245","journal-title":"AJSP Rev Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.105B10.BJJ-2023-0443.R1","article-title":"The British Orthopaedic Oncology Management (BOOM) audit","volume":"105-B","author":"Archer JE","year":"2023","unstructured":"Archer JE, Chauhan GS, Dewan V, et al.. The British Orthopaedic Oncology Management (BOOM) audit. Bone Joint J. 2023, 105-B:1115-22. 10.1302\/0301-620X.105B10.BJJ-2023-0443.R1","journal-title":"Bone Joint J"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.106B5.BJJ-2023-1381","article-title":"Controversies in orthopaedic oncology","volume":"106-B","author":"Jeys LM","year":"2024","unstructured":"Jeys LM, Thorkildsen J, Kurisunkal V, et al.. Controversies in orthopaedic oncology. Bone Joint J. 2024, 106-B:425-9. 10.1302\/0301-620X.106B5.BJJ-2023-1381","journal-title":"Bone Joint J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-22-00039","article-title":"Investigation of fellowship leadership in orthopaedic musculoskeletal oncology","volume":"6","author":"Moore ML","year":"2022","unstructured":"Moore ML, Elahi MA, Doan MK, et al.. Investigation of fellowship leadership in orthopaedic musculoskeletal oncology. J Am Acad Orthop Surg Glob Res Rev. 2022, 6:e22.00039. 10.5435\/JAAOSGlobal-D-22-00039","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-19-00271","article-title":"The changing nature of the oncology section of the orthopaedic in-training examination","volume":"28","author":"Schultz EM","year":"2020","unstructured":"Schultz EM, Frisby JC, Miskiel SA, Patel DK, Mulcahey MK, Kim TW. The changing nature of the oncology section of the orthopaedic in-training examination. J Am Acad Orthop Surg. 2020, 28:e532-9. 10.5435\/JAAOS-D-19-00271","journal-title":"J Am Acad Orthop Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-19-00181","article-title":"The quality of online orthopaedic oncology information","volume":"4","author":"Zade RT","year":"2020","unstructured":"Zade RT, Tartaglione JP, Chisena E, Adams CT, DiCaprio MR. The quality of online orthopaedic oncology information. J Am Acad Orthop Surg Glob Res Rev. 2020, 4:e19.00181. 10.5435\/JAAOSGlobal-D-19-00181","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-12561-6","article-title":"Trends in reimbursement for index surgical oncology procedures in contemporary practice: declining reimbursement for surgical oncology procedures-how low do we go?","volume":"29","author":"Hydrick TC","year":"2022","unstructured":"Hydrick TC, Haglin J, Wasif N. Trends in reimbursement for index surgical oncology procedures in contemporary practice: declining reimbursement for surgical oncology procedures-how low do we go?. Ann Surg Oncol. 2022, 29:8099-106. 10.1245\/s10434-022-12561-6","journal-title":"Ann Surg Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-22-00132","article-title":"Medicare payment for orthopaedic oncology procedures over the past 20 years","volume":"6","author":"Pollock JR","year":"2022","unstructured":"Pollock JR, Richman EH, Kuttner NP, et al.. Medicare payment for orthopaedic oncology procedures over the past 20 years. J Am Acad Orthop Surg Glob Res Rev. 2022, 6:e22.00132. 10.5435\/JAAOSGlobal-D-22-00132","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2023.10.015","article-title":"Open science practices need substantial improvement in prognostic model studies in oncology using machine learning","volume":"165","author":"Collins GS","year":"2024","unstructured":"Collins GS, Whittle R, Bullock GS, et al.. Open science practices need substantial improvement in prognostic model studies in oncology using machine learning. J Clin Epidemiol. 2024, 165:111199. 10.1016\/j.jclinepi.2023.10.015","journal-title":"J Clin Epidemiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-021-01774-z","article-title":"The use of mobile applications for the diagnosis and treatment of tumors in orthopaedic oncology: a systematic review","volume":"45","author":"Berger-Groch J","year":"2021","unstructured":"Berger-Groch J, Keitsch M, Reiter A, Weiss S, Frosch KH, Priemel M. The use of mobile applications for the diagnosis and treatment of tumors in orthopaedic oncology: a systematic review. J Med Syst. 2021, 45:99. 10.1007\/s10916-021-01774-z","journal-title":"J Med Syst"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvaf064","article-title":"EndoCompass project: research roadmap for calcium and bone endocrinology","volume":"193","author":"J\u00e4hn-Rickert K","year":"2025","unstructured":"J\u00e4hn-Rickert K, Zibar Tom\u0161i\u0107 K, Anastasilakis AD, et al.. EndoCompass project: research roadmap for calcium and bone endocrinology. Eur J Endocrinol. 2025, 193:ii23-34. 10.1093\/ejendo\/lvaf064","journal-title":"Eur J Endocrinol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1302\/2633-1462.210.BJO-2021-0077.R1","article-title":"Transfusion in orthopaedic surgery : a retrospective multicentre cohort study","volume":"2","author":"Blankstein AR","year":"2021","unstructured":"Blankstein AR, Houston BL, Fergusson DA, et al.. Transfusion in orthopaedic surgery : a retrospective multicentre cohort study. Bone Jt Open. 2021, 2:850-7. 10.1302\/2633-1462.210.BJO-2021-0077.R1","journal-title":"Bone Jt Open"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.107B2.BJJ-2024-0643.R1","article-title":"Identifying consensus and areas for future research in chondrosarcoma: a report from the Birmingham Orthopaedic Oncology Meeting","volume":"107-B","author":"Jeys LM","year":"2025","unstructured":"Jeys LM, Morris GV, Kurisunkal VJ, et al.. Identifying consensus and areas for future research in chondrosarcoma: a report from the Birmingham Orthopaedic Oncology Meeting. Bone Joint J. 2025, 107-B:246-52. 10.1302\/0301-620X.107B2.BJJ-2024-0643.R1","journal-title":"Bone Joint J"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.102B12.BJJ-2019-1136.R3","article-title":"Venous thromboembolism in orthopaedic oncology","volume":"102-B","author":"Lex JR","year":"2020","unstructured":"Lex JR, Evans S, Cool P, et al.. Venous thromboembolism in orthopaedic oncology. Bone Joint J. 2020, 102-B:1743-51. 10.1302\/0301-620X.102B12.BJJ-2019-1136.R3","journal-title":"Bone Joint J"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.19.00182","article-title":"Musculoskeletal infection in orthopaedic oncology: assessment of the 2018 international consensus meeting on musculoskeletal infection","volume":"101","author":"Strony J","year":"2019","unstructured":"Strony J, Brown S, Choong P, Ghert M, Jeys L, O'Donnell RJ. Musculoskeletal infection in orthopaedic oncology: assessment of the 2018 international consensus meeting on musculoskeletal infection. J Bone Joint Surg Am. 2019, 101:e107. 10.2106\/JBJS.19.00182","journal-title":"J Bone Joint Surg Am"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01212-6","article-title":"Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma","volume":"27","author":"Jerby-Arnon L","year":"2021","unstructured":"Jerby-Arnon L, Neftel C, Shore ME, et al.. Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma. Nat Med. 2021, 27:289-300. 10.1038\/s41591-020-01212-6","journal-title":"Nat Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.012","article-title":"Histone H3.3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis","volume":"183","author":"Chen CC","year":"2020","unstructured":"Chen CC, Deshmukh S, Jessa S, et al.. Histone H3.3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis. Cell. 2020, 183:1617-1633.e22. 10.1016\/j.cell.2020.11.012","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400019RR","article-title":"The molecular biology of NF2\/merlin on tumorigenesis and development","volume":"38","author":"Vlashi R","year":"2024","unstructured":"Vlashi R, Sun F, Zheng C, Zhang X, Liu J, Chen G. The molecular biology of NF2\/merlin on tumorigenesis and development. FASEB J. 2024, 38:e23809. 10.1096\/fj.202400019RR","journal-title":"FASEB J"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.01.010","article-title":"Transcriptional regulation of the Warburg effect in cancer by SIX1","volume":"33","author":"Li L","year":"2018","unstructured":"Li L, Liang Y, Kang L, et al.. Transcriptional regulation of the Warburg effect in cancer by SIX1. Cancer Cell. 2018, 33:368-385.e7. 10.1016\/j.ccell.2018.01.010","journal-title":"Cancer Cell"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00994","article-title":"Insulin-like growth factor 2 mRNA-binding protein 3 modulates aggressiveness of Ewing sarcoma by regulating the CD164-CXCR4 axis","volume":"10","author":"Mancarella C","year":"2020","unstructured":"Mancarella C, Caldoni G, Ribolsi I, et al.. Insulin-like growth factor 2 mRNA-binding protein 3 modulates aggressiveness of Ewing sarcoma by regulating the CD164-CXCR4 axis. Front Oncol. 2020, 10:994. 10.3389\/fonc.2020.00994","journal-title":"Front Oncol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00313","article-title":"Role of tumor-derived chemokines in osteolytic bone metastasis","volume":"9","author":"Coniglio SJ","year":"2018","unstructured":"Coniglio SJ. Role of tumor-derived chemokines in osteolytic bone metastasis. Front Endocrinol (Lausanne). 2018, 9:313. 10.3389\/fendo.2018.00313","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1100585","article-title":"Osteoid cell-derived chemokines drive bone-metastatic prostate cancer","volume":"13","author":"Johnson CS","year":"2023","unstructured":"Johnson CS, Cook LM. Osteoid cell-derived chemokines drive bone-metastatic prostate cancer. Front Oncol. 2023, 13:1100585. 10.3389\/fonc.2023.1100585","journal-title":"Front Oncol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28050290","article-title":"Current overview of treatment for metastatic bone disease","volume":"28","author":"Tsukamoto S","year":"2021","unstructured":"Tsukamoto S, Kido A, Tanaka Y, Facchini G, Peta G, Rossi G, Mavrogenis AF. Current overview of treatment for metastatic bone disease. Curr Oncol. 2021, 28:3347-72. 10.3390\/curroncol28050290","journal-title":"Curr Oncol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-020-00105-1","article-title":"Molecular mechanisms and clinical management of cancer bone metastasis","volume":"8","author":"Wang M","year":"2020","unstructured":"Wang M, Xia F, Wei Y, Wei X. Molecular mechanisms and clinical management of cancer bone metastasis. Bone Res. 2020, 8:30. 10.1038\/s41413-020-00105-1","journal-title":"Bone Res"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31020067","article-title":"Biopsy techniques for musculoskeletal tumors: basic principles and specialized techniques","volume":"31","author":"Mavrogenis AF","year":"2024","unstructured":"Mavrogenis AF, Altsitzioglou P, Tsukamoto S, Errani C. Biopsy techniques for musculoskeletal tumors: basic principles and specialized techniques. Curr Oncol. 2024, 31:900-17. 10.3390\/curroncol31020067","journal-title":"Curr Oncol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-07836-w","article-title":"Internal validation of modified Mirels' scoring system for pathologic femur fractures","volume":"25","author":"Desai VS","year":"2024","unstructured":"Desai VS, Amendola RL, Mann KA, Damron TA. Internal validation of modified Mirels' scoring system for pathologic femur fractures. BMC Musculoskelet Disord. 2024, 25:719. 10.1186\/s12891-024-07836-w","journal-title":"BMC Musculoskelet Disord"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06182-7","article-title":"Modification to Mirels scoring system location component improves fracture prediction for metastatic disease of the proximal femur","volume":"24","author":"Amendola RL","year":"2023","unstructured":"Amendola RL, Miller MA, Kaupp SM, Cleary RJ, Damron TA, Mann KA. Modification to Mirels scoring system location component improves fracture prediction for metastatic disease of the proximal femur. BMC Musculoskelet Disord. 2023, 24:65. 10.1186\/s12891-023-06182-7","journal-title":"BMC Musculoskelet Disord"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000001303","article-title":"Can a novel scoring system improve on the Mirels score in predicting the fracture risk in patients with multiple myeloma?","volume":"479","author":"Toci GR","year":"2021","unstructured":"Toci GR, Bressner JA, Morris CD, Fayad L, Levin AS. Can a novel scoring system improve on the Mirels score in predicting the fracture risk in patients with multiple myeloma?. Clin Orthop Relat Res. 2021, 479:521-30. 10.1097\/CORR.0000000000001303","journal-title":"Clin Orthop Relat Res"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.979201","article-title":"Efficacy and safety of stereotactic body radiotherapy for painful bone metastases: evidence from randomized controlled trials","volume":"12","author":"Wang Z","year":"2022","unstructured":"Wang Z, Li L, Yang X, et al.. Efficacy and safety of stereotactic body radiotherapy for painful bone metastases: evidence from randomized controlled trials. Front Oncol. 2022, 12:979201. 10.3389\/fonc.2022.979201","journal-title":"Front Oncol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2015.02.002","article-title":"Stereotactic body radiotherapy","volume":"27","author":"Dahele M","year":"2015","unstructured":"Dahele M, McLaren DB. Stereotactic body radiotherapy. Clin Oncol (R Coll Radiol). 2015, 27:249-50. 10.1016\/j.clon.2015.02.002","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1177\/1533033818800497","article-title":"Stereotactic body radiotherapy as an alternative to definitive surgery in cancers of various organs","volume":"17","author":"Shibamoto Y","year":"2018","unstructured":"Shibamoto Y, Onishi H. Stereotactic body radiotherapy as an alternative to definitive surgery in cancers of various organs. Technol Cancer Res Treat. 2018, 17:1533033818800497. 10.1177\/1533033818800497","journal-title":"Technol Cancer Res Treat"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.12.051","article-title":"Clinical outcomes after stereotactic body radiation therapy for nonspinal bone metastases: a systematic review and meta-analysis","volume":"119","author":"Singh R","year":"2024","unstructured":"Singh R, Valluri A, Lehrer EJ, et al.. Clinical outcomes after stereotactic body radiation therapy for nonspinal bone metastases: a systematic review and meta-analysis. Int J Radiat Oncol Biol Phys. 2024, 119:1099-109. 10.1016\/j.ijrobp.2023.12.051","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-19-00219","article-title":"Endoprosthetic reconstruction of the upper extremity in oncologic surgery","volume":"28","author":"Hennessy DW","year":"2020","unstructured":"Hennessy DW, Raskin KA, Schwab JH, Lozano-Calder\u00f3n SA. Endoprosthetic reconstruction of the upper extremity in oncologic surgery. J Am Acad Orthop Surg. 2020, 28:e319-27. 10.5435\/JAAOS-D-19-00219","journal-title":"J Am Acad Orthop Surg"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-24-00201","article-title":"Intercalary diaphyseal endoprosthetic reconstruction","volume":"9","author":"Damron TA","year":"2025","unstructured":"Damron TA, Malhotra A. Intercalary diaphyseal endoprosthetic reconstruction. J Am Acad Orthop Surg Glob Res Rev. 2025, 9:e24.00201. 10.5435\/JAAOSGlobal-D-24-00201","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1055\/a-1284-6896","article-title":"Endoprosthetics of the upper ankle joint (Article in German)","volume":"160","author":"Dohle J","year":"2022","unstructured":"Dohle J, Stukenborg-Colsman C, Plaa\u00df C. Endoprosthetics of the upper ankle joint (Article in German). Z Orthop Unfall. 2022, 160:341-60. 10.1055\/a-1284-6896","journal-title":"Z Orthop Unfall"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2024.02.021","article-title":"Robotic-assisted pediatric thoracic and abdominal tumor resection: an initial multi-center review","volume":"59","author":"Svetanoff WJ","year":"2024","unstructured":"Svetanoff WJ, Carter M, Diefenbach KA, et al.. Robotic-assisted pediatric thoracic and abdominal tumor resection: an initial multi-center review. J Pediatr Surg. 2024, 59:1619-25. 10.1016\/j.jpedsurg.2024.02.021","journal-title":"J Pediatr Surg"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-024-02131-5","article-title":"Navigation assistance in orthopedic oncosurgery: our early experience","volume":"16","author":"Bary A","year":"2025","unstructured":"Bary A, Gupta A, Meghashyam KS, Agarwal M. Navigation assistance in orthopedic oncosurgery: our early experience. Indian J Surg Oncol. 2025, 16:732-42. 10.1007\/s13193-024-02131-5","journal-title":"Indian J Surg Oncol"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000001108","article-title":"Mangled extremity: limb salvage for reconstruction versus primary amputation","volume":"29","author":"Tjardes T","year":"2023","unstructured":"Tjardes T, Marche B, Imach S. Mangled extremity: limb salvage for reconstruction versus primary amputation. Curr Opin Crit Care. 2023, 29:682-8. 10.1097\/MCC.0000000000001108","journal-title":"Curr Opin Crit Care"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-021-03008-x","article-title":"Primary amputation versus limb salvage in upper limb major trauma: a systematic review","volume":"32","author":"Nayar SK","year":"2022","unstructured":"Nayar SK, Alcock HM, Edwards DS. Primary amputation versus limb salvage in upper limb major trauma: a systematic review. Eur J Orthop Surg Traumatol. 2022, 32:395-403. 10.1007\/s00590-021-03008-x","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-023-04804-2","article-title":"Limb salvage versus primary amputation in Gustilo-Anderson IIIB and IIIC tibial fractures: a systematic review and meta-analysis","volume":"143","author":"Ng HJ","year":"2023","unstructured":"Ng HJ, Ang EJ, Premchand AX, Rajaratnam V. Limb salvage versus primary amputation in Gustilo-Anderson IIIB and IIIC tibial fractures: a systematic review and meta-analysis. Arch Orthop Trauma Surg. 2023, 143:4961-76. 10.1007\/s00402-023-04804-2","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.105B8.BJJ-2022-1418.R1","article-title":"Prophylactic antibiotics for massive endoprostheses in orthopaedic oncology","volume":"105-B","author":"Azamgarhi T","year":"2023","unstructured":"Azamgarhi T, Warren S, Fouch S, Standing JF, Gerrand C. Prophylactic antibiotics for massive endoprostheses in orthopaedic oncology. Bone Joint J. 2023, 105-B:850-6. 10.1302\/0301-620X.105B8.BJJ-2022-1418.R1","journal-title":"Bone Joint J"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2020.0015","article-title":"The role of interventional radiology in elective orthopaedic practice","volume":"81","author":"Truneh T","year":"2020","unstructured":"Truneh T, Lintin L, Warakaulle D, Mckean D. The role of interventional radiology in elective orthopaedic practice. Br J Hosp Med (Lond). 2020, 81:1-10. 10.12968\/hmed.2020.0015","journal-title":"Br J Hosp Med (Lond)"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2022.220130R1","article-title":"Spondylolysis and isthmic spondylolisthesis: a guide to diagnosis and management","volume":"35","author":"Mohile NV","year":"2022","unstructured":"Mohile NV, Kuczmarski AS, Lee D, Warburton C, Rakoczy K, Butler AJ. Spondylolysis and isthmic spondylolisthesis: a guide to diagnosis and management. J Am Board Fam Med. 2022, 35:1204-16. 10.3122\/jabfm.2022.220130R1","journal-title":"J Am Board Fam Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/494884-orthopaedic-oncology-in-contemporary-practice-a-comprehensive-review-of-primary-bone-tumours-metastatic-pathways-and-evolving-surgical-techniques","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:36:19Z","timestamp":1780914979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/494884-orthopaedic-oncology-in-contemporary-practice-a-comprehensive-review-of-primary-bone-tumours-metastatic-pathways-and-evolving-surgical-techniques"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":46,"URL":"https:\/\/doi.org\/10.7759\/cureus.110438","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,8]]}}}